LOCUS       D88357                   780 bp    mRNA    linear   HUM 12-MAY-1998
DEFINITION  Homo sapiens mRNA for CDC2 delta T, complete cds.
ACCESSION   D88357
VERSION     D88357.1
KEYWORDS    deletion type cdc2 variant.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 780)
  AUTHORS   Ohta,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (11-OCT-1996) to the DDBJ/EMBL/GenBank databases.
            Contact:Tomohiko Ohta
            St. Marianna University School of Medicine, First Department of
            Surgery; 2-16-1 Sugao, Miyamae-ku, Kawasaki, Kanagawa 216, Japan
REFERENCE   2
  AUTHORS   Ohta,T., Okamoto,K., Isohashi,F., Shibata,K., Fukuda,M.,
            Yamaguchi,S. and Xiong,Y.
  TITLE     T-loop deletion of CDC2 from breast cancer tissues eliminates
            binding to cyclin B1 and cyclin-dependent kinase inhibitor p21
  JOURNAL   Cancer Res. 58, 1095-1098 (1998)
COMMENT     
FEATURES             Location/Qualifiers
     source          1..780
                     /db_xref="H-InvDB:HIT000102006"
                     /db_xref="taxon:9606"
                     /mol_type="mRNA"
                     /organism="Homo sapiens"
                     /sex="female"
                     /tissue_type="breast cancer"
     CDS             28..750
                     /note="The coded protein conserves two of the three
                     phosphorylation sites (T14 and Y15), ATP-binding site and
                     the cyclin binding site (PSTAIR). It lacks a part of
                     T-loop including T161."
                     /note="deletion type cdc2 variant"
                     /product="CDC2 delta T"
                     /protein_id="BAA26001.1"
                     /translation="MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGV
                     PSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDS
                     SLVKVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIF
                     RALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKR
                     ISGKMALNHPYFNDLDNQIKKM"
BASE COUNT          251 a          143 c          162 g          224 t
ORIGIN      
        1 cgggatctac cataccattg actaactatg gaagattata ccaaaataga gaaaattgga
       61 gaaggtacct atggagttgt gtataagggt agacacaaaa ctacaggtca agtggtagcc
      121 atgaaaaaaa tcagactaga aagtgaagag gaaggggttc ctagtactgc aattcgggaa
      181 atttctctat taaaggaact tcgtcatcca aatatagtca gtcttcagga tgtgcttatg
      241 caggattcca ggttatatct catctttgag tttctttcca tggatctgaa gaaatacttg
      301 gattctatcc ctcctggtca gtacatggat tcttcacttg ttaaggtagt aacactctgg
      361 tacagatctc cagaagtatt gctggggtca gctcgttact caactccagt tgacatttgg
      421 agtataggca ccatatttgc tgaactagca actaagaaac cacttttcca tggggattca
      481 gaaattgatc aactcttcag gattttcaga gctttgggca ctcccaataa tgaagtgtgg
      541 ccagaagtgg aatctttaca ggactataag aatacatttc ccaaatggaa accaggaagc
      601 ctagcatccc atgtcaaaaa cttggatgaa aatggcttgg atttgctctc gaaaatgtta
      661 atctatgatc cagccaaacg aatttctggc aaaatggcac tgaatcatcc atattttaat
      721 gatttggaca atcagattaa gaagatgtag ctttctgaca aaaagtttcc atatgttatg
//