LOCUS EF559316 3425 bp mRNA linear HUM 21-NOV-2007
DEFINITION Homo sapiens NKCC2 variant A (SLC12A1) mRNA, complete cds.
ACCESSION EF559316
VERSION EF559316.2
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3425)
AUTHORS Di Fulvio,M., Garzon-Muvdi,T. and Alvarez-Leefmans,F.J.
TITLE Molecular cloning and characterization of NKCC2A in non-renal
tissues
JOURNAL Unpublished
REFERENCE 2 (bases 1 to 3425)
AUTHORS Di Fulvio,M., Garzon-Muvdi,T. and Alvarez-Leefmans,F.J.
TITLE Direct Submission
JOURNAL Submitted (16-APR-2007) Pharmacology & Toxicology, Wright State
University, 3640 Colonel Glenn Hwy, 063 MSB, Dayton, OH 45435, USA
REFERENCE 3 (bases 1 to 3425)
AUTHORS Di Fulvio,M., Garzon-Muvdi,T. and Alvarez-Leefmans,F.J.
TITLE Direct Submission
JOURNAL Submitted (21-NOV-2007) Pharmacology & Toxicology, Wright State
University, 3640 Colonel Glenn Hwy, 063 MSB, Dayton, OH 45435, USA
REMARK Sequence update by submitter
COMMENT On Nov 21, 2007 this sequence version replaced EF559316.1.
FEATURES Location/Qualifiers
source 1..3425
/db_xref="H-InvDB:HIT000469077"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/tissue_type="dorsal root ganglion"
gene 1..3425
/gene="SLC12A1"
CDS 15..3314
/gene="SLC12A1"
/note="Na/K/2Cl cotransporter; solute carrier protein"
/codon_start=1
/product="NKCC2 variant A"
/protein_id="ABU69043.2"
/translation="MSLNNSSNVFLDSVPSNTNRFQVSVINENHESSAAADDNTDPPH
YEETSFGDEAQKRLRISFRPGNQECYDNFLQSGETAKTDASFHAYDSHTNTYYLQTFG
HNTMDAVPKIEYYRNTGSISGPKVNRPSLLEIHEQLAKNVAVTPSSADRVANGDGIPG
DEQAENKEDDQAGVVKFGWVKGVLVRCMLNIWGVMLFIRLSWIVGEAGIGLGVLIILL
STMVTSITGLSTSAIATNGFVRGGGAYYLISRSLGPEFGGSIGLIFAFANAVAVAMYV
VGFAETVVDLLKESDSMMVDPTNDIRIIGSITVVILLGISVAGMEWEAKAQVILLVIL
LIAIANFFIGTVIPSNNEKKSRGFFNYQASIFAENFGPRFTKGEGFFSVFAIFFPAAT
GILAGANISGDLEDPQDAIPRGTMLAIFITTVAYLGVAICVGACVVRDATGNMNDTII
SGMNCNGSAACGLGYDFSRCRHEPCQYGLMNNFQVMSMVSGFGPLITAGIFSATLSSA
LASLVSAPKVFQALCKDNIYKALQFFAKGYGKNNEPLRGYILTFLIAMAFILIAELNT
IAPIISNFFLASYALINFSCFHASYAKSPGWRPAYGIYNMWVSLFGAVLCCAVMFVIN
WWAAVITYVIEFFLYVYVTCKKPDVNWGSSTQALSYVSALDNALELTTVEDHVKNFRP
QCIVLTGGPMTRPALLDITHAFTKNSGLCICCEVFVGPRKLCVKEMNSGMAKKQAWLI
KNKIKAFYAAVAADCFRDGVRSLLQASGLGRMKPNTLVIGYKKNWRKAPLTEIENYVG
IIHDAFDFEIGVVIVRISQGFDISQVLQVQEELERLEQERLALEATIKDNECEEESGG
IRGLFKKAGKLNITKTTPKKDGSINTSQSMHVGEFNQKLVEASTQFKKKQEKGTIDVW
WLFDDGGLTLLIPYILTLRKKWKDCKLRIYVGGKINRIEEEKIAMASLLSKFRIKFAD
IHIIGDINIRPNKESWKVFEEMIEPYRLHESCKDLTTAEKLKRETPWKITDAELEAVK
EKSYRQVRLNELLQEHSRAANLIVLSLPVARKGSISDLLYMAWLEILTKNLPPVLLVR
GNHKNVLTFYS"
BASE COUNT 988 a 711 c 798 g 928 t
ORIGIN
1 atcaattttg gaagatgtca ctgaacaact cttccaatgt atttctggat tcagtgccca
61 gtaataccaa tcgctttcaa gttagtgtca taaatgagaa ccatgagagc agtgcagctg
121 cagatgacaa tactgaccca ccacattatg aagaaacctc ttttggggat gaagctcaga
181 aaagactcag aatcagcttt aggcctggga atcaggagtg ctatgacaat ttcctccaaa
241 gtggagaaac tgctaaaaca gatgccagtt ttcacgctta tgattctcac acaaacacat
301 actatctaca aacttttggc cacaacacca tggatgccgt tcccaagata gagtactatc
361 gtaacaccgg cagcatcagt gggcccaagg tcaaccgacc cagcctgctt gagattcacg
421 agcaactcgc aaagaatgtg gcagtcaccc caagttcagc tgacagagtt gctaacggtg
481 atgggatacc tggagatgaa caagctgaaa ataaggaaga tgatcaagct ggtgttgtga
541 agtttggatg ggtgaaaggt gtgctggtaa gatgcatgct gaacatctgg ggagtcatgc
601 tcttcattcg cctctcctgg attgttggag aagctggaat tggtcttgga gttctcataa
661 ttcttctttc caccatggta acttctatta ctgggttgtc aacttctgcg atagcaacta
721 acgggtttgt tcgtggaggt ggggcctact atcttatttc cagaagttta gggcccgagt
781 tcggtgggtc aataggcctg atctttgctt ttgctaatgc agtggctgtt gctatgtatg
841 tggtgggatt tgctgagact gtagtagatc ttcttaagga gagtgattcg atgatggtgg
901 atccaaccaa tgacatccgg attataggct ccatcacagt ggtgattctt ctaggaattt
961 cagtagctgg aatggaatgg gaggcaaagg cccaagtcat tcttctggtc attcttctaa
1021 ttgctattgc aaacttcttc attggaactg tcattccatc caacaatgag aaaaagtcca
1081 gaggtttctt taattaccaa gcatcaatat ttgcagaaaa ctttgggcca cgcttcacaa
1141 agggtgaagg cttcttctct gtctttgcca tttttttccc agcagctact gggattcttg
1201 ctggtgccaa tatctcagga gatttggagg atccccaaga tgccatcccc agaggaacca
1261 tgctggccat tttcatcacc actgttgcct acttaggggt tgcaatttgt gtaggggcct
1321 gtgtggtccg agatgccacc gggaacatga atgacaccat catttctggg atgaactgca
1381 atggttcagc agcatgtggg ttgggctatg acttctcaag atgtcgacat gaaccatgtc
1441 agtacgggct gatgaacaat ttccaggtca tgagcatggt atcagggttc ggccccctca
1501 tcactgcggg aatcttttct gcaacactct cctccgccct ggcctccctt gtcagcgcac
1561 ccaaagtgtt ccaggctctg tgcaaggaca acatctacaa agccctgcag ttttttgcaa
1621 agggatatgg gaaaaacaat gaacccctga gaggatatat tctcactttt cttatagcca
1681 tggcatttat tcttattgcg gaactgaaca ccattgctcc catcatctcc aactttttcc
1741 tggcctcata tgcacttatt aatttctcct gcttccatgc ctcttatgcc aaatctccag
1801 gatggagacc tgcgtatgga atttacaaca tgtgggtatc tctttttgga gctgttttgt
1861 gctgtgcagt catgtttgtc atcaactggt gggcagctgt catcacctat gtcattgaat
1921 tcttccttta cgtctatgtg acttgtaaga agccagatgt gaactggggc tcctccacac
1981 aggctctttc ctacgtgagt gctttagaca atgctctgga attaaccaca gtggaagacc
2041 acgtaaaaaa cttcaggccc cagtgcattg tcttaacagg gggacccatg acaagacctg
2101 ctctcctgga cataactcac gcctttacca agaacagtgg cctttgcatc tgctgtgaag
2161 tctttgtggg accgcgcaaa ctgtgtgtta aggagatgaa cagtggcatg gcgaaaaaac
2221 aggcctggct tataaagaac aaaatcaagg ctttttatgc tgcagtggcg gcagactgtt
2281 tcagggatgg tgtccgaagt cttcttcagg cctcaggctt aggaagaatg aaaccaaaca
2341 ctctggtgat tggatataag aaaaactgga ggaaagctcc cttgacagag attgagaact
2401 acgtgggaat catacatgat gcatttgatt ttgagattgg cgtggttata gtcagaatca
2461 gccaaggatt tgacatctct caggttcttc aggtgcaaga ggaattagag agattagaac
2521 aggagagact agcattggaa gcgactatca aagataatga gtgtgaagag gaaagtggag
2581 gcatccgagg cttgtttaaa aaagctggca agttgaacat tactaagaca acgcctaaaa
2641 aagatggcag cattaacaca agccagtcga tgcatgtggg agagttcaac cagaaattgg
2701 tggaagccag cactcaattt aaaaagaaac aagaaaaagg cacaattgat gtttggtggt
2761 tgtttgatga tggagggtta acacttctta tcccctatat cttaactctc agaaaaaaat
2821 ggaaagactg taaattaaga atctatgtgg gagggaagat caaccgcatt gaagaagaaa
2881 aaattgcaat ggcttccctt ctgagcaaat ttaggataaa atttgcagac atccatatca
2941 tcggtgacat caacattagg ccaaacaaag agagctggaa agtctttgaa gagatgattg
3001 aaccatatcg tctccatgaa agctgcaaag atttaacaac tgctgagaaa ttaaaaagag
3061 aaactccgtg gaaaattaca gatgcagaac tggaagcagt caaggaaaag agttaccgcc
3121 aagttcgact gaatgaactc ttacaggagc actccagagc tgctaatctc attgtcctga
3181 gccttcccgt ggcaagaaag ggatccatat cggatttgtt gtatatggct tggttggaaa
3241 tcctcacaaa gaacctccca cctgtcttac tagttagagg aaatcacaaa aatgtcttga
3301 cattttactc ttaaaacatg aaagattgga atacatttta acttaatgta atgcataatt
3361 aagaaacatg ttccagtact ttatgttgta aatctgatct atggatatgc aacctctgga
3421 gagga
//