LOCUS HUMC3GP 4070 bp mRNA linear HUM 13-DEC-2007
DEFINITION Homo sapiens mRNA for C3G protein, complete cds.
ACCESSION D21239
VERSION D21239.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4070)
AUTHORS Matsuda,M.
TITLE Direct Submission
JOURNAL Submitted (20-OCT-1993) to the DDBJ/EMBL/GenBank databases.
Contact:Michiyuki Matsuda
National Institute of Infectious Diseases, Department of
Pathology; 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8640, Japan
REFERENCE 2
AUTHORS Knudsen,B., Feller,S. and Hanafusa,H.
TITLE Four proline-rich sequences of the guanine-nucleotide exchange
factor C3G bind with unique specificity to the first Src homology
3 domain of Crk
JOURNAL J. Biol. Chem. 269, 32781-32787 (1994)
REFERENCE 3
AUTHORS Tanaka,S., Morishita,T., Hashimoto,Y., Hattori,S., Nakamura,S.,
Shibuya,M., Matuoka,K., Takenawa,T., Kurata,T., Nagashima,K. and
Matsuda,M.
TITLE C3G, a guanine nucleotide-releasing protein expressed
ubiquitously, binds to the Src homology 3 domains of CRK and
GRB2/ASH proteins
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 91, 3443-3447 (1994)
COMMENT
FEATURES Location/Qualifiers
source 1..4070
/clone="pC3G2"
/db_xref="H-InvDB:HIT000101096"
/db_xref="taxon:9606"
/mol_type="mRNA"
/organism="Homo sapiens"
/tissue_type="spleen and placenta"
CDS 131..3364
/codon_start=1
/function="ras guanine nucleotide releasing factor"
/note="1897-2047 bp: binding site for SH3 domains of CRK
and GRB2/ASH protein"
/note="2630-3322 bp: guanine nucleotide releasing factor;
homologous region to CDC25"
/product="C3G protein"
/protein_id="BAA04770.1"
/translation="MDTDSQRSHLSSFTMKLMDKFHSPKIKRTPSKKGKPAEVSVKIP
EKPVNKEATDRFLPEGYPLPLDLEQQAVEFMSTSAVASRSQRQKNLSWLEEKEKEVVS
ALRYFKTIVDKMAIDKKVLEMLPGSASKVLEAILPLVQNDPRIQHSSALSSCYSRVYQ
SLANLIRWSDQVMLEGVNSEDKEMVTTVKGVIKAVLDGVKELVRLTIEKQGRPSPTSP
VKPSSPASKPDGPAELPLTDREVEILNKTTGMSQSTELLPDATDEEVAPPKPPLPGIR
VVDNSPPPALTPKKRQSAPSPTRVAVVAPMSRATSGSSLPVGINRQDFDVDCYAQRRL
SGGSHSYGGESPRLSPCSSIDKLSKSDEQLSSLDRDSGQCSRNTSCETLDHYDPDYEF
LQQDLSNADQIPQQTAWNLSPLPESLGESGSPFLGPPFQLPLGGHPQPDGPLAPGQQT
DTPPALPEKKRRSAASQTADGSGCRVSYERHPSQYDNISGEDLQSTAPIPSVPYAPFA
AILPFQHGGSSAPVEFVGDFTAPESTGDPEKPPPLPEKKNKHMLAYMQLLEDYSEPQP
SMFYQTPQNEHIYQQKNKLLMEVYGFSDSFSGVDSVQELAPPPALPPKQRQLEPPAGK
DGHPRDPSAVSGVPGKDSRDGSERAPKSPDALESAQSEEEVDELSLIDHNEIMSRLTL
KQEGDDGPDVRGGSGDILLVHATETDRKDLVLYCEAFLTTYRTFISPEELIKKLQYRY
EKFSPFADTFKKRVSKNTFFVLVRVVDELCLVELTEEILKLLMELVFRLVCNGELSLA
RVLRKNILDKVDQKKLLRCATSSQPLAARGVAARPGTLHDFHSHEIAEQLTLLDAELF
YKIEIPEVLLWAKEQNEEKSPNLTQFTEHFNNMSYWVRSIIMLQEKAQDRERLLLKFI
KIMKHLRKLNNFNSYLAILSALDSAPIRRLEWQKQTSEGLAEYCTLIDSSSSFRAYRA
ALSEVEPPCIPYLGLILQDLTFVHLGNPDYIDGKVNFSKRWQQFNILDSMRCFQQAHY
DMRRNDDIINFFNDFSDHLAEEALWELSLKIKPRNITRRKTDREEKT"
BASE COUNT 939 a 1197 c 1148 g 786 t
ORIGIN
1 gaattccctt ttctgggcac cgccttctgc tagggggttg tagatgaaag tgcctgctcc
61 cagagaagct tgtctaacct agcacagttt ctaagctacc caggctgcca gaccgagcga
121 ccgtgctgcc atggacacag actctcagcg ttctcatctc tcttccttca ccatgaagct
181 gatggacaaa ttccactcac ccaaaatcaa gagaacgcca tcaaagaagg gaaaaccagc
241 tgaggtgtcc gtaaagattc cagagaagcc tgtgaacaaa gaggcaacag acagatttct
301 accagagggc taccctctcc ccttggatct ggagcagcag gcagtagaat ttatgtccac
361 cagtgctgtg gcttccaggt ctcaaaggca gaagaacctg agctggctgg aggagaaaga
421 gaaggaagtt gtcagtgccc tgcgctactt taagaccatt gtggacaaaa tggcaattga
481 taagaaggta ctggagatgc ttccagggtc agccagcaag gtgctggagg ccatcttacc
541 cctggtgcag aacgatcctc gaattcagca cagctcagcc ctctcttcct gctatagccg
601 agtgtaccaa agcctcgcca acctcattcg ctggtctgac caagtgatgc tggaaggcgt
661 gaactcagaa gacaaggaga tggtgacgac tgtgaagggg gtcatcaagg ctgtgctgga
721 tggagtgaag gagctggtca ggctcaccat cgagaagcag ggacgtccgt ctccgacgag
781 ccccgtgaag cccagttccc ctgccagcaa gcctgatggc ccagcagagc tccccctgac
841 agaccgcgag gtagagatcc taaacaagac gactgggatg tcacagtcaa ctgagctcct
901 cccagatgcc acggatgaag aggtcgcgcc ccccaagcct cctctgcctg gcattcgggt
961 ggttgataat agtcctccac cagcattgac acccaagaaa agacagtcgg cgccgtcccc
1021 tacccgagtg gctgtggtgg cccccatgag ccgagccacc agtggctcca gtttgcctgt
1081 tggaatcaat aggcaggatt ttgatgttga ctgttacgca cagaggcgac tgtcaggagg
1141 cagccactca tatggtggag agtcgccccg cctctccccc tgcagcagca tagacaagct
1201 cagcaagtca gacgagcagc tgtcctctct ggacagggac agtgggcagt gctcccggaa
1261 cacaagctgt gaaacactag accactatga tcccgactat gaattcctcc agcaagacct
1321 ctctaacgca gaccagatac ctcagcagac ggcctggaac cttagcccgt tgccagagtc
1381 tttgggggag tctgggtctc catttcttgg ccctcctttc cagctgcctc ttggcggcca
1441 tccccagcca gacggacctc tggccccagg gcagcagaca gatacgccac ctgctctccc
1501 cgagaagaag cgcaggagcg cagcctccca gacggcggac ggctctggct gcagggtgtc
1561 ctacgagcgg catccctcgc agtatgacaa catctctggg gaggacctgc agagcacagc
1621 cccgatccca tccgtcccct acgcgccctt tgctgctatt ctgccctttc agcatggagg
1681 ttcctcagcc cctgtcgaat ttgtgggtga ttttactgct cctgagtcaa ccggtgaccc
1741 agaaaaacca cctcctctac cagagaagaa aaacaaacac atgctggcct acatgcagtt
1801 gctggaggac tactcggagc cgcagccctc tatgttctac cagacgccac agaacgagca
1861 catctaccag cagaagaaca agctcctcat ggaggtatac ggcttcagcg actccttcag
1921 tggggtggac tccgtgcagg agctggcccc gccgcccgcc ctacccccca agcagcggca
1981 gctggagcca ccggctggga aagacggaca tcccagagat ccctcagcgg tcagcggcgt
2041 ccctgggaag gacagcagag acggcagtga gagggcccca aagtcaccag atgctctgga
2101 gtcggctcag tcggaggagg aagtggacga gctgtccctc attgaccaca acgaaattat
2161 gtccaggctg acgctcaagc aggagggtga tgacgggccg gacgtccgcg gaggatctgg
2221 ggacatctta ctggtccatg ctactgagac tgacaggaaa gatttggtgt tgtactgcga
2281 ggcattcctg accacctaca ggaccttcat ctccccagag gagctcatca agaagctgca
2341 gtacagatat gagaaattct ctccctttgc cgacacattc aagaagcgcg tcagcaagaa
2401 cacgttcttc gtgctggtac gggtggtgga tgagctctgc ctggtggagt tgacagaaga
2461 gatcctgaag ctgctgatgg aactggtctt ccgcctggtg tgcaatgggg agctgagcct
2521 ggcccgtgtg ctccggaaga acatcctgga caaggtggac cagaagaagc tactcaggtg
2581 tgccacctcc agccagcccc tggcagcccg gggggtagca gccaggccgg ggaccttgca
2641 cgactttcac agccatgaga tagcggagca gctaacgctg ctggatgctg agctcttcta
2701 taaaatagag attcctgagg ttttgctttg ggcaaaagag cagaatgagg agaagagccc
2761 caacttgacc cagttcacgg agcacttcaa caacatgtcc tactgggtcc ggtccataat
2821 catgttacag gaaaaggccc aggacaggga acggctgctc ttgaagttca tcaagatcat
2881 gaagcacttg cggaagctga ataacttcaa ctcctacttg gccatcctct ctgccctgga
2941 ctcggcgccc atccgcaggc tggagtggca gaagcagact tcagagggcc tggccgagta
3001 ctgcacactg atcgacagct cgtcctcctt ccgagcctac cgggccgccc tctcggaggt
3061 ggaaccgccg tgcatcccgt acctggggct gatcctgcag gacctgacct tcgttcacct
3121 gggaaaccca gactacatcg acgggaaagt gaacttctcc aagcggtggc agcagttcaa
3181 catcctcgac agcatgcgct gcttccagca ggcgcactat gacatgcgga ggaacgacga
3241 cattataaac ttcttcaatg acttcagtga ccacctggct gaggaggccc tatgggaact
3301 gtctctgaaa attaaaccca ggaacataac aaggagaaaa acagaccggg aagagaagac
3361 ctaggagcag acgccgggat ccaggagaat gctcgagggg cgcagagggc agctcccaga
3421 ccggagagga ccttggacct gttaggcgca tggcaggagt cccggcctcg gagccatgag
3481 gctggccagc cctcagcggg gccgggcggg agctggagcc tgccagccgc ttcctgcctc
3541 cttcctctgt gggagcagac ccgtgggcct cagggcagcc agcaggcagg tcttgttgcc
3601 aatttacaaa ccggtggttt tctggtttgg ttttgttttc tgcttttact tccatctctc
3661 ccctcttgac cttccaccca ctcccctcca gggagagagc agcagagacc tcatcagcag
3721 accaaggaag tggtgggtgc tccccctccc taagctccag ggtccctgaa tcttctgaaa
3781 tctcaaatga gtggaggcct cctggggtgg cctgtcctgc aggggccctg gaatgggggc
3841 aagcagctgg gtgggcagaa tgcagagtag actcggggga ggatcctttc actttccgct
3901 tccccttctg atgcatggag gatggtgtga gcttttcagc aggcccggaa aggtacgcag
3961 gtgacgcctt agcagccccg cagctggtgc tctgccccgc ggtactggcg ccatcagggc
4021 ctcccttgcc cgcctgagag cagcagcagt ctctgtcatc ccgtcgcccc
//