LOCUS D44466 3176 bp mRNA linear HUM 16-FEB-2008
DEFINITION Homo sapiens mRNA for proteasome subunit p112, complete cds.
ACCESSION D44466
VERSION D44466.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3176)
AUTHORS Tanaka,K.
TITLE Direct Submission
JOURNAL Submitted (24-DEC-1994) to the DDBJ/EMBL/GenBank databases.
Contact:Keiji Tanaka
The Univ. of Tokushima, Inst. for Enz. Res.; 3-18-15 Kuramoto-cho,
Tokushima, Tokushima 770, Japan
REFERENCE 2
AUTHORS Yokota,K., Akioka,H., Shimizu,Y., Tanahashi,N., Tsurumi,C.,
Noda,C., Toh-E,A., Fujimuro,M., Yokosawa,H., DeMartino,G.,
Slaughter,C. and Tanaka,K.
TITLE cDNA cloning of a regulatory subunit p112 of the human 26S
proteasome and functional analysis of its homologous gene SEN3 of
Saccharomyces cerevisiae
JOURNAL Unpublished (1995)
REFERENCE 3
AUTHORS Yokota,K., Kagawa,S., Shimizu,Y., Akioka,H., Tsurumi,C., Noda,C.,
Fujimuro,M., Yokosawa,H., Fujiwara,T., Takahashi,E., Ohba,M.,
Yamasaki,M., DeMartino,G.N., Slaughter,C.A., Toh-e,A. and Tanaka,K.
TITLE cDNA cloning of p112, the largest regulatory subunit of the human
26S proteasome, and functional analysis of its yeast homologue,
sen3p
JOURNAL Mol. Biol. Cell 7, 853-870 (1996)
COMMENT
FEATURES Location/Qualifiers
source 1..3176
/cell_line="HepG2"
/db_xref="H-InvDB:HIT000101480"
/db_xref="taxon:9606"
/mol_type="mRNA"
/organism="Homo sapiens"
CDS 81..2942
/codon_start=1
/product="proteasome subunit p112"
/protein_id="BAA07918.1"
/translation="MITSAAGIISLLDEDEPQLKEFALHKLNAVVNDFWAEISESVDK
IEVLYEDEGFRSRQFAALVASKVFYHLGAFEESLNYALGARDLFNVNDNSEYVETIIA
KCIDHYTKQCVENADLPEGEKKPIDQRLEGIVNKMFQRCLDDHKYKQAIGIALETRRL
DVFEKTILESNDVPGMLAYSLKLCMSLMQNKQFRNKVLRVLVKIYMNLEKPDFINVCQ
CLIFLDDPQAVSDILEKLVKEDNLLMAYQICFDLYESASQQFLSSVIQNLRTVGTPIA
SVPGSTNTGTVPGSEKDSDSMETEEKTSSAFVGKTPEASPEPKDQTLKMIKILSGEMA
IELHLQFLIRNNNTDLMILKNTKDAVRNSVCHTATVIANSFMHCGTTSDQFLRDNLEW
LARATNWAKFTATASLGVIHKGHEKEALQLMATYLPKDTSPGSAYQEGGGLYALGLIH
ANHGGDIIDYLLNQLKNASNDIVRHGGSLGLGLAAMGTARQDVYDLLKTNLYQDDAVT
GEAAGLALGLVMLGSKNAQAIEDMVGYAQETQHEKILRGLAVGIALVMYGRMEEADAL
IESLCRDKDPILRRSGMYTVAMAYCGSGNNKAIRRLLHVAVSDVNDDVRSAAVESLGF
ILFRTPEQCPSVVSLLSESYNPHVRYGAAMALGICCAGTGNKEAINLLEPMTNDPVNY
VRQGALIASALIMIQQTEITCPKVNQFRQLYSKVINDKHDDVMAKFGAILAQGILDAG
GHNVTISLQSRTGHTHMPSVVGVLVFTQFWFWFPLSHFLSLAYTPTCVIGLNKDLKMP
KVQYKSNCKPSTFAYPAPLEVPKEKEKEKVSTAVLSITAKAKKKEKEKEKKEEEKMEV
DEAEKKEEKEKKKEPEPNFQLLDNPARVMPAQLKVLTMPETCRYQPFKPLSIGGIIIL
KDTSEDIEELVEPVAAHGPKIEEEEQEPEPPEPFEYIDD"
regulatory 3148..3153
/regulatory_class="polyA_signal_sequence"
BASE COUNT 961 a 626 c 757 g 832 t
ORIGIN
1 tgaactgagc ggcccctgag ctgacagata cactgcgcag tggaacggcg agcgagccga
61 cgggcgagtg aggggcgcac atgatcacct cggccgctgg aattatttct cttctggatg
121 aagatgaacc acagcttaag gaatttgcac tacacaaatt gaatgcagtt gttaatgact
181 tctgggcaga aatttccgag tccgtagaca aaatagaggt tttatacgaa gatgaaggtt
241 tccggagtcg gcagtttgca gccttagtgg catctaaagt attttatcac ctgggggctt
301 ttgaggagtc tctgaattat gctcttggag caagggacct cttcaatgtc aatgataact
361 ctgaatatgt ggaaactatt atagcaaaat gcattgatca ctacaccaaa caatgtgtgg
421 aaaatgcaga tttgcctgaa ggagaaaaaa aaccaattga ccagagattg gaaggcatcg
481 taaataaaat gttccagcga tgtctagatg atcacaagta taaacaggct attggcattg
541 ctctggagac acgaagactg gacgtctttg aaaagaccat actggagtcg aatgatgtcc
601 caggaatgtt agcttatagc cttaagctct gcatgtcttt aatgcagaat aaacagtttc
661 ggaataaagt actaagagtt ctagttaaaa tctacatgaa cttggagaaa cctgatttca
721 tcaatgtttg tcagtgctta attttcttag atgatcctca ggctgtgagt gatatcttag
781 agaaactggt aaaggaagac aacctcctga tggcatatca gatttgtttt gatttgtatg
841 aaagtgctag ccagcagttt ttgtcatctg taatccagaa tcttcgaact gttggcaccc
901 ctattgcttc tgtgcctgga tccactaata cgggtactgt tccgggatca gagaaagaca
961 gtgactcgat ggaaacagaa gaaaagacaa gcagtgcatt tgtaggaaag acaccagaag
1021 ccagtccaga gcctaaggac cagactttga aaatgattaa aattttaagt ggtgaaatgg
1081 ctattgagtt acatctgcag ttcttaatac gaaacaataa tacagacctc atgattctaa
1141 aaaacacaaa ggatgcagta cggaattctg tatgtcatac tgcaaccgtt atagcaaact
1201 cttttatgca ctgtgggaca accagtgacc agtttcttag agataatttg gaatggttag
1261 ccagagccac taactgggca aaatttactg ctacagccag tttgggtgta attcataagg
1321 gtcatgaaaa agaagcatta cagttaatgg caacatacct tcccaaggat acttctccag
1381 gatcagccta tcaggaaggt ggaggtctct atgcactagg tcttattcat gccaatcatg
1441 gtggtgatat aattgactat ctgcttaatc agcttaagaa cgccagcaat gatatcgtta
1501 gacacggtgg cagtctgggc cttggtttgg cagccatggg aactgcacgt caagatgttt
1561 atgatttgct aaaaacaaac ctttatcagg atgatgcagt aacaggggaa gcagctggcc
1621 tggccctagg tttggttatg ttgggctcta aaaatgctca ggctattgag gacatggttg
1681 gttatgcaca agaaactcaa catgagaaga ttctgcgtgg tcttgcagtt ggcatagctt
1741 tagtaatgta tgggaggatg gaagaggctg atgctctcat tgaatctctc tgtcgtgaca
1801 aggacccaat tcttcgaagg tctggaatgt atactgtagc catggcttat tgtggctctg
1861 gtaacaacaa agcaattcga cgcctgctac atgtggctgt aagtgatgtg aatgatgatg
1921 tcaggagtgc agcagtagaa tcacttgggt tcattctatt cagaacccct gaacagtgcc
1981 caagtgttgt ctctttgttg tcagagagtt acaaccctca tgtgcgctac ggagctgcaa
2041 tggccttggg gatatgctgt gctggtacag gaaacaagga agccattaat ttgctagaac
2101 caatgacaaa cgaccccgtg aactacgtga ggcaaggggc actcatagct tcagctctca
2161 tcatgatcca gcagactgaa atcacttgtc caaaggtgaa tcagttcaga cagctgtatt
2221 ccaaagtcat caatgataag catgatgatg tcatggccaa gtttggcgct attctggccc
2281 agggcatact ggatgcaggt ggtcataatg tcacaatctc cttgcagtcc aggactgggc
2341 atactcatat gccttctgtg gttggcgtcc ttgtatttac ccagttttgg ttctggtttc
2401 ctctttcaca cttcctgtca ttggcttata cccctacctg tgtcattggc cttaacaagg
2461 acttaaagat gccgaaagtt cagtataaat cgaactgtaa accatccaca tttgcatatc
2521 ctgcccctct ggaagtacca aaagaaaaag aaaaggaaaa ggtttctact gctgtattat
2581 ctataactgc caaggctaaa aagaaggaaa aagaaaagga aaaaaaggag gaggagaaaa
2641 tggaagtgga tgaggcagag aaaaaggagg aaaaagagaa gaaaaaagaa cctgagccaa
2701 acttccagtt attggataac ccagcccgag ttatgcctgc ccagcttaag gtcctaacca
2761 tgccggagac ctgtagatac cagcctttca aaccactctc tattggaggc atcatcattc
2821 tgaaggatac cagtgaagac attgaggagc tggtggaacc tgtggcagca catggcccaa
2881 aaatcgagga ggaggaacaa gagccagaac ccccagaacc atttgagtat attgatgatt
2941 aaggaccaga ggatctcact tgcttatctg aagaagattg tccaggctca tattgggaat
3001 gcttatgagg aaattcatgc cgagacctgc tattcaatgc atgtatcgtt gcctctgcac
3061 tgacctgaag aaccctgtct ccaagtcttt ggttgaagag aagatatatg actgttgagt
3121 gtgctctttc acagaacttg gttttcaaat aaatataaga tctccagatg gacaag
//