LOCUS       EF589388                 648 bp    mRNA    linear   HUM 25-JAN-2021
DEFINITION  Homo sapiens clone AL-080L immunoglobulin lambda 6 light chain
            mRNA, partial cds.
ACCESSION   EF589388
VERSION     EF589388.2
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 648)
  AUTHORS   Prokaeva,T., Spencer,B., Kaut,M., Ozonoff,A., Doros,G.,
            Connors,L.H., Skinner,M. and Seldin,D.C.
  TITLE     Soft tissue, joint, and bone manifestations of AL amyloidosis:
            clinical presentation, molecular features, and survival
  JOURNAL   Arthritis Rheum. 56 (11), 3858-3868 (2007)
   PUBMED   17968927
REFERENCE   2  (bases 1 to 648)
  AUTHORS   Ward,J.E., Prokaeva,T., Spencer,B., Bodi,K.L., Seldin,D.C. and
            Skinner,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (01-MAY-2007) Amyloid Treatment and Research Program,
            Boston University School of Medicine, 715 Albany Street, K-510,
            Boston, MA 02118, USA
COMMENT     On Jan 25, 2021 this sequence version replaced EF589388.1.
FEATURES             Location/Qualifiers
     source          1..648
                     /db_xref="H-InvDB:HIT000469207"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /isolation_source="patient with primary amyloidosis"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /clone="AL-080L"
                     /cell_type="plasma cells"
                     /tissue_type="bone marrow"
     CDS             <1..>648
                     /codon_start=1
                     /product="immunoglobulin lambda 6 light chain"
                     /protein_id="ABU90549.2"
                     /translation="NFMLTQPHSVSESPGKTVTISCTRSSGSIVTNYVHWYQQRPGSL
                     PTTVIYEDNQRPSGVPDRFSGSIDSSSNSASLTISGLKTEDEADYYCQSYDSDSYVFG
                     TGTKVTVLGQPKANPTVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADGSPVK
                     AGVETTKPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS"
     V_region        1..300
                     /note="IGLV6-57*01"
     misc_feature    1..75
                     /note="FR1-IMGT"
     misc_feature    76..99
                     /note="CDR1-IMGT"
     misc_feature    100..150
                     /note="FR2-IMGT"
     misc_feature    151..159
                     /note="CDR2-IMGT"
     misc_feature    160..273
                     /note="FR3-IMGT"
     misc_feature    274..300
                     /note="CDR3-IMGT"
     J_segment       293..331
                     /note="IGLJ1*01"
     misc_feature    301..331
                     /note="FR4-IMGT"
     C_region        331..648
                     /note="IGLC1*02"
BASE COUNT          153 a          207 c          165 g          123 t
ORIGIN      
        1 aattttatgc tgactcagcc ccactctgtg tcggagtctc cggggaagac ggtcaccatc
       61 tcctgcaccc gcagcagtgg cagcattgtc accaactatg tgcactggta ccagcagcgc
      121 ccgggcagct tgcccaccac tgtgatctat gaagataacc aaagaccctc tggggtccct
      181 gatcggttct ctggctccat cgacagctcc tccaactctg cctccctcac catctctgga
      241 ctgaagactg aggacgaggc tgactactac tgtcagtctt atgatagcga ctcttatgtc
      301 ttcggaactg ggaccaaggt caccgtccta ggtcagccca aggccaaccc cactgtcact
      361 ctgttcccgc cctcctctga ggagctccaa gccaacaagg ccacactagt gtgtctgatc
      421 agtgacttct acccgggagc tgtgacagtg gcctggaagg cagatggcag ccccgtcaag
      481 gcgggagtgg agaccaccaa accctccaaa cagagcaaca acaagtacgc ggccagcagc
      541 tacctgagcc tgacgcccga gcagtggaag tcccacagaa gctacagttg ccaggtcacg
      601 catgaaggga gcaccgtgga gaagacagtg gcccctacag aatgttca
//