LOCUS DQ533874 6235 bp mRNA linear HUM 17-NOV-2006
DEFINITION Homo sapiens ROBO2 isoform b mRNA, complete cds, alternatively
spliced.
ACCESSION DQ533874
VERSION DQ533874.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 6235)
AUTHORS Yue,Y., Grossmann,B., Galetzka,D., Zechner,U. and Haaf,T.
TITLE Isolation and differential expression of two isoforms of the
ROBO2/Robo2 axon guidance receptor gene in humans and mice
JOURNAL Genomics 88 (6), 772-778 (2006)
PUBMED 16829019
REFERENCE 2 (bases 1 to 6235)
AUTHORS Yue,Y., Grossmann,B., Galetzka,D., Zechner,U. and Haaf,T.
TITLE Direct Submission
JOURNAL Submitted (08-MAY-2006) Institute for Human Genetics, Mainz
University School of Medicine, Langenbeckstrasse 1, Bldg.601, Mainz
55131, Germany
FEATURES Location/Qualifiers
source 1..6235
/db_xref="H-InvDB:HIT000392758"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="3"
/map="3p12.3"
CDS 644..4780
/note="roundabout axon guidance receptor-like 2 isoform b;
alternatively spliced"
/codon_start=1
/product="ROBO2 isoform b"
/protein_id="ABF83431.1"
/translation="MSLLMFTQLLLCGFLYVRVDGSRLRQEDFPPRIVEHPSDVIVSK
GEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRRSK
PDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAGEPAILECQPPRGH
PEPTIYWKKDKVRIDDKEERISIRGGKLMISNTRKSDAGMYTCVGTNMVGERDSDPAE
LTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDDADLPRGRYDIKDDY
TLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRPRDQIVAQGRTVTFP
CETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDAGYYICQ
ALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKCKATGDPLPVIS
WLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATSSSGETSWSAVLDVTES
GATISKNYDLSDLPGPPSKPQVTDVTKNSVTLSWQPGTPGTLPASAYIIEAFSQSVSN
SWQTVANHVKTTLYTVRGLRPNTIYLFMVRAINPQGLSDPSPMSDPVRTQDISPPAQG
VDHRQVQKELGDVLVRLHNPVVLTPTTVQVTWTVDRQPQFIQGYRVMYRQTSGLQATS
SWQNLDAKVPTERSAVLVNLKKGVTYEIKVRPYFNEFQGMDSESKTVRTTEEAPSAPP
QSVTVLTVGSYNSTSISVSWDPPPPDHQNGIIQEYKIWCLGNETRFHINKTVDAAIRS
VIIGGLFPGIQYRVEVAASTSAGVGVKSEPQPIIIGRRNEVVITENNNSITEQITDVV
KQPAFIAGIGGACWVILMGFSIWLYWRRKKRKGLSNYAVTFQRGDGGLMSNGSRPGLL
NAGDPSYPWLADSWPATSLPVNNSNSGPNEIGNFGRGDVLPPVPGQGDKTATMLSDGA
IYSSIDFTTKTSYNSSSQITQATPYATTQILHSNSIHELAVDLPDPQWKSSIQQKTDL
MGFGYSLPDQNKGNNGGKGGKKKKNKNSSKPQKNNGSTWANVPLPPPPVQPLPGTELE
HYAVEQQENGYDSDSWCPPLPVQTYLHQGLEDELEEDDDRVPTPPVRGVASSPAISFG
QQSTATLTPSPREEMQPMLQAHLDELTRAYQFDIAKQTWHIQSNNQPPQPPVPPLGYV
SGALISDLETDVADDDADDEEEALEIPRPLRALDQTPGSSMDNLDSSVTGKAFTSSQR
PRPTSPFSTDSNTSAALSQSQRPRPTKKHKGGRMDQQPALPHRREGMTDEEALVPYSK
PSFPSPGGHSSSGTASSKGSTGPRKTEVLRAGHQRNASDLLDIGYMGSNSQGQFTGEL
"
BASE COUNT 1900 a 1342 c 1418 g 1575 t
ORIGIN
1 ctcctctctt ttggaaaccg gagaggtgga gggagggcaa caccgctgca aaggagaggc
61 ccgccaagtc tgcccgcctg caaagtgttg ctttgacaca ttcttattat ggaagttaag
121 taaaaatata gacatattaa aaaataactc cggacgtgga gctgctacgg agaaggaaac
181 cgggggaaag aaaaccagta ggcaggccaa tggtttttcg gcagcgcgct ggcaagtttg
241 tggaacactt tctaggaatt aggtcttttc ctcccccttc atcatcttga cttctgaagg
301 aagaacttgg ctttggattg cagtggagcc taaggagaga gggttagaca cactcgaata
361 atccctctgg ctgggctgaa tttgtgggaa tttaggaagc cagagtgctg gaaatacagc
421 agcctttgaa gtaccctctg ttaatttgga tggatctcag tgtgccccgt tcgagacctc
481 tccaccaacc ccttctgatc ttgcgatttg ctcttcttga ctttaattag tatctaggaa
541 agtctaaact ttggacctac ctcttttttt gatactcatt tttgtacttt tgctctctgg
601 gattggtttc ttaaagaatc tggatccttt ttaatatgtc aaaatgagtc tgctgatgtt
661 tacacaacta ctgctctgtg gatttttata tgttcgggtt gatggatcgc gtcttcgcca
721 ggaggacttt cccccgcgga ttgtggagca tccttccgat gtcatcgtct ctaagggcga
781 gcccacgact ctgaactgca aggcggaggg ccggccaacg cccaccattg agtggtacaa
841 agatggggag cgagtggaga ctgacaagga cgatccccgg tcccacagga tgcttctgcc
901 cagcggatcc ttattcttct tgcgcatcgt gcacgggcgc aggagtaaac ctgatgaagg
961 aagctacgtt tgtgttgcga ggaactatct tggtgaagca gtgagtcgaa atgcgtctct
1021 ggaagtggca ttgttacgag atgacttccg acaaaacccc acagatgttg tagtggcagc
1081 tggagagcct gcaatcctgg agtgccagcc tccccgggga cacccagaac ccaccatcta
1141 ctggaaaaaa gacaaagttc gaattgatga caaggaagaa agaataagta tccgtggtgg
1201 aaaactgatg atctccaata ccaggaaaag tgatgcaggg atgtatactt gtgttggtac
1261 caatatggtg ggagaaaggg acagtgaccc agcagagctg actgtctttg aacgacccac
1321 atttctcagg aggccaatta accaggtggt actggaggaa gaagctgtag aatttcgttg
1381 tcaagtccaa ggagatcctc aaccaactgt gaggtggaaa aaggatgatg cagacttgcc
1441 aagaggaagg tatgacatca aagacgatta cacactaaga attaaaaaga ccatgagtac
1501 agatgaaggc acctatatgt gtattgctga gaatcgggtt ggaaaaatgg aagcctctgc
1561 tacactcacc gtccgagctc ccccacagtt tgtggttcgg ccaagagatc agattgttgc
1621 tcaaggtcga acagtgacat ttccctgtga aactaaagga aacccacagc cagctgtttt
1681 ttggcagaaa gaaggcagcc agaacctact tttcccaaac caaccccagc agcccaacag
1741 tagatgctca gtgtcaccaa ctggagacct cacaatcacc aacattcaac gttccgacgc
1801 gggttactac atctgccagg ctttaactgt ggcaggaagc attttagcaa aagctcaact
1861 ggaggttact gatgttttga cagatagacc tccacctata attctacaag gcccagccaa
1921 ccaaacgctg gcagtggatg gtacagcgtt actgaaatgt aaagccactg gtgatcctct
1981 tcctgtaatt agctggttaa aggagggatt tacttttccg ggtagagatc caagagcaac
2041 aattcaagag caaggcacac tgcagattaa gaatttacgg atttctgata ctggcactta
2101 tacttgtgtg gctacaagtt caagtggaga gacttcctgg agtgcagtgc tggatgtgac
2161 agagtctgga gcaacaatca gtaaaaacta tgatttaagt gacctgccag ggccaccatc
2221 caaaccgcag gtcactgatg ttactaagaa cagtgtcacc ttgtcctggc agccaggtac
2281 ccctggaacc cttccagcaa gtgcatatat cattgaggct ttcagccaat cagtgagcaa
2341 cagctggcag accgtggcaa accatgtaaa gaccaccctc tatactgtaa gaggactgcg
2401 gcccaataca atctacttat tcatggtcag agcgatcaac ccccaaggtc tcagtgaccc
2461 aagtcccatg tcagatcctg tgcgcacaca agatatcagc ccaccagcac aaggagtgga
2521 ccacaggcaa gtgcagaaag agctaggaga tgtccttgtc cgtcttcata atccagttgt
2581 gctgactccc accacggttc aggtcacatg gacggttgat cgccaacccc agtttatcca
2641 aggctaccga gtgatgtatc gtcagacttc aggtctgcag gcgacatctt cgtggcagaa
2701 tttagatgcc aaagtcccga ctgaacgaag tgctgtctta gtcaacctga aaaagggggt
2761 gacttatgaa attaaagtac ggccatattt taatgagttc caaggaatgg atagtgaatc
2821 taaaacggtt cgtactactg aagaagcccc aagtgcccca ccacagtctg tcactgtact
2881 gacagttgga agctacaata gcacaagtat tagtgtttcc tgggatcctc ctcctccaga
2941 tcaccagaat ggaattatcc aagaatacaa gatctggtgt ctaggaaatg aaacgcgatt
3001 ccatatcaac aaaactgtgg atgcagccat tcggtccgta ataattggtg gattattccc
3061 aggtattcaa taccgggtag aggttgcagc tagtaccagt gcaggggttg gagtaaagag
3121 tgagccacag ccaataataa tcgggagacg caatgaagtt gtcattactg aaaacaataa
3181 cagcataact gagcaaatca ctgatgtggt gaagcaacca gcctttatag ctggtattgg
3241 tggtgcctgc tgggtaattc tgatgggttt tagcatatgg ttgtattggc gaagaaagaa
3301 gaggaaggga ctcagtaatt atgctgttac gtttcaaaga ggagatggag gactaatgag
3361 caatggaagc cgtccaggtc ttctcaatgc tggtgatccc agctatccat ggcttgctga
3421 ttcttggcca gccacgagct tgccagtaaa taatagcaac agtggcccaa atgagattgg
3481 aaattttggc cgtggagatg tgctgccacc agttccaggc caaggggata aaacagcaac
3541 gatgctctca gatggagcca tttatagtag cattgacttc actaccaaaa ccagttacaa
3601 cagttccagc caaataacac aggctacccc atatgccacg acacagatct tgcattccaa
3661 cagcatacat gaattggctg tcgatctgcc tgatccacaa tggaaaagct caattcagca
3721 aaaaacagat ctgatgggat ttggttattc tctacctgat cagaacaaag gtaacaatgg
3781 tgggaaaggt ggaaaaaaga agaaaaataa aaactcttct aaaccacaga aaaacaatgg
3841 atccacttgg gccaatgtcc ctctacctcc ccccccagtc cagccccttc ctggcacgga
3901 gctggaacac tatgcagtgg aacaacaaga aaatggctat gacagtgata gctggtgccc
3961 accattgcca gtacaaactt acttacacca aggtctggaa gatgaactgg aagaagatga
4021 tgatagggtc ccaacacctc ctgttcgagg cgtggcttct tctcctgcta tctcctttgg
4081 acagcagtcc actgcaactc ttactccatc cccacgggaa gagatgcaac ccatgctgca
4141 ggctcacctg gatgagttga caagagccta tcagtttgat atagcaaaac aaacatggca
4201 cattcaaagc aataatcaac ctccacagcc tccagttcca ccgttaggtt atgtgtctgg
4261 agccttgatt tctgatttgg aaacggatgt tgcagatgat gatgccgacg acgaagagga
4321 agctttagaa atccccaggc ccctgagagc actggaccag actcctggat ccagcatgga
4381 caatctagac agctctgtga caggaaaagc ctttacctcc tctcaaagac ctcgacctac
4441 cagcccattt tctactgaca gtaacaccag tgcagccctg agtcaaagtc agaggcctcg
4501 gcccactaaa aaacacaagg gagggcggat ggaccaacaa ccagcattgc ctcatcgaag
4561 ggaaggaatg acagatgagg aggccttggt gccctatagc aagcccagtt tcccatctcc
4621 aggtggccac agctcatcag gaacagcttc ttctaaggga tccactggac ctaggaaaac
4681 cgaggtgttg agagcaggcc accagcgcaa tgccagcgac cttcttgaca taggatatat
4741 gggctccaac agtcaaggac agtttacagg tgaattatag taaatgagag gagacataca
4801 aagctgctct gaaggaccat caggtccgga ctcatggaag tgatgactct aaacagtgca
4861 atgaacaatt tatttatgta ctattaaaag aactgtaaat gcaatgtaaa gacacacagc
4921 cacacatatc ccacagatat tttcattgtg ttcttctctt aagtacacca cccaccttaa
4981 ctctttcttg tcaggagtat ataaaaaaga aagaaaacaa aactcgccct acaggaagaa
5041 aaggattctc ctctgtatat aatttctttt gtgcattgct atgcaagctc actcttttta
5101 gctctgctca tattattgtc tgttcttatt ggtctgttgt actatatgtg aattaatagg
5161 ctgtggtgcc atatattaac ttttaattgt gtaactttta tgtttaaatt ttgcactgca
5221 attttatttg gtgataagca caaatctcta ctcctcatga catgaagaaa aagactgaat
5281 gtgaagggag tttctgtact gtaagctaga ttggataatg atggctgtaa caaatcatgt
5341 tagatggttt tcagttgggg tgtagaaata ggaagatgca aaggaacaat ggtgttggca
5401 aagtcttctt tgaatatcag ggactgagtc aataaaaaaa atagtagaaa ggtggctttt
5461 actattgaca aaagccgggg tcaaaaaaag tagtttaagt cttaagactg aatatgcatt
5521 aaagtatgca ggtagcaaag atgtaataaa tttgcttaaa aaaagaaatt aaagttttat
5581 ttagaatcaa ttttacctgt cattgtaatt gacccatctg agaattacaa taagcaagag
5641 gaaattaagg tgttttgcaa gagctgtatt tatattacag ttttttaaaa acattttctg
5701 aattatcgta attaagctct ccaactcgtt aagtcagaat ataatatgaa gttccccaag
5761 gaaacgaaca aaatgaactc tagaatatct agcaaatagt taaagaagca atttattatt
5821 agggcatact cgggctgttt ccaaatataa actctattgc aatatcttat ttcatctttc
5881 taatacatgt acagtgcaca ctagaggata gagctgcatc acttaaattc atgacttaaa
5941 aaataataca gtttatatac aacttgtttt ttatttgatt aagaagtgaa gtttacgcca
6001 cccaatgtat agccaaattg tacgtgctta aaaaacagtg ccgagagtat gttcagttcg
6061 cagtaagtag atttattgga ataaatattc tatggtacat tctcagaaat tggcttccaa
6121 ctaaaatacg tttgacccat tttgaataag gaaattgaaa agaaaaattt aaaaggagaa
6181 aaaaatgcat gtttataaac tttttaaata aaaccagacc ttgtaagtgg acatt
//