LOCUS HUMDOCK180 6519 bp mRNA linear HUM 11-OCT-2008
DEFINITION Homo sapiens mRNA for DOCK180 protein, complete cds.
ACCESSION D50857
VERSION D50857.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 6519)
AUTHORS Matsuda,M.
TITLE Direct Submission
JOURNAL Submitted (03-JUN-1995) to the DDBJ/EMBL/GenBank databases.
Contact:Michiyuki Matsuda
National Institute of Health, Department of Pathology; 1-23-1
Toyama, Shinjuku-ku, Tokyo 162, Japan
REFERENCE 2
AUTHORS Hasegawa,H., Kiyokawa,E., Tanaka,S., Nagashima,K., Gotoh,N.,
Shibuya,M., Kurata,T. and Matsuda,M.
TITLE DOCK180, a major CRK-binding protein, alters cell morphology upon
translocation to the cell membrane
JOURNAL Mol. Cell. Biol. 16, 1770-1776 (1996)
COMMENT
FEATURES Location/Qualifiers
source 1..6519
/clone="C3X"
/db_xref="H-InvDB:HIT000101645"
/db_xref="taxon:9606"
/mol_type="mRNA"
/note="Japanese"
/organism="Homo sapiens"
/sex="female"
/tissue_type="placenta"
CDS 24..5621
/codon_start=1
/note="180-kDa protein downstream of CRK"
/note="CRK SH3-binding protein"
/product="DOCK180 protein"
/protein_id="BAA09454.1"
/translation="MTRWVPTKREEKYGVAFYNYDARGADELSLQIGDTVHILETYEG
WYRGYTLRKKSKKGIFPASYIHLKEAIVEGKGQHETVIPGDLPLIQEVTTTLREWSTI
WRQLYVQDNREMFRSVRHMIYDLIEWRSQILSGTLPQDELKELKKKVTAKIDYGNRIL
DLDLVVRDEDGNILDPELTSTISLFRAHEIASKQVEERLQEEKSQKQNIDINRQAKFA
ATPSLALFVNLKNVVCKIGEDAEVLMSLYDPVESKFISENYLVRWSSSGLPKDIDRLH
NLRAVFTDLGSKDLKREKISFVCQIVRVGRMELRDNNTRKLTSGLRRPFGVAVMDVTD
IINGKVDDEDKQHFIPFQPVAGENDFLQTVINKVIAAKEVNHKGQGLWVTLKLLPGDI
HQIRKEFPHLVDRTTAVARKTGFPEIIMPGDVRNDIYVTLVQGDFDKGSKTTAKNVEV
TVSVYDEDGKRLEHVIFPGAGDEAISEYKSVIYYQVKQPRWFETVKVAIPIEDVNRSH
LRFTFRHRSSQDSKDKSEKIFALAFVKLMRYDGTTLRDGEHDLIVYKAEAKKLEDAAT
YLSLPSTKAELEEKGHSATGKSMQSLGSCTISKDSFQISTLVCSTKLTQNVDLLGLLK
WRSNTSLLQQNLRQLMKVDGGEVVKFLQDTLDALFNIMMENSESETFDTLVFDALVFI
IGLIADRKFQHFNPVLETYIKKHFSATLAYTKLTKVLKNYVDGAEKPGVNEQLYKAMK
ALESIFKFIVRSRILFNQLYENKGEADFVESLLQLFRSINDMMSSMSDQTVRVKGAAL
KYLPTIVNDVKLVFDPKELSKMFTEFILNVPMGLLTIQKLYCLIEIVHSDLFTQHDCR
EILLPMMTDQLKYHLERQEDLEACCQLLSHILEVLYRKDVGPTQRHVQIIMEKLLRTV
NRTVISMGRDSELIGNFVACMTAILRQMEDYHYAHLIKTFGKMRTDVVDFLMETFIMF
KNLIGKNVYPFDWVIMNMVQNKVFLRAINQYADMLNKKFLDQANFELQLWNNYFHLAV
AFLTQESLQLENFSSAKRAKILNKYGDMRRQIGFEIRDMWYNLGQHKIKFIPEMVGPI
LEMTLIPETELRKATIPIFFDMMQCEFHSTRSFQMFENEIITKLDHEVEGGRGDEQYK
VLFDKILLEHCRKHKYLAKTGETFVKLVVRLMERLLDYRTIMHDENKENRMSCTVNVL
NFYKEIEREEMYIRYLYKLCDLHKECDNYTEAAYTLLLHAKLLKWSEDVCVAHLTQRD
GYQATTQGQLKEQLYQEIIHYFDKGKMWEEAIALGKELAEQYENEMFDYEQLSELLKK
QAQFYENIVKVIRPKPDYFAVGYYGQGFPTFLRGKVFIYRGKEYERREDFEARLLTQF
PNAEKMKTTSPPGDDIKNSPGQYIQCFTVKPKLDLPPKFHRPVSEQIVSFYRVNEVQR
FEYSRPIRKGEKNPDNEFANMWIERTIYTTAYKLPGILRWFEVKSVFMVEISPLENAI
ETMQLTNDKINSMVQQHLDDPSLPINPLSMLLNGIVDPAVMGGFANYEKAFFTDRYLQ
EHPEAHEKIEKLKDLIAWQIPFLAEGIRIHGDKVTEALRPFHERMEACFKQLKEKVEK
EYGVRIMPSSLDDRRGSRPRSMVRSFTMPSSSRPLSVASVSSLSSDSTPSRPGSDGFA
LEPLLPKKMHSRSQDKLDKDDLEKEKKDKKKEKRNSKHQEIFEKEFKPTDISLQQSEA
VILSETISPLRPQRPKSQVMNVIGSERRFSVSPSSPSSQQTPPPVTPRAKLSFSMQSS
LELNGMTGADVADVPPPLPLKGSVADYGNLMENQDLLGSPTPPPPPPHQRHLPPPLPS
KTPPPPPPKTTRKQTSVDSGIVQ"
BASE COUNT 1856 a 1498 c 1610 g 1555 t
ORIGIN
1 gcacgagcgg ctccggcggc gccatgacgc gctgggtgcc caccaagcgc gaggagaagt
61 acggcgtggc tttttataac tatgatgcca gaggagcgga tgaactttct ttacagatcg
121 gagacactgt gcacatctta gaaacatatg aagggtggta ccgaggttac acgttacgaa
181 aaaagtctaa gaagggtata tttcctgctt catatattca tcttaaagaa gcgatagttg
241 aaggaaaagg gcaacatgaa acagtcatcc cgggtgacct ccccctcatc caggaagtca
301 ccacgacact ccgagagtgg tccaccatct ggaggcagct ctacgtgcaa gataacaggg
361 agatgtttcg aagtgtgcgg cacatgatct atgaccttat tgaatggcga tcacaaattc
421 tttctggaac tctgcctcag gatgaactca aagaactgaa gaagaaggtc acagccaaaa
481 ttgattatgg aaacagaatt ctagatttgg acctggtggt tagagatgaa gatgggaata
541 ttttggatcc agaattaact agcacgatta gtctcttcag agctcatgaa atagcttcta
601 aacaagtgga ggaaaggtta caagaggaaa aatctcaaaa gcagaacata gatattaaca
661 gacaagccaa gtttgctgca accccttctc tggccttgtt tgtgaacctc aaaaatgtgg
721 tttgtaaaat aggagaagat gctgaagtcc tcatgtctct atatgaccct gtggagtcca
781 aattcatcag tgagaactac ctggttcgct ggtccagttc aggattacct aaagacatag
841 acagattaca taatttgcga gccgtgttta ctgacctcgg aagcaaagac ctgaaaaggg
901 agaaaatcag ttttgtctgt cagattgttc gcgtgggtcg catggagctg agggacaaca
961 acaccaggaa actgacctcg gggttgcggc gaccttttgg agtggctgtg atggatgtaa
1021 cagatataat aaatggaaaa gtagatgatg aagataagca gcatttcatt ccctttcagc
1081 cggtggcagg ggagaatgac ttccttcaga ctgttataaa caaagtcatc gctgccaaag
1141 aagtcaacca caaggggcag ggtttgtggg taacattgaa attacttcct ggagatatcc
1201 atcagatccg aaaagagttt ccgcatttag tggacaggac cacagctgtg gctcgaaaaa
1261 cagggtttcc ggagataatc atgcctggtg atgttcgaaa tgatatctat gtaacattag
1321 ttcaaggaga ttttgataaa ggaagcaaaa caacagcgaa gaacgtggag gtcacggtgt
1381 ctgtgtacga tgaggatggg aaacgattag agcatgtgat tttcccgggt gctggtgatg
1441 aagcgatttc agagtacaaa tctgtgattt actaccaagt aaagcagcca cgctggtttg
1501 agactgttaa ggtggccatt cccatcgagg acgttaaccg cagtcacctt cggtttacct
1561 tccgccacag gtcatcacag gactctaagg ataaatctga gaaaatattt gcactagcat
1621 ttgtcaagct gatgagatac gatggtacca ccctgcgaga cggagagcac gatcttatcg
1681 tctataaggc cgaagcgaag aagctggaag atgctgccac gtacttgagt ctgccctcca
1741 cgaaggcaga gttggaagaa aagggccact cggccaccgg caagagcatg cagagccttg
1801 ggagctgcac cattagcaag gactccttcc agatctccac gctcgtgtgc tccaccaaac
1861 tgactcagaa cgtggacctt ctggggctct tgaaatggcg ctccaacacc agcctgctgc
1921 agcagaactt gaggcagctg atgaaagtcg atggtggtga agtagtgaag tttcttcagg
1981 acacgttgga tgccctcttc aacatcatga tggagaactc agagagtgag acttttgaca
2041 cgttagtctt tgatgctctg gtatttatca ttggactgat tgctgataga aaatttcagc
2101 attttaatcc tgttttggaa acttacatta agaaacactt tagtgcaacg ttagcctaca
2161 cgaagttgac aaaagtgttg aagaactacg tggacggtgc tgagaagccg ggagtaaatg
2221 agcagctgta caaagccatg aaagcgctag aatccatctt caagttcatc gtgcgctcca
2281 ggatcctgtt caatcaactg tatgaaaaca agggagaggc tgacttcgtg gaatctttgc
2341 tgcagctctt caggtccatc aatgacatga tgagcagcat gtcagaccag accgtccggg
2401 tgaagggggc agcactgaaa tacttaccaa cgatcgtcaa cgatgtgaaa ttggtgtttg
2461 atcccaaaga gctcagcaaa atgtttactg aattcatcct caatgttccc atgggcttgc
2521 tgaccatcca gaaactctac tgcttgatcg aaatcgtcca cagtgacctc ttcacacagc
2581 atgactgcag agagatcctg cttcccatga tgaccgatca gctcaagtac catctggaga
2641 gacaggagga cctggaggcc tgctgtcagc tgctcagcca catcctggag gtgctgtaca
2701 ggaaggacgt ggggccaacc cagaggcacg tccagattat catggagaaa cttctccgga
2761 ccgtgaaccg aaccgtcatt tccatgggac gagattctga actcattgga aacttcgtgg
2821 cttgcatgac agctatttta cgacaaatgg aagattacca ttatgcccac ttgatcaaga
2881 cttttgggaa aatgaggact gatgtggtag atttcctaat ggaaacattc atcatgttta
2941 agaacctcat tggaaagaac gtttacccct tcgactgggt gatcatgaac atggtgcaaa
3001 ataaagtctt cctgcgagca attaatcagt atgcagatat gctgaacaaa aaatttctgg
3061 atcaagccaa ctttgagcta cagctgtgga acaactactt tcacctggct gttgctttcc
3121 ttactcaaga gtccctgcaa ctggagaatt tttcaagtgc caagagagcc aaaatcctta
3181 acaagtacgg agatatgagg agacagattg gctttgaaat cagagacatg tggtacaacc
3241 ttggtcaaca caagataaag ttcattccag aaatggtggg cccaatatta gaaatgacat
3301 taattcccga gacggagctg cgcaaagcca ccatccccat cttctttgat atgatgcagt
3361 gtgaattcca ttcgacccga agcttccaaa tgtttgaaaa tgagatcatc accaagctgg
3421 atcatgaagt cgaaggaggc agaggagacg aacagtacaa agtgttattt gataaaatcc
3481 ttctggaaca ctgcaggaag cacaaatacc tcgccaaaac aggagaaact tttgtaaaac
3541 tcgttgtgcg cttaatggaa aggcttttgg attatagaac catcatgcac gacgagaaca
3601 aagaaaaccg catgagctgc accgtcaatg tgctgaattt ctacaaagaa attgaaagag
3661 aagaaatgta tataaggtat ttgtacaagc tctgtgacct gcacaaggag tgtgataact
3721 acaccgaagc ggcttacacc ttgcttctcc atgcaaagct tcttaagtgg tcggaggatg
3781 tgtgtgtggc ccacctcacc cagcgggacg ggtaccaggc caccacgcag ggacagctga
3841 aggagcagct ctaccaggaa atcatccact acttcgacaa aggcaagatg tgggaggagg
3901 ccattgcctt gggcaaggag ctagccgagc agtatgagaa cgaaatgttt gattatgagc
3961 aactcagcga attgctgaaa aaacaggctc agttttatga aaacatcgtc aaagtgatca
4021 ggcccaagcc tgactatttt gctgttggct actacggaca agggttcccc acattcctgc
4081 ggggaaaagt tttcatttac cgagggaaag agtatgagcg ccgggaagat tttgaggctc
4141 ggctcttaac tcagtttcca aacgccgaga aaatgaagac aacatctcca ccaggcgacg
4201 atattaaaaa ctctcctggc cagtatattc agtgcttcac agtgaagccc aaactcgatc
4261 tgcctcctaa gtttcacagg ccagtgtcag agcagattgt aagtttttac agggtgaacg
4321 aggtccagcg atttgaatat tctcggccaa tccggaaggg agagaaaaac ccagacaatg
4381 aatttgcgaa tatgtggatc gagagaacca tatatacaac tgcatataaa ttacctggaa
4441 ttttaaggtg gtttgaggtc aagtctgttt tcatggtgga aatcagcccc ctggagaatg
4501 ccatcgagac catgcagctg acgaacgaca agatcaacag catggtgcag cagcacctgg
4561 atgaccccag cctgcccatc aacccgctct ccatgctcct gaacggcatc gtggacccag
4621 ctgtcatggg gggcttcgca aactacgaaa aggccttctt tacagaccgg tacctgcagg
4681 agcaccctga ggcccatgaa aagatcgaga agctcaagga cctgattgct tggcagattc
4741 cttttctggc cgaagggatc agaatccatg gagacaaagt cacggaggca ctgaggccgt
4801 tccacgagag gatggaggcc tgtttcaaac agctgaagga aaaggtggag aaagagtacg
4861 gcgtccgaat catgccctca agtctggatg atagaagagg cagccgcccc cggtccatgg
4921 tgcggtcctt cacgatgcct tcctcatccc gccctctgtc tgtggcctct gtctcttccc
4981 tctcatcgga cagcaccccc tccagaccag gctccgacgg gtttgccctg gagcctctcc
5041 tgccaaagaa aatgcactcc aggtcccagg acaagctgga caaggatgac ctggagaagg
5101 agaagaagga caagaagaag gaaaaaagga acagcaaaca tcaagagata tttgagaaag
5161 aatttaaacc caccgacatt tccctgcagc agtctgaggc tgtgatcctt tcggaaacga
5221 taagtcccct gcggccccag agaccgaaga gccaggtgat gaacgtcatt ggaagcgaaa
5281 ggcgcttctc ggtgtccccc tcgtcaccgt cctcccagca aacaccccct ccagttacac
5341 caagagccaa gctcagcttc agcatgcagt cgagcttgga gctgaacggc atgacggggg
5401 cggacgtggc cgatgtccca ccccctctgc ctctcaaagg cagcgtggca gattacggga
5461 atttgatgga aaaccaggac ttgctgggct cgccaacacc tccacctccc cctccacacc
5521 agaggcatct gccacctcca ctgcccagca aaactccgcc tcctccccct ccaaagacaa
5581 ctcgcaagca gacatcggtg gactctggga tcgtgcagtg acatcgcaag gctctctgga
5641 aagagtgtgc tgcccctccc catctccatg ccctctcctt ctgtgtcccc tgagtctgct
5701 gtttacctca ttgggcctgt gatgttaaca tttcgtgcga ctgctttttc ttcaaaggag
5761 ttcagttctc accatggagt gagtggcctt tagcgtcatg gagcaaggtg ggtctgggag
5821 gtagatatgg gtccgggatg tgccatcgta gttaccagag ttgggggcct ctgagtgtgt
5881 ctggctctga gagagtctga gtcttgccca aacattcttt ctttttgtgc caaatgactt
5941 gcatttgcaa agagctcaat tgctctgagc tcagccaagt aggagaggct aggccatcac
6001 tcttgggaag ctgtgtagtg atgatgtata agaatcctcc tcactgtcat gggatgttgt
6061 atccagcccc tccttgttcc agccggtggt gtgacttcgt tggttgaggt gtgtctccaa
6121 cctacatcag accatgaagt tcaacccctc cagggaagct cctgatttcc cctgcataat
6181 tgaaaatagg atattctcag ctattgaaca gttactaatt tatggggtgg aaacagcatt
6241 aagaatactg aatcaaatgg aaaaacaaat gaatacagga agataagtgt tcgttctttt
6301 ctgaaaaaag agtatgtgta ccacaagagc tggttttaat tgggtgaatt gtttttgtcc
6361 tcattctgta cagaaatttg tatatatgat ggttcttaga acttgtttta atttttgtgg
6421 tccttctgtt tattataata ggcgtccacc aatgattatc catatgtgtt cttaattttt
6481 aactgctgga agtgttaaaa cacacacacc ccggaattc
//