LOCUS DQ677336 1524 bp mRNA linear HUM 13-APR-2007
DEFINITION Homo sapiens tyrosine hydroxylase isoform D1b,2,8,9 (TH) mRNA,
complete cds, alternatively spliced.
ACCESSION DQ677336
VERSION DQ677336.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1524)
AUTHORS Roma,J., Saus,E., Cuadros,M., Reventos,J., Sanchez de Toledo,J. and
Gallego,S.
TITLE Characterisation of novel splicing variants of the tyrosine
hydroxylase C-terminal domain in human neuroblastic tumours
JOURNAL Biol. Chem. 388 (4), 419-426 (2007)
PUBMED 17391063
REFERENCE 2 (bases 1 to 1524)
AUTHORS Roma,J., Saus,E. and Gallego,S.
TITLE Direct Submission
JOURNAL Submitted (06-JUN-2006) Biomedical Research Unit, Vall Hebron
Hospital, Vall Hebron 119, Barcelona 08511, Spain
FEATURES Location/Qualifiers
source 1..1524
/db_xref="H-InvDB:HIT000393214"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="11"
/map="11p15"
gene 1..1524
/gene="TH"
CDS 10..1221
/gene="TH"
/note="aromatic amino acid hydroxylase; alternatively
spliced; lacks exons 1b, 2, 8, and 9"
/codon_start=1
/product="tyrosine hydroxylase isoform D1b,2,8,9"
/protein_id="ABG73364.1"
/translation="MPTPDATTPQAKGFRRAVSELDAKQAEAIMSPRFIGRRQSLIED
ARKEREAAVAAAAAAVPSEPGDPLEAVAFEEKEGKAVLNLLFSPRATKPSALSRAVKV
FETFEAKIHHLETRPAQRPRAGGPHLEYFVRLEVRRGDLAALLSGVRQVSEDVRSPAG
PKVPWFPRKVSELDKCHHLVTKFDPDLDLDHPGFSDQVYRQRRKLIAEIAFQYRHGDP
IPRVEYTAEEIATWDCCHELLGHVPMLADRTFAQFSQDIGLASLGASDEEIEKLSTLY
WFTVEFGLCKQNGEVKAYGAGLLSSYGELLHCLSEEPEIRAFDPEAAAVQPYQDQTYQ
SVYFVSESFSDAKDKLRSYASRIQRPFSVKFDPYTLAIDVLDSPQAVRRSLEGVQDEL
DTLAHALSAIG"
BASE COUNT 251 a 513 c 487 g 273 t
ORIGIN
1 cactgagcca tgcccacccc cgacgccacc acgccacagg ccaagggctt ccgcagggcc
61 gtgtctgagc tggacgccaa gcaggcagag gccatcatgt ccccgcggtt cattgggcgc
121 aggcagagcc tcatcgagga cgcccgcaag gagcgggagg cggcggtggc agcagcggcc
181 gctgcagtcc cctcggagcc cggggacccc ctggaggctg tggcctttga ggagaaggag
241 gggaaggccg tgctaaacct gctcttctcc ccgagggcca ccaagccctc ggcgctgtcc
301 cgagctgtga aggtgtttga gacgtttgaa gccaaaatcc accatctaga gacccggccc
361 gcccagaggc cgcgagctgg gggcccccac ctggagtact tcgtgcgcct cgaggtgcgc
421 cgaggggacc tggccgccct gctcagtggt gtgcgccagg tgtcagagga cgtgcgcagc
481 cccgcggggc ccaaggtccc ctggttccca agaaaagtgt cagagctgga caagtgtcat
541 cacctggtca ccaagttcga ccctgacctg gacttggacc acccgggctt ctcggaccag
601 gtgtaccgcc agcgcaggaa gctgattgct gagatcgcct tccagtacag gcacggcgac
661 ccgattcccc gtgtggagta caccgccgag gagattgcca cctgggactg ctgccacgag
721 ctgctggggc acgtgcccat gctggccgac cgcaccttcg cgcagttctc gcaggacatt
781 ggcctggcgt ccctgggggc ctcggatgag gaaattgaga agctgtccac gctgtactgg
841 ttcacggtgg agttcgggct gtgtaagcag aacggggagg tgaaggccta tggtgccggg
901 ctgctgtcct cctacgggga gctcctgcac tgcctgtctg aggagcctga gattcgggcc
961 ttcgaccctg aggctgcggc cgtgcagccc taccaagacc agacgtacca gtcagtctac
1021 ttcgtgtctg agagcttcag tgacgccaag gacaagctca ggagctatgc ctcacgcatc
1081 cagcgcccct tctccgtgaa gttcgacccg tacacgctgg ccatcgacgt gctggacagc
1141 ccccaggccg tgcggcgctc cctggagggt gtccaggatg agctggacac ccttgcccat
1201 gcgctgagtg ccattggcta ggtgcacggc gtccctgagg gcccttccca acctcccctg
1261 gtcctgcact gtcccggagc tcaggccctg gtgaggggct gggtcccggg tgccccccat
1321 gccctccctg ctgccaggct cccactgccc ctgcacctgc ttctcagcgc aacagctgtg
1381 tgtgcccgtg gtgaggttgt gctgcctgtg gtgaggtcct gtcctggctc ccagggtcct
1441 gggggctgct gcactgccct ccgcccttcc ctgacactgt ctgctgcccc aatcaccgtc
1501 acaataaaag aaactgtggt ctct
//