LOCUS       DQ924532                5532 bp    mRNA    linear   HUM 04-SEP-2007
DEFINITION  Homo sapiens pleckstrin homology domain-interacting protein variant
            1 (PHIP) mRNA, complete cds.
ACCESSION   DQ924532
VERSION     DQ924532.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5532)
  AUTHORS   Podcheko,A., Northcott,P., Bikopoulos,G., Lee,A., Bommareddi,S.R.,
            Kushner,J.A., Farhang-Fallah,J. and Rozakis-Adcock,M.
  TITLE     Identification of a WD40 repeat-containing isoform of PHIP as a
            novel regulator of beta-cell growth and survival
  JOURNAL   Mol. Cell. Biol. 27 (18), 6484-6496 (2007)
   PUBMED   17636024
REFERENCE   2  (bases 1 to 5532)
  AUTHORS   Rozakis-Adcock,M. and Podcheko,A.
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2006) Laboratory Medicine and Pathobiology,
            University of Toronto, 1 Kings College Circle, Toronto, ON M5S1A8,
            Canada
FEATURES             Location/Qualifiers
     source          1..5532
                     /db_xref="H-InvDB:HIT000468672"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q14"
     gene            1..5532
                     /gene="PHIP"
                     /gene_synonym="hPHIP1"
                     /gene_synonym="WDR11"
     CDS             1..5466
                     /gene="PHIP"
                     /gene_synonym="hPHIP1"
                     /gene_synonym="WDR11"
                     /note="WD40 and bromodomain-containing nuclear protein;
                     regulation of growth and apoptosis, transcription
                     regulator activity"
                     /codon_start=1
                     /product="pleckstrin homology domain-interacting protein
                     variant 1"
                     /protein_id="ABK76299.1"
                     /translation="MSCERKGLSELRSELYFLIARFLEDGPCQQAAQVLIREVAEKEL
                     LPRRTDWTGKEHPRTYQNLVKYYRHLAPDHLLQICHRLGPLLEQEIPQSVPGVQTLLG
                     AGRQSLLRTNKSCKHVVWKGSALAALHCGRPPESPVNYGSPPSIADTLFSRKLNGKYR
                     LERLVPTAVYQHMKMHKRILGHLSSVYCVTFDRTGRRIFTGSDDCLVKIWATDDGRLL
                     ATLRGHAAEISDMAVNYENTMIAAGSCDKMIRVWCLRTCAPLAVLQGHSASITSLQFS
                     PLCSGSKRYLSSTGADGTICFWLWDAGTLKINPRPAKFTERPRPGVQMICSSFSAGGM
                     FLATGSTDHIIRVYFFGSGQPEKISELEFHTDKVDSIQFSNTSNRFVSGSRDGTARIW
                     QFKRREWKSILLDMATRPAGQNLQGIEDKITKMKVTMVAWDRHDNTVITAVNNMTLKV
                     WNSYTGQLIHVLMGHEDEVFVLEPHPFDPRVLFSAGHDGNVIVWDLARGVKIRSYFNM
                     IEGQGHGAVFDCKCSPDGQHFACTDSHGHLLIFGFGSSSKYDKIADQMFFHSDYRPLI
                     RDANNFVLDEQTQQAPHLMPPPFLVDVDGNPHPSRYQRLVPGRENCREEQLIPQMGVT
                     SSGLNQVLSQQANQEISPLDSMIQRLQQEQDLRRSGEAGISNTSRLSRGSISSTSEVH
                     SPPNVGLRRSGQIEGVRQMHSNAPRSEIATERDLVAWSRRVVVPELSAGVASRQEEWR
                     TAKGEEEIKTYRSEEKRKHLTVPKENKIPTVSKNHAHEHFLDLGESKKQQTNQHNYRT
                     RSALEETPRPSEEIENGSSSSDEGEVVAVSGGTSEEEERAWHSDGSSSDYSSDYSDWT
                     ADAGINLQPPKKVPKNKTKKAESSSDEEEESEKQKQKQIKKEKKKVNEEKDGPISPKK
                     KKPKERKQKRLAVGELTENGLTLEEWLPSTWITDTIPRRCPFVPQMGDEVYYFRQGHE
                     AYVEMARKNKIYSINPKKQPWHKMELREQELMKIVGIKYEVGLPTLCCLKLAFLDPDT
                     GKLTGGSFTMKYHDMPDVIDFLVLRQQFDDAKYRRWNIGDRFRSVIDDAWWFGTIESQ
                     EPLQLEYPDSLFQCYNVCWDNGDTEKMSPWDMELIPNNAVFPEELGTSVPLTDGECRS
                     LIYKPLDGEWGTNPRDEECERIVAGINQLMTLDIASAFVAPVDLQAYPMYCTVVAYPT
                     DLSTIKQRLENRFYRRVSSLMWEVRYIEHNTRTFNEPGSPIVKSAKFVTDLLLHFIKD
                     QTCYNIIPLYNSMKKKVLSDSEDEEKDADVPGTSTRKRKDHQPRRRLRNRAQSYDIQA
                     WKKQCEELLNLIFQCEDSEPFRQPVDLLEYPDYRDIIDTPMDFATVRETLEAGNYESP
                     MELCKDVRLIFSNSKAYTPSKRSRIYSMSLRLSAFFEEHISSVLSDYKSALRFHKRNT
                     ITKRRKKRNRSSSVSSSAASSPERKKRILKPQLKSESSTSAFSTPTRSIPPRHNAAQI
                     NGKTESSSVVRTRSNRVVVDPVVTEQPSTSSAAKTFITKANASAIPGKTILENSVKHS
                     KALNTLSSPGQSSFSHGTRNNSAKENMEKEKPVKRKMKSSVLPKASTLSKSSAVIEQG
                     DCKNNALVPGTIQVNGHGGQPSKLVKRGPGRKPKVEVNTNSGEIIHKKRGRKPKKLQY
                     AKPEDLEQNNVHPIRDEVLPSSTCNFLSETNNVKEDLLQKKNRGGRKPKRKMKTQKLD
                     ADLLVPASVKVLRRSNRKKIDDPIDEEEEFEELKGSEPHMRTRNQGRRTAFYNEDDSE
                     EEQRQLLFEDTSLTFGTSSRGRVRKLTEKAKANLIGW"
BASE COUNT         1843 a         1055 c         1245 g         1389 t
ORIGIN      
        1 atgtcttgtg agaggaaagg cctctcggag ctgcgatcgg agctctactt cctcatcgcc
       61 cggttcctgg aagatggacc ctgtcagcag gcggctcagg tgctgatccg cgaggtggcc
      121 gagaaggagc tgctgccccg gcgcaccgac tggaccggga aggagcatcc caggacctac
      181 cagaatctgg tgaagtatta cagacactta gcacctgatc acttgctgca aatatgtcat
      241 cgactaggac ctcttcttga acaagaaatt cctcaaagtg ttcctggagt acaaacttta
      301 ttaggagctg gaagacagtc tttactacgc acaaataaaa gctgcaagca tgttgtgtgg
      361 aaaggatctg ctctggctgc gttgcactgt ggaagaccac ctgagtcacc agttaactat
      421 ggtagcccac ccagcattgc ggatactctg ttttcaagga agctgaatgg gaaatacaga
      481 cttgagcgac ttgttccaac tgcagtgtat cagcacatga aaatgcataa acgaattctt
      541 ggacacttgt catctgtgta ctgtgtaact tttgatcgaa ctggcagacg gatatttact
      601 ggttctgatg actgtcttgt gaaaatatgg gcaacagatg atgggaggtt gttagctacc
      661 ttaagaggac atgctgctga aatatcagac atggctgtaa actatgagaa taccatgata
      721 gcagctggaa gttgtgataa aatgatccga gtctggtgtc ttcgaacctg tgcacctttg
      781 gctgttcttc agggccatag tgcatctatt acatcactac agttctcacc attgtgcagt
      841 ggctcaaaga gatatctatc ttctactggg gcagatggca ctatttgttt ttggctctgg
      901 gatgctggaa cccttaaaat aaacccaaga cctgcaaaat ttacagagcg ccctcggcct
      961 ggagttcaaa tgatctgttc ttcttttagt gctggtggaa tgtttctggc gacgggaagc
     1021 acagatcata ttattcgggt ttattttttt ggatcaggtc agccagagaa aatatcagaa
     1081 ttggagtttc atactgacaa agttgacagt atccagtttt ccaacactag taacaggttt
     1141 gtaagtggca gtcgtgatgg gacagcacgt atttggcaat ttaaacgaag agagtggaag
     1201 agcattttgt tggatatggc tactcgtcca gcaggccaaa accttcaagg aatagaagat
     1261 aaaatcacaa aaatgaaggt tactatggta gcttgggatc gacatgacaa tacagttata
     1321 actgcagtta ataacatgac tctgaaagtt tggaattctt acactggtca actaattcat
     1381 gtcctgatgg gtcatgaaga tgaggtattt gttcttgaac cacacccgtt cgatcctaga
     1441 gttctctttt ctgctggtca tgatggaaac gtgatagtgt gggatctggc aagaggagtc
     1501 aaaatacgat cttatttcaa tatgattgaa ggccaaggac atggcgcagt atttgactgc
     1561 aaatgctctc ctgatggtca gcattttgca tgcacagact ctcatggaca tcttttaatt
     1621 tttggctttg ggtccagtag caaatatgac aagatagcag atcagatgtt ctttcatagt
     1681 gattatcggc cacttattcg tgatgccaac aattttgtat tagatgaaca gactcagcaa
     1741 gcacctcatc ttatgcctcc cccttttttg gttgatgttg atggtaaccc tcatccatca
     1801 agatatcaaa gattagttcc tggccgtgaa aattgcaggg aggagcaact catccctcag
     1861 atgggagtaa cttcctcagg actgaatcaa gttttaagtc agcaagcaaa ccaggagatc
     1921 agcccactgg acagcatgat tcaaagacta caacaggagc aagacctgag acgttctggt
     1981 gaagcaggta tcagtaatac cagccgttta agtagaggct ccataagttc tacctcagag
     2041 gttcattcac caccaaacgt aggactaaga cgtagtggac aaattgaagg tgtacggcaa
     2101 atgcacagca acgcaccaag aagtgaaata gccacagagc gggatctggt agcttggagt
     2161 cgaagggtgg tagtacccga gctatcagct ggtgtagcca gtaggcaaga agaatggaga
     2221 actgcaaagg gagaagaaga aataaagact tacaggtcag aagagaaaag aaaacactta
     2281 actgttccaa aagagaataa aatacccact gtctcaaaga atcatgctca tgagcatttc
     2341 ctggatcttg gagaatccaa aaagcaacag acaaatcaac acaattatcg tacaagatct
     2401 gcattggaag agactcctag accctcagaa gagatagaaa atggcagtag ttcttcagat
     2461 gaaggcgaag tagttgctgt cagtggtgga acatccgaag aagaagagag agcatggcac
     2521 agtgatggca gttctagtga ctactccagt gattactctg actggacagc agatgcagga
     2581 attaatctgc agccaccaaa gaaagttcct aagaataaaa ccaagaaagc agaaagcagt
     2641 tcagatgaag aagaagaatc tgaaaaacag aagcaaaaac agattaaaaa ggaaaagaaa
     2701 aaagtaaatg aagaaaaaga tggaccaata tcaccaaaga aaaagaagcc caaagaaaga
     2761 aaacaaaaga gattggctgt gggagaacta actgaaaatg gtttgacatt agaagaatgg
     2821 ttgccatcaa catggattac agataccatt ccccgaagat gtccatttgt gccacagatg
     2881 ggtgatgagg tttattattt ccgacaagga catgaagcct atgtcgaaat ggcccggaaa
     2941 aataaaatat atagtatcaa tcccaaaaaa caaccatggc ataaaatgga gctacgggaa
     3001 caagaactta tgaaaatagt tggcataaag tatgaagtgg gattacctac cctttgctgc
     3061 cttaaacttg cttttctaga tcctgatact ggtaaactga ctggcggatc atttaccatg
     3121 aaataccatg atatgcctga cgttatagat ttcctagtct tgagacaaca atttgatgat
     3181 gcaaaataca ggcgatggaa tataggtgac cgcttcaggt ctgtcataga tgatgcctgg
     3241 tggtttggaa caatcgaaag ccaggaacct cttcaacttg agtaccctga tagtctgttt
     3301 caatgctaca atgtttgctg ggacaatgga gatacagaaa agatgagtcc ttgggatatg
     3361 gagcttatac ctaataatgc tgtatttcct gaagaactag gtaccagtgt tcctttaact
     3421 gatggtgagt gcagatcact aatctataaa cctcttgatg gagaatgggg taccaatccc
     3481 agggatgaag aatgtgaaag aattgtggca ggaataaacc agttgatgac actagatatt
     3541 gcctcagcat ttgtggcccc cgtggatctg caagcctatc ccatgtattg cacagtagtg
     3601 gcatatccaa cggatctaag tacaattaaa caaagactgg aaaacaggtt ttacaggcgg
     3661 gtttcttccc taatgtggga agttcgatat atagagcata atacacgaac atttaatgag
     3721 cctggaagcc ctattgtgaa atctgctaaa ttcgtgactg atcttcttct acattttata
     3781 aaggatcaga cttgttataa cataattcca ctttataatt caatgaagaa gaaagttttg
     3841 tctgattctg aggatgaaga gaaagatgct gatgtgccag gaacttctac tcgaaaaagg
     3901 aaggaccatc agcctagaag aagattacgt aatagagccc agtcttacga tattcaagca
     3961 tggaagaaac agtgtgaaga attgttaaat ctcatatttc aatgtgaaga ttcagagcct
     4021 ttccgtcagc cggtagatct ccttgaatat ccagactaca gagacatcat tgacactcca
     4081 atggattttg ctaccgttag agaaacttta gaggctggga attatgagtc accaatggag
     4141 ttatgtaaag atgtcagact tattttcagt aattccaaag catatacacc aagcaaaaga
     4201 tcaaggattt acagcatgag tttgcgcctg tctgctttct ttgaagaaca cattagttca
     4261 gttttatcag attataaatc tgctcttcgt tttcataaaa gaaataccat aaccaaaagg
     4321 aggaagaaaa gaaacagaag cagctctgtt tccagtagtg ctgcatcaag ccctgaaagg
     4381 aaaaaaagga tcttaaaacc ccagctaaaa tcagaaagct ctacctctgc attctctaca
     4441 cctacacgat caataccgcc aagacacaat gctgctcaga taaacggtaa aacagaatct
     4501 agttctgtgg ttcgaaccag aagcaaccga gtggttgtag atccagttgt cactgagcaa
     4561 ccatctactt cttcagctgc aaagactttt attacaaaag ctaatgcatc tgcaatacca
     4621 gggaaaacaa tactagagaa ttctgtgaaa cattccaaag ctttgaatac tctttccagt
     4681 cctggtcaat ccagttttag tcatggcact aggaataatt ctgcaaaaga aaacatggaa
     4741 aaggaaaagc cagtcaaacg taaaatgaag tcatctgtac tcccaaaggc gtccactctt
     4801 tcaaagtcat cagctgtcat tgagcaagga gattgtaaga acaacgctct tgtaccagga
     4861 accattcaag taaatggcca tggaggacag ccatcaaaac ttgtgaagag gggacctgga
     4921 aggaaaccta aagtagaagt taataccaat agtggtgaaa ttatacacaa gaaaaggggt
     4981 agaaagccca aaaagctaca gtatgcaaag ccagaagatt tagagcaaaa taatgtgcat
     5041 cccatcagag atgaagtact tccttcttca acatgcaatt ttctttctga aactaataat
     5101 gtaaaggaag atttgttaca gaaaaagaat cgtggaggta ggaagcccaa aaggaagatg
     5161 aagacacaaa aattagatgc agatctccta gtccctgcaa gtgtcaaagt gttaaggaga
     5221 agtaaccgaa aaaagataga tgatcctata gatgaggaag aagagtttga agaactcaaa
     5281 ggctctgaac cccacatgag aactagaaat caaggtcgaa ggacagcttt ctataatgag
     5341 gatgactctg aagaggagca aaggcagctg ttgttcgaag acacctcttt aacttttgga
     5401 acttctagta gaggacgagt ccgaaagttg actgaaaaag caaaagctaa tttaattggt
     5461 tggtaacttg taccaaaata ttttacttca aaatctataa agcaggtaca gttaaggaat
     5521 aagtagaact aa
//