LOCUS DQ228003 7300 bp mRNA linear HUM 12-JAN-2006
DEFINITION Homo sapiens TRIOBP isoform 3 (TRIOBP) mRNA, complete cds.
ACCESSION DQ228003
VERSION DQ228003.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 7300)
AUTHORS Riazuddin,S., Khan,S.N., Ahmed,Z.M., Ghosh,M., Caution,K.,
Nazli,S., Kabra,M., Zafar,A.U., Chen,K., Naz,S., Antonellis,A.,
Pavan,W.J., Green,E.D., Wilcox,E.R., Friedman,P.L., Morell,R.J.,
Riazuddin,S. and Friedman,T.B.
TITLE Mutations in TRIOBP, Which Encodes a Putative
Cytoskeletal-Organizing Protein, Are Associated with Nonsyndromic
Recessive Deafness
JOURNAL Am. J. Hum. Genet. 78 (1), 137-143 (2006)
PUBMED 16385457
REFERENCE 2 (bases 1 to 7300)
AUTHORS Riazuddin,S., Ahmed,Z.M. and Friedman,T.B.
TITLE Mutations of TARA, encoding a putative cytoskeletal organizing
protein, are associated with nonsyndromic recessive deafness
JOURNAL Unpublished
REFERENCE 3 (bases 1 to 7300)
AUTHORS Riazuddin,S., Ahmed,Z.M. and Friedman,T.B.
TITLE Direct Submission
JOURNAL Submitted (26-SEP-2005) Laboratory of Molecular Genetics, National
Institute For Deafness and Other Communication Disorders, 5
Research Court, Rockville, MD 20850, USA
FEATURES Location/Qualifiers
source 1..7300
/db_xref="H-InvDB:HIT000342505"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/tissue_type="inner ear"
gene 1..7300
/gene="TRIOBP"
CDS 451..7032
/gene="TRIOBP"
/note="F-actin binding protein; TRIOBP-3"
/codon_start=1
/product="TRIOBP isoform 3"
/protein_id="ABB59559.1"
/translation="MIPRRPREGPRADSSQRAPSLLTRSPVGGDAAGQKKEDTGGGGR
SAGQHWARLRGESGLSLERHRSTLTQASSMTPHSGPRSTTSQASPAQRDTAQAASTRE
IPRASSPHRITQRDTSRASSTQQEISRASSTQQETSRASSTQEDTPRASSTQEDTPRA
SSTQWNTPRASSPSRSTQLDNPRTSSTQQDNPQTSFPTCTPQRENPRTPCVQQDDPRA
SSPNRTTQRENSRTSCAQRDNPKASRTSSPNRATRDNPRTSCAQRDNPRASSPSRATR
DNPTTSCAQRDNPRASRTSSPNRATRDNPRTSCAQRDNPRASSPSRATRDNPTTSCAQ
RDNPRASRTSSPNRATRDNPRTSCAQRDNPRASSPNRAARDNPTTSCAQRDNPRASRT
SSPNRATRDNPRTSCAQRDNPRASSPNRATRDNPTTSCAQRDNPRASRTSSPNRATRD
NPRTSCAQRDNPRASSPNRTTQQDSPRTSCARRDDPRASSPNRTIQQENPRTSCALRD
NPRASSPSRTIQQENPRTSCAQRDDPRASSPNRTTQQENPRTSCARRDNPRASSRNRT
IQRDNPRTSCAQRDNPRASSPNRTIQQENLRTSCTRQDNPRTSSPNRATRDNPRTSCA
QRDNLRASSPIRATQQDNPRTCIQQNIPRSSSTQQDNPKTSCTKRDNLRPTCTQRDRT
QSFSFQRDNPGTSSSQCCTQKENLRPSSPHRSTQWNNPRNSSPHRTNKDIPWASFPLR
PTQSDGPRTSSPSRSKQSEVPWASIALRPTQGDRPQTSSPSRPAQHDPPQSSFGPTQY
NLPSRATSSSHNPGHQSTSRTSSPVYPAAYGAPLTSPEPSQPPCAVCIGHRDAPRASS
PPRYLQHDPFPFFPEPRAPESEPPHHEPPYIPPAVCIGHRDAPRASSPPRHTQFDPFP
FLPDTSDAEHQCQSPQHEPLQLPAPVCIGYRDAPRASSPPRQAPEPSLLFQDLPRAST
ESLVPSMDSLHECPHIPTPVCIGHRDAPSFSSPPRQAPEPSLFFQDPPGTSMESLAPS
TDSLHGSPVLIPQVCIGHRDAPRASSPPRHPPSDLAFLAPSPSPGSSGGSRGSAPPGE
TRHNLEREEYTVLADLPPPRRLAQRQPGPQAQCSSGGRTHSPGRAEVERLFGQERRKS
EAAGAFQAQDEGRSQQPSQGQSQLLRRQSSPAPSRQVTMLPAKQAELTRRSQAEPPHP
WSPEKRPEGDRQLQGSPLPPRTSARTPERELRTQRPLESGQAGPRQPLGVWQSQEEPP
GSQGPHRHLERSWSSQEGGLGPGGWWGCGEPSLGAAKAPEGAWGGTSREYKESWGQPE
AWEEKPTHELPRELGKRSPLTSPPENWGGPAESSQSWHSGTPTAVGWGAEGACPYPRG
SERRPELDWRDLLGLLRAPGEGVWARVPSLDWEGLLELLQARLPRKDPAGHRDDLARA
LGPELGPPGTNDVPEQESHSQPEGWAEATPVNGHSPALQSQSPVQLPSPACTSTQWPK
IKVTRGPATATLAGLEQTGPLGSRSTAKGPSLPELQFQPEEPEESEPSRGQDPLTDQK
QADSADKRPAEGKAGSPLKGRLVTSWRMPGDRPTLFNPFLLSLGVLRWRRPDLLNFKK
GWMSILDEPGEPPSPSLTTTSTSQWKKHWFVLTDSSLKYYRDSTAEEADELDGEIDLR
SCTDVTEYAVQRNYGFQIHTKDAVYTLSAMTSGIRRNWIEALRKTVRPTSAPDVTKLS
DSNKENALHSYSTQKGPLKAGEQRAGSEVISRGGPRKADGQRQALDYVELSPLTQASP
QRARTPARTPDRLAKQEELERDLAQRSEERRKWFEATDSRTPEVPAGEGPRRGLGAPL
TEDQQNRLSEEIEKKWQELEKLPLRENKRVPLTALLNQSRGERRGPPSDGHEALEKEV
QALRAQLEAWRLQGEAPQSALRSQEDGHIPPGYISQEACERSLAEMESSHQQVMEELQ
RHHERELQRLQQEKEWLLAEETAATASAIEAMKKAYQEELSRELSKTRSLQQGPDGLR
KQHQSDVEALKRELQVLSEQYSQKCLEIGALMRQAEEREHTLRRCQQEGQELLRHNQE
LHGRLSEEIDQLRGFIASQGMGNGCGRSNERSSCELEVLLRVKENELQYLKKEVQCLR
DELQMMQKDKRFTSGKYQDVYVELSHIKTRSEREIEQLKEHLRLAMAALQEKESMRNS
LAE"
BASE COUNT 1714 a 2596 c 1951 g 1039 t
ORIGIN
1 cccaggggag gaggtgaaat tcctcagctc tccaccaaga ttggccacaa aagcctgatc
61 ccctggaaca cagcaggcct cacatagacg gtcagccatt ggatcatagg aactgccctg
121 gcctgactca cccaatatgg aggaggtgcc tggggatgcc ctgtgtgaac actttgaggc
181 caacatactt acccagaacc gctgtcaaaa ctgcttccac cctgaggagg cccatggagc
241 aagataccag gagctcagga gcccttcagg tgctgaggtg ccctactgcg acctgcctcg
301 atgtccacct gcccctgagg acccactcag cgcctcaacc tccggctgcc agtctgtggt
361 ggacccaggc ctcaggccag ggcccaagag gactgggaca ctgttgagag gcaggaggag
421 gaggccccca gctgggacga gctcgcagtg atgatcccga ggaggcctcg ggaggggccg
481 agagctgaca gctcccaaag ggctccgtct ctcctcacca ggtcccctgt gggaggagat
541 gctgcaggcc agaaaaagga ggacaccggc ggtgggggcc ggagcgcagg acagcactgg
601 gcaaggctcc ggggagaaag cgggttgtcc ctggagcggc accggtcaac actgacccag
661 gcttcctcca tgacaccaca cagtggacct cgaagcacca cgtctcaggc ttctcctgcc
721 caaagggaca ctgctcaggc tgcctctaca cgtgaaatcc ccagagcctc ctctccccat
781 cgaatcaccc aaagggacac ctccagggcc tcatccaccc aacaggaaat ctccagggcc
841 tcatccaccc aacaggaaac ctccagggcc tcatccaccc aagaggacac ccctagggcc
901 tcatccaccc aagaggacac ccccagggcc tcatctacac agtggaacac ccccagagct
961 tcctctccct cacgaagcac ccaactggat aaccccagaa cctcttctac ccagcaggac
1021 aacccccaaa cttcttttcc tacttgtact ccccagcggg aaaaccccag gacaccctgt
1081 gtccagcagg acgatcccag agcctcctct cccaacagaa ccactcaacg agagaattcc
1141 agaacatcct gtgcccagcg ggacaatccc aaagcctcca gaacctcctc tcccaataga
1201 gccacacgag acaaccccag aacatcctgc gcccagcggg acaatcccag agcctcctct
1261 cccagtagag ctacacgaga caaccccaca acatcctgtg cccagcggga caatcccaga
1321 gcctccagaa cctcctctcc caatagagcc acacgagaca accccagaac atcctgtgcc
1381 cagcgggaca atcccagagc ctcctctccc agtagagcta cacgagacaa ccccacaaca
1441 tcctgtgccc agcgggacaa tcccagagcc tccagaacct cctctcccaa tagagccaca
1501 cgagacaacc ccagaacatc ctgcgcccag cgggacaatc ccagagcctc ctctcccaat
1561 agagctgcac gagacaaccc cacaacatcc tgtgcccagc gggacaatcc cagagcctcc
1621 agaacctcct ctcccaatag agccacacga gacaacccca gaacatcctg tgcccagcgg
1681 gacaatccca gagcctcctc tcccaataga gctacacgag acaaccccac aacatcctgt
1741 gcccagcggg acaatcccag agcctccaga acctcctctc ccaatagagc cacacgagat
1801 aaccccagaa catcctgtgc ccagcgggac aatcccagag cctcctctcc caacagaacc
1861 acccaacaag acagccccag aacatcctgt gcccgacggg acgatcccag agcctcctct
1921 cctaacagaa ccatccaaca agagaacccc agaacatcct gtgccctacg ggacaatccc
1981 agagcctcct ctcccagcag aaccatccaa caagagaacc ccagaacatc ctgtgcccaa
2041 cgggacgatc ccagagcctc ctctcctaac agaaccaccc aacaagagaa ccccagaaca
2101 tcctgtgccc gacgggacaa tcccagagcc tcctctcgca acagaaccat ccagcgagac
2161 aaccccagaa catcctgtgc ccagcgggac aatcccagag cctcctctcc taacagaacc
2221 atccaacaag agaacctcag aacatcctgt acccgacagg acaatcccag gacctcctct
2281 cccaatagag ccacacgaga caaccccaga acatcctgtg cccagcggga caatctcaga
2341 gcctcctctc ccatcagagc cacccaacag gacaacccca gaacttgtat tcaacagaac
2401 atccccagat catcttctac ccaacaagac aaccctaaaa cctcttgtac caaacgagat
2461 aacctcagac ccacttgtac acagcgggac cgcacacagt ccttttcctt tcaacgagac
2521 aaccctggaa cctcctcatc tcaatgctgc acccaaaagg agaatctgag accatcatct
2581 ccccaccgct ccactcaatg gaacaatccc aggaattcat ctccccatcg tactaacaaa
2641 gacatcccct gggcctcgtt tcccctccgg ccaactcaga gtgatggtcc ccgaacctct
2701 tccccatctc gctccaagca aagcgaggtt ccctgggcat ccatcgccct ccggccaacc
2761 caaggtgaca ggcctcagac atcctctccc agcaggccag cccagcatga cccaccccag
2821 tcctcctttg gccccaccca gtacaacttg ccatcccggg ccacctcttc ctcccataac
2881 ccaggccacc agagcacctc ccgaacttcc tcacctgtgt accccgctgc ctatggggct
2941 cccctgacct ctcctgagcc ctcccagcct ccatgtgctg tgtgcattgg gcaccgggat
3001 gcccctcgag cctcttcgcc ccctcgctat ttgcagcacg accccttccc cttcttccca
3061 gagccccgcg cccctgagag tgaaccgccc caccacgagc ctccctatat accacctgct
3121 gtgtgcattg gacaccgaga tgccccccgg gcgtcctcgc ccccccgcca cacccaattt
3181 gaccccttcc ccttcctccc agacacatca gatgccgagc atcagtgtca gtccccccaa
3241 cacgagcccc ttcagctccc tgcacctgtg tgtattgggt accgagatgc accccgggcc
3301 tcctccccac cacgccaggc cccagagcct tccctcttat tccaggacct ccccagggcc
3361 agcacagaga gccttgtccc ttccatggac tctctgcacg agtgccccca catccccacc
3421 cctgtgtgca ttgggcaccg ggatgcaccc tccttctcat ccccaccacg ccaggctcct
3481 gagccatccc tcttcttcca ggatccccct ggaactagta tggagagcct ggccccctcc
3541 actgactctc tgcatggctc cccagtgctg atcccccaag tgtgcatcgg gcaccgggat
3601 gcaccccgag cctcctcccc accccgccac ccacccagtg acctagcgtt cctggcaccc
3661 tcaccttcac cgggcagctc tgggggctcc cggggctcag cgcctcccgg ggagaccagg
3721 cacaacttgg agcgggagga gtacactgtg ctggccgacc tgcccccacc caggaggctg
3781 gcccagagac agccagggcc ccaggcgcag tgcagcagcg ggggccgcac ccacagccct
3841 ggccgtgcag aggtggagcg cctcttcggg caagagcgca ggaagtccga ggcagcgggg
3901 gccttccagg cccaggacga gggacggtca cagcagccca gccaaggcca gagccaactt
3961 ctccgaagac agtccagccc tgcccccagc aggcaggtga ccatgctccc tgccaaacag
4021 gcagaactga cccggcggag ccaagcagag ccccctcatc cttggagtcc tgagaagaga
4081 cctgagggag atcggcagct ccaggggtcc ccgctgcccc ccaggacatc agccaggacc
4141 cctgagaggg agctgcggac acagagacct ctggagagtg gccaagcagg cccaagacag
4201 cctctggggg tgtggcagag tcaggaggaa ccgccagggt cccagggccc tcatagacac
4261 ctagaaagga gctggagcag ccaggaggga ggcctgggcc ctgggggctg gtggggatgt
4321 ggagagccca gcctgggggc agccaaagcc ccggagggag catggggggg cacttccagg
4381 gagtacaagg agagctgggg gcagccagag gcctgggagg agaagcccac tcatgagctc
4441 cccagagaac taggaaagag aagcccactc acgagccccc ctgagaactg gggaggcccc
4501 gcagagtcct cacaatcctg gcactctggg acacccactg ctgtgggctg gggggcagag
4561 ggagcgtgtc catacccgcg tggctctgag aggcgacccg agcttgactg gagggatctg
4621 cttggccttc tccgggcacc aggagagggg gtctgggccc gtgtccccag cctggactgg
4681 gagggcctct tggagctcct gcaggccagg ctgccccgca aggacccagc tggacacagg
4741 gatgacctgg ccagggcttt agggccagag ctgggtcccc caggcacaaa cgatgtccct
4801 gagcaggagt cacacagcca gccagaaggc tgggccgagg ccaccccagt caatggacac
4861 agccccgcac tgcagtccca gagcccggtc cagctgccca gccctgcctg cacctccacc
4921 cagtggccaa agatcaaagt gacaagagga ccagcgaccg caactctggc aggcctggag
4981 cagacgggcc ccctggggag caggagcact gcgaagggcc ccagcttgcc agagctgcag
5041 ttccaaccag aggagcctga ggagtcagaa ccaagcagag gccaagaccc cctgactgac
5101 cagaagcagg cagactcggc agacaagagg ccagcagagg gcaaggctgg gagcccgctc
5161 aagggccgac tggtgacctc atggcggatg cccggggacc ggcccacgct gttcaatccg
5221 ttcctgctgt ctctgggggt cctcaggtgg cgaaggcccg atctgctcaa cttcaagaag
5281 ggatggatgt cgatcttgga cgagcctgga gagcctccct ccccctcgct caccaccacc
5341 tctacttcgc agtggaagaa acattggttt gtgctgacag attcaagtct caaatattac
5401 agagactcca ctgctgagga ggcagatgag ctggatggtg agatcgacct gcgttcctgc
5461 acggatgtca ctgagtacgc ggtgcagcgc aactatggct tccagatcca caccaaggat
5521 gctgtctata ccttgtcggc catgacctca ggcatccggc ggaactggat cgaggctctg
5581 agaaagaccg tacgtccaac ttcagcccca gatgtcacca agctctcgga ctctaacaag
5641 gagaacgcgc tgcacagcta cagcacccag aagggccccc tgaaggcagg ggagcagcgg
5701 gcgggctctg aggtcatcag ccggggtggc cctcggaagg cggacgggca gcgtcaggcc
5761 ttggactacg tggagctctc gccgctgacc caggcttccc cgcagcgggc ccgcacccca
5821 gcccgcactc ctgaccgcct ggccaagcag gaggagctgg agcgggacct ggcccagcgc
5881 tccgaggagc ggcgcaagtg gtttgaggcc acagacagca ggaccccaga ggtgcctgct
5941 ggtgaggggc cgcgccgggg cctgggtgcc cccctgactg aggaccagca aaaccggctt
6001 agtgaggaga tcgagaagaa gtggcaggag ctggagaagc tgcccctgcg ggagaataag
6061 cgggtgcccc tcactgccct gctcaaccaa agccgcggag agcgccgagg gcccccaagt
6121 gacggccacg aggcactgga gaaggaggtt caggctcttc gggcccagct ggaggcgtgg
6181 cgtctccaag gggaggctcc tcagagtgca ctgagatccc aggaggatgg ccacatcccc
6241 ccgggctaca tctcacagga ggcatgtgag cgcagcctgg cagagatgga gtcctcgcac
6301 cagcaggtga tggaggagct gcagcggcac cacgagcggg agctgcagcg cctgcagcag
6361 gagaaggagt ggctcctggc tgaggagacg gcagccacgg cctcagccat tgaagccatg
6421 aagaaggcct accaggaaga gctgagccga gagctgagca aaacacggag tctccagcag
6481 ggcccggatg gcctccggaa gcagcaccag tcagatgtgg aggcactgaa gcgagagctg
6541 caggtgctat cggagcagta ctcgcagaag tgcctggaga ttggggcact catgcggcag
6601 gctgaggagc gcgagcacac gctgcgccgc tgccagcagg agggccagga gctgctgcgc
6661 cacaaccagg agctgcatgg ccgcctgtca gaggagatag accagctgcg cggcttcatt
6721 gcctcgcagg gcatgggcaa tggctgcggg cgcagcaacg agcggagttc ctgcgagcta
6781 gaggtgctgc ttcgcgtaaa agaaaacgaa ctccagtacc taaagaagga ggtgcagtgc
6841 ctccgggacg agctccagat gatgcagaag gacaagcgct tcacctcggg aaagtaccag
6901 gacgtctatg tggagctgag ccacatcaag acacggtctg agcgggagat cgagcagctg
6961 aaggagcacc tgcgtcttgc catggccgcc ctccaggaga aggagtcgat gcgcaacagc
7021 ctggctgagt agaggtcccg cccagctgca gaccctccag gctggaggac cagccgccct
7081 ccttccctcc tggatggaag taaaaagcca agctttctcc ccaccctctg tgggccacac
7141 gtgcacttgc acccaccaca cacacacaca cacacacaca cacacacaca gacacacaga
7201 cacatacgca cacacgtgca cacatgtaca cacggataca cacacacaca cacacactgc
7261 atatctgagc gcgcccctcg cactgggtct caccttgcac
//