LOCUS EF467324 1450 bp mRNA linear HUM 05-MAY-2008
DEFINITION Homo sapiens virus-induced signaling adapter variant 1b (VISA)
mRNA, complete cds, alternatively spliced.
ACCESSION EF467324
VERSION EF467324.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1450)
AUTHORS Lad,S.P., Yang,G., Scott,D.A., Chao,T.H., Correia Jda,S., de la
Torre,J.C. and Li,E.
TITLE Identification of MAVS splicing variants that interfere with
RIGI/MAVS pathway signaling
JOURNAL Mol. Immunol. 45 (8), 2277-2287 (2008)
PUBMED 18207245
REFERENCE 2 (bases 1 to 1450)
AUTHORS Lad,S., Yang,G., Correia,J.D.S., Mathison,J. and Li,E.
TITLE Direct Submission
JOURNAL Submitted (02-MAR-2007) Immunology, The Scripps Research Institute,
10550 North Torrey Pines Road, La Jolla, CA 92037, USA
FEATURES Location/Qualifiers
source 1..1450
/db_xref="H-InvDB:HIT000468803"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/PCR_primers="fwd_seq: ggatccatgccgtttgctgaagacaag,
rev_seq: aagcttctagtgcagacgccgcc"
gene 1..1450
/gene="VISA"
CDS 1..375
/gene="VISA"
/note="VISA1b; exon 3 deletion induces frameshift; CARD
domain-containing; activates IRF3, inhibits VISA-induced
NF-kB activation; alternatively spliced"
/codon_start=1
/product="virus-induced signaling adapter variant 1b"
/protein_id="ABR24162.1"
/translation="MPFAEDKTYKYICRNFSNFCNVDVVEILPYLPCLTARDQDRLRA
TCTLSGNRDTLWHLFNTLQRRPGWVEYFIAALRGCELVDLADEVASVYQSYQPQFRAS
PADAQPQSHPKESRWWPPGVLL"
BASE COUNT 294 a 482 c 401 g 273 t
ORIGIN
1 atgccgtttg ctgaagacaa gacctataag tatatctgcc gcaatttcag caatttttgc
61 aatgtggatg ttgtagagat tctgccttac ctgccctgcc tcacagcaag agaccaggat
121 cgactgcggg ccacctgcac actctcaggg aaccgggaca ccctctggca tctcttcaat
181 acccttcagc ggcggcccgg ctgggtggag tacttcattg cggcactgag gggctgtgag
241 ctagttgatc tcgcggacga agtggcctct gtctaccaga gctaccagcc tcaattcaga
301 gcaagccctg cagacgctca gccccagagc catcccaagg aatccagatg gtggccccct
361 ggagtcctcc tctgacctgg cagccctcag ccctctgacc tccagcgggc atcaggagca
421 ggacacagaa ctgggcagta cccacacagc aggtgcgacc tccagcctca caccatcccg
481 tgggcctgtg tctccatctg tctccttcca gcccctggcc cgttccaccc ccagggcaag
541 ccgcttgcct ggacccacag ggtcagttgt atctactggc acctccttct cctcctcatc
601 ccctggcttg gcctctgcag gggctgcaga gggtaaacag ggtgcagaga gtgaccaggc
661 cgagcctatc atctgctcca gtggggcaga ggcacctgcc aactctctgc cctccaaagt
721 gcctaccacc ttgatgcctg tgaacacagt ggccctgaaa gtgcctgcca acccagcatc
781 tgtcagcaca gtgccctcca agttgccaac tagctcaaag ccccctggtg cagtgccttc
841 taatgcgctc accaatccag caccatccaa attgcccatc aactcaaccc gtgctggcat
901 ggtgccatcc aaagtgccta ctagcatggt gctcaccaag gtgtctgcca gcacagtccc
961 cactgacggg agcagcagaa atgaggagac cccagcagct ccaacacccg ccggcgccac
1021 tggaggcagc tcagcctggc tagacagcag ctctgagaat aggggccttg ggtcggagct
1081 gagtaagcct ggcgtgctgg catcccaggt agacagcccg ttctcgggct gcttcgagga
1141 tcttgccatc agtgccagca cctccttggg catggggccc tgccatggcc cagaggagaa
1201 tgagtataag tccgagggca cctttgggat ccacgtggct gagaacccca gcatccagct
1261 cctggagggc aaccctgggc cacctgcgga cccggatggc ggccccaggc cacaagccga
1321 ccggaagttc caggagaggg aggtgccatg ccacaggccc tcacctgggg ctctgtggct
1381 ccaggtggct gtgacagggg tgctggtagt cacactcctg gtggtgctgt accggcggcg
1441 tctgcactag
//