LOCUS D83921 1389 bp mRNA linear ROD 27-DEC-2006
DEFINITION Mus musculus mRNA for Lefty prepro-protein, complete cds.
ACCESSION D83921
VERSION D83921.1
KEYWORDS TGF-beta superfamily; transforming growth factor beta
superfamily; left-right asymmetric expression; L-R determination;
cysteine-knot motif.
SOURCE Mus musculus (house mouse)
ORGANISM Mus musculus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE 1 (bases 1 to 1389)
AUTHORS Hamada,H.
TITLE Direct Submission
JOURNAL Submitted (05-MAR-1996) to the DDBJ/EMBL/GenBank databases.
Contact:Hiroshi Hamada
Osaka University, Institute for Molecular & Cellular Biology;
Yamada-oka 1-3, Suita, Osaka 565, Japan
REFERENCE 2
AUTHORS Hamada,H.
TITLE Mouse mRNA for Lefty prepro-protein, complete cds.
JOURNAL Unpublished (1996)
REFERENCE 3 (bases 1 to 1223)
AUTHORS Meno,C., Saijoh,Y., Fujii,H., Ikeda,M., Yokoyama,T., Yokoyama,M.,
Toyoda,Y. and Hamada,H.
TITLE Left-right asymmetric expression of the TGF-beta-family member
lefty in mouse embryos
JOURNAL Nature 381, 151-155 (1996)
COMMENT
FEATURES Location/Qualifiers
source 1..1389
/cell_line="P19"
/cell_type="embryonal carcinoma cell"
/clone="549"
/db_xref="taxon:10090"
/mol_type="mRNA"
/note="Common name: Mouse"
/organism="Mus musculus"
CDS 89..1195
/codon_start=1
/function="morphogen for L-R determination"
/gene="lefty"
/product="Lefty prepro-protein"
/protein_id="BAA12121.1"
/translation="MPFLWLCWALWALSLVSLREALTGEQILGSLLQQLQLDQPPVLD
KADVEGMVIPSHVRTQYVALLQHSHASRSRGKRFSQNLREVAGRFLVSETSTHLLVFG
MEQRLPPNSELVQAVLRLFQEPVPRTALRRQKRLSPHSARARVTIEWLRFRDDGSNRT
ALIDSRLVSIHESGWKAFDVTEAVNFWQQLSRPRQPLLLQVSVQREHLGPGTWSSHKL
VRFAAQGTPDGKGQGEPQLELHTLDLKDYGAQGNCDPEAPVTEGTRCCRQEMYLDLQG
MKWAENWILEPPGFLTYECVGSCLQLPESLTSRWPFLGPRQCVASEMTSLPMIVSVKE
GGRTRPQVVSLPNMRVQTCSCASDGALIPRRLQP"
BASE COUNT 276 a 415 c 431 g 265 t
ORIGIN
1 gtaccgtacc attcctccgc agactcaaga ccctttcagg acacctcagg gacacacaca
61 tccaaggctc ctcttcccgg acagcaccat gccattcctg tggctctgct gggcactctg
121 ggcactgtcg ctggttagcc tcagggaagc cctgaccgga gagcagatcc tgggcagcct
181 gctgcaacag ctgcagctcg atcaaccgcc agtcctggac aaggctgatg tggaagggat
241 ggtcatcccc tcgcacgtga ggactcagta tgtggccctg ctacaacaca gccatgccag
301 ccgctcccga ggcaagaggt tcagccagaa ccttcgagag gtggcaggca ggttcctggt
361 gtcagagacc tccactcacc tgctagtgtt cggaatggag cagcggctgc cgcctaacag
421 cgagctggtg caggctgtgc tgcggctgtt ccaggagcct gtgcccagaa cagctctccg
481 gaggcaaaag aggctgtccc cacacagtgc ccgggctcgg gtcaccattg aatggctgcg
541 cttccgcgac gacggctcca accgcactgc ccttatcgat tctaggctcg tgtccatcca
601 cgagagcggc tggaaggcct tcgacgtgac cgaggccgtg aacttctggc agcagctgag
661 ccggccgagg cagccgctgc tgctccaggt gtcggtgcag agggagcatc tggggccggg
721 aacctggagc tcacacaagt tggttcgttt cgcggcgcag gggacgccgg atggcaaggg
781 gcagggcgag ccacagctgg agctgcacac gctggacctc aaggactatg gagctcaagg
841 caattgtgac cccgaggcac cagtgactga aggcacccga tgctgtcgcc aggagatgta
901 cctggacctg caggggatga agtgggccga gaactggatc ctagaaccgc cagggttcct
961 gacatatgaa tgtgtgggca gctgcctgca gctaccggag tccctgacca gcaggtggcc
1021 atttctgggg cctcggcagt gtgtcgcctc agagatgacc tccctgccca tgattgtcag
1081 cgtgaaggag ggaggcagga ccaggcctca agtggtcagc ctgcccaaca tgagggtgca
1141 gacctgtagc tgcgcctcag atggggcgct catacccagg aggctgcagc cataggcgcn
1201 gggtgtggct tccccaagga tgtgcctttc atgcaaatct gaagtgctca ttatactggg
1261 agagctgggg attctaactc cctaatgggc aatccctgtg tgtgctcttt gcttcctctg
1321 aagtagcctc atccctaaat ttttaccttc gaggaatgtg actcgctggc ccntggaggc
1381 gctctgacc
//