LOCUS DQ139833 4198 bp mRNA linear HUM 13-SEP-2005
DEFINITION Homo sapiens Rho-specific guanine nucleotide exchange factor
GrinchGEF mRNA, complete cds.
ACCESSION DQ139833
VERSION DQ139833.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4198)
AUTHORS Winkler,S., Mohl,M., Wieland,T. and Lutz,S.
TITLE GrinchGEF--a novel Rho-specific guanine nucleotide exchange factor
JOURNAL Biochem. Biophys. Res. Commun. 335 (4), 1280-1286 (2005)
PUBMED 16112081
REFERENCE 2 (bases 1 to 4198)
AUTHORS Winkler,S., Mohl,M., Wieland,T. and Lutz,S.
TITLE Direct Submission
JOURNAL Submitted (21-JUL-2005) Pharmacology and Toxicology, University of
Heidelberg, Maybachstrasse 14, Mannheim 68169, Germany
FEATURES Location/Qualifiers
source 1..4198
/db_xref="H-InvDB:HIT000341936"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="1"
/map="1p36.13"
/cell_line="HEK293"
CDS 1..3708
/note="guanine nucleotide exchange factor; KIAA1626,
variant of ARHGEF10L"
/codon_start=1
/product="GrinchGEF"
/protein_id="AAZ73162.1"
/translation="MASSNPPPQPAIGDQLVPGVPGPPSEAEDDPGEAFEFDDSDDEE
DTSAALGVPSLAPERDTDPPLIHLDSIPVTDPDPAAAPPGTGVPAWVSNGDAADAAFS
GARHSSWKRKSSRRIDRFTFPALEEDVIYDDVPCESPDAHQPGAERNLLYEDAHRAGA
PRQAEDLGWSSSEFESYSEDSGEEAKPEVEVEPAKHRVSFQPKMTQLMKAAKSGTKDG
LEKTRMAVMRKVSFLHRKDVLGDSEEEDMGLLEVSVSDIKPPAPELGPMPEGLSPQQV
VRRHILGSIVQSEGSYVESLKRILQDYRNPLMEMEPKALSARKCQVVFFRVKEILHCH
SMFQIALSSRVAEWDSTEKIGDLFVASFSKSMVLDVYSDYVNNFTSAMSIIKKACLTK
PAFLEFLKRRQVCSPDRVTLYGLMVKPIQRFPQFILLLQDMLKNTPRGHPDRLSLQLA
LTELETLAEKLNEQKRLADQVAEIQQLTKSVSDRSSLNKLLTSGQRQLLLCETLTETV
YGDRGQLIKSKERRVFLLNDMLVCANINFKGQLEISSLVPLGPKYVVKWNTALPQVQV
VEVGQDGGTYDKDNVLIQHSGAKKASASGQAQNKVYLGPPRLFQELQDLQKDLAVVEQ
ITLLISTLHGTYQNLNMTVAQDWCLALQRLMRVKEEEIHSANKCRLRLLLPGKPDKSG
RPISFMVVFITPNPLSKISWVNRLHLAKIGLREENQPGWLCPDEDKKSKAPFWCPILA
CCIPAFSSRALSLQLGALVHSPVNCPLLGFSAVSTSLPQGYLWVGGGQEGAGGQVEIF
SLNRPSPRTVKSFPLAAPVLCMEYIPELEEEAESRDESPTVADPSATVHPTICLGLQD
GSILLYSSVDTGTQCLVSCRSPGLQPVLCLRHSPFHLLAGLQDGTLAAYPRTSGGVLW
DLESPPVCLTVGPGPVRTLLSLEDAVWASCGPRVTVLEATTLQPQQSFEAHQDEAVSV
THMVKAGSGVWMAFSSGTSIRLFHTETLEHLQEINIATRTTFLLPGQKHLCVTSLLIC
QGLLWVGTDQGVIVLLPVPRLEGIPKITGKGMVSLNGHCGPVAFLAVATSILAPDILR
SDQEEAEGPRAEEDKPDGQAHEPMPDSHVGRELTRKKGILLQYRLRSTAHLPGPLLSM
REPAPADGAALEHSEEDGSIYEMADDPDVWVRSRPCARDAHRKEICSVAIISGGQGYR
NFGSALGSSGRQAPCGETDSTLLIWQVPLML"
BASE COUNT 848 a 1303 c 1287 g 760 t
ORIGIN
1 atggcttcct ccaaccctcc tccacagcct gccataggag atcagctggt tccaggagtc
61 ccaggccccc cctctgaggc agaggacgac ccaggagagg cgtttgagtt tgatgacagt
121 gatgatgaag aggacaccag cgcagccctg ggcgtcccca gccttgctcc tgagagggac
181 acagaccccc cactgatcca cttggactcc atccctgtca ctgacccaga cccagcagct
241 gctccacccg gcacaggggt gccagcctgg gtgagcaatg gggatgcagc ggacgcagcc
301 ttctccgggg cccggcactc cagctggaag cggaagagtt cccgtcgcat tgaccggttc
361 actttccccg ccctggaaga ggatgtgatt tatgacgacg tcccctgcga gagcccagat
421 gcgcatcagc ccggggcaga gaggaacctg ctctacgagg atgcgcaccg ggctggggcc
481 cctcggcagg cggaagacct aggctggagc tccagtgagt tcgagagcta cagcgaggac
541 tcgggggagg aggccaagcc ggaggtcgag gtcgagcccg ccaagcaccg agtgtccttc
601 cagcccaaga tgacccagct catgaaggcc gccaagagcg ggaccaagga tgggctggag
661 aagacacgga tggccgtgat gcgcaaagtc tccttcctgc acaggaagga cgtcctcggt
721 gactcggagg aggaggacat ggggctcctg gaggtcagcg tttcggacat caagccccca
781 gccccagagc tgggccccat gccagagggc ctgagccctc agcaggtggt ccggaggcat
841 atcctgggct ccatcgtgca gagcgaaggc agctacgtgg agtctctgaa gcggatactc
901 caggactacc gcaaccccct gatggagatg gagcccaagg cgctgagcgc ccgcaagtgc
961 caggtggtgt tcttccgcgt gaaggagatc ctgcactgcc actccatgtt ccagatcgcc
1021 ctgtcctccc gcgtggctga gtgggattcc accgagaaga tcggggacct cttcgtggcc
1081 tcgttttcca agtccatggt gctagatgtg tacagtgact acgtgaacaa cttcaccagt
1141 gccatgtcca tcatcaagaa ggcctgcctc accaagcctg ccttcctcga gttcctcaag
1201 cgacggcagg tgtgcagccc agaccgtgtc accctctacg ggctgatggt caagcccatc
1261 cagaggttcc cacagttcat actcctgctt caggacatgc tgaagaacac ccccaggggc
1321 catccggaca ggctgtcgct gcagctggcc ctcacagagc tggagacgct ggctgagaag
1381 ctgaacgagc agaagcggct ggctgaccag gtggctgaga tccagcagct gaccaagagc
1441 gtcagtgacc gcagcagcct caacaagctg ttgacctcag gccagcggca gctgctcctg
1501 tgtgagacgt tgacggagac cgtgtacggt gaccgcgggc agctaattaa gtccaaggag
1561 cgtcgggtct tcctgctcaa cgacatgctt gtctgtgcca acatcaactt caagggccag
1621 ctggagatca gcagcctggt gcccctgggg cccaagtatg tggtgaagtg gaacacggcg
1681 ctgccccagg tgcaggtggt ggaggtgggc caggacggtg gcacctatga caaggacaat
1741 gtgctcatcc agcactcagg cgccaagaag gcctctgcct cagggcaggc tcagaataag
1801 gtgtacctcg gccccccacg cctcttccag gagctgcagg acctgcagaa ggacctggcc
1861 gtggtggagc agatcacgct tctcatcagc acgctgcacg gcacctacca gaacctgaac
1921 atgactgtgg ctcaagactg gtgcctggcc ctgcagaggc tgatgcgggt gaaggaggaa
1981 gagatccact cggccaacaa gtgccgtctc aggctcctgc ttcctgggaa acccgacaag
2041 tccggccgcc ccattagctt catggtggtt ttcatcaccc ccaaccccct gagcaagatt
2101 tcctgggtca acaggttaca tttggccaaa atcggactcc gggaggagaa ccagccaggc
2161 tggctatgcc cggatgagga caagaagagc aaagccccat tctggtgccc gatcctggcc
2221 tgctgcatcc ctgccttctc ctcccgggca ctcagcctgc agcttggggc cctggtccac
2281 agtcctgtca actgtcccct gctgggtttc tcagcagtca gcacctccct tccacagggc
2341 tacctctggg tcgggggcgg acaggaaggc gcagggggcc aggtggaaat cttttccttg
2401 aaccggccct cgccccgcac cgtcaagtcc ttcccactgg cagcccctgt gctctgcatg
2461 gagtatatcc cggagctgga ggaggaggcg gagagcagag acgagagccc gacagttgct
2521 gacccctcgg ccacggtgca tccaaccatc tgcctcgggc tccaggatgg cagcatcctc
2581 ctctacagca gtgtggacac tggcacccag tgcctggtga gctgcaggag cccaggtctg
2641 cagcctgtgc tctgcctgcg acacagcccc ttccacctgc tcgctggcct gcaggatggg
2701 acccttgctg cttaccctcg gaccagcgga ggtgtcctgt gggacctgga gagccctccc
2761 gtgtgcctga ctgtggggcc cgggcctgtc cgcaccctgt tgagcctgga ggatgccgtg
2821 tgggccagct gtgggccccg ggtcactgtc ctggaagcca ccaccctgca gcctcagcaa
2881 agcttcgagg cgcaccagga cgaggcagtg agcgtgacac acatggtgaa ggcgggcagc
2941 ggcgtctgga tggccttctc ctccggcacc tccatccgcc tcttccacac tgagaccctg
3001 gagcatctgc aagagatcaa catcgccacc aggaccacct tcctcctgcc aggccagaag
3061 cacttgtgtg tcaccagcct cctgatctgc cagggtctgc tctgggtggg cactgaccag
3121 ggtgtcatcg tcctgctgcc cgtgcctcgg ctggaaggca tccccaagat cacagggaaa
3181 ggcatggtct cactcaatgg gcactgtggg cctgtggcct tcctggctgt ggctaccagc
3241 atcctggccc ctgacatcct gcggagtgac caggaggagg ctgaggggcc ccgggctgag
3301 gaggacaagc cagacgggca ggcacacgag cccatgcccg acagccacgt gggccgagag
3361 ctgacccgca agaagggcat cctcttgcag taccgcctgc gctccaccgc acacctcccg
3421 ggcccgctgc tctccatgcg ggagccggcg cctgctgatg gcgcagcttt ggagcacagc
3481 gaggaggacg gctccattta cgagatggcc gacgaccccg acgtctgggt gcgcagccgg
3541 ccctgcgccc gcgacgccca ccgcaaggag atttgctctg tggccatcat ctccggcggg
3601 cagggctacc gcaactttgg cagcgctctg ggcagcagtg ggaggcaggc cccgtgtggg
3661 gagacggaca gcaccctcct catctggcag gtgcccttga tgctatagcg cctcccctct
3721 cccctcagag ggcacagctg caggcctgac caaggccacg cccggctctc gtgctctagg
3781 acctgcacgg gacttgtgga tgggcctgga ctctccagaa actacttggg ccagagcaaa
3841 ggaaaacctc ttgttttaaa aaaatttttt tcagagtgtt ttggggagga gttttagggc
3901 ttggggagag ggaggacaca tctggaggaa atggccttct ttttaaaagc aaaaaaacac
3961 aaaacctcac aactgcctgg caagcccagt atcacttgtt tgggccctag cgggactcca
4021 aggcagccac acgcccctcc tggaagggtg tgtgcgtgtg agtgtgtgcg agtgtgtggg
4081 ctggtgtgtg aatatctata aataagtata tatggtgtat attatatgtg tataaataaa
4141 gtctgtacat attggagctc tgggagatgc tggaataaaa gacaagagtt acatctgg
//