LOCUS HUMMUPCAD 6972 bp mRNA linear HUM 27-DEC-2006
DEFINITION Homo sapiens CAD mRNA for multifunctional protein CAD, complete
cds.
ACCESSION D78586
VERSION D78586.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 6972)
AUTHORS Iwahana,H.
TITLE Direct Submission
JOURNAL Submitted (01-DEC-1995) to the DDBJ/EMBL/GenBank databases.
Contact:Hiroyuki Iwahana
School of Medicine, The University of Tokushima, Otsuka Dept. of
Clin. & Mol. Nutr.; Kuramoto 3-18-15, Tokushima, Tokushima 770,
Japan
REFERENCE 2
AUTHORS Iwahana,H., Fujimura,M., Ii,S., Kondo,M., Moritani,M.,
Takahashi,Y., Yamaoka,T., Yoshimoto,K. and Itakura,M.
TITLE Molecular cloning of a human cDNA encoding a trifunctional enzyme
of carbamoyl-phosphate synthetase-aspartate
transcarbamoylase-dihydroorotase in de novo pyrimidine synthesis
JOURNAL Biochem. Biophys. Res. Commun. 219, 249-255 (1996)
COMMENT
FEATURES Location/Qualifiers
source 1..6972
/cell_line="TIG-1-20"
/cell_type="fibroblast"
/db_xref="H-InvDB:HIT000101756"
/db_xref="taxon:9606"
/dev_stage="fetus"
/mol_type="mRNA"
/organism="Homo sapiens"
/tissue_type="fetal lung"
5'UTR 1..26
CDS 27..6704
/codon_start=1
/gene="CAD"
/note="carbamoyl-phosphate synthetase II (EC 6.3.5.5) +
aspartate carbamoyltransferase (EC 2.1.3.2) +
dihydroorotase (EC 3.5.2.3)"
/product="multifunctional protein CAD"
/protein_id="BAA11423.1"
/translation="MAALVLEDGSVLRGQPFGAAVSTAGEVVFQTGMVGYPEALTDPS
YKAQILVLTYPLIGNYGIPPDEMDEFGLCKWFESSGIHVAALVVGECCPTPSHWSATR
TLHEWLQQHGIPGLQGVDTRELTKKLREQGSLLGKLVQNGTEPSSLPFLDPNARPLVP
EVSIKTPRVFNTGGAPRILALDCGLKYNQIRCLCQRGAEVTVVPWDHALDSQEYEGLF
LSNGPGDPASYPSVVSTLSRVLSEPNPRPVFGICLGHQLLALAIGAKTYKMRYGNRGH
NQPCLLVGSGRCFLTSQNHGFAVETDSLPADWAPLFTNANDGSNEGIVHNSLPFFSVQ
FHPEHQAGPSDMELLFDIFLETVKEATAGNPGGQTVRERLTERLCPPGIPTPGSGLPP
PRKVLILGSGGLSIGQAGEFDYSGSQAIKALKEENIQTLLINPNIATVQTSQGLADKV
YFLPITPHYVTQVIRNERPDGVLLTFGGQTALNCGVELTKAGVLARYGVRVLGTTVET
IELTEDRRAFAARMAEIGEHVAPSEAGNSLEQAQAAAERLGYPVLVRAAFAVGGLGSG
FASNREELSALVAPAFAHTSQVLVDKSLKGWKEIEYEVVRDAYGNCVTVCNMENLDPL
GIHTGESIVVAPSQTLNDREYQLLRQTAIKVTQHLGIVGECNVQYALNPESEQYYIIE
VNARLSRSSALASKATGYPLAYVAAKLALGIPLPELRNSVTGGTAAFEPSVDYCVVKI
PRWDLSKFLRVSTKIGSCMKSVGEVMGIGRSFEEAFQKALRMVDENCVGFDHTVKPVS
DMELETPTDKRIFVVAAALWAGYSVDRLYELTRIDRWFLHRMKRIIAHAQLLEQHRGQ
PLPPDLLQQAKCLGFSDKQIALAVLSTELAVRKLRQELGICPAVKQIDTVAAEWPAQT
NYLYLTYWGTTHDLTFRTPHVLVLGSGVYRIGSSVEFDWCAVGCIQQLRKMGYKTIMV
NYNPETVSTDYDMCDRLYFDEISFEVVMDIYELENPEGVILSMGGQLPNNMAMALHRQ
QCRVLGTSPEAIDSAENRFKFSRLLDTIGISQPQWRELSDLESARQFCQTVGYPCVVR
PSYVLSGAAMNVAYADGDLERFLSSAAAVSKEHPVVISKFIQEAKEIDVDAVASDGVV
AAIAISEHVENAGVHSGDATLVTPPQDITAKTLERIKAIVHAVGQELQVTGPFNLQLI
AKDDQLKVIECNVRVSRSFPFVSKTLGVDLVALATRVIMGEEVEPVGLMTGSGVVGVK
VPQFSFSRLAGADVVLGVEMTSTGEVAGFGESRCEAYLKAMLSTGFKIPKKNILLTIG
SYKNKSELLPTVRLLESLGYSLYASLGTADFYTEHGVKVTAVDWHFEEAVDGECPPQR
SILEQLAEKNFELVINLSMRGAGGRRLSSFVTKGYRTRRLAADFSVPLIIDIKCTKLF
VEALGQIGPAPPLKVHVDCMTSQKLVRLPGLIDVHVHLREPGGTHKEDFASGTAAALA
GGITMVCAMPNTRPPIIDGPALALAQKLAEAGARCDFALFLGASSENAGTLGTVAGSA
AGLKLYLNETFSELRLDSVVQWMEHFETWPSHLPIVAHAEQQTVAAVLMVAQLTQRSV
HICHVARKEEILLIKAAKARGLPVTCEVAPHHLFLSHDDLERLGPGKGEVRPELGSRQ
DVEALWEDMAVIDCFASDHAPHTLEEKCGSRPPPGFPGLETMLPLLLTAVSEGRLSLD
DLLQRLHHNPRRIFHLPPQEDTYVEVDLEHEWTIPSHMPFSKAHWTPFEGQKVKGTVR
RVVLRGEVAYIDGQVLVPPGYGQDVRKWPQGAVPQLPPSAPATSEMTTTPERPRRGIP
GLPDGRFHLPPRIHRASDPGLPAEEPKEKSSRKVAEPELMGTPDGTCYPPPPVPRQAS
PQNLGTPGLLHPQTSPLLHSLVGQHILSVQQFTKDQMSHLFNVAHTLRMMVQKERSLD
ILKGKVMASMFYEVSTRTSSSFAAAMARLGGAVLSFSEATSSVQKGESLADSVQTMSC
YADVVVLRHPQPGAVELAAKHCRRPVINAGDGVGEHPTQALLDIFTIREELGTVNGMT
ITMVGDLKHGRTVHSLACLLTQYRVSLRYVAPPSLRMPPTVRAFVASRGTKQEEFESI
EEALPDTDVLYMTRIQKERFGSTQEYEACFGQFILTPHIMTRAKKKMVVMHPMPRVNE
ISVEVDSDPRAAYFRQAENGMYIRMALLATVLGRF"
3'UTR 6705..6972
regulatory 6949..6954
/regulatory_class="polyA_signal_sequence"
polyA_site 6972
BASE COUNT 1437 a 1998 c 2025 g 1512 t
ORIGIN
1 cgcccccgcc tctgagctcc cttcccatgg cggccctagt gttggaggac gggtcggtcc
61 tgcggggcca gccctttggg gccgccgtgt cgactgccgg ggaagtggtg tttcaaaccg
121 gcatggtcgg ctaccccgag gccctcactg atccctccta caaggcacag atcttagtgc
181 tcacctatcc tctgatcggc aactatggca tccccccaga tgaaatggat gagttcggtc
241 tctgcaagtg gtttgaatcc tcgggcatcc acgtagcagc actggtagtg ggagagtgct
301 gtcctactcc cagccactgg agtgccaccc gcaccctgca tgagtggctg cagcagcatg
361 gcatccctgg cttgcaagga gtagacactc gggagctgac caagaagttg cgggaacagg
421 ggtctctgct ggggaagctg gtccagaatg gaacagaacc ttcatccctg ccattcttgg
481 accccaatgc ccgccccctg gtaccagagg tctccattaa gactccacgg gtattcaata
541 cagggggtgc ccctcggatc cttgctttgg actgtggcct caagtataat cagatccgat
601 gcctctgcca gcgtggggct gaggtcactg tggtaccctg ggaccatgca ctagacagcc
661 aagagtatga gggtctcttc ttaagtaatg ggcctggtga ccctgcctcc tatcccagtg
721 tcgtatccac actgagccgt gttttatctg agcctaatcc ccgacctgtc tttgggatct
781 gcctgggaca ccagctattg gccttagcca ttggggccaa gacttacaag atgagatatg
841 ggaaccgagg ccataaccag ccctgcttgt tggtgggctc tgggcgctgc tttctgacat
901 cccagaacca tgggtttgct gtggagacag actcactgcc agcagactgg gctcctctct
961 tcaccaacgc caatgatggt tccaatgaag gcattgtgca caacagcttg cctttcttca
1021 gtgtccagtt tcacccagag caccaagctg gcccttcaga tatggaactg cttttcgata
1081 tctttctgga aactgtgaaa gaggccacag ctgggaaccc tgggggccag acagttagag
1141 agcggctgac tgagcgcctc tgtccccctg ggattcccac tcccggctct ggacttccac
1201 caccacgaaa ggttctgatc ctgggctcag ggggcctctc cattggccaa gctggagaat
1261 ttgactactc gggctctcag gcaattaagg ccctgaagga ggaaaacatc cagacgttgc
1321 tgatcaaccc caatattgcc acagtgcaga cctcccaggg gctggccgac aaggtctatt
1381 ttcttcccat aacacctcat tatgtaaccc aggtgatacg taatgaacgc cccgatggtg
1441 tgttactgac ttttgggggc cagactgctc tgaactgtgg tgtggagctg accaaggccg
1501 gggtgctggc tcggtatggg gtccgggtcc tgggcacaac agtggagacc attgagctga
1561 ccgaggatcg acgggccttt gctgccagaa tggcagagat cggagagcat gtggccccga
1621 gcgaggcagg aaattctctt gaacaggccc aggcagccgc tgaacggctg gggtaccctg
1681 tgctagtgcg tgcagccttt gccgtgggtg gcctgggctc tggctttgcc tctaacaggg
1741 aggagctctc tgctctcgtg gccccagctt ttgcccatac cagccaagtg ctagtagaca
1801 agtctctgaa gggatggaag gagattgagt acgaggtggt gagagacgcc tatggcaact
1861 gtgtcacggt gtgtaacatg gagaacttgg acccactggg catccacact ggtgagtcca
1921 tagtggtggc ccctagccag acactgaatg acagggagta tcagctcctg aggcagacag
1981 ctatcaaggt gacccagcac ctgggaattg ttggggagtg caatgtgcag tatgccttga
2041 accctgagtc tgagcagtat tacatcattg aagtgaatgc caggctctct cgcagctctg
2101 ccctggccag taaggccaca ggttatccac tggcttatgt ggcagccaag ctagcattgg
2161 gcatcccttt gcctgagctc aggaactctg tgacaggggg tacagcagcc tttgaaccca
2221 gcgtggatta ttgtgtggtg aagattcctc gatgggacct tagcaagttc ctgcgagtca
2281 gcacaaagat tgggagctgc atgaagagcg ttggtgaagt catgggcatt gggcgttcat
2341 ttgaggaggc cttccagaag gccctgcgca tggtggatga gaactgtgtg ggctttgatc
2401 acacagtgaa accagtcagc gatatggagt tggagactcc aacagataag cggatttttg
2461 tggtggcagc tgctttgtgg gctggttatt cagtggaccg cctgtatgag ctcacacgca
2521 tcgaccgctg gttcctgcac cgaatgaagc gtatcatcgc acatgcccag ctgctagaac
2581 aacaccgtgg acagcctttg ccgccagacc tgctgcaaca ggccaagtgt cttggcttct
2641 cagacaaaca gattgccctt gcagttctga gcacagagct ggctgttcgc aagctgcgtc
2701 aggaactggg gatctgtcca gcagtgaaac agattgacac agttgcagct gagtggccag
2761 cccagacaaa ttacctatac ctaacgtatt ggggcaccac ccatgacctc acctttcgaa
2821 cacctcatgt cctagtcctt ggctctggcg tctaccgtat tggctccagt gttgagtttg
2881 actggtgtgc tgtaggctgc atccagcagc tccgaaagat gggatataag accatcatgg
2941 tgaactataa cccagagaca gtcagcaccg actatgacat gtgtgatcga ctctactttg
3001 atgagatctc ttttgaggtg gtgatggaca tctatgagct cgagaaccct gaaggtgtga
3061 tcctatccat gggtggacag ctgcccaaca acatggccat ggcgttgcat cggcagcagt
3121 gccgggtgct gggcacctcc cctgaagcca ttgactcggc tgagaaccgt ttcaagtttt
3181 cccggctcct tgacaccatt ggtatcagcc agcctcagtg gagggagctc agtgacctcg
3241 agtctgctcg ccaattctgc cagaccgtgg ggtacccctg tgtggtgcgc ccctcctatg
3301 tgctgagcgg tgctgctatg aatgtggcct acgcggatgg agacctggag cgcttcctga
3361 gcagcgcagc agccgtctcc aaagagcatc ccgtggtcat ctccaagttc atccaggagg
3421 ctaaggagat tgacgtggat gccgtggcct ctgatggtgt ggtggcagcc atcgccatct
3481 ctgagcatgt ggagaatgca ggtgtgcatt caggtgatgc gacgctggtg acccccccac
3541 aagatatcac tgccaaaacc ctggagcgga tcaaagccat tgtgcatgct gtgggccagg
3601 agctacaggt cacaggaccc ttcaatctgc agctcattgc caaggatgac cagctgaaag
3661 ttattgaatg caacgtacgt gtctctcgct ccttcccctt cgtttccaag acactgggtg
3721 tggacctagt agccttggcc acgcgggtca tcatggggga agaagtggaa cctgtggggc
3781 taatgactgg ttctggagtc gtgggagtaa aggtgcctca gttctccttc tcccgcttgg
3841 cgggtgctga cgtggtgttg ggtgtggaaa tgaccagtac tggggaggtg gccggctttg
3901 gggagagccg ctgtgaggca tacctcaagg ccatgctaag cactggcttt aagatcccca
3961 agaagaatat cctgctgacc attggcagct ataagaacaa aagcgagctg ctcccaactg
4021 tgcggctact ggagagcctg ggctacagcc tctatgccag tctcggcaca gctgacttct
4081 acactgagca tggcgtcaag gtaacagctg tggactggca ctttgaggag gctgtggatg
4141 gtgagtgccc accacagcgg agcatcctgg agcagctagc tgagaaaaac tttgagctgg
4201 tgattaacct gtcaatgcgt ggagctgggg gccggcgtct ctcctccttt gtcaccaagg
4261 gctaccgcac ccgacgcttg gccgctgact tctccgtgcc cctaatcatc gatatcaagt
4321 gcaccaaact ctttgtggag gccctaggcc agatcgggcc agcccctcct ttgaaggtgc
4381 atgttgactg tatgacctcc caaaagcttg tgcgactgcc gggattgatt gatgtccatg
4441 tgcacctgcg ggaaccaggt gggacacata aggaggactt tgcttcaggc acagccgctg
4501 ccctggctgg gggtatcacc atggtgtgtg ccatgcctaa tacccggccc cccatcattg
4561 acggccctgc tctggccctg gcccagaagc tggcagaggc tggcgcccgg tgcgactttg
4621 cgctattcct tggggcctcg tctgaaaatg caggaacctt gggcaccgtg gccgggtctg
4681 cagccgggct gaagctttac ctcaatgaga ccttctctga gctgcggctg gacagcgtgg
4741 tccagtggat ggagcatttc gagacatggc cctcccacct ccccattgtg gctcacgcag
4801 agcagcaaac cgtggctgct gtcctcatgg tggctcagct cactcagcgc tcagtgcaca
4861 tatgtcacgt ggcacggaag gaggagatcc tgctaattaa agctgcaaag gcacggggct
4921 tgccagtgac ctgcgaggtg gctccccacc acctgttcct aagccatgat gacctggagc
4981 gcctggggcc tgggaagggg gaggtccggc ctgagcttgg ctcccgccag gatgtggaag
5041 ccctgtggga ggacatggct gtcatcgact gctttgcctc agaccatgct ccccatacct
5101 tggaggagaa gtgtgggtcc aggcccccac ctgggttccc agggttagag accatgctgc
5161 cactactcct gacggctgta agcgagggcc ggctcagcct ggacgacctg ctgcagcgat
5221 tgcaccacaa tcctcggcgc atctttcacc tgcccccgca ggaggacacc tatgtggagg
5281 tggatctgga gcatgagtgg acaattccca gccacatgcc cttctccaag gcccactgga
5341 caccttttga agggcagaaa gtgaagggca ccgtccgccg tgtggtcctg cgaggggagg
5401 ttgcctatat cgatgggcag gttctggtac ccccgggcta tggacaggat gtacggaagt
5461 ggccacaggg ggctgttcct cagctcccac cctcagcccc tgccactagt gagatgacca
5521 cgacacctga aagaccccgc cgtggcatcc cagggcttcc tgatggccgc ttccatctgc
5581 cgccccgaat ccatcgagcc tccgacccag gtttgccagc tgaggagcca aaggagaagt
5641 cctctcggaa ggtagccgag ccagagctga tgggaacccc tgatggcacc tgctaccctc
5701 caccaccagt accgagacag gcatctcccc agaacctggg gacccctggc ttgctgcacc
5761 cccagacctc acccctgctg cactcattag tgggccaaca tatcctgtcc gtccagcagt
5821 tcaccaagga tcagatgtct cacctgttca atgtggcaca cacactgcgt atgatggtgc
5881 agaaggagcg gagcctcgac atcctgaagg ggaaggtcat ggcctccatg ttctatgaag
5941 tgagcacacg gaccagcagc tcctttgcag cagccatggc ccggctggga ggtgctgtgc
6001 tcagcttctc ggaagccaca tcgtccgtcc agaagggcga atccctggct gactccgtgc
6061 agaccatgag ctgctatgcc gacgtcgtcg tgctccggca cccccagcct ggagcagtgg
6121 agctggccgc caagcactgc cggaggccag tgatcaatgc tggggatggg gtcggagagc
6181 accccaccca ggccctgctg gacatcttca ccatccgtga ggagctggga actgtcaatg
6241 gcatgacgat cacgatggtg ggtgacctga agcacggacg cacagtacat tccctggcct
6301 gcctgctcac ccagtatcgt gtcagcctgc gctacgtggc acctcccagc ctgcgcatgc
6361 cacccactgt gcgggccttc gtggcctccc gcggcaccaa gcaggaggaa ttcgagagca
6421 ttgaggaggc gctgcctgac actgatgtgc tctacatgac tcgaatccag aaggaacgat
6481 ttggctctac ccaggagtac gaagcttgct ttggtcagtt catcctcact ccccacatca
6541 tgacccgggc caagaagaag atggtggtga tgcacccgat gccccgtgtc aacgagataa
6601 gcgtggaagt ggactcggat ccccgcgcag cctacttccg ccaggctgag aacggcatgt
6661 acatccgcat ggctctgtta gccaccgtgc tgggccgttt ctaggggcct ggcttcctca
6721 gcctcttctc tttaggccca gctgctgggc aaggaattcc agtgcctcct acgggggcag
6781 cacacttaga tattcctgga catccagatt gctcacatgt gctgaccaca cttcaggctc
6841 tggactggag ctctctggca tgggggtggg gcctcagatg ctggggccca gtctgcccca
6901 tcttcattcc tgcaccttaa acctgtacag tcatttttct actgacttaa taaacagccg
6961 agctgtccct tg
//