LOCUS D38127 4639 bp DNA linear HUM 15-SEP-2007
DEFINITION Homo sapiens IP gene for prostacyclin receptor, complete cds.
ACCESSION D38127 D38128
VERSION D38127.2
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4639)
AUTHORS Ogawa,Y.
TITLE Direct Submission
JOURNAL Submitted (03-SEP-1994) to the DDBJ/EMBL/GenBank databases.
Contact:Yoshihiro Ogawa
Kyoto University School of Medicine, Second Division, Department
of Medicine; 54 Shogoin, Kawahara-cho, Sakyo-ku, Kyoto, Kyoto 606,
Japan
REFERENCE 2
AUTHORS Ogawa,Y., Tanaka,I., Inoue,M., Yoshitake,Y., Isse,N., Nakagawa,O.,
Itoh,H., Yoshimasa,T., Narumiya,S. and Nakao,K.
TITLE Structural organization and chromosomal assignment of the human
prostacyclin receptor gene
JOURNAL Genomics 27, 142-148 (1995)
COMMENT
FEATURES Location/Qualifiers
source 1..4639
/chromosome="19"
/db_xref="H-InvDB:HIT000391591"
/db_xref="taxon:9606"
/mol_type="genomic DNA"
/organism="Homo sapiens"
repeat_region 22..29
/note="consensus sequence ( CCC(A/C)N(G/C)(G/C)(G/C) )"
regulatory 71..76
/note="acute phase reactant regulatory element"
/regulatory_class="other"
regulatory 206..211
/note="acute phase reactant regulatory element"
/regulatory_class="other"
regulatory 218..223
/note="acute phase reactant regulatory element"
/regulatory_class="other"
repeat_region 340..346
/note="human polyomavirus JC promoter element"
repeat_region 508..515
/note="consensus sequence ( CCC(A/C)N(G/C)(G/C)(G/C) )"
protein_bind 525..530
/bound_moiety="Myb"
/note="c-myb binding motif"
repeat_region 811..818
/note="consensus sequence ( CCC(A/C)N(G/C)(G/C)(G/C) )"
protein_bind 843..848
/bound_moiety="Myb"
/note="c-myb binding motif"
repeat_region 912..918
/note="consensus sequence ( TGACTCT )"
repeat_region 925..932
/note="consensus sequence ( CCC(A/C)N(G/C)(G/C)(G/C) )"
repeat_region 930..937
/note="consensus sequence ( CCC(A/C)N((G/C)(G/C)(G/C) )"
repeat_region 955..962
/note="human polyomavirus JC promoter element"
repeat_region 959..966
/note="human polyomavirus JC promoter element"
repeat_region 1023..1030
/note="human polyomavirus JC promoter element"
regulatory 1064..1068
/note="inverted CCAAT box"
/regulatory_class="other"
regulatory 1067..1072
/note="binding site ( GGGCGG )"
/regulatory_class="GC_signal"
protein_bind 1112..1119
/bound_moiety="GRE"
/note="glucocortcoid (receptor binding/response element (
AGAACAGT ))"
repeat_region 1126..1133
/note="human polyomavirus JC promoter element (
GGGNGG(A/G)(A/G) )"
regulatory 1126..1131
/note="binding site (GGGCGG)"
/regulatory_class="GC_signal"
repeat_region 1180..1187
/note="human polyomavirus JC promoter element (
GGGNGG(A/G)(A/G) )"
repeat_region 1192..1199
/note="human polyomavirus JC promoter element (
GGGNGG(A/G)(A/G) )"
exon 1220..1320
/number=1
intron 1321..2079
/number=1
exon 2080..2859
/number=2
CDS join(2092..2859,2995..3387)
/codon_start=1
/gene="IP"
/note="prostanoid receptor family"
/product="prostacyclin receptor"
/protein_id="BAA07325.1"
/translation="MADSCRNLTYVRGSVGPATSTLMFVAGVVGNGLALGILSARRPA
RPSAFAVLVTGLAATDLLGTSFLSPAVFVAYARNSSLLGLARGGPALCDAFAFAMTFF
GLASMLILFAMAVERCLALSHPYLYAQLDGPRCARLALPAIYAFCVLFCALPLLGLGQ
HQQYCPGSWCFLRMRWAQPGGAAFSLAYAGLVALLVAAIFLCNGSVTLSLCRMYRQQK
RHQGSLGPRPRTGEDEVDHLILLALMTVVMAVCSLPLTIRCFTQAVAPDSSSEMGDLL
AFRFYAFNPILDPWVFILFRKAVFQRLKLWVCCLCLGPAHGDSQTPLSQLASGRRDPR
APSAPVGKEGSCVPLSAWGEGQVEPLPPTQQSSGSAVGTSSKAEASVACSLC"
misc_structure 2140..2205
/note="putative transmembrane domain I"
misc_structure 2245..2322
/note="putative transmembrane domain II"
misc_structure 2374..2436
/note="putative transmembrane domain III"
misc_structure 2494..2565
/note="putative transmembrane domain IV"
misc_structure 2635..2715
/note="putative transmembrane domain V"
misc_structure join(2797..2859,2995..3009)
/note="putative transmembrane domain VI"
misc_structure 2797..2859
/note="portion of putative transmembrane domain VI (in
exon2)"
intron 2860..>2879
/note="5'end of intron 2"
/number=2
gap 2880..2979
/estimated_length=unknown
intron <2980..2994
/note="3'end of intron2"
/number=2
exon 2995..4193
/number=3
/product="prostacyclin receptor"
misc_structure 2995..3009
/note="portion of putative transmembrane domain VI (in
exon 3)"
misc_structure 3049..3114
/note="putative transmembrane domain VII"
regulatory 4172..4177
/regulatory_class="polyA_signal_sequence"
regulatory 4176..4181
/regulatory_class="polyA_signal_sequence"
polyA_site 4192..4193
/note="putative"
polyA_site 4205..4206
/note="putative"
misc_feature 4207..4210
/note="GT cluster ( (C/T)GTGTT(C/T)(C/T) )"
misc_feature 4212..4216
/note="GT cluster ( (C/T)GTGTT(C/T)(C/T) )"
misc_feature 4266..4269
/note="GT cluster ( (C/T)GTGTT(C/T)(C/T) )"
misc_feature 4271..4274
/note="GT cluster ( (C/T)GTGTT(C/T)(C/T) )"
misc_feature 4291..4293
/note="GT cluster ( (C/T)GTGTT(C/T)(C/T) )"
misc_feature 4305..4310
/note="GT cluster ( (C/T)GTGTT(C/T)(C/T) )"
misc_feature 4318..4323
/note="GT cluster ( (C/T)GTGTT(C/T)(C/T) )"
misc_feature 4332..4334
/note="GT cluster ( (C/T)GTGTT(C/T)(C/T) )"
misc_feature 4344..4348
/note="GT cluster ( (C/T)GTGTT(C/T)(C/T) )"
misc_feature 4377..4380
/note="GT cluster ( (C/T)GTGTT(C/T)(C/T) )"
misc_feature 4408..4411
/note="GT cluster ( (C/T)GTGTT(C/T)(C/T) )"
misc_feature 4413..4421
/note="GC cluster ( (C/T)GTGTT(C/T)(C/T) )"
misc_feature 4428..4430
/note="GT cluster ( (C/T)GTGTT(C/T)(C/T) )"
misc_feature 4475..4479
/note="GT cluster ( (C/T)GTGTT(C/T)(C/T) )"
misc_feature 4481..4485
/note="GT cluster ( (C/T)GTGTT(C/T)(C/T) )"
misc_feature 4507..4509
/note="GT cluster ( (C/T)GTGTT(C/T)(C/T) )"
misc_feature 4514..4519
/note="GT cluster ( (C/T)GTGTT(C/T)(C/T) )"
misc_feature 4532..4534
/note="GC cluster ( (C/T)GTGTT(C/T)(C/T) )"
repeat_region 4537..4542
/note="CAAAA motif"
repeat_region 4543..4547
/note="CAAAA motif"
repeat_region 4550..4557
/note="CAAAA motif"
misc_feature 4585..4587
/note="GT cluster ( (C/T)GTGTT(C/T)(C/T) )"
misc_feature 4592..4594
/note="GT cluster ( (C/T)GTGTT(C/T)(C/T) )"
misc_feature 4597..4603
/note="GT cluster ( (C/T)GTGTT(C/T)(C/T) )"
misc_feature 4633..4636
/note="GT cluster ( (C/T)GTGTT(C/T)(C/T) )"
BASE COUNT 964 a 1273 c 1468 g 834 t
ORIGIN
1 gggcccctga gtcccgtgtt accccacgca cagagaagga ggctgaagtc taccagctcc
61 ctctcctcac ctgggaccat ctcgcagcaa gaaaaaaggt ggtcagatgg aaacaggaag
121 ccaagtcgaa tggatctgag accgtccccc tgagaaacag cggggctcag agagggtctc
181 tgaggtttta tctggccctt ttgggctggg aggctgcctg ggaagccacc gactccgtgg
241 gaagggagac ccgtgaacgc tgtgcgggta gtgggaacat gtgggtctgt cacactggcc
301 cgaggctgca gcggtggtgg cttggctgtg tttggggagg gtgggggaca catggcagca
361 atgttggagc tgtggacagc ttcctgtgat caaaatatga ttcctgaagg tcaaggtcac
421 cagagcttgg cctggggcct aggggtgctg tgcgagaagt cggacggtgg cccagtgcta
481 cctttccatc atgggccatg gaagtctccc aagcctgtcc ctgacaactg gacaccaaat
541 acaccccttc atgctttctt ctcgggtctc tgcagggtga gctgggtgcc cagggacagg
601 ctcgagggac tggcatgtct ctctctggcc aagcctcctt cctcagcttt ctggaaggag
661 tgaattgtgt ccagggacca gaactctcag tggtgtctgg aaaacactac atcagagagg
721 aatttcctgg tcatttctca atccctgggc aatgtcctca gccccggggc ctggagccca
781 gaatagatcc cagaggccac cctgagacag cccaggccaa gaccacccca ctgaagcctg
841 gtcaactgtg ctcttcaggt ccctcctaga ggccccctac taccccggga ggctccaagc
901 ctaagtgatg gtgactcagg aattccccac ccaggccaga gagggagaca ctgggggagg
961 gaggagacct gtgtgtgggg aggtggcagg tggctcagtg atgggaacca agagaggatg
1021 tggggaggag agtggaggca gcgatgggag atggatgtcc tggattgggc gggtggacgg
1081 ggagtgggga gtgtgccagg gggccctctg gagaacagtg agggagggcg gggcagagag
1141 aggaaatgaa aaagctgggg tgagcaggca agctgaggag ggtgggaagg agggagggac
1201 ggagggagga gggaaggaga agctgacaca cagaccgaca caggcagcga gagacacgag
1261 gagcaaagca agtgaaggca cagacgcacg ggacaggaga gcctgggcaa gactggagag
1321 gtgcggtgag gggctgggga tgcagcaaca cagagcagga gcaggtagag ggtgtggggt
1381 tagagggaga aaggtacggg gaggacaagg acaagggagg ggacagagac agggagatat
1441 cagcaagaga ccgagagaca gggagggaaa gaactggcaa tgcccggatg ttctctgtct
1501 ctttaatggc agaaacagag ctagagaagg aaagaaacag gaggtggtgg gggggtggtg
1561 ggtgtcaggc atggtggctc acacctgtaa tctcagcact ttgggaagcc aaggtggatg
1621 gatcacctga ggtcaggagt tcgagaccag cctgaccaac atggtggaac cccgtctcta
1681 ctgaaaatac aaaaattagc tgggcgtggt agtggacgcc tgtaatctca tctactccag
1741 aggctggggc aggagaatcg cttgaaccca ggaggtggag gttgcagtga gccgagatca
1801 tgccattgct ctccatcctg gacaacagag tgagactctg tctcaaaaga aacgaaagaa
1861 aagaaagaga gaaagagaaa caggaaggtg gggagagaca gagagagata ctggagaagc
1921 cagaggggag aggactgcat acctgcacac acaggagaac tgggggttgg ctgggaggcc
1981 ccagctgcca aaaggactgg ccagcaggga catctgagtg ggctgggtgg tgggggtagc
2041 cctggctccc tctgaccccc caccttggga accctccagc ccagacctgg gatggcggat
2101 tcgtgcagga acctcaccta cgtgcggggc tcggtggggc cggccaccag caccctgatg
2161 ttcgtggccg gtgtggtggg caacgggctg gccctgggca tcctgagcgc acggcgaccg
2221 gcgcgcccct cggccttcgc ggtgctggtc accggactgg cggccaccga cctgctgggc
2281 accagcttcc tgagcccggc cgtgttcgtg gcctatgcgc gcaacagctc cctgctgggc
2341 ctggcccgag gcggccccgc cctgtgcgat gccttcgcct tcgccatgac cttcttcggc
2401 ctggcgtcca tgctcatcct ctttgccatg gccgtggagc gctgcctggc gctgagccac
2461 ccctacctct acgcgcagct ggacgggccc cgctgcgccc gcctggcgct gccagccatc
2521 tacgccttct gcgtcctctt ctgcgcgctg cccctgctgg gcctgggcca acaccagcag
2581 tactgccccg gcagctggtg cttcctccgc atgcgctggg cccagccggg cggcgccgcc
2641 ttctcgctgg cctacgccgg cctggtggcc ctgctggtgg ctgccatctt cctctgcaac
2701 ggctcggtca ccctcagcct ctgccgcatg taccgccagc agaagcgcca ccagggctct
2761 ctgggtccac ggccgcgcac cggagaggac gaggtggacc acctgatcct gctggccctc
2821 atgacagtgg tcatggccgt gtgctccctg cctctcacgg tgagtcccct ccggagctgn
2881 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
2941 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnt caccctgccc tcagatccgc
3001 tgcttcaccc aggctgtcgc ccctgacagc agcagtgaga tgggggacct ccttgccttc
3061 cgcttctacg ccttcaaccc catcctggac ccctgggtct tcatcctttt ccgcaaggct
3121 gtcttccagc gactcaagct ctgggtctgc tgcctgtgcc tcgggcctgc ccacggagac
3181 tcgcagacac ccctttccca gctcgcctcc gggaggaggg acccaagggc cccctctgct
3241 cctgtgggaa aggaggggag ctgcgtgcct ttgtcggctt ggggcgaggg gcaggtggag
3301 cccttgcctc ccacacagca gtccagcggc agcgccgtgg gaacgtcgtc caaagcagaa
3361 gccagcgtcg cctgctccct ctgctgacat ttcaagctga ccctgtgatc tctgccctgt
3421 cttcgggcga caggagccag aaaatcaggg acatggctga tggctgcgga tgctggaacc
3481 ttggccccca aactctgggg ccgatcagct gctgtttctc ctgcggcagg gcagtcgctg
3541 ctggctctgg gaagagagtg agggacagag gaaacgttta tcctggagtg cagaaagaat
3601 ggttctctca aaataaccag tggcctggcc gacctgctct ggccctggat tccccatcca
3661 tctcattgtc taaatattta gaaggcggag aagttcccag aggcttctgt acagtcaggt
3721 ctgctctggt ctgggtgctg gctccaatct gcgtccactt aggaggccca actgcccacc
3781 ccaagtcccc aggggatggc cctccccctc taccaagcca ctccaagagc cagccccctt
3841 tctgctccac aaaaaccaca gttattggaa aagctccctg ccttcccttg ccgctggtcc
3901 cccaccaggc ttgggagccc tggcatccca aaggggcaac gggaggaagg ggaggctgct
3961 gcattgtggg tgatgacgta ggacatgtgc ttggtacaaa aagggcctga gacattccac
4021 ctagcttgac tggctgcaag atgagaactg gggggggtgc aggtggtggg gagacagatg
4081 gagaagctgg cagatgaagg gtgggggctg cggatcccag ggactgcccc agaacacaaa
4141 cccaagtcct gtgcctgtcc ccagggtcct gaataaataa aagcctcctt gcagagcctg
4201 acctcatgtt atgtgtcctt agagccctca ccaagatttc attcattcat tcattcaaca
4261 gatacttggc tgggcaccat agcacatgcc tgtaatccca gcactttggg aggttcaggt
4321 gggaggatcc cttgagccca ggagtttgag accagctcgg gcaatatatc gagaacttgt
4381 ctctacaaaa aaattttaaa aattagctgg gcgtggtggt gcacacctgt agtcccagct
4441 cctaggaagg ctgagacaag aggatcacct gaacgtggga ggttgaggct gcagtgagct
4501 gagatcgtgc cactgggtga cggcgtgaca ctgtctcaaa aacaaaaccc aaaaaaaccc
4561 tcaaccttcc actgaaattc agcagtgctg attgcctggt gttaaggaca cagacaagcc
4621 cctgctccac cctgggccc
//