LOCUS D30783 4627 bp mRNA linear HUM 06-SEP-1997
DEFINITION Homo sapiens mRNA for epiregulin, complete cds.
ACCESSION D30783
VERSION D30783.1
KEYWORDS growth regulator.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4627)
AUTHORS Toyoda,H.
TITLE Direct Submission
JOURNAL Submitted (24-MAY-1994) to the DDBJ/EMBL/GenBank databases.
Contact:Hitoshi Toyoda
Research Center, Taisho Pharmaceutical Co., Ltd.; No.403
Yoshino-cho, 1-chome, Ohmiya, Saitama 330, Japan
REFERENCE 2
AUTHORS Toyoda,H., Komurasaki,T., Uchida,D. and Morimoto,S.
TITLE Distribution of mRNA for human epiregulin, a differentially
expressed member of the epidermal growth factor family
JOURNAL Biochem. J. 326, 69-75 (1997)
COMMENT
FEATURES Location/Qualifiers
source 1..4627
/cell_line="HCT-15"
/cell_type="epithelial"
/db_xref="H-InvDB:HIT000101339"
/db_xref="taxon:9606"
/mol_type="mRNA"
/organism="Homo sapiens"
/tissue_type="colorectal adenocarcinoma"
CDS 167..676
/codon_start=1
/note="EGF-related peptide"
/product="epiregulin"
/protein_id="BAA22146.1"
/translation="MTAGRRMEMLCAGRVPALLLCLGFHLLQAVLSTTVIPSCIPGES
SDNCTALVQTEDNPRVAQVSITKCSSDMNGYCLHGQCIYLVDMSQNYCRCEVGYTGVR
CEHFFLTVHQPLSKEYVALTVILIILFLITVVGSTYYFCRWYRNRKSKEPKKEYERVT
SGDPELPQV"
mat_peptide 353..490
/product="epiregulin"
misc_feature 521..574
/note="transmembrane domain"
regulatory 4580..4585
/note="early mRNA polyadenylation signal"
/regulatory_class="polyA_signal_sequence"
regulatory 4584..4589
/note="early mRNA polyadenylation signal"
/regulatory_class="polyA_signal_sequence"
BASE COUNT 1426 a 836 c 836 g 1529 t
ORIGIN
1 tcacttgcct gatatttcca gtgtcagagg gacacagcca acgtggggtc ccttctaggc
61 tgacagccgc tctccagcca ctgccgcgag cccgtctgct cccgccctgc ccgtgcactc
121 tccgcagccg ccctccgcca agccccagcg cccgctccca tcgccgatga ccgcggggag
181 gaggatggag atgctctgtg ccggcagggt ccctgcgctg ctgctctgcc tgggtttcca
241 tcttctacag gcagtcctca gtacaactgt gattccatca tgtatcccag gagagtccag
301 tgataactgc acagctttag ttcagacaga agacaatcca cgtgtggctc aagtgtcaat
361 aacaaagtgt agctctgaca tgaatggcta ttgtttgcat ggacagtgca tctatctggt
421 ggacatgagt caaaactact gcaggtgtga agtgggttat actggtgtcc gatgtgaaca
481 cttcttttta accgtccacc aacctttaag caaagagtat gtggctttga ccgtgattct
541 tattattttg tttcttatca cagtcgtcgg ttccacatat tatttctgca gatggtacag
601 aaatcgaaaa agtaaagaac caaagaagga atatgagaga gttacctcag gggatccaga
661 gttgccgcaa gtctgaatgg cgccatcaaa cttatgggca gggataacag tgtgcctggt
721 taatattaat attccatttt attaataata tttatgttgg gtcaagtgtt aggtcaataa
781 cactgtattt taatgtactt gaaaaatgtt tttatttttg ttttattttt gacagactat
841 ttgctaatgt ataatgtgca gaaaatattt aatatcaaaa gaaaattgat atttttatac
901 aagtaatttc ctgagctaaa tgcttcattg aaagcttcaa agtttatatg cctggtgcac
961 agtgcttaga agtaagcaat tcccaggtca tagctcaaga attgttagca aatgacagat
1021 ttctgtaagc ctatatatat agtcaaatcg atttagtaag tatgtttttt atgttcctca
1081 aatcagtgat aattggtttg actgtaccat ggtttgatat gtagttggca ccatggtatc
1141 atatattaaa acaataatgc aattagaatt tgggagaagc aaatataggt cctgtgttaa
1201 acactacaca tttgaaacaa gctaaccctg gggagtctat ggtctcttca ctcaggtctc
1261 agctataatt ctgttatatg aggggcagtg gacagttccc tatgccaact cacgactcct
1321 acaggtacta gtcactcatc taccagattc tgcctatgta aaatgaattg aaaaacaatt
1381 ttctgtaatc ttttatttaa gtagtgggca tttcatagct tcacaatgtt ccttttttgt
1441 atattacaac atttatgtga ggtaattatt gctcaacaga caattagaaa aaagtccaca
1501 cttgaagcct aaatttgtgc tttttaagaa tatttttaga ctatttcttt ttataggggc
1561 tttgctgaat tctaacatta aatcacagcc caaaatttga tggactaatt attattttaa
1621 aatatatgaa gacaataatt ctacatgttg tcttaagatg gaaatacagt tatttcatct
1681 tttattcaag gaagttttaa ctttaataca gctcagtaaa tggcttcttc tagaatgtaa
1741 agttatgtat ttaaagttgt atcttgacac aggaaatggg aaaaaactta aaaattaata
1801 tggtgtattt ttccaaatga aaaatctcaa ttgaaagctt ttaaaatgta gaaacttaaa
1861 cacaccttcc tgtggaggct gagatgaaaa ctagggctca ttttcctgac atttgtttat
1921 tttttggaag agacaaagat ttcttctgca ctctgagccc ataggtctca gagagttaat
1981 aggagtattt ttgggctatt gcataaggag ccactgctgc caccactttt ggattttatg
2041 ggaggctcct tcatcgaatg ctaaaccttt gagtagagtc tccctggatc acataccagg
2101 tcagggagga tctgttcttc ctctacgttt atcctggcat gtgctagggt aaacgaaggc
2161 ataataagcc atggctgacc tctggagcac caggtgccag gacttgtctc catgtgtatc
2221 catgcattat ataccctggt gcaatcacac gactgtcatc taaagtcctg gccctggccc
2281 ttactattag gaaaataaac agacaaaaac aagtaaatat atatggtcct atacatattg
2341 tatatatatt catatacaaa catgtatgta tacatgacct taatggatca tagaattgca
2401 gtcatttggt gctctgctaa ccatttatat aaaacttaaa aacaagagaa aagaaaaatc
2461 aattagatct aaacagttat ttctgtttcc tatttaatat agctgaagtc aaaatatgta
2521 agaacacatt ttaaatactc tacttacagt tggccctctg tggttagttc cacatctgtg
2581 gattcaacca accaaggacg gaaaatgctt aaaaaataat acaacaacaa caaaaaatac
2641 attataacaa ctatttactt tttttttttt ctttttgaga tggagtctcg ctctgttgcc
2701 caggttggag tgcagtggca cgatctcggc tcactgcaac ctcacctccc gggttcaaga
2761 gatcctcctg cctcagcctc ctgagcagct gggactacag gcgcatgcca ccatgcccag
2821 ctaatttttg tatttttagt agaggcgggg tttcaccatg ttggccagga tggtctcaat
2881 ctcctaacct tgagatccac cctccacagc ctcccaaact gctgggatta caggcgtgag
2941 ccaccgcacg tagcatttac attaggtatt acaagtaatg taaagatgat ttaagtatac
3001 aggaggatgt gaataggtta tatgcaagca ctatgccctt ttatataagt gacttgaaca
3061 tctgtgcccg attttagtat gtgcaggggg gcgatctggg aatcagtccc ctgtggatac
3121 caaggtacaa ctgtatttat taacgcttac tagatgtgag gagagtctga atattttcag
3181 tgatcttggc tgtttcaaaa aaatctattg acttttcaat aaatcagctg caatccattt
3241 atttcattta caaaagattt attgtaagcc tctcaatctt ggtttttcag ttgatcttaa
3301 gcatgtcaat tcataaaaac aagtcatttt tgtatttttc atctttaaga atgcttaaaa
3361 aagctaatcc ctaaaatagt tagatctttg taaatgcata ttaaataata aagtatgacc
3421 cacattactt tttatgggtg aaaataagac aaaaataata gttttagtga ggatggtgct
3481 gagtaaacat aaaaactgat ttgctctcag ctgatgtgtc ctgtacacag tgggaagatt
3541 ttagttcaca cttagtctaa ctcccccatt ttacagattt ctcactatat atatttctag
3601 aaggggctat gcatattcaa tgtattgaga accaaagcaa ccacaaatgc ataaatgcat
3661 aatttatggt cttcaaccaa ggccacataa taacccagtt aacttactct ttaaccagga
3721 atattaagtt ctataactag tactcaaggt ttaaccttaa aattaagatt tccttaacct
3781 taaccttaaa attgatatta tattaaacat acataataca atgtaactcc actgttctcc
3841 tgaatatttt ttgctctaat ctctctgccg aaagtcaaag tgatgggaga attggtatac
3901 tggtatgact acgtcttaag tcagattttt atttatgagt ctttgagact aaattcaatc
3961 accaccaggt atcaaatcaa cttttatgca gcaaatatat gattctagtg tctgactttt
4021 gttaaattca gtaatgcagt ttttaaaaac ctgtatctga cccactttgt aatttttgct
4081 ccaatatcca ttctgtagac ttttgaaaaa aaagttttta atttgatgcc caatatattc
4141 tgaccgttaa aaaattcttg ttcatatggg agaaggggga gtaatgactt gtacaaacag
4201 tatttctggt gtatatttta atgtttttaa aaagagtaat ttcatttaaa tatctgttat
4261 tcaaatttga tgatgttaaa tgtaatataa tgtattttct ttttattttg cactctgtaa
4321 ttgcactttt taagtttgaa gagccatttt ggtaaacggt ttttattaaa gatgctatgg
4381 aacataaagt tgtattgcat gcaatttaaa gtaacttatt tgactatgaa tattatcgga
4441 ttactgaatt gtatcaattt gtttgtgttc aatatcagct ttgataattg tgtaccttaa
4501 gatattgaag gagaaaatag ataatttaca agatattatt aatttttatt tatttttctt
4561 gggaattgaa aaaaattgaa ataaataaaa atgcattgaa catcttgcat tcaaaatctt
4621 cactgac
//