LOCUS D63851 3692 bp mRNA linear HUM 13-FEB-1999
DEFINITION Homo sapiens Munc-18-1 mRNA for unc-18 homologue, complete cds.
ACCESSION D63851
VERSION D63851.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3692)
AUTHORS Gengyo-Ando,K.
TITLE Direct Submission
JOURNAL Submitted (15-AUG-1995) to the DDBJ/EMBL/GenBank databases.
Contact:Keiko Gengyo-Ando
Tokyo Women's Medical College; 8-1 Kawada-cho, Shinjuku-ku, Tokyo
162, Japan
REFERENCE 2
AUTHORS Gengyo-Ando,K., Kitayama,H., Mukaida,M. and Ikawa,Y.
TITLE not determined
JOURNAL Unpublished (1995)
REFERENCE 3
AUTHORS Gengyo-Ando,K., Kitayama,H., Mukaida,M. and Ikawa,Y.
TITLE A murine neural-specific homolog corrects cholinergic defects in
caenorhabditis elegans unc-18 mutants
JOURNAL J. Neurosci. 16, 6695-6702 (1996)
COMMENT Sequence updated (07-Mar-1997) by:Keiko Gengyo-Ando
FEATURES Location/Qualifiers
source 1..3692
/clone="2A23-23"
/clone_lib="lambda ZAPII"
/db_xref="H-InvDB:HIT000101691"
/db_xref="taxon:9606"
/dev_stage="Fetus"
/mol_type="mRNA"
/organism="Homo sapiens"
/sex="female"
/tissue_type="brain"
CDS 70..1854
/codon_start=1
/gene="Munc-18-1"
/product="unc-18 homologue"
/protein_id="BAA19483.1"
/translation="MAPIGLKAVVGEKIMHDVIKKVKKKGEWKVLVVDQLSMRMLSSC
CKMTDIMTEGITIVEDINKRREPLPSLEAVYLITPSEKSVHSLISDFKDPPTAKYRAA
HVFFTDSCPDALFNELVKSRAAKVIKTLTEINIAFLPYESQVYSLDSADSFQSFYSPH
KAQMKNPILERLAEQIATLCATLKEYPAVRYRGEYKDNALLAQLIQDKLDAYKADDPT
MGEGPDKARSQLLILDRGFDPSSPVLHELTFQAMSYDLLPIENDVYKYETSGIGEARV
KEVLLDEDDDLWIALRHKHIAEVSQEVTRSLKDFSSSKRMNTGEKTTMRDLSQMLKKM
PQYQKELSKYSTHLHLAEDCMKHYQGTVDKLCRVEQDLAMGTDAEGEKIKDPMRAIVP
ILLDANVSTYDKIRIILLYIFLKNGITEENLNKLIQHAQIPPEDSEIITNMAHLGVPI
VTDSTLRRRSKPERKERISEQTYQLSRWTPIIKDIMEDTIEDKLDTKHYPYISTRSSA
SFSTTAVSARYGHWHKNKAPGEYRSGPRLIIFILGGVSLNEMRCAYEVTQANGKWEVL
IGSTHILTPQKLLDTLKKLNKTDEEISS"
BASE COUNT 919 a 1013 c 884 g 876 t
ORIGIN
1 cctgaggagg cggcggggtc cgcaggcgtc gcgggacgag gagatcggag ccgggagact
61 cgcgcagcca tggcccccat tggcctcaaa gctgttgtcg gagagaagat tatgcatgat
121 gtgataaaga aggtcaagaa gaagggggaa tggaaggtgc tggtggtgga tcagttaagc
181 atgaggatgc tgtcctcctg ctgcaagatg acagacatca tgaccgaggg cataacgatt
241 gtggaagata tcaataagcg cagagagccg ctccccagcc tggaggctgt gtatctcatc
301 actccatccg agaagtccgt ccactctctc atcagtgact ttaaggaccc gccgactgct
361 aaataccggg ctgcacacgt cttcttcact gactcttgtc cagatgccct gtttaatgaa
421 ctggtaaaat cccgagcagc caaagtcatc aaaactctga cggaaatcaa tattgcattt
481 ctcccgtatg aatcccaggt ctattccttg gactctgctg actctttcca aagcttctac
541 agtccccaca aggctcagat gaagaatcct atactggagc gcctggcaga gcagatcgcg
601 accctttgtg ccaccctgaa ggagtacccg gctgtgcggt atcgggggga atacaaggac
661 aatgccctgc tggctcagct aatccaggac aagctcgatg cctataaagc tgatgatcca
721 acaatggggg agggcccaga caaggcacgc tcccagctcc tgatcctgga tcgaggcttt
781 gaccccagct cccctgtgct ccatgaattg acttttcagg ctatgagtta tgatctgctg
841 cctatcgaaa atgatgtata caagtatgag accagcggca tcggggaggc acgggtgaag
901 gaggtgctcc tggatgagga cgacgacctg tggatagcac tgcgccacaa gcacatcgca
961 gaggtgtccc aggaagtcac ccggtctctg aaagattttt cttctagcaa gagaatgaat
1021 actggagaga agaccaccat gcgggacctg tcccagatgc tgaagaagat gcctcagtac
1081 cagaaagagc tcagcaagta ctccacccac ctgcaccttg ctgaggactg tatgaagcat
1141 taccaaggca ccgtagacaa actctgccga gtggagcagg acctggccat gggcacagat
1201 gctgagggag agaagatcaa ggaccctatg cgagccatcg tccccattct gctggatgcc
1261 aatgtcagca cttatgacaa aatccgcatc atccttctct acatcttttt gaagaatggc
1321 atcacggagg aaaacctgaa caaactgatc cagcacgccc agataccccc ggaggatagt
1381 gagatcatca ccaacatggc tcacctcggc gtgcccatcg tcaccgattc cacgctgcgt
1441 cgccggagca agccggagcg gaaggaacgc atcagcgagc agacctacca gctctcacgg
1501 tggactccga ttatcaagga catcatggag gacactattg aggacaaact tgacaccaaa
1561 cactaccctt atatctctac ccgttcctct gcctccttca gtaccaccgc cgtcagcgcc
1621 cgctatgggc actggcataa gaacaaggcc ccaggtgagt accgcagtgg cccccgcctc
1681 atcattttca tccttggggg tgtgagcctg aatgagatgc gctgcgccta cgaggtgacc
1741 caggccaacg gaaagtggga ggtgctgata ggatccacac acatcctcac cccacagaaa
1801 ctgctggaca cactgaagaa actgaataaa acagatgaag aaataagcag ttaaaaaaat
1861 aagtcgcccc tccaaaacac gcccccatcc cacagcgctc cgcaggttcc caccaccgcc
1921 cgcctcagtt cctttgcgtc tgttgcctcc ccagccctgc acgccctggc tggcactgtt
1981 gccgctgcaa tctcgtgttc aagtgatgcc ctcatcttgt ttgaaacaaa agaaaataat
2041 gcattgtgtt ttttaaaaag agtatcttat acatgtatcc taaaaagaga agctcatgtg
2101 caattggtgc acagcaggag aaatttctgg actgttagga tgaatggacg ccttctcccc
2161 gttatttaag atttgtgacc ttgtacataa ccctgggtga cgtgcacatt gcttgggtat
2221 ggaacggtag aaatttgggt gtttttaaaa ccttgtttgg ggttgttcct gtccttgttg
2281 agaatcatag agatgtctgt gttcttggag tatttcacac tgaggactaa tctgctatct
2341 tcattccagt ccctacccct cagtgcctgc tctcatccaa ataacctggg aggtgacaat
2401 caggatatct caggaggtcc aaggtggaac agacctcttt ggctttccca gcgtctcata
2461 cccccggtag tgcagctgtg ggtggaggct ggggtgtctg cacgaagtca ggccagcgtc
2521 ctcctccaca gcctgtcact gccccctccc cagcctgtgt ccacagtgct gtgatcccga
2581 gggaagtcct ccagtctaag tcacagtgcc ctgacaggtg agaagcaaac tcccactgga
2641 agcctccatc tctttggaaa aacagttagt ctggagcctg tggcccaggc ccttctgtcc
2701 ccaggcatca tcccaacagc tcattttccc tagtccgcct tcgttcaagg gtcaggaatg
2761 gaccagaaca gatgggttct ggaggcccct gaacagaggg ctatggctgt ggagaaggtt
2821 cttggacccg ttggactcac acagaccctg taccctctcg gcaagcatct tcagtcagat
2881 tatcctcagt ttcagatact tcataatacc ttgtgttgtg tggggtcata catcatcgtg
2941 tttgtaagag aagatggtca ttttattctc tgtataaaac ttagctctaa agcagaaact
3001 aaagcagcaa atgcaggaag gctgtctcgc catcctcaag actcagcagc tctcattctc
3061 cagtggtgag cacaccattt gtgctgctgc tgttgtcgtg aaatataata acagtggaag
3121 tcacaaaaat gtcccctgcc cagccccctc gccgcccttg acctcctgca ggccatgtgt
3181 gtattacttg tctagtgatg tcctctcaaa agtgctgtac gcgagctcgg cgccacctcc
3241 gcctcccttt cagagcctgc tccccgccct ctccgctcgc tgcattgtgg tgttctcttc
3301 tcaaggcttt gaaatctccc cttgcactga gattagtcgt cagatctctc cccgtctccc
3361 tcccaactta tacgacctga tttccttagg acggaaccgc aggcacctgc gccgggcgtc
3421 ttactcccgc tgcttgttct gtcccctccc tcggaccaaa cagtgctcat gcttcaggac
3481 cttgtttgtc gaagatgttg gtttcccttt ctctgttatt tatataaaaa taatttatca
3541 aaaggatatt ttaaaaaagc tagtctgtct tgaaacttgt ttaccttaaa attatcagaa
3601 tctcagtgtt tgaaagtact gaagcacaaa catatatcat ctctgtacca ttctgtacta
3661 aagcacttga gtctaataaa taaagaaatc ag
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