LOCUS DQ464902 2607 bp mRNA linear HUM 16-DEC-2009
DEFINITION Homo sapiens nexilin (NEXN) mRNA, complete cds.
ACCESSION DQ464902
VERSION DQ464902.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2607)
AUTHORS Hassel,D., Dahme,T., Erdmann,J., Meder,B., Huge,A., Stoll,M.,
Just,S., Hess,A., Ehlermann,P., Weichenhan,D., Grimmler,M.,
Liptau,H., Hetzer,R., Regitz-Zagrosek,V., Fischer,C., Nurnberg,P.,
Schunkert,H., Katus,H.A. and Rottbauer,W.
TITLE Nexilin mutations destabilize cardiac Z-disks and lead to dilated
cardiomyopathy
JOURNAL Nat. Med. 15 (11), 1281-1288 (2009)
PUBMED 19881492
REFERENCE 2 (bases 1 to 2607)
AUTHORS Hassel,D., Dahme,T. and Rottbauer,W.
TITLE Direct Submission
JOURNAL Submitted (28-MAR-2006) Internal Medicine III/Cardiology,
University of Heidelberg, Im Neuenheimer Feld 380, Heidelberg
69120, Germany
FEATURES Location/Qualifiers
source 1..2607
/db_xref="H-InvDB:HIT000392344"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="1"
gene 1..2607
/gene="NEXN"
CDS 185..2212
/gene="NEXN"
/codon_start=1
/product="nexilin"
/protein_id="ABE97925.1"
/translation="MNDISQKAEILLSSSKPVPKTYVPKLGKGDVKDKFEAMQRAREE
RNQRRSRDEKQRRKEQYIREREWNRRKQEIKEMLASDDEEDVSSKVEKAYVPKLTGTV
KGRFAEMEKQRQEEQRKRTEEERKRRIEQDMLEKRKIQRELAKRAEQIEDINNTGTES
ASEEGDDSLLITVVPVKSYKTSGKMKKNFEDLEKEREEKERIKYEEDKRIRYEEQRPS
LKEAKCLSLVMDDEIESEAKKESLSPGKLKLTFEELERQRQENRKKQAEEEARKRLEE
EKRAFEEARRQMVNEDEENQDTAKIFKGYRPGKLKLSFEEMERQRREDEKRKAEEEAR
RRIEEEKKAFAEARRNMVVDDDSPEMYKTISQEFLTPGKLEINFEELLKQKMEEEKRR
TEEERKHKLEMEKQEFEQLRQEMGEEEEENETFGLSREYEELIKLKRSGSIQAKNLKS
KFEKIGQLSEKEIQKKIEEERARRRAIDLEIKEREAENFHEEDDVDVRPARKSEAPFT
HKVNMKARFEQMAKAREEEEQRRIEEQKLLRMQFEQREIDAALQKKREEEEEEEGSIM
NGSTAEDEEQTRSGAPWFKKPLKNTSVVDSEPVRFTVKVTGEPKPEITWWFEGEILQD
GEDYQYIERGETYCLYLPETFPEDGGEYMCKAVNNKGSAASTCILTIESKN"
BASE COUNT 1041 a 420 c 595 g 551 t
ORIGIN
1 agaggactcc cagcggctgg agcagaagtg ttagcggcca gagctcccag acccctaccc
61 acagccaggc gggacgcgca cagtccctcc acgcggaaag aagtaccttc gccggtcacc
121 ggctcctgca gggtgcaaat atatacagag cttcataatc agcccaagac cacatagagc
181 aaacatgaat gatatttccc aaaaggctga gattctgctt tcttcatcta aacctgtccc
241 aaaaacctat gtaccaaaac ttggcaaggg tgatgtaaag gataagtttg aagccatgca
301 gagagccagg gaagaaagaa atcaaaggag atctagagac gaaaaacaaa gaagaaaaga
361 acaatatatt agagagagag aatggaacag gagaaagcag gagattaaag aaatgcttgc
421 ttctgatgat gaggaagatg tatcttctaa agtagaaaag gcttatgttc caaaattaac
481 aggaactgtg aagggtagat ttgctgaaat ggagaaacaa agacaagagg aacaaaggaa
541 gagaacggag gaggaacgaa aacgcagaat tgagcaggat atgttagaaa agaggaaaat
601 acagcgtgaa ttagcaaaaa gggctgaaca gattgaggac ataaacaata cgggaactga
661 atcagcatca gaggaaggag atgattcact acttataact gtggtacctg tcaaatcata
721 taaaacatct ggaaaaatga aaaagaattt tgaggatcta gaaaaagaac gtgaagagaa
781 agaaaggatc aagtacgagg aagataaaag aataagatat gaagaacaac gaccatctct
841 caaggaagca aagtgtcttt cattagttat ggatgatgaa atagaaagtg aagcaaaaaa
901 agaatcactt tctcccggaa aattgaaact aacttttgaa gaactggagc gacaaagaca
961 agaaaaccga aagaagcaag ctgaagagga agcaagaaaa cgtttagaag aagagaagcg
1021 tgcttttgaa gaagcaaggc ggcaaatggt aaatgaagat gaggaaaacc aagacacagc
1081 aaaaattttt aaagggtacc gccctggtaa actcaaactc agttttgaag aaatggaaag
1141 gcaaagaaga gaagatgaaa aaaggaaagc agaagaagaa gccagaagga gaatagagga
1201 agaaaagaag gcgtttgctg aagcaaggag aaatatggta gtagatgatg actccccaga
1261 gatgtataag acaatctctc aagaatttct tacaccggga aaactggaaa ttaattttga
1321 agaattatta aaacaaaaaa tggaagaaga aaaacgacga acagaggagg aacggaagca
1381 taagctagaa atggagaaac aagaatttga acaactgaga caggaaatgg gagaggaaga
1441 ggaagaaaat gaaacctttg gattgagcag agaatatgaa gaactgatca aattaaaaag
1501 gagtggctct attcaagcta aaaacctaaa aagcaagttt gaaaaaattg gacagttgtc
1561 tgaaaaagaa atacagaaaa aaatagaaga agagcgagca agaaggagag caattgacct
1621 tgaaattaaa gagcgagaag ctgaaaattt tcatgaggaa gatgatgttg atgttaggcc
1681 tgcaagaaaa agcgaggctc catttactca caaagtgaat atgaaagcta gatttgaaca
1741 aatggctaag gcaagagaag aagaagaaca aagaagaatt gaagaacaaa agttactacg
1801 catgcagttt gaacaaaggg aaattgatgc agcactacaa aagaaaagag aagaggagga
1861 ggaggaagaa ggtagcatca tgaatggctc cactgctgaa gatgaagagc aaaccagatc
1921 aggagctcca tggttcaaga agcctcttaa aaacacatca gttgtagaca gtgagccagt
1981 cagatttacg gttaaagtaa caggagaacc caaaccagaa attacatggt ggtttgaagg
2041 agaaatactg caggatggag aagactatca atatattgaa aggggagaaa cttactgcct
2101 ttacttacca gaaactttcc cagaagatgg aggagagtat atgtgtaaag cagtcaacaa
2161 taaaggatct gcagctagta cctgtattct taccattgaa agtaagaatt aatcactctt
2221 tttatctttt attctattaa tttttttttc cttaaaatca cttttcttct tctctttttt
2281 agctgatgac tactagctcc cctcccctct ccctggaact ttctctttca ctccaacttt
2341 cttactacat ccatcttttc tgtggcgggg ccaaaaaagg aaaccaggag tgccactatg
2401 ctgacttctt attccttttc ataacagtct tcaaagcaca gctcatctaa agaatgccta
2461 cttcttttcc aaataagcat cagatttatc gcctattatg cagtaacagt caataaaatg
2521 tacttatggg ggggaattac tcaattattc tatcagaacc tattataaag actgtatttc
2581 ccatagacgt ttacagcaac tatgttt
//