LOCUS DQ228005 7502 bp mRNA linear HUM 20-DEC-2005
DEFINITION Homo sapiens TRIOBP isoform 6 (TRIOBP) mRNA, complete cds.
ACCESSION DQ228005
VERSION DQ228005.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 7502)
AUTHORS Riazuddin,S., Khan,S.N., Ahmed,Z.M., Ghosh,M., Caution,K.,
Nazli,S., Kabra,M., Zafar,A.U., Chen,K., Naz,S., Antonellis,A.,
Pavan,W.J., Green,E.D., Wilcox,E.R., Friedman,P.L., Morell,R.J.,
Riazuddin,S. and Friedman,T.B.
TITLE Mutations in TRIOBP, which encodes a putative
cytoskeletal-organizing protein, are associated with nonsyndromic
recessive deafness
JOURNAL Am. J. Hum. Genet. 78 (1), 137-143 (2006)
PUBMED 16385457
REFERENCE 2 (bases 1 to 7502)
AUTHORS Riazuddin,S., Ahmed,Z.M. and Friedman,T.B.
TITLE Mutations of TARA, encoding a putative cytoskeletal organizing
protein, are associated with nonsyndromic recessive deafness
JOURNAL Unpublished
REFERENCE 3 (bases 1 to 7502)
AUTHORS Riazuddin,S., Ahmed,Z.M. and Friedman,T.B.
TITLE Direct Submission
JOURNAL Submitted (29-SEP-2005) Laboratory of Molecular Genetics, National
Institute For Deafness and Other Communication Disorders, 5
Research Court, Rockville, MD 20850, USA
FEATURES Location/Qualifiers
source 1..7502
/db_xref="H-InvDB:HIT000342507"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/tissue_type="inner ear"
gene 1..7502
/gene="TRIOBP"
CDS 137..7234
/gene="TRIOBP"
/note="F-actin binding protein; TRIOBP-6"
/codon_start=1
/product="TRIOBP isoform 6"
/protein_id="ABB59561.1"
/translation="MEEVPGDALCEHFEANILTQNRCQNCFHPEEAHGARYQELRSPS
GAEVPYCDLPRCPPAPEDPLSASTSGCQSVVDPGLRPGPKRGPSPSAGLPEEGPTAAP
RSRSRELEAVPYLEGLTTSLCGSCNEDPGSDPTSSPDSATPDDTSNSSSVDWDTVERQ
EEEAPSWDELAVMIPRRPREGPRADSSQRAPSLLTRSPVGGDAAGQKKEDTGGGGRSA
GQHWARLRGESGLSLERHRSTLTQASSMTPHSGPRSTTSQASPAQRDTAQAASTREIP
RASSPHRITQRDTSRASSTQQEISRASSTQQETSRASSTQEDTPRASSTQEDTPRASS
TQWNTPRASSPSRSTQLDNPRTSSTQQDNPQTSFPTCTPQRENPRTPCVQQDDPRASS
PNRTTQRENSRTSCAQRDNPKASRTSSPNRATRDNPRTSCAQRDNPRASSPSRATRDN
PTTSCAQRDNPRASRTSSPNRATRDNPRTSCAQRDNPRASSPSRATRDNPTTSCAQRD
NPRASRTSSPNRATRDNPRTSCAQRDNPRASSPNRAARDNPTTSCAQRDNPRASRTSS
PNRATRDNPRTSCAQRDNPRASSPNRATRDNPTTSCAQRDNPRASRTSSPNRATRDNP
RTSCAQRDNPRASSPNRTTQQDSPRTSCARRDDPRASSPNRTIQQENPRTSCALRDNP
RASSPSRTIQQENPRTSCAQRDDPRASSPNRTTQQENPRTSCARRDNPRASSRNRTIQ
RDNPRTSCAQRDNPRASSPNRTIQQENLRTSCTRQDNPRTSSPNRATRDNPRTSCAQR
DNLRASSPIRATQQDNPRTCIQQNIPRSSSTQQDNPKTSCTKRDNLRPTCTQRDRTQS
FSFQRDNPGTSSSQCCTQKENLRPSSPHRSTQWNNPRNSSPHRTNKDIPWASFPLRPT
QSDGPRTSSPSRSKQSEVPWASIALRPTQGDRPQTSSPSRPAQHDPPQSSFGPTQYNL
PSRATSSSHNPGHQSTSRTSSPVYPAAYGAPLTSPEPSQPPCAVCIGHRDAPRASSPP
RYLQHDPFPFFPEPRAPESEPPHHEPPYIPPAVCIGHRDAPRASSPPRHTQFDPFPFL
PDTSDAEHQCQSPQHEPLQLPAPVCIGYRDAPRASSPPRQAPEPSLLFQDLPRASTES
LVPSMDSLHECPHIPTPVCIGHRDAPSFSSPPRQAPEPSLFFQDPPGTSMESLAPSTD
SLHGSPVLIPQVCIGHRDAPRASSPPRHPPSDLAFLAPSPSPGSSGGSRGSAPPGETR
HNLEREEYTVLADLPPPRRLAQRQPGPQAQCSSGGRTHSPGRAEVERLFGQERRKSEA
AGAFQAQDEGRSQQPSQGQSQLLRRQSSPAPSRQVTMLPAKQAELTRRSQAEPPHPWS
PEKRPEGDRQLQGSPLPPRTSARTPERELRTQRPLESGQAGPRQPLGVWQSQEEPPGS
QGPHRHLERSWSSQEGGLGPGGWWGCGEPSLGAAKAPEGAWGGTSREYKESWGQPEAW
EEKPTHELPRELGKRSPLTSPPENWGGPAESSQSWHSGTPTAVGWGAEGACPYPRGSE
RRPELDWRDLLGLLRAPGEGVWARVPSLDWEGLLELLQARLPRKDPAGHRDDLARALG
PELGPPGTNDVPEQESHSQPEGWAEATPVNGHSPALQSQSPVQLPSPACTSTQWPKIK
VTRGPATATLAGLEQTGPLGSRSTAKGPSLPELQFQPEEPEESEPSRGQDPLTDQKQA
DSADKRPAEGKAGSPLKGRLVTSWRMPGDRPTLFNPFLLSLGVLRWRRPDLLNFKKGW
MSILDEPGEPPSPSLTTTSTSQWKKHWFVLTDSSLKYYRDSTAEEADELDGEIDLRSC
TDVTEYAVQRNYGFQIHTKDAVYTLSAMTSGIRRNWIEALRKTVRPTSAPDVTKLSDS
NKENALHSYSTQKGPLKAGEQRAGSEVISRGGPRKADGQRQALDYVELSPLTQASPQR
ARTPARTPDRLAKQEELERDLAQRSEERRKWFEATDSRTPEVPAGEGPRRGLGAPLTE
DQQNRLSEEIEKKWQELEKLPLRENKRVPLTALLNQSRGERRGPPSDGHEALEKEVQA
LRAQLEAWRLQGEAPQSALRSQEDGHIPPGYISQEACERSLAEMESSHQQVMEELQRH
HERELQRLQQEKEWLLAEETAATASAIEAMKKAYQEELSRELSKTRSLQQGPDGLRKQ
HQSDVEALKRELQVLSEQYSQKCLEIGALMRQAEEREHTLRRCQQEGQELLRHNQELH
GRLSEEIDQLRGFIASQGMGNGCGRSNERSSCELEVLLRVKENELQYLKKEVQCLRDE
LQMMQKDKRFTSGKYQDVYVELSHIKTRSEREIEQLKEHLRLAMAALQEKESMRNSLA
E"
BASE COUNT 1751 a 2674 c 2006 g 1071 t
ORIGIN
1 cccaggggag gaggtgaaat tcctcagctc tccaccaaga ttggccacaa aagcctgatc
61 ccctggaaca cagcaggcct cacatagacg gtcagccatt ggatcatagg aactgccctg
121 gcctgactca cccaatatgg aggaggtgcc tggggatgcc ctgtgtgaac actttgaggc
181 caacatactt acccagaacc gctgtcaaaa ctgcttccac cctgaggagg cccatggagc
241 aagataccag gagctcagga gcccttcagg tgctgaggtg ccctactgcg acctgcctcg
301 atgtccacct gcccctgagg acccactcag cgcctcaacc tccggctgcc agtctgtggt
361 ggacccaggc ctcaggccag ggcccaagag gggcccatcc ccctcagcag ggctcccaga
421 agagggtccc acagctgccc ccaggagcag gagccgggag cttgaggcag taccctatct
481 ggagggcctg accacttcct tgtgtggcag ctgcaacgag gaccccggct ctgaccccac
541 ctccagccct gactccgcca cccctgatga taccagcaac tcgtcctctg tggactggga
601 cactgttgag aggcaggagg aggaggcccc cagctgggac gagctcgcag tgatgatccc
661 gaggaggcct cgggaggggc cgagagctga cagctcccaa agggctccgt ctctcctcac
721 caggtcccct gtgggaggag atgctgcagg ccagaaaaag gaggacaccg gcggtggggg
781 ccggagcgca ggacagcact gggcaaggct ccggggagaa agcgggttgt ccctggagcg
841 gcaccggtca acactgaccc aggcttcctc catgacacca cacagtggac ctcgaagcac
901 cacgtctcag gcttctcctg cccaaaggga cactgctcag gctgcctcta cacgtgaaat
961 ccccagagcc tcctctcccc atcgaatcac ccaaagggac acctccaggg cctcatccac
1021 ccaacaggaa atctccaggg cctcatccac ccaacaggaa acctccaggg cctcatccac
1081 ccaagaggac acccctaggg cctcatccac ccaagaggac acccccaggg cctcatctac
1141 acagtggaac acccccagag cttcctctcc ctcacgaagc acccaactgg ataaccccag
1201 aacctcttct acccagcagg acaaccccca aacttctttt cctacttgta ctccccagcg
1261 ggaaaacccc aggacaccct gtgtccagca ggacgatccc agagcctcct ctcccaacag
1321 aaccactcaa cgagagaatt ccagaacatc ctgtgcccag cgggacaatc ccaaagcctc
1381 cagaacctcc tctcccaata gagccacacg agacaacccc agaacatcct gcgcccagcg
1441 ggacaatccc agagcctcct ctcccagtag agctacacga gacaacccca caacatcctg
1501 tgcccagcgg gacaatccca gagcctccag aacctcctct cccaatagag ccacacgaga
1561 caaccccaga acatcctgtg cccagcggga caatcccaga gcctcctctc ccagtagagc
1621 tacacgagac aaccccacaa catcctgtgc ccagcgggac aatcccagag cctccagaac
1681 ctcctctccc aatagagcca cacgagacaa ccccagaaca tcctgcgccc agcgggacaa
1741 tcccagagcc tcctctccca atagagctgc acgagacaac cccacaacat cctgtgccca
1801 gcgggacaat cccagagcct ccagaacctc ctctcccaat agagccacac gagacaaccc
1861 cagaacatcc tgtgcccagc gggacaatcc cagagcctcc tctcccaata gagctacacg
1921 agacaacccc acaacatcct gtgcccagcg ggacaatccc agagcctcca gaacctcctc
1981 tcccaataga gccacacgag ataaccccag aacatcctgt gcccagcggg acaatcccag
2041 agcctcctct cccaacagaa ccacccaaca agacagcccc agaacatcct gtgcccgacg
2101 ggacgatccc agagcctcct ctcctaacag aaccatccaa caagagaacc ccagaacatc
2161 ctgtgcccta cgggacaatc ccagagcctc ctctcccagc agaaccatcc aacaagagaa
2221 ccccagaaca tcctgtgccc aacgggacga tcccagagcc tcctctccta acagaaccac
2281 ccaacaagag aaccccagaa catcctgtgc ccgacgggac aatcccagag cctcctctcg
2341 caacagaacc atccagcgag acaaccccag aacatcctgt gcccagcggg acaatcccag
2401 agcctcctct cctaacagaa ccatccaaca agagaacctc agaacatcct gtacccgaca
2461 ggacaatccc aggacctcct ctcccaatag agccacacga gacaacccca gaacatcctg
2521 tgcccagcgg gacaatctca gagcctcctc tcccatcaga gccacccaac aggacaaccc
2581 cagaacttgt attcaacaga acatccccag atcatcttct acccaacaag acaaccctaa
2641 aacctcttgt accaaacgag ataacctcag acccacttgt acacagcggg accgcacaca
2701 gtccttttcc tttcaacgag acaaccctgg aacctcctca tctcaatgct gcacccaaaa
2761 ggagaatctg agaccatcat ctccccaccg ctccactcaa tggaacaatc ccaggaattc
2821 atctccccat cgtactaaca aagacatccc ctgggcctcg tttcccctcc ggccaactca
2881 gagtgatggt ccccgaacct cttccccatc tcgctccaag caaagcgagg ttccctgggc
2941 atccatcgcc ctccggccaa cccaaggtga caggcctcag acatcctctc ccagcaggcc
3001 agcccagcat gacccacccc agtcctcctt tggccccacc cagtacaact tgccatcccg
3061 ggccacctct tcctcccata acccaggcca ccagagcacc tcccgaactt cctcacctgt
3121 gtaccccgct gcctatgggg ctcccctgac ctctcctgag ccctcccagc ctccatgtgc
3181 tgtgtgcatt gggcaccggg atgcccctcg agcctcttcg ccccctcgct atttgcagca
3241 cgaccccttc cccttcttcc cagagccccg cgcccctgag agtgaaccgc cccaccacga
3301 gcctccctat ataccacctg ctgtgtgcat tggacaccga gatgcccccc gggcgtcctc
3361 gcccccccgc cacacccaat ttgacccctt ccccttcctc ccagacacat cagatgccga
3421 gcatcagtgt cagtcccccc aacacgagcc ccttcagctc cctgcacctg tgtgtattgg
3481 gtaccgagat gcaccccggg cctcctcccc accacgccag gccccagagc cttccctctt
3541 attccaggac ctccccaggg ccagcacaga gagccttgtc ccttccatgg actctctgca
3601 cgagtgcccc cacatcccca cccctgtgtg cattgggcac cgggatgcac cctccttctc
3661 atccccacca cgccaggctc ctgagccatc cctcttcttc caggatcccc ctggaactag
3721 tatggagagc ctggccccct ccactgactc tctgcatggc tccccagtgc tgatccccca
3781 agtgtgcatc gggcaccggg atgcaccccg agcctcctcc ccaccccgcc acccacccag
3841 tgacctagcg ttcctggcac cctcaccttc accgggcagc tctgggggct cccggggctc
3901 agcgcctccc ggggagacca ggcacaactt ggagcgggag gagtacactg tgctggccga
3961 cctgccccca cccaggaggc tggcccagag acagccaggg ccccaggcgc agtgcagcag
4021 cgggggccgc acccacagcc ctggccgtgc agaggtggag cgcctcttcg ggcaagagcg
4081 caggaagtcc gaggcagcgg gggccttcca ggcccaggac gagggacggt cacagcagcc
4141 cagccaaggc cagagccaac ttctccgaag acagtccagc cctgccccca gcaggcaggt
4201 gaccatgctc cctgccaaac aggcagaact gacccggcgg agccaagcag agccccctca
4261 tccttggagt cctgagaaga gacctgaggg agatcggcag ctccaggggt ccccgctgcc
4321 ccccaggaca tcagccagga cccctgagag ggagctgcgg acacagagac ctctggagag
4381 tggccaagca ggcccaagac agcctctggg ggtgtggcag agtcaggagg aaccgccagg
4441 gtcccagggc cctcatagac acctagaaag gagctggagc agccaggagg gaggcctggg
4501 ccctgggggc tggtggggat gtggagagcc cagcctgggg gcagccaaag ccccggaggg
4561 agcatggggg ggcacttcca gggagtacaa ggagagctgg gggcagccag aggcctggga
4621 ggagaagccc actcatgagc tccccagaga actaggaaag agaagcccac tcacgagccc
4681 ccctgagaac tggggaggcc ccgcagagtc ctcacaatcc tggcactctg ggacacccac
4741 tgctgtgggc tggggggcag agggagcgtg tccatacccg cgtggctctg agaggcgacc
4801 cgagcttgac tggagggatc tgcttggcct tctccgggca ccaggagagg gggtctgggc
4861 ccgtgtcccc agcctggact gggagggcct cttggagctc ctgcaggcca ggctgccccg
4921 caaggaccca gctggacaca gggatgacct ggccagggct ttagggccag agctgggtcc
4981 cccaggcaca aacgatgtcc ctgagcagga gtcacacagc cagccagaag gctgggccga
5041 ggccacccca gtcaatggac acagccccgc actgcagtcc cagagcccgg tccagctgcc
5101 cagccctgcc tgcacctcca cccagtggcc aaagatcaaa gtgacaagag gaccagcgac
5161 cgcaactctg gcaggcctgg agcagacggg ccccctgggg agcaggagca ctgcgaaggg
5221 ccccagcttg ccagagctgc agttccaacc agaggagcct gaggagtcag aaccaagcag
5281 aggccaagac cccctgactg accagaagca ggcagactcg gcagacaaga ggccagcaga
5341 gggcaaggct gggagcccgc tcaagggccg actggtgacc tcatggcgga tgcccgggga
5401 ccggcccacg ctgttcaatc cgttcctgct gtctctgggg gtcctcaggt ggcgaaggcc
5461 cgatctgctc aacttcaaga agggatggat gtcgatcttg gacgagcctg gagagcctcc
5521 ctccccctcg ctcaccacca cctctacttc gcagtggaag aaacattggt ttgtgctgac
5581 agattcaagt ctcaaatatt acagagactc cactgctgag gaggcagatg agctggatgg
5641 tgagatcgac ctgcgttcct gcacggatgt cactgagtac gcggtgcagc gcaactatgg
5701 cttccagatc cacaccaagg atgctgtcta taccttgtcg gccatgacct caggcatccg
5761 gcggaactgg atcgaggctc tgagaaagac cgtacgtcca acttcagccc cagatgtcac
5821 caagctctcg gactctaaca aggagaacgc gctgcacagc tacagcaccc agaagggccc
5881 cctgaaggca ggggagcagc gggcgggctc tgaggtcatc agccggggtg gccctcggaa
5941 ggcggacggg cagcgtcagg ccttggacta cgtggagctc tcgccgctga cccaggcttc
6001 cccgcagcgg gcccgcaccc cagcccgcac tcctgaccgc ctggccaagc aggaggagct
6061 ggagcgggac ctggcccagc gctccgagga gcggcgcaag tggtttgagg ccacagacag
6121 caggacccca gaggtgcctg ctggtgaggg gccgcgccgg ggcctgggtg cccccctgac
6181 tgaggaccag caaaaccggc ttagtgagga gatcgagaag aagtggcagg agctggagaa
6241 gctgcccctg cgggagaata agcgggtgcc cctcactgcc ctgctcaacc aaagccgcgg
6301 agagcgccga gggcccccaa gtgacggcca cgaggcactg gagaaggagg ttcaggctct
6361 tcgggcccag ctggaggcgt ggcgtctcca aggggaggct cctcagagtg cactgagatc
6421 ccaggaggat ggccacatcc ccccgggcta catctcacag gaggcatgtg agcgcagcct
6481 ggcagagatg gagtcctcgc accagcaggt gatggaggag ctgcagcggc accacgagcg
6541 ggagctgcag cgcctgcagc aggagaagga gtggctcctg gctgaggaga cggcagccac
6601 ggcctcagcc attgaagcca tgaagaaggc ctaccaggaa gagctgagcc gagagctgag
6661 caaaacacgg agtctccagc agggcccgga tggcctccgg aagcagcacc agtcagatgt
6721 ggaggcactg aagcgagagc tgcaggtgct atcggagcag tactcgcaga agtgcctgga
6781 gattggggca ctcatgcggc aggctgagga gcgcgagcac acgctgcgcc gctgccagca
6841 ggagggccag gagctgctgc gccacaacca ggagctgcat ggccgcctgt cagaggagat
6901 agaccagctg cgcggcttca ttgcctcgca gggcatgggc aatggctgcg ggcgcagcaa
6961 cgagcggagt tcctgcgagc tagaggtgct gcttcgcgta aaagaaaacg aactccagta
7021 cctaaagaag gaggtgcagt gcctccggga cgagctccag atgatgcaga aggacaagcg
7081 cttcacctcg ggaaagtacc aggacgtcta tgtggagctg agccacatca agacacggtc
7141 tgagcgggag atcgagcagc tgaaggagca cctgcgtctt gccatggccg ccctccagga
7201 gaaggagtcg atgcgcaaca gcctggctga gtagaggtcc cgcccagctg cagaccctcc
7261 aggctggagg accagccgcc ctccttccct cctggatgga agtaaaaagc caagctttct
7321 ccccaccctc tgtgggccac acgtgcactt gcacccacca cacacacaca cacacacaca
7381 cacacacaca cagacacaca gacacatacg cacacacgtg cacacatgta cacacggata
7441 cacacacaca cacacacact gcatatctga gcgcgcccct cgcactgggt ctcaccttgc
7501 ac
//