LOCUS DQ924532 5532 bp mRNA linear HUM 04-SEP-2007 DEFINITION Homo sapiens pleckstrin homology domain-interacting protein variant 1 (PHIP) mRNA, complete cds. ACCESSION DQ924532 VERSION DQ924532.1 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 5532) AUTHORS Podcheko,A., Northcott,P., Bikopoulos,G., Lee,A., Bommareddi,S.R., Kushner,J.A., Farhang-Fallah,J. and Rozakis-Adcock,M. TITLE Identification of a WD40 repeat-containing isoform of PHIP as a novel regulator of beta-cell growth and survival JOURNAL Mol. Cell. Biol. 27 (18), 6484-6496 (2007) PUBMED 17636024 REFERENCE 2 (bases 1 to 5532) AUTHORS Rozakis-Adcock,M. and Podcheko,A. TITLE Direct Submission JOURNAL Submitted (28-AUG-2006) Laboratory Medicine and Pathobiology, University of Toronto, 1 Kings College Circle, Toronto, ON M5S1A8, Canada FEATURES Location/Qualifiers source 1..5532 /db_xref="H-InvDB:HIT000468672" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="6" /map="6q14" gene 1..5532 /gene="PHIP" /gene_synonym="hPHIP1" /gene_synonym="WDR11" CDS 1..5466 /gene="PHIP" /gene_synonym="hPHIP1" /gene_synonym="WDR11" /note="WD40 and bromodomain-containing nuclear protein; regulation of growth and apoptosis, transcription regulator activity" /codon_start=1 /product="pleckstrin homology domain-interacting protein variant 1" /protein_id="ABK76299.1" /translation="MSCERKGLSELRSELYFLIARFLEDGPCQQAAQVLIREVAEKEL LPRRTDWTGKEHPRTYQNLVKYYRHLAPDHLLQICHRLGPLLEQEIPQSVPGVQTLLG AGRQSLLRTNKSCKHVVWKGSALAALHCGRPPESPVNYGSPPSIADTLFSRKLNGKYR LERLVPTAVYQHMKMHKRILGHLSSVYCVTFDRTGRRIFTGSDDCLVKIWATDDGRLL ATLRGHAAEISDMAVNYENTMIAAGSCDKMIRVWCLRTCAPLAVLQGHSASITSLQFS PLCSGSKRYLSSTGADGTICFWLWDAGTLKINPRPAKFTERPRPGVQMICSSFSAGGM FLATGSTDHIIRVYFFGSGQPEKISELEFHTDKVDSIQFSNTSNRFVSGSRDGTARIW QFKRREWKSILLDMATRPAGQNLQGIEDKITKMKVTMVAWDRHDNTVITAVNNMTLKV WNSYTGQLIHVLMGHEDEVFVLEPHPFDPRVLFSAGHDGNVIVWDLARGVKIRSYFNM IEGQGHGAVFDCKCSPDGQHFACTDSHGHLLIFGFGSSSKYDKIADQMFFHSDYRPLI RDANNFVLDEQTQQAPHLMPPPFLVDVDGNPHPSRYQRLVPGRENCREEQLIPQMGVT SSGLNQVLSQQANQEISPLDSMIQRLQQEQDLRRSGEAGISNTSRLSRGSISSTSEVH SPPNVGLRRSGQIEGVRQMHSNAPRSEIATERDLVAWSRRVVVPELSAGVASRQEEWR TAKGEEEIKTYRSEEKRKHLTVPKENKIPTVSKNHAHEHFLDLGESKKQQTNQHNYRT RSALEETPRPSEEIENGSSSSDEGEVVAVSGGTSEEEERAWHSDGSSSDYSSDYSDWT ADAGINLQPPKKVPKNKTKKAESSSDEEEESEKQKQKQIKKEKKKVNEEKDGPISPKK KKPKERKQKRLAVGELTENGLTLEEWLPSTWITDTIPRRCPFVPQMGDEVYYFRQGHE AYVEMARKNKIYSINPKKQPWHKMELREQELMKIVGIKYEVGLPTLCCLKLAFLDPDT GKLTGGSFTMKYHDMPDVIDFLVLRQQFDDAKYRRWNIGDRFRSVIDDAWWFGTIESQ EPLQLEYPDSLFQCYNVCWDNGDTEKMSPWDMELIPNNAVFPEELGTSVPLTDGECRS LIYKPLDGEWGTNPRDEECERIVAGINQLMTLDIASAFVAPVDLQAYPMYCTVVAYPT DLSTIKQRLENRFYRRVSSLMWEVRYIEHNTRTFNEPGSPIVKSAKFVTDLLLHFIKD QTCYNIIPLYNSMKKKVLSDSEDEEKDADVPGTSTRKRKDHQPRRRLRNRAQSYDIQA WKKQCEELLNLIFQCEDSEPFRQPVDLLEYPDYRDIIDTPMDFATVRETLEAGNYESP MELCKDVRLIFSNSKAYTPSKRSRIYSMSLRLSAFFEEHISSVLSDYKSALRFHKRNT ITKRRKKRNRSSSVSSSAASSPERKKRILKPQLKSESSTSAFSTPTRSIPPRHNAAQI NGKTESSSVVRTRSNRVVVDPVVTEQPSTSSAAKTFITKANASAIPGKTILENSVKHS KALNTLSSPGQSSFSHGTRNNSAKENMEKEKPVKRKMKSSVLPKASTLSKSSAVIEQG DCKNNALVPGTIQVNGHGGQPSKLVKRGPGRKPKVEVNTNSGEIIHKKRGRKPKKLQY AKPEDLEQNNVHPIRDEVLPSSTCNFLSETNNVKEDLLQKKNRGGRKPKRKMKTQKLD ADLLVPASVKVLRRSNRKKIDDPIDEEEEFEELKGSEPHMRTRNQGRRTAFYNEDDSE EEQRQLLFEDTSLTFGTSSRGRVRKLTEKAKANLIGW" BASE COUNT 1843 a 1055 c 1245 g 1389 t ORIGIN 1 atgtcttgtg agaggaaagg cctctcggag ctgcgatcgg agctctactt cctcatcgcc 61 cggttcctgg aagatggacc ctgtcagcag gcggctcagg tgctgatccg cgaggtggcc 121 gagaaggagc tgctgccccg gcgcaccgac tggaccggga aggagcatcc caggacctac 181 cagaatctgg tgaagtatta cagacactta gcacctgatc acttgctgca aatatgtcat 241 cgactaggac ctcttcttga acaagaaatt cctcaaagtg ttcctggagt acaaacttta 301 ttaggagctg gaagacagtc tttactacgc acaaataaaa gctgcaagca tgttgtgtgg 361 aaaggatctg ctctggctgc gttgcactgt ggaagaccac ctgagtcacc agttaactat 421 ggtagcccac ccagcattgc ggatactctg ttttcaagga agctgaatgg gaaatacaga 481 cttgagcgac ttgttccaac tgcagtgtat cagcacatga aaatgcataa acgaattctt 541 ggacacttgt catctgtgta ctgtgtaact tttgatcgaa ctggcagacg gatatttact 601 ggttctgatg actgtcttgt gaaaatatgg gcaacagatg atgggaggtt gttagctacc 661 ttaagaggac atgctgctga aatatcagac atggctgtaa actatgagaa taccatgata 721 gcagctggaa gttgtgataa aatgatccga gtctggtgtc ttcgaacctg tgcacctttg 781 gctgttcttc agggccatag tgcatctatt acatcactac agttctcacc attgtgcagt 841 ggctcaaaga gatatctatc ttctactggg gcagatggca ctatttgttt ttggctctgg 901 gatgctggaa cccttaaaat aaacccaaga cctgcaaaat ttacagagcg ccctcggcct 961 ggagttcaaa tgatctgttc ttcttttagt gctggtggaa tgtttctggc gacgggaagc 1021 acagatcata ttattcgggt ttattttttt ggatcaggtc agccagagaa aatatcagaa 1081 ttggagtttc atactgacaa agttgacagt atccagtttt ccaacactag taacaggttt 1141 gtaagtggca gtcgtgatgg gacagcacgt atttggcaat ttaaacgaag agagtggaag 1201 agcattttgt tggatatggc tactcgtcca gcaggccaaa accttcaagg aatagaagat 1261 aaaatcacaa aaatgaaggt tactatggta gcttgggatc gacatgacaa tacagttata 1321 actgcagtta ataacatgac tctgaaagtt tggaattctt acactggtca actaattcat 1381 gtcctgatgg gtcatgaaga tgaggtattt gttcttgaac cacacccgtt cgatcctaga 1441 gttctctttt ctgctggtca tgatggaaac gtgatagtgt gggatctggc aagaggagtc 1501 aaaatacgat cttatttcaa tatgattgaa ggccaaggac atggcgcagt atttgactgc 1561 aaatgctctc ctgatggtca gcattttgca tgcacagact ctcatggaca tcttttaatt 1621 tttggctttg ggtccagtag caaatatgac aagatagcag atcagatgtt ctttcatagt 1681 gattatcggc cacttattcg tgatgccaac aattttgtat tagatgaaca gactcagcaa 1741 gcacctcatc ttatgcctcc cccttttttg gttgatgttg atggtaaccc tcatccatca 1801 agatatcaaa gattagttcc tggccgtgaa aattgcaggg aggagcaact catccctcag 1861 atgggagtaa cttcctcagg actgaatcaa gttttaagtc agcaagcaaa ccaggagatc 1921 agcccactgg acagcatgat tcaaagacta caacaggagc aagacctgag acgttctggt 1981 gaagcaggta tcagtaatac cagccgttta agtagaggct ccataagttc tacctcagag 2041 gttcattcac caccaaacgt aggactaaga cgtagtggac aaattgaagg tgtacggcaa 2101 atgcacagca acgcaccaag aagtgaaata gccacagagc gggatctggt agcttggagt 2161 cgaagggtgg tagtacccga gctatcagct ggtgtagcca gtaggcaaga agaatggaga 2221 actgcaaagg gagaagaaga aataaagact tacaggtcag aagagaaaag aaaacactta 2281 actgttccaa aagagaataa aatacccact gtctcaaaga atcatgctca tgagcatttc 2341 ctggatcttg gagaatccaa aaagcaacag acaaatcaac acaattatcg tacaagatct 2401 gcattggaag agactcctag accctcagaa gagatagaaa atggcagtag ttcttcagat 2461 gaaggcgaag tagttgctgt cagtggtgga acatccgaag aagaagagag agcatggcac 2521 agtgatggca gttctagtga ctactccagt gattactctg actggacagc agatgcagga 2581 attaatctgc agccaccaaa gaaagttcct aagaataaaa ccaagaaagc agaaagcagt 2641 tcagatgaag aagaagaatc tgaaaaacag aagcaaaaac agattaaaaa ggaaaagaaa 2701 aaagtaaatg aagaaaaaga tggaccaata tcaccaaaga aaaagaagcc caaagaaaga 2761 aaacaaaaga gattggctgt gggagaacta actgaaaatg gtttgacatt agaagaatgg 2821 ttgccatcaa catggattac agataccatt ccccgaagat gtccatttgt gccacagatg 2881 ggtgatgagg tttattattt ccgacaagga catgaagcct atgtcgaaat ggcccggaaa 2941 aataaaatat atagtatcaa tcccaaaaaa caaccatggc ataaaatgga gctacgggaa 3001 caagaactta tgaaaatagt tggcataaag tatgaagtgg gattacctac cctttgctgc 3061 cttaaacttg cttttctaga tcctgatact ggtaaactga ctggcggatc atttaccatg 3121 aaataccatg atatgcctga cgttatagat ttcctagtct tgagacaaca atttgatgat 3181 gcaaaataca ggcgatggaa tataggtgac cgcttcaggt ctgtcataga tgatgcctgg 3241 tggtttggaa caatcgaaag ccaggaacct cttcaacttg agtaccctga tagtctgttt 3301 caatgctaca atgtttgctg ggacaatgga gatacagaaa agatgagtcc ttgggatatg 3361 gagcttatac ctaataatgc tgtatttcct gaagaactag gtaccagtgt tcctttaact 3421 gatggtgagt gcagatcact aatctataaa cctcttgatg gagaatgggg taccaatccc 3481 agggatgaag aatgtgaaag aattgtggca ggaataaacc agttgatgac actagatatt 3541 gcctcagcat ttgtggcccc cgtggatctg caagcctatc ccatgtattg cacagtagtg 3601 gcatatccaa cggatctaag tacaattaaa caaagactgg aaaacaggtt ttacaggcgg 3661 gtttcttccc taatgtggga agttcgatat atagagcata atacacgaac atttaatgag 3721 cctggaagcc ctattgtgaa atctgctaaa ttcgtgactg atcttcttct acattttata 3781 aaggatcaga cttgttataa cataattcca ctttataatt caatgaagaa gaaagttttg 3841 tctgattctg aggatgaaga gaaagatgct gatgtgccag gaacttctac tcgaaaaagg 3901 aaggaccatc agcctagaag aagattacgt aatagagccc agtcttacga tattcaagca 3961 tggaagaaac agtgtgaaga attgttaaat ctcatatttc aatgtgaaga ttcagagcct 4021 ttccgtcagc cggtagatct ccttgaatat ccagactaca gagacatcat tgacactcca 4081 atggattttg ctaccgttag agaaacttta gaggctggga attatgagtc accaatggag 4141 ttatgtaaag atgtcagact tattttcagt aattccaaag catatacacc aagcaaaaga 4201 tcaaggattt acagcatgag tttgcgcctg tctgctttct ttgaagaaca cattagttca 4261 gttttatcag attataaatc tgctcttcgt tttcataaaa gaaataccat aaccaaaagg 4321 aggaagaaaa gaaacagaag cagctctgtt tccagtagtg ctgcatcaag ccctgaaagg 4381 aaaaaaagga tcttaaaacc ccagctaaaa tcagaaagct ctacctctgc attctctaca 4441 cctacacgat caataccgcc aagacacaat gctgctcaga taaacggtaa aacagaatct 4501 agttctgtgg ttcgaaccag aagcaaccga gtggttgtag atccagttgt cactgagcaa 4561 ccatctactt cttcagctgc aaagactttt attacaaaag ctaatgcatc tgcaatacca 4621 gggaaaacaa tactagagaa ttctgtgaaa cattccaaag ctttgaatac tctttccagt 4681 cctggtcaat ccagttttag tcatggcact aggaataatt ctgcaaaaga aaacatggaa 4741 aaggaaaagc cagtcaaacg taaaatgaag tcatctgtac tcccaaaggc gtccactctt 4801 tcaaagtcat cagctgtcat tgagcaagga gattgtaaga acaacgctct tgtaccagga 4861 accattcaag taaatggcca tggaggacag ccatcaaaac ttgtgaagag gggacctgga 4921 aggaaaccta aagtagaagt taataccaat agtggtgaaa ttatacacaa gaaaaggggt 4981 agaaagccca aaaagctaca gtatgcaaag ccagaagatt tagagcaaaa taatgtgcat 5041 cccatcagag atgaagtact tccttcttca acatgcaatt ttctttctga aactaataat 5101 gtaaaggaag atttgttaca gaaaaagaat cgtggaggta ggaagcccaa aaggaagatg 5161 aagacacaaa aattagatgc agatctccta gtccctgcaa gtgtcaaagt gttaaggaga 5221 agtaaccgaa aaaagataga tgatcctata gatgaggaag aagagtttga agaactcaaa 5281 ggctctgaac cccacatgag aactagaaat caaggtcgaa ggacagcttt ctataatgag 5341 gatgactctg aagaggagca aaggcagctg ttgttcgaag acacctcttt aacttttgga 5401 acttctagta gaggacgagt ccgaaagttg actgaaaaag caaaagctaa tttaattggt 5461 tggtaacttg taccaaaata ttttacttca aaatctataa agcaggtaca gttaaggaat 5521 aagtagaact aa //