LOCUS D50678 4468 bp mRNA linear HUM 23-MAY-2008
DEFINITION Homo sapiens mRNA for apolipoprotein E receptor 2, complete cds.
ACCESSION D50678
VERSION D50678.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4468)
AUTHORS Kim,D.-H., Iijima,H., Gotou,K., Sakai,J., Ishii,H., Kim,H.J.,
Suzuki,H., Kondo,H., Saeki,S. and Yamamoto,T.
TITLE Direct Submission
JOURNAL Submitted (26-MAY-1995) to the DDBJ/EMBL/GenBank databases.
Contact:Dong-Ho Kim
Tohoku University, Gene Research Center; 1-1
Tsutsumidouri-Amamiyamachi, Aobaku, Sendai, Miyagi 981, Japan
REFERENCE 2 (bases 46 to 4468)
AUTHORS Kim,D.-H., Iijima,H., Gotou,K., Sakai,J., Ishii,H., Kim,H.J.,
Suzuki,H., Kondo,H., Saeki,S. and Yamamoto,T.
TITLE Human Apolipoprotein E Receptor 2: a novel lipoprotein receptor of
the low density lipoprotein receptor family predominantly
expressed in brain
JOURNAL J. Biol. Chem. 271, 8373-8380 (1996)
COMMENT
FEATURES Location/Qualifiers
source 1..4468
/clone="pNR1"
/db_xref="H-InvDB:HIT000101578"
/db_xref="taxon:9606"
/mol_type="mRNA"
/organism="Homo sapiens"
/tissue_type="placenta"
5'UTR <1..102
CDS 103..2994
/codon_start=1
/product="apolipoprotein E receptor 2 precursor"
/protein_id="BAA09328.1"
/translation="MGLPEPGPLRLLALLLLLLLLLLLRLQHLAAAAADPLLGGQGPA
KECEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHER
WKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADE
AGCATLCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGCADPACGPREFRCGGDGG
GACIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATVSQFACRSGECVHLG
WRCDGDRDCKDKSDEADCPLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCL
QGLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVN
YKGYFKCECYPGYEMDLLTKNCKAAGGKSPSLIFTNRYEVRRIDLVKRNYSRLIPMLK
NVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVH
KHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIE
KSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISS
TDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELK
QPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAPQS
TSTTTLASTMTRTVPATTRAPGTTVHRSTYQNHSTETPSLTAAVPSSVSVPRAPSISP
STLSPATSNHSQHYANEDSKMGSTVTAAVIGIIVPIVVIALLCMSGYLIWRNWKRKNT
KSMNFDNPVYRKTTEEEDEDELHIGRTAQIGHVYPAAISSFDRPLWAEPCLGETREPE
DPAPALKELFVLPGEPRSQLHQLPKNPLSELPVVKSKRVALSLEDDGLP"
sig_peptide 103..225
mat_peptide 226..2991
/note="homologous to the low density lipoprotein receptor
and very low density lipoprotein receptor"
/product="apolipoprotein E receptor 2"
3'UTR 2995..4468
regulatory 4274..4279
/regulatory_class="polyA_signal_sequence"
regulatory 4446..4451
/regulatory_class="polyA_signal_sequence"
polyA_site 4468
BASE COUNT 1086 a 1161 c 1200 g 1021 t
ORIGIN
1 gcagcggcaa ccccggcgcc gcggcaagga ctcggagggc tgagacgcgg cggcggcggc
61 gcggggagcg cggggcgcgg cggccggagc cccgggcccg ccatgggcct ccccgagccg
121 ggccctctcc ggcttctggc gctgctgctg ctgctgctgc tgctgctgct gctgcggctc
181 cagcatcttg cggcggcagc ggctgatccg ctgctcggcg gccaagggcc ggccaaggag
241 tgcgaaaagg accaattcca gtgccggaac gagcgctgca tcccctctgt gtggagatgc
301 gacgaggacg atgactgctt agaccacagc gacgaggacg actgccccaa gaagacctgt
361 gcagacagtg acttcacctg tgacaacggc cactgcatcc acgaacggtg gaagtgtgac
421 ggcgaggagg agtgtcctga tggctccgat gagtccgagg ccacttgcac caagcaggtg
481 tgtcctgcag agaagctgag ctgtggaccc accagccaca agtgtgtacc tgcctcgtgg
541 cgctgcgacg gggagaagga ctgcgagggt ggagcggatg aggccggctg tgctaccttg
601 tgcgccccgc acgagttcca gtgcggcaac cgctcgtgcc tggccgccgt gttcgtgtgc
661 gacggcgatg acgactgtgg tgacggcagc gatgagcgcg gctgtgcaga cccggcctgc
721 gggccccgcg agttccgctg cggcggcgat ggcggcggcg cctgcatccc ggagcgctgg
781 gtctgcgacc gccagtttga ctgcgaggac cgctcggacg aggcagccga gctctgcggc
841 cgcccgggcc ccggggccac gtccgcgccc gccgcctgcg ccaccgtctc ccagttcgcc
901 tgccgcagcg gcgagtgcgt gcacctgggc tggcgctgcg acggcgaccg cgactgcaaa
961 gacaaatcgg acgaggccga ctgcccactg ggcacctgcc gtggggacga gttccagtgt
1021 ggggatggga catgtgtcct tgcaatcaag cactgcaacc aggagcagga ctgtccagat
1081 gggagtgatg aagctggctg cctacagggg ctgaacgagt gtctgcacaa caatggcggc
1141 tgctcacaca tctgcactga cctcaagatt ggctttgaat gcacgtgccc agcaggcttc
1201 cagctcctgg accagaagac ctgtggcgac attgatgagt gcaaggaccc agatgcctgc
1261 agccagatct gtgtcaatta caagggctat tttaagtgtg agtgctaccc tggctacgag
1321 atggacctac tgaccaagaa ctgcaaggct gctggtggaa agagcccatc cctaatcttc
1381 accaaccggt acgaggtgcg gaggatcgac ctggtgaagc ggaactattc acgcctcatc
1441 cccatgctca agaatgtcgt ggcactagat gtggaagttg ccaccaatcg catctactgg
1501 tgtgacctct cctaccgtaa gatctatagc gcctacatgg acaaggccag tgacccgaaa
1561 gagcaggagg tcctcattga cgagcagttg cactctccag agggcctggc agtggactgg
1621 gtccacaagc acatctactg gactgactcg ggcaataaga ccatctcagt ggccacagtt
1681 gatggtggcc gccgacgcac tctcttcagc cgtaacctca gtgaaccccg ggccatcgct
1741 gttgaccccc tgcgagggtt catgtattgg tctgactggg gggaccaggc caagattgag
1801 aaatctgggc tcaacggtgt ggaccggcaa acactggtgt cagacaatat tgaatggccc
1861 aacggaatca ccctggatct gctgagccag cgcttgtact gggtagactc caagctacac
1921 caactgtcca gcattgactt cagtggaggc aacagaaaga cgctgatctc ctccactgac
1981 ttcctgagcc acccttttgg gatagctgtg tttgaggaca aggtgttctg gacagacctg
2041 gagaacgagg ccattttcag tgcaaatcgg ctcaatggcc tggaaatctc catcctggct
2101 gagaacctca acaacccaca tgacattgtc atcttccatg agctgaagca gccaagagct
2161 ccagatgcct gtgagctgag tgtccagcct aatggaggct gtgaatacct gtgccttcct
2221 gctcctcaga tctccagcca ctctcccaag tacacatgtg cctgtcctga cacaatgtgg
2281 ctgggtccag acatgaagag gtgctaccga gcacctcaat ctacctcaac tacgacgtta
2341 gcttctacca tgacgaggac agtacctgcc accacaagag cccccgggac caccgtccac
2401 agatccacct accagaacca cagcacagag acaccaagcc tgacagctgc agtcccaagc
2461 tcagttagtg tccccagggc tcccagcatc agcccgtcta ccctaagccc tgcaaccagc
2521 aaccactccc agcactatgc aaatgaagac agtaagatgg gctcaacagt cactgccgct
2581 gttatcggga tcatcgtgcc catagtggtg atagccctcc tgtgcatgag tggatacctg
2641 atctggagaa actggaagcg gaagaacacc aaaagcatga attttgacaa cccagtctac
2701 aggaaaacaa cagaagaaga agatgaagat gagctccata tagggagaac tgctcagatt
2761 ggccatgtct atcctgcagc aatcagcagc tttgatcgcc cactgtgggc agagccctgt
2821 cttggggaga ccagagaacc ggaagaccca gcccctgccc tcaaggagct ttttgtcttg
2881 ccgggggaac caaggtcaca gctgcaccaa ctcccgaaga accctctttc cgagctgcct
2941 gtcgtcaaat ccaagcgagt ggcattaagc cttgaagatg atggactacc ctgaggatgg
3001 gatcaccccc ttcgtgcctc atggaattca gtcccatgca ctacactctg gatggtgtat
3061 gactggatga atgggtttct atatatgggt ctgtgtgagt gtatgtgtgt gtgtgatttt
3121 ttttttaaat ttatgttgcg gaaaggtaac cacaaagtta tgatgaactg caaacatcca
3181 aaggatgtga gagtttttct atgtataatg ttttatacac tttttaactg gttgcactac
3241 ccatgaggaa ttcgtggaat ggctactgct gactaacatg atgcacataa ccaaatgggg
3301 gccaatggca cagtacctta ctcatcattt aaaaactata tttacagaag atgtttggtt
3361 gctggggggg cttttttggg ttttggggca tttgtttttt gtaaataaga tgattatgct
3421 ttgtggctat ccatcaacat aagtaaaaaa aaaaaaaaaa cacttcaact ccctccccca
3481 tttagattat ttattaacat attttaaaaa tcagatgagt tctataaata atttagagaa
3541 gtgagagtat ttatttttgg catgtttggc ccaccacaca gactctgtgt gtgtatgtgt
3601 gtgtttatat gtgtatgtgt gtgacaggaa aatctgtaga gaagaggcac atctatggct
3661 actgttcaaa tacataaaga taaatttatt ttcacacagt ccacaagggg tatatcttgt
3721 agttttcaga aaagcctttg gaaatctgga tcaggaaata gataccatgg tttgtgcaat
3781 tatgtagtaa aaaaggcaaa tcttttcacc tctggctatt cctgagaccc caggaagtca
3841 ggaaaagcct ttcagctcac ccatggctgc tgtgactcct accagggctt tcttggcttt
3901 ggcgaaggtc agtgtacaga cattccatgg taccagagtg ctcagaaagt caagatagga
3961 tatgcctcac cctcagctac tccttgtttt aaagttcagc tctttgagta acttcttcaa
4021 tttctttcag gacacttggg ttgaattcag taagtttcct ctgaagcacc ctgaagggtg
4081 ccatccttac agagctaagt ggagacgttt ccagatcagc ccaagtttac tatagagact
4141 ggcccaggca ctgaatgtct aggacatgct gtggatgaag ataaagatgg tggaataggt
4201 tttatcacat ctcttatttc tcttttcccc ttactctcta ccatttcctt tatgtgggga
4261 aacattttaa ggtaataaat aggttactta ccatcatatg ttcatataga tgaaactaat
4321 ttttggctta agtcagaaca actggccccc aattgaagtc atatttgtgg ggggaaatgg
4381 catacgcaat attatattat attggatatt tatgttcaca caggaatttg gtttactgct
4441 ttgtaaataa aagggaaaac tccgggta
//