LOCUS DQ067453 5692 bp mRNA linear HUM 10-FEB-2009
DEFINITION Homo sapiens diaphanous-1 (DIAPH1) mRNA, complete cds.
ACCESSION DQ067453
VERSION DQ067453.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 5692)
AUTHORS Hudson,B.I., Kalea,A.Z., Del Mar Arriero,M., Harja,E.,
Boulanger,E., D'Agati,V. and Schmidt,A.M.
TITLE Interaction of the RAGE cytoplasmic domain with diaphanous-1 is
required for ligand-stimulated cellular migration through
activation of Rac1 and Cdc42
JOURNAL J. Biol. Chem. 283 (49), 34457-34468 (2008)
PUBMED 18922799
REFERENCE 2 (bases 1 to 5692)
AUTHORS Hudson,B.I., Arriero,M. and Schmidt,A.M.
TITLE The Cytoplasmic Domain of RAGE Interacts with Diaphanous-1: a
Mechanism to Bridge Signal Transduction & Cellular Migration
JOURNAL Unpublished
REFERENCE 3 (bases 1 to 5692)
AUTHORS Hudson,B.I., Arriero,M. and Schmidt,A.M.
TITLE Direct Submission
JOURNAL Submitted (17-MAY-2005) Surgery, Columbia University, 630 W 168th
St, P&S 17-501, New York, NY 10032, USA
FEATURES Location/Qualifiers
source 1..5692
/db_xref="H-InvDB:HIT000391713"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="5"
/map="5q31"
/tissue_type="lung"
/note="RT-PCR clone"
gene 1..5692
/gene="DIAPH1"
5'UTR 1..15
/gene="DIAPH1"
CDS 16..3804
/gene="DIAPH1"
/codon_start=1
/product="diaphanous-1"
/protein_id="AAZ23040.1"
/translation="MEPPGGSLGPGRGTRDKKKGRSPDELPSAGGDGGKSKKFLERFT
SMRIKKEKEKPNSAHRNSSASYGDDPTAQSLQDVSDEQVLVLFEQMLLDMNLNEEKQQ
PLREKDIIIRREMVSQYLYTSKAGMSQKESSKSAMMYIQELRSGLRDMPLLSCLESLR
VSLNNNPVSWVQTFGAEGLASLLDILKRLHGEKEETAGSYDSRNKHEIIRCLKAFMNN
KFGIKAMLETEEGILLLVRAMDPAVPNMMIDAAKLLSALCILPQPEDMNERVLEAMTE
RAEMDEVERFQPLLDGLKSGTTIALKVGCLQLINALITPAEELDFRVHIRSELMRLGL
HQVLQDLREIENEDMRVQLNVFDEQGEEDSYDLKGRLDDIRMEMDDFNEVFQILLNTV
KDSKAEPHFLSILQHLLLVRNDYEARPQYYKLIEECISQIVLHKNGADPDFKCRHLQI
EIEGLIDQMIDKTKVEKSEAKAAELEKKLDSELTARHELQVEMKKMESDFEQKLQDLQ
GEKDALHSEKQQIATEKQDLEAEVSQLTGEVAKLTKELEDAKKEMASLSAAAITVPPS
VPSRAPVPPAPPLPGDSGTIIPPPPAPGDSTTPPPPPPPPPPPPLPGGVCISSPPSLP
GGTAISPPPPLSGDATIPPPPPLPEGVGIPSPSSLPGSTAIPPPPPLPGSARIPPPPP
PLPGSAGIPPPPPPLPGEAGMPPPPPPLPGGPGIPPPPPFPGGPGIPPPPPGMGMPPP
PPFGFGVPAAPVLPFGLTPKKLYKPEVQLRRPNWSKLVAEDLSQDCFWTKVKEDRFEN
NELFAKLTLTFSAQTKTSKAKKDQEGGEEKKSVQKKKVKELKVLDSKTAQNLSIFLGS
FRMPYQEIKNVILEVNEAVLTESMIQNLIKQMPEPEQLKMLSELKDEYDDLAESEQFG
VVMGTVPRLRPRLNAILFKLQFSEQVENIKPEIVSVTAACEELRKSESFSNLLEITLL
VGNYMNAGSRNAGAFGFNISFLCKLRDTKSTDQKMTLLHFLAELCENDYPDVLKFPDE
LAHVEKASRVSAENLQKNLDQMKKQISDVERDVQNFPAATDEKDKFVEKMTSFVKDAQ
EQYNKLRMMHSNMETLYKELGEYFLFDPKKLSVEEFFMDLHNFRNMFLQAVKENQKRR
ETEEKMRRAKLAKEKAEKERLEKQQKREQLIDMNAEGDETGVMDSLLEALQSGAAFRR
KRGPRQANRKAGCAVTSLLASELTKDDAMAAVPAKVPKNSETFPTILEEAKELVGRAS
"
3'UTR 3805..5692
/gene="DIAPH1"
regulatory 5555..5560
/regulatory_class="polyA_signal_sequence"
/gene="DIAPH1"
polyA_site 5692
/gene="DIAPH1"
BASE COUNT 1429 a 1425 c 1442 g 1396 t
ORIGIN
1 agcgtgaacc gggacatgga gccgcccggc gggagcctgg ggcccggccg cgggacccgg
61 gacaagaaga agggccggag cccagatgag ctgccctcgg cgggcggcga cggcggcaaa
121 tctaagaaat ttctggagag atttaccagc atgagaatta agaaggagaa ggaaaagccc
181 aattctgctc atagaaattc ttctgcatca tatggggatg atcccacagc acagtcattg
241 caagatgttt cagatgaaca agtgctggtt ctctttgaac agatgctgct ggatatgaac
301 ctgaatgagg agaaacagca acctttgagg gagaaggaca tcatcatcag gagggagatg
361 gtgtcccaat acttgtacac ctccaaggct ggcatgagcc agaaggagag ctctaagtct
421 gccatgatgt atattcagga gttgaggtca ggcttgcggg atatgcctct gctcagctgc
481 ctggagtccc ttcgtgtgtc tctcaacaac aaccctgtca gttgggtgca aacatttggt
541 gctgaaggct tggcctcctt attggacatt cttaaacgac ttcatggtga gaaagaagag
601 actgctggga gttacgatag ccggaacaag catgagatca ttcgctgctt gaaagctttt
661 atgaacaaca agtttggaat caaggccatg ttggagacag aagaaggaat cctactgctg
721 gtcagagcca tggatcctgc tgttcccaac atgatgattg atgcagctaa gctgctttct
781 gctctttgta ttctaccgca gccagaggac atgaatgaaa gggttttgga ggcaatgaca
841 gaaagagctg agatggatga agtggaacgt ttccagccgc tgctggatgg attaaaaagt
901 ggaaccacta ttgcactgaa ggttggatgc ctacagctga tcaatgctct catcacacca
961 gcggaggaac ttgacttccg agttcacatc agaagtgaac tgatgcgttt ggggctacat
1021 caggtgttgc aggaccttcg agagattgaa aatgaagata tgagagtgca actaaatgtg
1081 tttgatgaac aaggggaaga ggattcctat gacctgaagg gacggctgga tgacattcgc
1141 atggagatgg atgactttaa tgaagtcttt cagattctct taaacacagt gaaggattca
1201 aaggcagagc cacacttcct ttccatcctg cagcacttac tcttggtccg aaatgactat
1261 gaggccagac ctcagtacta taagttgatt gaagaatgta tttcccagat agttctgcac
1321 aagaacgggg ctgatcctga cttcaagtgc cggcacctcc agattgagat tgagggatta
1381 attgatcaaa tgattgataa gacaaaggtg gagaaatctg aagccaaagc tgcagagctg
1441 gaaaagaagt tggactcaga gttaacagcc cgacatgagc tacaggtgga aatgaaaaag
1501 atggaaagtg actttgagca gaagcttcaa gatcttcagg gagaaaaaga tgcactgcat
1561 tctgaaaagc agcaaattgc cacagagaaa caggacctgg aagcagaggt gtcccagctc
1621 acaggagagg ttgccaagct gacaaaggaa ctggaagatg ccaagaaaga aatggcttcc
1681 ctctctgcgg cagctattac tgtacctcct tctgttccta gtcgtgctcc tgttccccct
1741 gcccctcctt tacctggtga ctctggcact attattccac caccacctgc tcctggggat
1801 agtaccactc ctcctcctcc tcctcctcct cctcctccac ctcctttgcc tgggggtgtt
1861 tgcatctcct cacccccttc tttacctgga ggtactgcta tctctccacc ccctcctttg
1921 tctggggatg ctaccatccc tccaccccct cctttgcctg agggtgttgg catcccttca
1981 ccctcttctt tgcctgggag tactgccatc cccccacctc ctcctttgcc tgggagtgct
2041 agaatccccc caccaccacc tcctttgcct gggagtgctg gtattccccc cccacctcct
2101 cccttgcctg gagaagcagg aatgccacct cctcctcccc ctcttcctgg tggtcctgga
2161 atccctccac ctcctccatt tcccggaggc cctggcattc ctccacctcc acccggaatg
2221 ggtatgcctc cacctccccc atttggattt ggagttcctg cagccccagt tctgccattt
2281 ggattaaccc ccaaaaagct ttataagcca gaggtgcagc tccggaggcc aaactggtcc
2341 aagcttgtgg ctgaggacct ctcccaggac tgcttctgga caaaggtgaa ggaggaccgc
2401 tttgagaaca atgaactttt cgccaaactt acccttacct tctctgccca gaccaagact
2461 tccaaagcca agaaggatca agaaggtgga gaagaaaaga aatctgtgca aaagaaaaaa
2521 gtaaaagagt taaaggtgtt ggattcaaag acagcccaga atctctcaat ctttttgggt
2581 tccttccgca tgccctatca agagattaag aatgtcatcc tggaggtgaa tgaggctgtt
2641 ctgactgagt ctatgatcca gaacctcatt aagcaaatgc cagagccaga gcagttaaaa
2701 atgctttctg aactgaagga tgaatatgat gacctggctg agtcagagca gtttggcgtg
2761 gtgatgggca ctgtgccccg actgcggcct cgcctcaatg ccattctctt caagctacaa
2821 ttcagcgagc aagtggagaa tatcaagcca gagattgtgt ctgtcactgc tgcatgtgag
2881 gagttacgta agagtgagag cttttccaat ctcctagaga ttaccttgct tgttggaaat
2941 tacatgaatg ctggctccag aaatgctggt gcttttggct tcaatatcag cttcctctgt
3001 aagcttcgag acaccaagtc cacagatcag aagatgacgt tgttacactt cttggctgag
3061 ttgtgtgaga atgactatcc cgatgtcctc aagtttccag acgagcttgc ccatgtggag
3121 aaagccagcc gagtttctgc tgaaaacttg caaaagaacc tagatcagat gaagaaacaa
3181 atttctgatg tggaacgtga tgttcagaat ttcccagctg ccacagatga aaaagacaag
3241 tttgttgaaa aaatgaccag ctttgtgaag gatgcacagg aacagtataa caagctgcgg
3301 atgatgcatt ctaacatgga gaccctctat aaggagctgg gcgagtactt cctctttgac
3361 cccaagaagt tgtctgttga agaatttttc atggatcttc acaattttcg gaatatgttt
3421 ttgcaagcag tcaaggagaa ccagaagcgg cgggagacag aagaaaagat gaggcgagca
3481 aaactagcca aggagaaggc agagaaggag cggctagaga agcagcagaa gagagagcaa
3541 ctcatagaca tgaatgcaga gggcgatgag acaggtgtga tggacagtct tctagaagcc
3601 ctgcagtcag gggcagcatt ccgacggaag agagggcccc gtcaagccaa caggaaggcc
3661 gggtgtgcag tcacatctct gctagcttcg gagctgacca aggatgatgc catggctgct
3721 gttcctgcca aggtgcccaa gaacagtgag acattcccca caatccttga ggaagccaag
3781 gagttggttg gccgtgcaag ctaatgtggg tcctgtgacc gcggcagctc ctcagcggag
3841 ccgcagactg tcctgccctg cagcatgtgc ctaaaggctc aaggggatat tcctctgggg
3901 tggccactcc caccaccctg gccctgtctt tctctctggc ctgctgctct ctcaacatca
3961 catacagctt cagctgcctg gaggccagaa ggaaagggca gtgcagggga ggcctgagcc
4021 cgacttagcc agccctggct gttgtattac caaagcaggg tccatgtttg ctgccttaac
4081 cctgtctcct ctctgttact cagagggcct catctcagac aaggcccagc ctgctttttc
4141 tcagccctga ctttctaatg ggctttcccc cctaggtcag tcttgctgga tttgtgcttt
4201 tcttttgtgg tttctctggc cctgagaata gcatggggct tgtaaacctt tgggctagat
4261 ccctcctttc attgctgttg tctctgctct tccctctcct ggctgtggtt atttattatt
4321 agtggtgtgg cactgggagc tgctcctaag gaagcaggga gcaaatccca cctttacccc
4381 accttcctgg gaaaggcctc caaagcaaag gatctggacc agtttccctg ctgtgctgtg
4441 gcccaggcca gagcctgtgg gcaggcaggc agggcatagc gacagtgtgg gacctgcccc
4501 cagcttctgc cacgctttat gcccttgcct ctctggacgc tctgcaccaa ccccaggcta
4561 ctgagccacc ttccctcctc atgccttccc tgagctttgg tgcatctcat ctggactatg
4621 ggttgtactg tgaccatccc aacacctcac cctctgtcta caaggaaatg ggaggtggag
4681 ggttgtactg tgaccatccc aacacctcac cctctgtcta caaggaaatg ggaggtggag
4741 cctcctggct gagaaattgt tttgcaaatg gatctatttt tgtatgaaaa aaaaaatttt
4801 tttaaagaaa actgttcctt ccccctttcc cctccataat gtaagaagct ttggtggcag
4861 gttacagagt tctgggattt cttctcacag gcccaatcct gaatgtgccc ctggaccttc
4921 tggacccttg agtccaaggc agatcctctc tcccagggaa tccgacacag gaggaacccc
4981 ttctctggtt gagctgggcc aggcctaaga gtagcaggaa ctctaagacc acagagtttt
5041 ttataaatgt ataaatgtat caagccaaat gtgcagatgc taactggaca ttctggggaa
5101 ctgggcacca ggagtgcctt catacactgt accccagctc tcttctaaaa gagaagtggg
5161 tgggcacact gaactgtttg gtggccccaa ccacaggaag ctgcaattct gtggcttagg
5221 gtgatacttt tgccctcctt gtgcccctct cagctttcca tccccagcta ggaagaaaga
5281 atggcactct tggcttggcc cagaattaga gttattagag caagagagag cttaggaagc
5341 atgagggcaa ctatagtgag gccttattgc caggagggag ggttttggtt gctggcgctt
5401 gtgtataaag gggcaagagc agctcctttg gactattcct gggaggactc tgatgcaggg
5461 cgtctgttgc tcccctgggt cacctcctcc ctgctcgctg acatctgggg ctttgaccct
5521 ttctttttta atctactttt gctaagatgc atttaataaa aaaaaagaga gagagagaga
5581 ggtgtgaggg acaaaatgca aacctatttc ccttgcctca taggcttctg ggatgtcatc
5641 acctccagtt tgttggtttt gtttccaact gttaataaag cattgaaaca gt
//