LOCUS DQ677337 1536 bp mRNA linear HUM 13-APR-2007
DEFINITION Homo sapiens tyrosine hydroxylase isoform D2,8,9 (TH) mRNA,
complete cds, alternatively spliced.
ACCESSION DQ677337
VERSION DQ677337.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1536)
AUTHORS Roma,J., Saus,E., Cuadros,M., Reventos,J., Sanchez de Toledo,J. and
Gallego,S.
TITLE Characterisation of novel splicing variants of the tyrosine
hydroxylase C-terminal domain in human neuroblastic tumours
JOURNAL Biol. Chem. 388 (4), 419-426 (2007)
PUBMED 17391063
REFERENCE 2 (bases 1 to 1536)
AUTHORS Roma,J., Saus,E. and Gallego,S.
TITLE Direct Submission
JOURNAL Submitted (06-JUN-2006) Biomedical Research Unit, Vall Hebron
Hospital, Vall Hebron 119, Barcelona 08511, Spain
FEATURES Location/Qualifiers
source 1..1536
/db_xref="H-InvDB:HIT000393215"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="11"
/map="11p15"
gene 1..1536
/gene="TH"
CDS 10..1233
/gene="TH"
/note="aromatic amino acid hydroxylase; alternatively
spliced; lacks exons 2, 8, and 9"
/codon_start=1
/product="tyrosine hydroxylase isoform D2,8,9"
/protein_id="ABG73365.1"
/translation="MPTPDATTPQAKGFRRAVSELDAKQAEAIMVRGQSPRFIGRRQS
LIEDARKEREAAVAAAAAAVPSEPGDPLEAVAFEEKEGKAVLNLLFSPRATKPSALSR
AVKVFETFEAKIHHLETRPAQRPRAGGPHLEYFVRLEVRRGDLAALLSGVRQVSEDVR
SPAGPKVPWFPRKVSELDKCHHLVTKFDPDLDLDHPGFSDQVYRQRRKLIAEIAFQYR
HGDPIPRVEYTAEEIATWDCCHELLGHVPMLADRTFAQFSQDIGLASLGASDEEIEKL
STLYWFTVEFGLCKQNGEVKAYGAGLLSSYGELLHCLSEEPEIRAFDPEAAAVQPYQD
QTYQSVYFVSESFSDAKDKLRSYASRIQRPFSVKFDPYTLAIDVLDSPQAVRRSLEGV
QDELDTLAHALSAIG"
BASE COUNT 255 a 514 c 493 g 274 t
ORIGIN
1 cactgagcca tgcccacccc cgacgccacc acgccacagg ccaagggctt ccgcagggcc
61 gtgtctgagc tggacgccaa gcaggcagag gccatcatgg taagagggca gtccccgcgg
121 ttcattgggc gcaggcagag cctcatcgag gacgcccgca aggagcggga ggcggcggtg
181 gcagcagcgg ccgctgcagt cccctcggag cccggggacc ccctggaggc tgtggccttt
241 gaggagaagg aggggaaggc cgtgctaaac ctgctcttct ccccgagggc caccaagccc
301 tcggcgctgt cccgagctgt gaaggtgttt gagacgtttg aagccaaaat ccaccatcta
361 gagacccggc ccgcccagag gccgcgagct gggggccccc acctggagta cttcgtgcgc
421 ctcgaggtgc gccgagggga cctggccgcc ctgctcagtg gtgtgcgcca ggtgtcagag
481 gacgtgcgca gccccgcggg gcccaaggtc ccctggttcc caagaaaagt gtcagagctg
541 gacaagtgtc atcacctggt caccaagttc gaccctgacc tggacttgga ccacccgggc
601 ttctcggacc aggtgtaccg ccagcgcagg aagctgattg ctgagatcgc cttccagtac
661 aggcacggcg acccgattcc ccgtgtggag tacaccgccg aggagattgc cacctgggac
721 tgctgccacg agctgctggg gcacgtgccc atgctggccg accgcacctt cgcgcagttc
781 tcgcaggaca ttggcctggc gtccctgggg gcctcggatg aggaaattga gaagctgtcc
841 acgctgtact ggttcacggt ggagttcggg ctgtgtaagc agaacgggga ggtgaaggcc
901 tatggtgccg ggctgctgtc ctcctacggg gagctcctgc actgcctgtc tgaggagcct
961 gagattcggg ccttcgaccc tgaggctgcg gccgtgcagc cctaccaaga ccagacgtac
1021 cagtcagtct acttcgtgtc tgagagcttc agtgacgcca aggacaagct caggagctat
1081 gcctcacgca tccagcgccc cttctccgtg aagttcgacc cgtacacgct ggccatcgac
1141 gtgctggaca gcccccaggc cgtgcggcgc tccctggagg gtgtccagga tgagctggac
1201 acccttgccc atgcgctgag tgccattggc taggtgcacg gcgtccctga gggcccttcc
1261 caacctcccc tggtcctgca ctgtcccgga gctcaggccc tggtgagggg ctgggtcccg
1321 ggtgcccccc atgccctccc tgctgccagg ctcccactgc ccctgcacct gcttctcagc
1381 gcaacagctg tgtgtgcccg tggtgaggtt gtgctgcctg tggtgaggtc ctgtcctggc
1441 tcccagggtc ctgggggctg ctgcactgcc ctccgccctt ccctgacact gtctgctgcc
1501 ccaatcaccg tcacaataaa agaaactgtg gtctct
//