LOCUS HUMMACT 1518 bp mRNA linear HUM 07-DEC-2007 DEFINITION Homo sapiens mRNA for mitochondrial acetoacetyl-CoA thiolase precursor, complete cds. ACCESSION D90228 M61117 VERSION D90228.1 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 AUTHORS Fukao,T., Yamaguchi,S., Kano,M., Orii,T., Fujiki,Y., Osumi,T. and Hashimoto,T. TITLE Molecular cloning and sequence of the complementary DNA encoding human mitochondrial acetoacetyl-coenzyme A thiolase and study of the variant enzymes in cultured fibroblasts from patients with 3-Ketothiolase deficiency JOURNAL J. Clin. Invest. 86, 2086-2092 (1990) COMMENT These data kindly submitted in computer readable form by: Toshiyuki Fukao Department of Pediatrics Gifu University School of Medicine 40 Tsukasa-machi Gifu 500 Japan FEATURES Location/Qualifiers source 1..1518 /db_xref="H-InvDB:HIT000102073" /db_xref="taxon:9606" /mol_type="mRNA" /organism="Homo sapiens" /tissue_type="liver" CDS 77..1360 /codon_start=1 /EC_number="2.3.1.9" /product="mitochondrial acetoacetyl-CoA thiolase precursor" /protein_id="BAA14278.1" /translation="MAVLAALLRSGARSRSPLLRRLVQEIRYVERSYVSKPTLKEVVI VSATRTPIGSFLGSLSLLPATKLGSIAIQGAIEKAGIPKEEVKEAYMGNVLQGGEGQA PTRQAVLGAGLPISTPCTTINKVCASGMKAIMMASQSLMCGHQDVMVAGGMESMSNVP YVMNRGSTPYGGVKLEDLIVKDGLTDVYNKIHMGSCAENTAKKLNIARNEQDAYAINS YTRSKAAWEAGKFGNEVIPVTVTVKGQPDVVVKEDEEYKRVDFSKVPKLKTVFQKENG TVTAANASTLNDGAAALVLMTADAAKRLNVTPLARIVAFADAAVEPIDFPIAPVYAAS MVLKDVGLKKEDIAMWEVNEAFSLVVLANIKMLEIDPQKVNINGGAVSLGHPIGMSGA RIVGHLTHALKQGEYGLASICNGGGGASAMLIQKL" sig_peptide 77..175 /note="leader peptide" mat_peptide 176..1357 misc_feature 452..454 /note="put. active site (Cys)" BASE COUNT 454 a 283 c 390 g 391 t ORIGIN 1 aggccgctag ggtgcggggt tggggaggag gccgctagtc tacgcctgtg gagccgatac 61 tcagccctct gcgaccatgg ctgtgctggc ggcacttctg cgcagcggcg cccgcagccg 121 cagccccctg ctccggaggc tggtgcagga aataagatat gtggaacgga gttatgtatc 181 aaaacccact ttgaaggaag tggtcatagt aagtgctaca agaacaccca ttggatcttt 241 tttaggcagc ctttccttgc tgccagccac taagcttggt tccattgcaa ttcagggagc 301 cattgaaaag gcagggattc caaaagaaga agtgaaagaa gcatacatgg gtaatgttct 361 acaaggaggt gaaggacaag ctcctacaag gcaggcagta ttgggtgcag gcttacctat 421 ttctactcca tgtaccacca taaacaaagt ttgtgcttca ggaatgaaag ccatcatgat 481 ggcctctcaa agtcttatgt gtggacatca ggatgtgatg gtggcaggtg ggatggagag 541 catgtccaat gttccatatg taatgaacag aggatcaaca ccatatggtg gggtaaagct 601 tgaagatttg attgtaaaag acgggctaac tgatgtctac aataaaattc atatgggcag 661 ctgtgctgag aatacagcaa agaagctgaa tattgcacga aatgaacagg acgcttatgc 721 tattaattct tataccagaa gtaaagcagc atgggaagct gggaaatttg gaaatgaagt 781 tattcctgtc acagttacag taaaaggtca accagatgta gtggtgaaag aagatgaaga 841 atataaacgt gttgatttta gcaaagttcc aaagctgaag acagttttcc agaaagaaaa 901 tggcacagta acagctgcca atgccagtac actgaatgat ggagcagctg ctctggttct 961 catgacggca gatgcagcga agaggctcaa tgttacacca ctggcaagaa tagtagcatt 1021 tgctgacgct gctgtagaac ctattgattt tccaattgct cctgtatatg ctgcatctat 1081 ggttcttaaa gatgtgggat tgaaaaaaga agatattgca atgtgggaag taaatgaagc 1141 ctttagtctg gttgtactag caaacattaa aatgttggag attgatcccc aaaaagtgaa 1201 tatcaatgga ggagctgttt ctctgggaca tccaattggg atgtctggag ccaggattgt 1261 tggtcatttg actcatgcct tgaagcaagg agaatacggt cttgccagta tttgcaatgg 1321 aggaggaggt gcttctgcca tgctaattca gaagctgtag acaacctctg ctatttaagg 1381 agacaaccct atgtgaccag aaggcctgct gtaatcagtg tgactactgt gggtcagctt 1441 atattcagat aagctgtttc attttttatt attttctatg ttaactttta aaaatcaaaa 1501 tgatgaaatc ccaaaaca //