LOCUS HUMPTGS2 10997 bp DNA linear HUM 26-SEP-2008
DEFINITION Homo sapiens PTGS2 gene for prostaglandin endoperoxide synthase-2,
complete cds.
ACCESSION D28235
VERSION D28235.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 10997)
AUTHORS Tanabe,T.
TITLE Direct Submission
JOURNAL Submitted (19-FEB-1994) to the DDBJ/EMBL/GenBank databases.
Contact:Tadashi Tanabe
National Cardiovascular Center Research Institute, Pharmacology;
5-7-1 Fujishiro-dai, Suita, Osaka 565, Japan
REFERENCE 2
AUTHORS Hla,T. and Neilson,K.
TITLE Human cyclooxygenase-2 cDNA
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 89, 7384-7388 (1992)
REFERENCE 3
AUTHORS Kosaka,T., Miyata,A., Ihara,H., Hara,S., Sugimoto,T., Takeda,O.,
Takahashi,E. and Tanabe,T.
TITLE Characterization of the human gene (PTGS2) encoding
prostaglandin-endoperoxide synthase 2
JOURNAL Eur. J. Biochem. 221, 889-897 (1994)
COMMENT
FEATURES Location/Qualifiers
source 1..10997
/chromosome="1"
/clone_lib="EMBL3"
/db_xref="taxon:9606"
/map="1q25.2-q25.3"
/mol_type="genomic DNA"
/organism="Homo sapiens"
/tissue_type="Japanese peripheral blood"
regulatory 81..90
/note="CArG box"
/regulatory_class="other"
protein_bind 93..101
/bound_moiety="NF-IL6"
protein_bind 144..150
/bound_moiety="PEA-1"
protein_bind 328..333
/bound_moiety="myb"
regulatory 460..465
/note="GATA-1"
/regulatory_class="other"
protein_bind 584..589
/bound_moiety="myb"
regulatory 734..739
/note="XRE (xenobiotic-response element)"
/regulatory_class="other"
protein_bind 883..888
/bound_moiety="myb"
protein_bind 982..990
/bound_moiety="NF-IL6"
regulatory 1005..1010
/note="GATA-1"
/regulatory_class="other"
regulatory 1121..1127
/note="CRE (cAMP-response element)"
/regulatory_class="other"
protein_bind 1243..1252
/bound_moiety="NF-kappaB"
protein_bind 1291..1296
/bound_moiety="PEA-3"
protein_bind 1421..1426
/bound_moiety="Sp-1"
protein_bind 1468..1477
/bound_moiety="NF-kappaB"
protein_bind 1559..1567
/bound_moiety="NF-IL6"
regulatory 1632..1638
/note="CRE"
/regulatory_class="other"
regulatory 1660..1666
/regulatory_class="TATA_box"
exon 1691..1876
/number=1
CDS join(1825..1876,2677..2793,2914..3057,3711..3854,
4570..4751,5484..5567,5687..5933,6215..6501,7003..7150,
7637..8046)
/codon_start=1
/EC_number="1.14.99.1"
/gene="PTGS2"
/product="prostaglandin endoperoxide synthase-2"
/protein_id="BAA05698.1"
/translation="MLARALLLCAVLALSHTANPCCSHPCQNRGVCMSVGFDQYKCDC
TRTGFYGENCSTPEFLTRIKLFLKPTPNTVHYILTHFKGFWNVVNNIPFLRNAIMSYV
LTSRSHLIDSPPTYNADYGYKSWEAFSNLSYYTRALPPVPDDCPTPLGVKGKKQLPDS
NEIVEKLLLRRKFIPDPQGSNMMFAFFAQHFTHQFFKTDHKRGPAFTNGLGHGVDLNH
IYGETLARQRKLRLFKDGKMKYQIIDGEMYPPTVKDTQAEMIYPPQVPEHLRFAVGQE
VFGLVPGLMMYATIWLREHNRVCDVLKQEHPEWGDEQLFQTSRLILIGETIKIVIEDY
VQHLSGYHFKLKFDPELLFNKQFQYQNRIAAEFNTLYHWHPLLPDTFQIHDQKYNYQQ
FIYNNSILLEHGITQFVESFTRQIAGRVAGGRNVPPAVQKVSQASIDQSRQMKYQSFN
EYRKRFMLKPYESFEELTGEKEMSAELEALYGDIDAVELYPALLVEKPRPDAIFGETM
VEVGAPFSLKGLMGNVICSPAYWKPSTFGGEVGFQIINTASIQSLICNNVKGCPFTSF
SVPDPELIKTVTINASSSRSGLDDINPTVLLKERSTEL"
sig_peptide 1825..1875
mat_peptide join(1876,2677..2793,2914..3057,3711..3854,4570..4751,
5484..5567,5687..5933,6215..6501,7003..7150,7637..8043)
/product="prostaglandin endoperoxide synthase-2"
intron 1877..2676
/number=1
protein_bind 2596..2602
/bound_moiety="AP-1"
exon 2677..2793
/number=2
intron 2794..2913
/number=2
exon 2914..3057
/number=3
intron 3058..3710
/number=3
exon 3711..3854
/number=4
intron 3855..4569
/number=4
exon 4570..4751
/number=5
misc_difference 4651
/citation=[2]
/replace="g"
intron 4752..5483
/number=5
exon 5484..5567
/number=6
intron 5568..5686
/number=6
exon 5687..5933
/number=7
misc_difference 5840
/citation=[2]
/replace="a"
intron 5934..6214
/number=7
exon 6215..6501
/number=8
intron 6502..7002
/number=8
exon 7003..7150
/number=9
intron 7151..7636
/number=9
exon 7637..>9979
/number=10
regulatory 8062..8066
/note="Shaw-Kamen's sequence (ATTTA)"
/regulatory_class="other"
regulatory 8066..8070
/note="Shaw-Kamen's sequence"
/regulatory_class="other"
regulatory 8070..8074
/note="Shaw-Kamen's sequence"
/regulatory_class="other"
regulatory 8093..8097
/note="Shaw-Kamen's sequence"
/regulatory_class="other"
regulatory 8101..8105
/note="Shaw-Kamen's sequence"
/regulatory_class="other"
regulatory 8111..8115
/note="Shaw-Kamen's sequence"
/regulatory_class="other"
regulatory 8524..8528
/note="Shaw-Kamen's sequence"
/regulatory_class="other"
regulatory 8688..8692
/note="Shaw-Kamen's sequence"
/regulatory_class="other"
regulatory 8825..8829
/note="Shaw-Kamen's sequence"
/regulatory_class="other"
regulatory 8993..8997
/note="Shaw-Kamen's sequence"
/regulatory_class="other"
regulatory 9138..9142
/note="Shaw-Kamen's sequence"
/regulatory_class="other"
regulatory 9468..9472
/note="Shaw-Kamen's sequence"
/regulatory_class="other"
regulatory 9559..9563
/note="Shaw-Kamen's sequence"
/regulatory_class="other"
regulatory 9684..9688
/note="Shaw-Kamen's sequence"
/regulatory_class="other"
regulatory 9776..9780
/note="Shaw-Kamen's sequence"
/regulatory_class="other"
regulatory 9801..9805
/note="Shaw-Kamen's sequence"
/regulatory_class="other"
regulatory 9818..9822
/note="Shaw-Kamen's sequence"
/regulatory_class="other"
regulatory 9974..9979
/regulatory_class="polyA_signal_sequence"
regulatory 10010..10014
/note="Shaw-Kamen's sequence"
/regulatory_class="other"
regulatory 10156..10160
/note="Shaw-Kamen's sequence"
/regulatory_class="other"
regulatory 10234..10238
/note="Shaw-Kamen's sequence"
/regulatory_class="other"
regulatory 10286..10291
/regulatory_class="polyA_signal_sequence"
regulatory 10504..10508
/note="Shaw-Kamen's sequence"
/regulatory_class="other"
regulatory 10533..10538
/regulatory_class="polyA_signal_sequence"
regulatory 10559..10563
/note="Shaw-Kamen's sequence"
/regulatory_class="other"
regulatory 10752..10756
/note="Shaw-Kamen's sequence"
/regulatory_class="other"
BASE COUNT 3448 a 2000 c 2005 g 3544 t
ORIGIN
1 attattaaat tatcaaaaag aaaatgatcc acgctcttag ttgaaatttc atgtaagatt
61 ccatgcaata aataggagtg ccataaatgg aatgatgaaa tatgactaga ggaggagaaa
121 ggcttcctag atgagatgga attttagtca tccgtgtctc atgaagaatc agatgtgtac
181 actaagcaaa acagttaaaa aaaaaacctc caagtgagtc tcttatttat ttttttctta
241 taagacttct acaaattgag gtacctggtg tagttttatt tcaggtttta tgctgtcatt
301 ttcctgtaat gctaaggact taggacataa ctgaattttc tattttccac ttcttttctg
361 gtgtgtgtgt atatatatat gtatatatac acacacacat atacatatat atatttttta
421 gtatctcacc ctcacatgct cctccctgag cactacccat gatagatgtt aaacaaaagc
481 aaagatgaaa ttccagctgt caaaatctcc cttccatcta attaattcct catccaacta
541 tgttccaaaa cgagaataga aaattagccc caataagccc aggcaactga aaagtaaatg
601 ctatgttgta ctttgatcca tggtcacaac tcataatctt ggaaaagtgg acagaaaaga
661 caaaagagtg aactttaaaa ctcgaattta ttttaccagt atctcctatg aagggctagt
721 aaccaaaata atccacgcat cagggagaga aatgccttaa ggcatacgtt ttggacattt
781 agcgtccctg caaattctgg ccatcgccgc ttcctttgtc catcagaagg caggaaactt
841 tatattggtg acccgtggag ctcacattaa ctatttacag ggtaactgct taggaccagt
901 attatgagga gaatttacct ttcccgcctc tctttccaag aaacaaggag ggggtgaagg
961 tacggagaac agtatttctt ctgttgaaag caacttagct acaaagataa attacagcta
1021 tgtacactga aggtagctat ttcattccac aaaataagag ttttttaaaa agctatgtat
1081 gtatgtgctg catatagagc agatatacag cctattaagc gtcgtcacta aaacataaaa
1141 catgtcagcc tttcttaacc ttactcgccc cagtctgtcc cgacgtgact tcctcgaccc
1201 tctaaagacg tacagaccag acacggcggc ggcggcggga gaggggattc cctgcgcccc
1261 cggacctcag ggccgctcag attcctggag aggaagccaa gtgtccttct gccctccccc
1321 ggtatcccat ccaaggcgat cagtccagaa ctggctctcg gaagcgctcg ggcaaagact
1381 gcgaagaaga aaagacatct ggcggaaacc tgtgcgcctg gggcggtgga actcggggag
1441 gagagggagg gatcagacag gagagtgggg actaccccct ctgctcccaa attggggcag
1501 cttcctgggt ttccgatttt ctcatttccg tgggtaaaaa accctgcccc caccgggctt
1561 acgcaatttt tttaagggga gaggagggaa aaatttgtgg ggggtacgaa aaggcggaaa
1621 gaaacagtca tttcgtcaca tgggcttggt tttcagtctt ataaaaagga aggttctctc
1681 ggttagcgac caattgtcat acgacttgca gtgagcgtca ggagcacgtc caggaactcc
1741 tcagcagcgc ctccttcagc tccacagcca gacgccctca gacagcaaag cctacccccg
1801 cgccgcgccc tgcccgccgc tgcgatgctc gcccgcgccc tgctgctgtg cgcggtcctg
1861 gcgctcagcc atacaggtga gtacctggcg ccgcgcaccg gggactccgg ttccacgcac
1921 ccgggcagag tttccgctct gacctcctgg gtctatccca gtactccgac ttctctccga
1981 atagagaagc tacgtgactt gggaaagagc ttggaccgct agagtccgaa agaactccgt
2041 ggatattcca gctttcccac aagcactgat cattatgagc cagttactta accgatctga
2101 gacactctca cctcctaaat agggatagat gatactaatt tgcaggttgt cattatgata
2161 agacaggatc tgatcaatat atgtgaattg tttatatttg gaaccttttt attgagtgga
2221 agaagttgtt ttaaatattc tagtcagttc tttcctgctc ccaggaaagc ccggattatg
2281 ttttaagata agcaaaatgt cttaaaagta agctgtttta ctttgaattt ttccctaaat
2341 gttgattagt gtactagatc cattttaatt tggaaagtga agtgctactt atttgaactt
2401 cttaaaaatg ctaattttaa catctaaaga gttaactaag aaaagcttag taacatgatg
2461 taccaagttg aatatgctgt tatccttatt tagaatagaa aattggtatt tctacgtttt
2521 atccattcta aggcaggtta aaaaattgta tttccatgac tacctatata tttcttgaat
2581 ttattattgt aaagttgatt catagtcaaa caattaaatg tttaaattaa gattaagaca
2641 ctagagaatg atttatttgc tgtcctttaa ttgcagcaaa tccttgctgt tcccacccat
2701 gtcaaaaccg aggtgtatgt atgagtgtgg gatttgacca gtataagtgc gattgtaccc
2761 ggacaggatt ctatggagaa aactgctcaa cacgtaagtt tgtcctttgg ttgcctcatt
2821 aggagtgggg ctggatacag ttatcattgt atagatttgt gtcttataat gagtcccatt
2881 aatttctccc tccctttctt cgtcttcttg cagcggaatt tttgacaaga ataaaattat
2941 ttctgaaacc cactccaaac acagtgcact acatacttac ccacttcaag ggattttgga
3001 acgttgtgaa taacattccc ttccttcgaa atgcaattat gagttatgtg ttgacatgta
3061 agtacaagtg tctttctaag gtttttagcc ttctcaaaga aaaatatgct ttataatact
3121 gtaagcctaa tctaaaaaca tatttccaag cttatcaaaa agactttaag atagctttta
3181 agtttgcctt ccatcttaat cgccaaaaat attgacattt agtcccatcc agtttataca
3241 gtctgctcac aactctgtat acctcttcta acctttactg tttggtcagt ttgtggaggt
3301 agcatggtcc agctgtttat tgaatgccca tgggccacag aattgttctg aacatgtagc
3361 acccattaaa ataaatttgg atttggatca gcaagaaaat aactttccat gattctaaag
3421 tgggtgccat actcagccat tcctttcata ggcctcttgg atagtgagca gatggctacc
3481 tgaaaaatca atattgccag attataatgt gcagagtata tgtattttat taaagatgta
3541 tttcaagtgg ccattagact ataaagtgta gttgtttaaa aatagatttt ttttattttg
3601 gagttacatt caacctcagg tgccactttc cacattttac aataaaaata atggttgatt
3661 tacttaacaa atgagaataa ataaaacatt tttttctttg aaaatttcag ccagatcaca
3721 tttgattgac agtccaccaa cttacaatgc tgactatggc tacaaaagct gggaagcctt
3781 ctctaacctc tcctattata ctagagccct tcctcctgtg cctgatgatt gcccgactcc
3841 cttgggtgtc aaaggtgagt aagaagaatc cattagagat gtattaacta taagacgggc
3901 tgcattgctg ccaaaaaaaa aaattgacct tagactacca tttatttatt aacaaaagca
3961 gtttttactt ttagcatggt tatctatggg tattttttaa agtatgagtc tatataaact
4021 attatgtaaa agcaaatgag cgtcttggta taatgtctta atattttcaa attatttctt
4081 tagaaatgaa ataattctaa ttaaaataga taaaatcatt cagtaagaag ttgttccacc
4141 atatcttaga actgttgttt atattatgat cctattcaca attgtaattc tcatataaat
4201 gaagaattca tgtcctttcc agggaaatgg ttgaagctgg aaaccatcat tttcagcaaa
4261 ctaacacagg aacagaaaac caaacgctgc atattctcac tcataagtgg gagttgaaca
4321 atgagaccac acggacacag ggaggggaac atcatacact ggggcttgtc gaagggtggg
4381 gggctagggg agggatagca ttaagagaaa tacctaacgt agatgacaag ttgatgggtg
4441 cagcaaacca ccatggcgca tgtatacggt atcgataagc ttgatatcga attcttggta
4501 gattgacagt caccatctcc tttcttgaat acatagatgg attcttacct tagctttctc
4561 atttttcagg taaaaagcag cttcctgatt caaatgagat tgtggaaaaa ttgcttctaa
4621 gaagaaagtt catccctgat ccccagggct caaacatgat gtttgcattc tttgcccagc
4681 acttcacgca tcagtttttc aagacagatc ataagcgagg gccagctttc accaacgggc
4741 tgggccatgg ggtaagatag agttaatatc ttagagttag taaaattata ccaaatcata
4801 gtcaagggct aacattaaag gagatataca gatagataga tccaaataac ttatccactt
4861 tttttaaaaa gaagtcttat ctataaaaac cttaaaggaa ttttccattt acttcactgg
4921 tctagtaaaa ttatacacac acacagacat gcacacacat atataaacat tcacacacat
4981 acatatgtac aggtattgtt atttgtaatt tgacccttgt attttttagt ttaaaatgtt
5041 agtactgcaa aatgttatgt cctcaaaaac acattgtacc atgattatgc cgctttcaat
5101 attgtaaagt gaggtttttg ccgcattatt attttttgga tttcaatagc atagcttcaa
5161 gttattcgta agaatttttt ataaataata catttttata cttttttata attaccatat
5221 catcatagtg aagtatataa tatatatgat ataagctcaa tatagtatat taattccgtt
5281 aaacacaaag acatatcagt ttgtagcttt ggtggataaa caaattaatt tagcaattca
5341 tggctatgaa aaatgtatat tttatttaaa aattttaaag aaagctaaat gatcaaatta
5401 tttaatgatg aattatatga tagacacttt atataagaaa aacttcaaca gcaacaaatt
5461 aaaatttttt catcattttc taggtggact taaatcatat ttacggtgaa actctggcta
5521 gacagcgtaa actgcgcctt ttcaaggatg gaaaaatgaa atatcaggta tgcttccttt
5581 gactattaag acttagttat taccgcttat acccatattt taaaatccct aaaaatgtgt
5641 tccttaactt tttaactgat gtttatttat ttatttattt ttttagataa ttgatggaga
5701 gatgtatcct cccacagtca aagatactca ggcagagatg atctaccctc ctcaagtccc
5761 tgagcatcta cggtttgctg tggggcagga ggtctttggt ctggtgcctg gtctgatgat
5821 gtatgccaca atctggctgc gggaacacaa cagagtatgc gatgtgctta aacaggagca
5881 tcctgaatgg ggtgatgagc agttgttcca gacaagcagg ctaatactga taggtaaaca
5941 agaaaatgat ttatataaaa ccctcttccc cagggaaaat tagtgtgcta tctttgttat
6001 gttttgagta atgacaagat gtggtaaatg aaaactcaca cattctatat acattaaata
6061 tgtaagcatg actgataaaa tagctatctt ttgatactga caaggaagaa aacagaaatg
6121 aaggaatagc aaattttaaa aattgcattc cagttgcttg aaagcttgtg atcagatgca
6181 ataaatgttt ttattattta ttttgtgcaa ataggagaga ctattaagat tgtgattgaa
6241 gattatgtgc aacacttgag tggctatcac ttcaaactga aatttgaccc agaactactt
6301 ttcaacaaac aattccagta ccaaaatcgt attgctgctg aatttaacac cctctatcac
6361 tggcatcccc ttctgcctga cacctttcaa attcatgacc agaaatacaa ctatcaacag
6421 tttatctaca acaactctat attgctggaa catggaatta cccagtttgt tgaatcattc
6481 accaggcaaa ttgctggcag ggtaagcatt attattgaaa accaaaacaa aagactagtc
6541 agtaacttta gaatttctgc cacggaaatt atttttctta aacttactaa aagagtagtt
6601 agttatattg ctagtaaaat tattttattg atataagaag cctaactttg tttgaaaagt
6661 ctaaactttt agtctagtct acagttgtca gacaaatagc aaattgtacc cctaccttaa
6721 aaatattttc aaaaagtatc tataatctta taggaataaa tattttaggc ttgaatacta
6781 gtgttatttt tgaaatgtaa aaaggcaaat tagttctagg ctggtgtccc attgaatttt
6841 aagcagagct cctgttgaaa tgtaggtaag catctttcca gcaaataaaa attgtctccg
6901 ctgggagttt cagttttacc tgatttgtac ctaaggcaag ctgaatacaa acagtaaata
6961 tgcctaaaat tctggtttta caactaattt tactttccac aggttgctgg tggtaggaat
7021 gttccacccg cagtacagaa agtatcacag gcttccattg accagagcag gcagatgaaa
7081 taccagtctt ttaatgagta ccgcaaacgc tttatgctga agccctatga atcatttgaa
7141 gaacttacag gtaagaaaca gtttctaaac ttcttcgttt tttgtttgtt tgtttgtttt
7201 tgttgttttt ggttttcttt tcgagatgga gccgccctct gtcacccagg ctggagtgca
7261 gtggcgccat ctcggctcac tgcaacctcc gcctcctggg ttcaagcaat tctcctgcct
7321 caacttcctg agtagctggg actacaggct cacgtcgcac gcatggataa ttttttgtat
7381 tttcagtata gacggggttt caccgtgtta gccaggctgg tctcaaactc ctgacctagt
7441 gatccgccgg cttcggcctc ccgaagtgct gggattacag gcgtgagcca ccgcgcctgg
7501 cccctaaact tcttaaaaga atcaggggtc aaatggaaac agagaagttg gcagcaaatt
7561 gagcaaaaga atcaaactgt tttttatttt gtgaagtttg acattggttg tatctctgtc
7621 ttcatcgcct tcacaggaga aaaggaaatg tctgcagagt tggaagcact ctatggtgac
7681 atcgatgctg tggagctgta tcctgccctt ctggtagaaa agcctcggcc agatgccatc
7741 tttggtgaaa ccatggtaga agttggagca ccattctcct tgaaaggact tatgggtaat
7801 gttatatgtt ctcctgccta ctggaagcca agcacttttg gtggagaagt gggttttcaa
7861 atcatcaaca ctgcctcaat tcagtctctc atctgcaata acgtgaaggg ctgtcccttt
7921 acttcattca gtgttccaga tccagagctc attaaaacag tcaccatcaa tgcaagttct
7981 tcccgctccg gactagatga tatcaatccc acagtactac taaaagaacg ttcgactgaa
8041 ctgtagaagt ctaatgatca tatttattta tttatatgaa ccatgtctat taatttaatt
8101 atttaataat atttatatta aactccttat gttacttaac atcttctgta acagaagtca
8161 gtactcctgt tgcggagaaa ggagtcatac ttgtgaagac ttttatgtca ctactctaaa
8221 gattttgctg ttgctgttaa gtttggaaaa cagtttttat tctgttttat aaaccagaga
8281 gaaatgagtt ttgacgtctt tttacttgaa tttcaactta tattataaga acgaaagtaa
8341 agatgtttga atacttaaac actgtcacaa gatggcaaaa tgctgaaagt ttttacactg
8401 tcgatgtttc caatgcatct tccatgatgc attagaagta actaatgttt gaaattttaa
8461 agtacttttg gttatttttc tgtcatcaaa caaaaacagg tatcagtgca ttattaaatg
8521 aatatttaaa ttagacatta ccagtaattt catgtctact ttttaaaatc agcaatgaaa
8581 caataatttg aaatttctaa attcataggg tagaatcacc tgtaaaagct tgtttgattt
8641 cttaaagtta ttaaacttgt acatatacca aaaagaagct gtcttggatt taaatctgta
8701 aaatcagtag aaattttact acaattgctt gttaaaatat tttataagtg atgttccttt
8761 ttcaccaaga gtataaacct ttttagtgtg actgttaaaa cttcctttta aatcaaaatg
8821 ccaaatttat taaggtggtg gagccactgc agtgttatct taaaataaga atattttgtt
8881 gagatattcc agaatttgtt tatatggctg gtaacatgta aaatctatat cagcaaaagg
8941 gtctaccttt aaaataagca ataacaaaga agaaaaccaa attattgttc aaatttaggt
9001 ttaaactttt gaagcaaact tttttttatc cttgtgcact gcaggcctgg tactcagatt
9061 ttgctatgag gttaatgaag taccaagctg tgcttgaata acgatatgtt ttctcagatt
9121 tcctgttgta cagtttaatt tagcagtcca tatcacattg caaaagtagc aatgacctca
9181 taaaatacct cttcaaaatg cttaaattca tttcacacat taattttatc tcagtcttga
9241 agccaattca gtaggtgcat tggaatcaag cctggctacc tgcatgctgt tccttttctt
9301 ttcttctttt agccattttg ctaagagaca cagtcttctc agctacttcg tttctcctat
9361 tttgttttac tagttttaag atcagagttc actttctttg gactctgcct atattttctt
9421 acctgaactt ttgcaagttt tcaggtaaac ctcagctcag gactgctatt tagctcctct
9481 taagaagatt aaaagagaaa aaaaaaggcc cttttaaaaa tagtatacac ttattttaag
9541 tgaaaagcag agaattttat ttatagctaa ttttagctat ctgtaaccaa gatggatgca
9601 aagaggctag tgcctcagag agaactgtac ggggtttgtg actggaaaaa gttacgttcc
9661 cattctaatt aatgcccttt cttatttaaa aacaaaacca aatgatatct aagtagttct
9721 cagcaataat aataatgacg ataatacttc ttttccacat ctcattgtca ctgacattta
9781 atggtactgt atattactta atttattgaa gattattatt tatgtcttat taggacacta
9841 tggttataaa ctgtgtttaa gcctacaatc attgattttt ttttgttatg tcacaatcag
9901 tatattttct ttggggttac ctctctgaat attatgtaaa caatccaaag aaatgattgt
9961 attaagattt gtgaataaat ttttagaaat ctgattggca tattgagata tttaaggttg
10021 aatgtttgtc cttaggatag gcctatgtgc tagcccacaa agaatattgt ctcattagcc
10081 tgaatgtgcc ataagactga ccttttaaaa tgttttgagg gatctgtgga tgcttcgtta
10141 atttgttcag ccacaattta ttgagaaaat attctgtgtc aagcactgtg ggttttaata
10201 tttttaaatc aaacgctgat tacagataat agtatttata taaataattg aaaaaaattt
10261 tcttttggga agagggagaa aatgaaataa atatcattaa agataactca ggagaatctt
10321 ctttacaatt ttacgtttag aatgtttaag gttaagaaag aaatagtcaa tatgcttgta
10381 taaaacactg ttcactgttt tttttaaaaa aaaaacttga tttgttatta acattgatct
10441 gctgacaaaa cctgggaatt tgggttgtgt atgcgaatgt ttcagtgcct cagacaaatg
10501 tgtatttaac ttatgtaaaa gataagtctg gaaataaatg tctgtttatt tttgtactat
10561 ttaaaaattg acagatcttt tctgaagata aactttgatt gtttctatac atctttgtca
10621 tatgacataa gatttctctg aagcattact cttaaaccat tatcttgcat tctcctacct
10681 attcaaaact aggactggcc cttcatgaaa tggttttgcc ctcaattata tagaggcttc
10741 ctagagtcac tatttaaatc tcataatcct tattcactgc gacactgtgt tggaaaatgt
10801 ctagtttgtg tatctttaca gaagatggca aacaagctta ttttcattgc ctagtctaga
10861 agaagaagaa aaaaatacac aataaggcaa agaataagac atatattatg aagggggcac
10921 aaagttaaga agttcaaaga ggaggaaatt atacaaagtt gggcaaatca ttgatgcaaa
10981 agctcatagg cttttgt
//