LOCUS EF471397 1665 bp mRNA linear HUM 10-NOV-2009
DEFINITION Homo sapiens mahogunin variant 1.2 (MGRN1) mRNA, complete cds,
alternatively spliced.
ACCESSION EF471397
VERSION EF471397.2
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1665)
AUTHORS Perez-Oliva,A.B., Olivares,C., Jimenez-Cervantes,C. and
Garcia-Borron,J.C.
TITLE Mahogunin ring finger-1 (MGRN1) E3 ubiquitin ligase inhibits
signaling from melanocortin receptor by competition with Galphas
JOURNAL J. Biol. Chem. 284 (46), 31714-31725 (2009)
PUBMED 19737927
REFERENCE 2 (bases 1 to 1665)
AUTHORS Perez-Oliva,A.B., Garcia-Borron,J.C. and Jimenez-Cervantes,C.
TITLE Primary sequence of two new natural alternative-spliced variants of
the human MGRN1 gene
JOURNAL Unpublished
REFERENCE 3 (bases 1 to 1665)
AUTHORS Perez-Oliva,A.B., Garcia-Borron,J.C. and Jimenez-Cervantes,C.
TITLE Direct Submission
JOURNAL Submitted (06-MAR-2007) Biochemistry and Molecular Biology,
University of Murcia, Campus de Espinardo, Espinardo 30100, Spain
REFERENCE 4 (bases 1 to 1665)
AUTHORS Perez-Oliva,A.B., Garcia-Borron,J.C. and Jimenez-Cervantes,C.
TITLE Direct Submission
JOURNAL Submitted (12-DEC-2008) Biochemistry and Molecular Biology,
University of Murcia, Campus de Espinardo, Espinardo 30100, Spain
REMARK Sequence update by submitter
COMMENT On Dec 12, 2008 this sequence version replaced EF471397.1.
FEATURES Location/Qualifiers
source 1..1665
/db_xref="H-InvDB:HIT000395499"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="16"
/map="16p13.3"
gene 1..1665
/gene="MGRN1"
CDS 1..1665
/gene="MGRN1"
/note="putative E-3 ligase; alternatively spliced; lacks
exon 12"
/codon_start=1
/product="mahogunin variant 1.2"
/protein_id="ABO69623.2"
/translation="MGSILSRRIAGVEDIDIQANSAYRYPPKSGNYFASHFFMGGEKF
DTPHPEGYLFGENMDLNFLGSRPVQFPYVTPAPHEPVKTLRSLVNIRKDSLRLVRYKD
DADSPTEDGDKPRVLYSLEFTFDADARVAITIYCQASEEFLNGRAVYSPKSPSLQSET
VHYKRGVSQQFSLPSFKIDFSEWKDDELNFDLDRGVFPVVIQAVVDEGDVVEVTGHAH
VLLAAFEKHMDGSFSVKPLKQKQIVDRVSYLLQEIYGIENKNNQETKPSDDENSDNSN
ECVVCLSDLRDTLILPCRHLCLCTSCADTLRYQANNCPICRLPFRALLQIRAVRKKPG
ALSPVSFSPVLAQSLEHDEHSNSDSVPPGYEPISLLEALNGLRAVSPAIPSAPLYEEI
TYSGISDGLSQASCPLAAIDHILDSSRQKGRPQSKAPDSTLRSPSSPIHEEDEEKLSE
DVDAPPPLGGAELALRESSSPESFITEEVDESSSPQQGTRAASIENVLQDSSPEHCGR
GPPADIYLPGRPTSMETAHGLATTSPTWPPLGGPSPDPSAAELTPL"
BASE COUNT 342 a 579 c 459 g 285 t
ORIGIN
1 atgggctcca ttctcagccg ccgcatcgcg ggggtggagg acatcgacat ccaggcgaac
61 tcggcctatc gctaccctcc gaagtccgga aactactttg cttcgcactt tttcatggga
121 ggagagaaat tcgacacccc ccaccctgaa ggttacctct ttggagagaa catggatctg
181 aacttcctgg gcagccgccc ggtccagttt ccctacgtca ctcctgcccc ccacgagccc
241 gtgaagacgc tgcggagcct ggtgaacatc cgcaaagact ccctgcggct ggtgaggtac
301 aaagacgatg ccgacagccc caccgaggac ggcgacaagc cccgggtgct ctacagcctg
361 gagttcacct tcgacgccga tgcccgcgtg gccatcacca tctactgcca ggcatcggag
421 gagttcctga acggcagggc agtatacagc cccaagagcc cctcgctaca gtccgagacc
481 gtccactaca agagaggggt gagccagcag ttctccctgc cctccttcaa gattgacttc
541 tcggaatgga aggatgacga gctgaacttt gacctggacc ggggcgtgtt tccagtagtc
601 atccaggctg tggtggacga aggagatgtg gtggaagtga ctggccacgc ccacgtgctc
661 ttggctgcct ttgaaaagca catggacggc agcttctctg tgaagccttt aaagcagaag
721 caaattgtgg accgggtcag ctacctcctg caggagatct atggcattga gaacaagaac
781 aaccaggaga ccaagccctc ggacgacgag aacagcgaca acagcaacga gtgtgtggtg
841 tgcctgtccg acctgcggga cacgctgatc ctgccctgcc gccacctgtg cctctgtacc
901 tcctgcgccg acacgctgcg ctaccaggcc aacaactgcc ccatctgccg gctgcctttc
961 cgggccctcc tgcagatccg ggcggtgcgg aagaagccag gagccctgtc ccccgtgtcc
1021 ttcagccccg tcctggccca gagcctggag catgatgagc actctaactc tgacagcgtc
1081 ccacctggct acgagcccat ctcgctgctc gaggcgctca acggcctccg ggctgtctcc
1141 ccggccatcc cctcggcccc tctttatgaa gaaatcacct attcaggcat ctcggacggc
1201 ctgtcccagg ccagctgtcc cctcgcggct atcgaccaca tcctggacag cagccgccag
1261 aagggcaggc cgcagagcaa ggcccccgac agcaccctac ggtccccgtc ttcccccatc
1321 cacgaagagg atgaggagaa gctctccgag gacgtggacg cccctccccc actgggtggc
1381 gcagagctgg ccctgcggga aagcagctcc cctgagagtt tcataacaga agaggttgat
1441 gagtcgtcgt caccacagca agggacccga gcagcttcca ttgagaatgt cctgcaggac
1501 agcagccccg agcactgtgg ccgaggccca cctgctgaca tctacctgcc aggacggccc
1561 acctccatgg agacggccca cggcctcgcc accaccagcc ccacctggcc tccacttggt
1621 ggccccagcc ccgatcccag cgccgccgag ctgaccccac tctga
//