LOCUS D84361 2160 bp mRNA linear HUM 27-DEC-2006
DEFINITION Homo sapiens mRNA for p52 and p64 isoforms of N-Shc, complete cds.
ACCESSION D84361
VERSION D84361.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2160)
AUTHORS Nakamura,T.
TITLE Direct Submission
JOURNAL Submitted (09-APR-1996) to the DDBJ/EMBL/GenBank databases.
Contact:Takeshi Nakamura
Sumitomo Electric Industries, Biomedical R&D Department; 1,
Taya-cho, Sakae-ku, Yokohama, Kanagawa 244, Japan
REFERENCE 2
AUTHORS Nakamura,T.
TITLE Human mRNA for p52 and p64 isoforms of N-Shc, complete cds.
JOURNAL Unpublished (1996)
REFERENCE 3
AUTHORS Nakamura,T., Sanokawa,R., Sasaki,Y., Ayusawa,D., Oishi,M. and
Mori,N.
TITLE N-Shc: a neural-specific adapter molecule that mediates signaling
from neurotrophin/Trk to Ras/MAPK pathway
JOURNAL Oncogene 13, 1111-1121 (1996)
COMMENT
FEATURES Location/Qualifiers
source 1..2160
/db_xref="H-InvDB:HIT000101875"
/db_xref="taxon:9606"
/mol_type="mRNA"
/organism="Homo sapiens"
/tissue_type="brain"
CDS 181..1965
/codon_start=1
/product="p64 isoform of N-Shc"
/protein_id="BAA12322.1"
/translation="MLPRTKYNRFRNDSVTSVDDLLHSLSVSGGGGKVSAARATPAAA
PYLVSGEALRKAPDDGPGSLGHLLHKVSHLKLSSSGLRGLSSAARERAGARLSGSCSA
PSLAAPDGSAPSAPRAPAMSAARKGRPGDEPLPRPPRGAPHASDQVLGPGVTYVVKYL
GCIEVLRSMRSLDFSTRTQITREAISRVCEAVPGAKGAFKKRKPPSKMLSSILGKSNL
QFAGMSISLTISTASLNLRTPDSKQIIANHHMRSISFASGGDPDTTDYVAYVAKDPVN
RRACHILECCDGLAQDVIGSIGQAFELRFKQYLQCPTKIPALHDRMQSLDEPWTEEEG
DGSDHPYYNSIPSKMPPPGGFLDTRLKPRPHAPDTAQFAGKEQTYYQGRHLGDTFGED
WQQTPLRQGSSDIYSTPEGKLHVAPTGEAPTYVNTQQIPPQAWPAAVSSAESSPRKDL
FDMKPFEDALKNQPLGPVLSKAASVECISPVSPRAPDAKMLEELQAETWYQGEMSRKE
AEGLLEKDGDFLVRKSTTNPGSFVLTGMHNGQAKHLLLVDPEGTIRTKDRVFDSISHL
INHHLESSLPIVSAGSELCLQQPVERKQ"
CDS 541..1965
/codon_start=1
/product="p52 isoform of N-Shc"
/protein_id="BAA12323.1"
/translation="MSAARKGRPGDEPLPRPPRGAPHASDQVLGPGVTYVVKYLGCIE
VLRSMRSLDFSTRTQITREAISRVCEAVPGAKGAFKKRKPPSKMLSSILGKSNLQFAG
MSISLTISTASLNLRTPDSKQIIANHHMRSISFASGGDPDTTDYVAYVAKDPVNRRAC
HILECCDGLAQDVIGSIGQAFELRFKQYLQCPTKIPALHDRMQSLDEPWTEEEGDGSD
HPYYNSIPSKMPPPGGFLDTRLKPRPHAPDTAQFAGKEQTYYQGRHLGDTFGEDWQQT
PLRQGSSDIYSTPEGKLHVAPTGEAPTYVNTQQIPPQAWPAAVSSAESSPRKDLFDMK
PFEDALKNQPLGPVLSKAASVECISPVSPRAPDAKMLEELQAETWYQGEMSRKEAEGL
LEKDGDFLVRKSTTNPGSFVLTGMHNGQAKHLLLVDPEGTIRTKDRVFDSISHLINHH
LESSLPIVSAGSELCLQQPVERKQ"
BASE COUNT 480 a 665 c 636 g 378 t
ORIGIN
1 ggcttttaac ggtgggaggg caccatcctc ttgctctgct ctcgttctcc agaaggctgt
61 cccggggccc ccactctccg tcccgctccg gggacagtgg ctcgcctgct atgcgcggca
121 gcccgcgccg gggccggcac cagcagcgcc cgggcggatg cagcgagccc acggaggggc
181 atgcttccac gcaccaagta taaccgcttc aggaatgact cggtgacatc ggtcgatgac
241 cttctccaca gcctgtcggt gagcggcggc ggaggcaagg tttcggcggc gcgcgcgacc
301 ccggcggcgg ctccctactt ggtgtccggc gaggcgctgc gcaaggcgcc cgacgatggg
361 cccggcagcc tgggccacct gctccacaag gtgtcccacc tgaaactctc cagctcgggc
421 ctccgcggcc tgtcgtcggc cgcccgggag cgggcgggcg cgcggctctc gggcagctgc
481 agcgcgccca gcctggccgc cccggacggc agtgcgccct cggcgccccg cgccccggcc
541 atgagcgccg ccaggaaggg ccggcccggc gacgagccgc tgcccaggcc ccctcggggg
601 gcgccgcacg ccagcgacca ggtgctgggg cccggagtca cctacgtggt caagtacttg
661 gggtgcattg aagttctgcg ctcaatgagg tctcttgact tcagtacaag aacacaaatt
721 accagggaag ccatcagccg cgtctgtgaa gctgtgcctg gtgcgaaggg agccttcaag
781 aagagaaagc ctccaagcaa aatgctgtcc agcatcttgg gaaagagcaa cctccagttt
841 gcgggaatga gcatctctct gaccatctcc acggccagtc tgaacctgcg aactccggac
901 tccaaacaga tcatagcgaa tcaccacatg cggtccatct ccttcgcctc tgggggagac
961 ccggacacaa ctgactatgt tgcatatgtg gctaaggacc ctgttaatcg cagagcttgt
1021 cacattttgg aatgctgtga tgggctggcc caggatgtca tcggctccat cggacaagcc
1081 tttgagctcc ggtttaagca atatttacag tgtcctacca agattcccgc tctccatgat
1141 cgaatgcaga gtctggatga gccatggacg gaagaggagg gagatggctc agaccaccca
1201 tactacaaca gcatcccaag caagatgcct cctccagggg gctttcttga tactagactg
1261 aaacccagac cccatgctcc tgacacagcc cagtttgcag gaaaagagca gacttattac
1321 cagggaagac acttaggaga cacttttggc gaagactggc agcaaacacc tttaaggcaa
1381 gggtcctcgg acatctacag cacgccagaa gggaaactgc acgtggcccc cacgggagaa
1441 gcacccacct acgtcaacac tcagcagatc ccaccacagg cctggccggc tgcggtcagc
1501 agtgctgaga gcagcccgag gaaagacctc tttgacatga aaccttttga agatgctctc
1561 aagaaccagc ccttggggcc cgtgttaagc aaggcagcct ccgtggagtg catcagccct
1621 gtgtcaccta gagccccaga tgccaagatg ctggaggaac tgcaagccga gacttggtac
1681 caaggagaga tgagcaggaa ggaggcagag gggctgctgg agaaagacgg agacttcctg
1741 gtcaggaaga gcaccaccaa cccgggctcc tttgtcctca cgggcatgca caatggccag
1801 gccaagcacc tgctgctcgt ggacccagaa ggcacgatcc ggacaaagga cagagtcttt
1861 gacagtatca gccacctcat caaccaccac ctagaaagca gcctgcccat tgtctctgca
1921 gggagtgagc tgtgtctcca gcagccagtg gagaggaagc agtgacctgg ccagcactgc
1981 tcccagcact gcgcaccagg tcaggaggac ctggagtgga ctagaatcgg ggctgctgga
2041 actgggacag ctncctgtgg ctcagagcct tcttcaaaag cttcaaaagg aaggcttcct
2101 ttaaggtcaa gtttcataaa cttggttctg aatttctcat atgcatatta aaggtgtaca
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