LOCUS DQ174270 1623 bp mRNA linear HUM 09-SEP-2005
DEFINITION Homo sapiens mitochondrial anti-viral signaling protein (MAVS)
mRNA, complete cds; nuclear gene for mitochondrial product.
ACCESSION DQ174270
VERSION DQ174270.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1623)
AUTHORS Seth,R.B., Sun,L., Ea,C.-K. and Chen,Z.J.
TITLE Identification and Characterization of MAVS, a Mitochondrial
Anti-Viral Signaling Protein that Activates NF-kB and IRF3
JOURNAL Cell (2005) In press
REFERENCE 2 (bases 1 to 1623)
AUTHORS Seth,R.B., Sun,L., Ea,C.-K. and Chen,Z.J.
TITLE Direct Submission
JOURNAL Submitted (19-AUG-2005) Molecular Biology, UT Southwestern Medical
Center/HHMI, 5323 Harry Hines Blvd, Dallas, TX 75390, USA
FEATURES Location/Qualifiers
source 1..1623
/db_xref="H-InvDB:HIT000342100"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
gene 1..1623
/gene="MAVS"
CDS 1..1623
/gene="MAVS"
/note="contains N-terminal CARD-like domain and C-terminal
transmembrane domain; both CARD-like and transmembrane
domains are essential to activate NF-kB, IRF3 and IRF7 to
induce interferons; essential for anti-viral innate immune
responses"
/codon_start=1
/product="mitochondrial anti-viral signaling protein"
/protein_id="AAZ80417.1"
/translation="MPFAEDKTYKYICRNFSNFCNVDVVEILPYLPCLTARDQDRLRA
TCTLSGNRDTLWHLFNTLQRRPGWVEYFIAALRGCELVDLADEVASVYESYQPRTSDR
PPDPLEPPSLPAERPGPPTPAAAHSIPYNSCREKEPSYPMPVQETQAPESPGENSEQA
LQTLSPRAIPRNPDGGPLESSSDLAALSPLTSSGHQEKDTELGSTHTAGATSSLTPSR
GPVSPSVSFQPLARSTPRASRLPGPTGSVVSTGTSFSSSSPGLASAGAAEGKQGAESD
QAEPIICSSGAEAPANSLPSKVPTTLMPVNTVALKVPANPASVSTVPSKLPTSSKPPG
AVPSNALTNPAPSKLPINSTRAGMVPSKVPTSMVLTKVSASTVPTDGSSRNEETPAAP
TPAGATGGSSAWLDSSFENRGLGSELSKPGVLASQVDSPFSGCFEDLAISASTSLGMG
PCHGPEENEYKSEGTFGIHVAENPSIQLLEGNPGPPADPDGGPRPQADRKFQEREVPC
HRPSPGALWLQVAVTGVLVVTLLVVLYRRRLH"
BASE COUNT 334 a 548 c 448 g 293 t
ORIGIN
1 atgccgtttg ctgaagacaa gacctataag tatatctgcc gcaatttcag caatttttgc
61 aatgtggatg ttgtagagat tctgccttac ctgccctgcc tcacagcaag agaccaggat
121 cgactgcggg ccacctgcac actctcaggg aaccgggaca ccctctggca tctcttcaat
181 acccttcagc ggcggcccgg ctgggtggag tacttcattg cggcactgag gggctgtgag
241 ctagttgatc tcgcggacga agtggcctct gtctacgaga gctaccagcc tcggacctcg
301 gaccgtcccc cagacccact ggagccaccg tcacttcctg ctgagaggcc agggcccccc
361 acacctgctg cggcccacag catcccctac aacagctgca gagagaagga gccaagttac
421 cccatgcctg tccaggagac ccaggcgcca gagtccccag gagagaattc agagcaagcc
481 ctgcagacgc tcagccccag agccatccca aggaatccag atggtggccc cctggagtcc
541 tcctctgacc tggcagccct cagccctctg acctccagcg ggcatcagga gaaggacaca
601 gaactgggca gtacccacac agcaggtgcg acctccagcc tcacaccatc ccgtgggcct
661 gtgtctccat ctgtctcctt ccagcccctg gcccgttcca cccccagggc aagccgcttg
721 cctggaccca cagggtcagt tgtatctact ggcacctcct tctcctcctc atcccctggc
781 ttggcctctg caggggctgc agagggtaaa cagggtgcag agagtgacca ggccgagcct
841 atcatctgct ccagtggggc agaggcacct gccaactctc tgccctccaa agtgcctacc
901 accttgatgc ctgtgaacac agtggccctg aaagtgcctg ccaacccagc atctgtcagc
961 acagtgccct ccaagttgcc aactagctca aagccccctg gtgcagtgcc ttctaatgcg
1021 ctcaccaatc cagcaccatc caaattgccc atcaactcaa cccgtgctgg catggtgcca
1081 tccaaagtgc ctactagcat ggtgctcacc aaggtgtctg ccagcacagt ccccactgac
1141 gggagcagca gaaatgagga gaccccagca gctccaacac ccgccggcgc cactggaggc
1201 agctcagcct ggctagacag cagctttgag aataggggcc ttgggtcgga gctgagtaag
1261 cctggcgtgc tggcatccca ggtagacagc ccgttctcgg gctgcttcga ggatcttgcc
1321 atcagtgcca gcacctcctt gggcatgggg ccctgccatg gcccagagga gaatgagtat
1381 aagtccgagg gcacctttgg gatccacgtg gctgagaacc ccagcatcca gctcctggag
1441 ggcaaccctg ggccacctgc ggacccggat ggcggcccca ggccacaagc cgaccggaag
1501 ttccaggaga gggaggtgcc atgccacagg ccctcacctg gggctctgtg gctccaggtg
1561 gctgtgacag gggtgctggt agtcacactc ctggtggtgc tgtaccggcg gcgtctgcac
1621 tag
//