LOCUS DQ902581 2278 bp mRNA linear HUM 19-SEP-2006
DEFINITION Homo sapiens tyrosinase-related protein 2 mRNA, complete cds,
alternatively spliced.
ACCESSION DQ902581
VERSION DQ902581.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2278)
AUTHORS Khong,H.T. and Rosenberg,S.A.
TITLE Pre-existing immunity to tyrosinase-related protein (TRP)-2, a new
TRP-2 isoform, and the NY-ESO-1 melanoma antigen in a patient with
a dramatic response to immunotherapy
JOURNAL J. Immunol. 168 (2), 951-956 (2002)
PUBMED 11777994
REFERENCE 2 (bases 1 to 2278)
AUTHORS Liu,G., Khong,H.T., Wheeler,C.J., Yu,J.S., Black,K.L. and Ying,H.
TITLE Molecular and functional analysis of tyrosinase-related protein
(TRP)-2 as a cytotoxic T lymphocyte target in patients with
malignant glioma
JOURNAL J. Immunother. 26 (4), 301-312 (2003)
PUBMED 12843792
REFERENCE 3 (bases 1 to 2278)
AUTHORS Khong,H.T.
TITLE Direct Submission
JOURNAL Submitted (15-AUG-2006) Mitchell Cancer Institute, University of
South Alabama, 307 N. University Blvd., MSB 2015, Mobile, AL 36688,
USA
FEATURES Location/Qualifiers
source 1..2278
/db_xref="H-InvDB:HIT000393991"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/tissue_type="melanoma"
CDS 293..1951
/note="dopachrome tautomerase; alternatively spliced; two
exons were in-frame between exons 6 and 7; TRP2"
/codon_start=1
/product="tyrosinase-related protein 2"
/protein_id="ABI73976.1"
/translation="MSPLWWGFLLSCLGCKILPGAQGQFPRVCMTVDSLVNKECCPRL
GAESANVCGSQQGRGQCTEVRADTRPWSGPYILRNQDDRELWPRKFFHRTCKCTGNFA
GYNCGDCKFGWTGPNCERKKPPVIRQNIHSLSPQEREQFLGALDLAKKRVHPDYVITT
QHWLGLLGPNGTQPQFANCSVYDFFVWLHYYSVRDTLLGPGRPYRAIDFSHQGPAFVT
WHRYHLLCLERDLQRLIGNESFALPYWNFATGRNECDVCTDQLFGAARPDDPTLISRN
SRFSSWETVCDSLDDYNHLVTLCNGTYEGLLRRNQMGRNSMKLPTLKDIRDCLSLQKF
DNPPFFQNSTFSFRNALEGFDKADGTLDSQVMSLHNLVHSFLNGTNALPHSAANDPIF
VVISNRLLYNATTNILEHVRKEKATKELPSLHVLVLHSFTDAIFDEWMKRFNPPADAW
PQELAPIGHNRMYNMVPFFPPVTNEELFLTSDQLGYSYAIDLPVSVEETPGWPTTLLV
VMGTLVALVGLFVLLAFLQYRRLRKGYTPLMETHLSSKRYTEEA"
BASE COUNT 637 a 518 c 528 g 595 t
ORIGIN
1 atggtgagaa gcgctaccct cattaaattt ggttgttaga ggcgcttcta aggaaattaa
61 gtctgttagt tgtttgaatc acataaaatt gtgtgtgcac gttcatgtac acatgtgcac
121 acatgtaacc tctgtgattc ttgtgggtat ttttttaaga agaaaggaat agaaagcaaa
181 gaaaaataaa aaatactgaa aagaaaagac tgaaagagta gaagataagg agaaaagtac
241 gacagagaca aggaaagtaa gagagagaga gagctctccc aattataaag ccatgagccc
301 cctttggtgg gggtttctgc tcagttgctt gggctgcaaa atcctgccag gagcccaggg
361 tcagttcccc cgagtctgca tgacggtgga cagcctagtg aacaaggagt gctgcccacg
421 cctgggtgca gagtcggcca atgtctgtgg ctctcagcaa ggccgggggc agtgcacaga
481 ggtgcgagcc gacacaaggc cctggagtgg tccctacatc ctacgaaacc aggatgaccg
541 tgagctgtgg ccaagaaaat tcttccaccg gacctgcaag tgcacaggaa actttgccgg
601 ctataattgt ggagactgca agtttggctg gaccggtccc aactgcgagc ggaagaaacc
661 accagtgatt cggcagaaca tccattcctt gagtcctcag gaaagagagc agttcttggg
721 cgccttagat ctcgcgaaga agagagtaca ccccgactac gtgatcacca cacaacactg
781 gctgggcctg cttgggccca atggaaccca gccgcagttt gccaactgca gtgtttatga
841 tttttttgtg tggctccatt attattctgt tagagataca ttattaggac caggacgccc
901 ctacagggcc atagatttct cacatcaagg acctgcattt gttacctggc accggtacca
961 tttgttgtgt ctggaaagag atctccagcg actcattggc aatgagtctt ttgctttgcc
1021 ctactggaac tttgccactg ggaggaacga gtgtgatgtg tgtacagacc agctgtttgg
1081 ggcagcgaga ccagacgatc cgactctgat tagtcggaac tcaagattct ccagctggga
1141 aactgtctgt gatagcttgg atgactacaa ccacctggtc accttgtgca atggaaccta
1201 tgaaggtttg ctgagaagaa atcaaatggg aagaaacagc atgaaattgc caaccttaaa
1261 agacatacga gattgcctgt ctctccagaa gtttgacaat cctcccttct tccagaactc
1321 taccttcagt ttcaggaatg ctttggaagg gtttgataaa gcagatggga ctctggattc
1381 tcaagtgatg agccttcata atttggttca ttccttcctg aacgggacaa acgctttgcc
1441 acattcagcc gccaatgatc ccatttttgt ggtgatttct aatcgtttgc tttacaatgc
1501 tacaacaaac atccttgaac atgtaagaaa agagaaagcg accaaggaac tcccttccct
1561 gcatgtgctg gttcttcatt cctttactga tgccatcttt gatgagtgga tgaaaagatt
1621 taatcctcct gcagatgcct ggcctcagga gctggcccct attggtcaca atcggatgta
1681 caacatggtt cctttcttcc ctccagtgac taatgaagaa ctctttttaa cctcagacca
1741 acttggctac agctatgcca tcgatctgcc agtttcagtt gaagaaactc caggttggcc
1801 cacaactctc ttagtagtca tgggaacact ggtggctttg gttggtcttt ttgtgctgtt
1861 ggcttttctt caatatagaa gacttcgaaa aggatataca cccctaatgg agacacattt
1921 aagcagcaag agatacacag aagaagccta gggtgctcat gccttaccta agagaagagg
1981 ctggccaagc cacagttctg acgctgacaa taaaggaact aatcctcact gttccttctt
2041 gagttgaaga tctttgacat aggttcttct atagtgatga tgatctcatt cagaagatgc
2101 ttagctgtag tttccgcttt gcttgcttgt ttaacaaacc caactaaagt gcttgaggct
2161 acctctacct tcaaataaag atagacctga caatttgtga tatctaataa taaccccccc
2221 cccaatattg attaagcctc ctccttttct gaaagcattt aaaaaaaaca aaaaaaaa
//