LOCUS HUMPTPB1 8119 bp mRNA linear HUM 11-FEB-2003
DEFINITION Homo sapiens PTP-BAS mRNA for protein tyrosine phosphatase type 1,
complete cds.
ACCESSION D21209
VERSION D21209.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 8119)
AUTHORS Maekawa,K.
TITLE Direct Submission
JOURNAL Submitted (15-OCT-1993) to the DDBJ/EMBL/GenBank databases.
Contact:Kazuhiko Maekawa
Shionogi Institute for Medical Science; 2-5-1 Mishima, Settsu,
Osaka 566, Japan
REFERENCE 2
AUTHORS Maekawa,K., Imagawa,N., Nagamatsu,M. and Harada,S.
TITLE Molecular cloning of a novel protein-tyrosine phosphatase
containing a membrane-binding domain and GLGF repeats
JOURNAL FEBS Lett. 337, 200-206 (1994)
COMMENT
FEATURES Location/Qualifiers
source 1..8119
/cell_line="KU812E"
/cell_type="basophilic leukemia cell"
/clone_lib="Lambda Zap II"
/db_xref="H-InvDB:HIT000101090"
/db_xref="taxon:9606"
/mol_type="mRNA"
/note="clones BAS-[1-4]"
/organism="Homo sapiens"
CDS 64..7521
/codon_start=1
/gene="PTP-BAS"
/product="protein tyrosine phosphatase type 1"
/protein_id="BAA04750.1"
/translation="MHVSLAEALEVRGGPLQEEEIWAVLNQSAESLQELFRKVSLADP
AALGFIISPWSLLLLPSGSVSFTDENISNQDLRAFTAPEVLQNQSLTSLSDVEKIHIY
SLGMTLYWGADYEVPQSQPIKLGDHLNSILLGMCEDVIYARVSVRTVLDACSAHIRNS
NCAPSFSYVKHLVKLVLGNLSGTDQLSCNSEQKPDRSQAIRDRLRGKGLPTGRSSTSD
VLDIQKPPLSHQTFLNKGLSKSMGFLSIKDTQDENYFKDILSDNSGREDSENTFSPYQ
FKTSGPEKKPIPGIDVLSKKKIWASSMDLLCTADRDFSSGETATYRRCHPEAVTVRTS
TTPRKKEARYSDGSIALDIFGPQKMDPIYHTRELPTSSAISSALDRIRERQKKLQVLR
EAMNVEEPVRRYKTYHGDVFSTSSESPSIISSESDFRQVRRSEASKRFESSSGLPGVD
ETLSQGQSQRPSRQYETPFEGNLINQEIMLKRQEEELMQLQAKMALRQSRLSLYPGDT
IKASMLDITRDPLREIALETAMTQRKLRNFFGPEFVKMTIEPFISLDLPRSILTKKGK
NEDNRRKVNIMLLNGQRLELTCDTKTICKDVFDMVVAHIGLVEHHLFALATLKDNEYF
FVDPDLKLTKVAPEGWKEEPKKKTKATVNFTLFFRIKFFMDDVSLIQHTLTCHQYYLQ
LRKDILEERMHCDDETSLLLASLALQAEYGDYQPEVHGVSYFRMEHYLPARVMEKLDL
SYIKEELPKLHNTYVGASEKETELEFLKVCQRLTEYGVHFHRVHPEKKSQTGILLGVC
SKGVLVFEVHNGVRTLVLRFPWRETKKISFSKKKITLQNTSDGIKHGFQTDNSKICQY
LLHLCSYQHKFQLQMRARQSNQDAQDIERASFRSLNLQAESVRGFNMGRAISTGSLAS
STLNKLAVRPLSVQAEILKRLSCSELSLYQPLQNSSKEKNDKASWEEKPREMSKSYHD
LSQASLYPHRKNVIVNMEPPPQTVAELVGKPSHQMSRSDAESLAGVTKLNNSKSVASL
NRSPERRKHESDSSSIEDPGQAYVLGMTMHSSGNSSSQVPLKENDVLHKRWSIVSSPE
REITLVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLIS
VNSVSLEGVSHHAAIEILQNAPEDVTLVISQPKEKISKVPSTPVHLTNEMKNYMKKSS
YMQDSAIDSSSKDHHWSRGTLRHISENSFGPSGGLREGSLSSQDSRTESASLSQSQVN
GFFASHLGDQTWQESQHGSPSPSVISKATEKETFTDSNQSKTKKPGISDVTDYSDRGD
SDMDEATYSSSQDHQTPKQESSSSVNTSNKMNFKTFSSSPPKPGDIFEVELAKNDNSL
GISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVE
TLRNTGQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQNAQGQGPEKVKKTTQVKDYSFV
TEENTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGD
VILKVNGASLKGLSQQEVISALRGTAPEVFLLLCRPPPGVLPEIDTALLTPLQSPAQV
LPNSSKDSSQPSCVEQSTSSDENEMSDKSKKQCKSPSRRDSYSDSSGSGEDDLVTAPA
NISNSTWSSALHQTLSNMVSQAQSHHEAPKSQEDTICTMFYYPQKIPNKPEFEDSNPS
PLPPDMAPGQSYQPQSESASSSSMDKYHIHHISEPTRQENWTPLKNDLENHLEDFELE
VELLITLIKSEKGSLGFTVTKGNQRIGCYVHDVIQDPAKSDGRLKPGDRLIKVNDTDV
TNMTHTDAVNLLRAASKTVRLVIGRVLELPRIPMLPHLLPDITLTCNKEELGFSLCGG
HDSLYQVVYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLEEVNRALDMSLPSL
VLKATRNDLPVVPSSKRSAVSAPKSTKGNGSYSVGSCSQPALTPNDSFSTVAGEEINE
ISYPKGKCSTYQIKGSPNLTLPKESYIQEDDIYDDSQEAEVIQSLLDVVDEEAQNLLN
ENNAAGYSCGPGTLKMNGKLSEERTEDTDCDGSPLPEYFTEATKMNGCEEYCEEKVKS
ESLIQKPQEKKTDDDEITWGNDELPIERTNHEDSDKDHSFLTNDELAVLPVVKVLPSG
KYTGANLKSVIRVLRGLLDQGIPSKELENLQELKPLDQCLIGQTKENRRKNRYKNILP
YDATRVPLGDEGGYINASFIKIPVGKEEFVYIACQGPLPTTVGDFWQMIWEQKSTVIA
MMTQEVEGEKIKCQRYWPNILGKTTMVSNRLRLALVRMQQLKGFVVRAMTLEDIQTRE
VRHISHLNFTAWPDHDTPSQPDDLLTFISYMRHIHRSGPIITHCSAGIGRSGTLICID
VVLGLISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVILYVLTRLQAEEEQKQQ
PQLLK"
regulatory 7593..7598
/regulatory_class="polyA_signal_sequence"
regulatory 7667..7672
/regulatory_class="polyA_signal_sequence"
regulatory 7872..7877
/regulatory_class="polyA_signal_sequence"
regulatory 8096..8101
/regulatory_class="polyA_signal_sequence"
polyA_site 8119
BASE COUNT 2597 a 1674 c 1742 g 2106 t
ORIGIN
1 cgtccctgca gccctcgccc ggcgctccag tagcaggacc cggtctcggg accagccggt
61 aatatgcacg tgtcactagc tgaggccctg gaggttcggg gtggaccact tcaggaggaa
121 gaaatatggg ctgtattaaa tcaaagtgct gaaagtctcc aagaattatt cagaaaagta
181 agcctagctg atcctgctgc ccttggcttc atcatttctc catggtctct gctgttgctg
241 ccatctggta gtgtgtcatt tacagatgaa aatatttcca atcaggatct tcgagcattc
301 actgcaccag aggttcttca aaatcagtca ctaacttctc tctcagatgt tgaaaagatc
361 cacatttatt ctcttggaat gacactgtat tggggggctg attatgaagt gcctcagagc
421 caacctatta agcttggaga tcatctcaac agcatactgc ttggaatgtg tgaggatgtt
481 atttacgctc gagtttctgt tcggactgtg ctggatgctt gcagtgccca cattaggaat
541 agcaattgtg caccctcatt ttcctacgtg aaacacttgg taaaactggt tctgggaaat
601 ctttctggga cagatcagct ttcctgtaac agtgaacaaa agcctgatcg aagccaggct
661 attcgagatc gattgcgagg aaaaggatta ccaacaggaa gaagctctac ttctgatgta
721 ctagacatac aaaagcctcc actctctcat cagacctttc ttaacaaagg gcttagtaaa
781 tctatgggat ttctgtccat caaagataca caagatgaga attatttcaa ggacatttta
841 tcagataatt ctggacgtga agattctgaa aatacattct ccccttacca gttcaaaact
901 agtggcccag aaaaaaaacc catccctggc attgatgtgc tttctaagaa gaagatctgg
961 gcttcatcca tggacttgct ttgtacagct gacagagact tctcttcagg agagactgcc
1021 acatatcgtc gttgtcaccc tgaggcagta acagtgcgga cttcaactac tcctagaaaa
1081 aaggaggcaa gatactcaga tggaagtata gccttggata tctttggccc tcagaaaatg
1141 gatccaatat atcacactcg agaattgccc acctcctcag caatatcaag tgctttggac
1201 cgaatccgag agagacaaaa gaaacttcag gttctgaggg aagccatgaa tgtagaagaa
1261 ccagttcgaa gatacaaaac ttatcatggt gatgtcttta gtacctccag tgaaagtcca
1321 tctattattt cctctgaatc agatttcaga caagtgagaa gaagtgaagc ctcaaagagg
1381 tttgaatcca gcagtggtct cccaggggta gatgaaacct taagtcaagg ccagtcacag
1441 agaccgagca gacaatatga aacacccttt gaaggcaact taattaatca agagatcatg
1501 ctaaaacggc aagaggaaga actgatgcag ctacaagcca aaatggccct tagacagtct
1561 cggttgagcc tatatccagg agacacaatc aaagcgtcca tgcttgacat caccagggat
1621 ccgttaagag aaattgccct agaaacagcc atgactcaaa gaaaactgag gaatttcttt
1681 ggccctgagt ttgtgaaaat gacaattgaa ccatttatat ctttggattt gccacggtct
1741 attcttacta agaaagggaa gaatgaggat aaccgaagga aagtaaacat aatgcttctg
1801 aacgggcaaa gactggaact gacctgtgat accaaaacta tatgtaaaga tgtgtttgat
1861 atggttgtgg cacatattgg cttagtagag catcatttgt ttgctttagc taccctcaaa
1921 gataatgaat atttctttgt tgatcctgac ttaaaattaa ccaaagtggc cccagaggga
1981 tggaaagaag aaccaaagaa aaagaccaaa gccactgtta attttacttt gtttttcaga
2041 attaaatttt ttatggatga tgttagtcta atacaacata ctctgacgtg tcatcagtat
2101 taccttcagc ttcgaaaaga tattttggag gaaaggatgc actgtgatga tgagacttcc
2161 ttattgctgg catccttggc tctccaggct gagtatggag attatcaacc agaggttcat
2221 ggtgtgtctt actttagaat ggagcactat ttgcccgcca gagtgatgga gaaacttgat
2281 ttatcctata tcaaagaaga gttacccaaa ttgcataata cctatgtggg agcttctgaa
2341 aaagagacag agttagaatt tttaaaggtc tgccaaagac tgacagaata tggagttcat
2401 tttcaccgag tgcaccctga gaagaagtca caaacaggaa tattgcttgg agtctgttct
2461 aaaggtgtcc ttgtgtttga agttcacaat ggagtgcgca cattggtcct tcgctttcca
2521 tggagggaaa ccaagaaaat atctttttct aaaaagaaaa tcacattgca aaatacatca
2581 gatggaataa aacatggctt ccagacagac aacagtaaga tatgccagta cctgctgcac
2641 ctctgctctt accagcataa gttccagcta cagatgagag caagacagag caaccaagat
2701 gcccaagata ttgagagagc ttcgtttagg agcctgaatc tccaagcaga gtctgttaga
2761 ggatttaata tgggacgagc aatcagcact ggcagtctgg ccagcagcac cctcaacaaa
2821 cttgctgttc gacctttatc agttcaagct gagattctga agaggctatc ctgctcagag
2881 ctgtcgcttt accagccatt gcaaaacagt tcaaaagaga agaatgacaa agcttcatgg
2941 gaggaaaagc ctagagagat gagtaaatca taccatgatc tcagtcaggc ctctctctat
3001 ccacatcgga aaaatgtcat tgttaacatg gaacccccac cacaaaccgt tgcagagttg
3061 gtgggaaaac cttctcacca gatgtcaaga tctgatgcag aatctttggc aggagtgaca
3121 aaacttaata attcaaagtc tgttgcgagt ttaaatagaa gtcctgaaag gaggaaacat
3181 gaatcagact cctcatccat tgaagaccct gggcaagcat atgttctagg aatgactatg
3241 catagttctg gaaactcttc atcccaagta cccttaaaag aaaatgatgt gctacacaaa
3301 agatggagca tagtatcttc accagaaagg gagatcacct tagtgaacct gaaaaaagat
3361 gcaaagtatg gcttgggatt tcaaattatt ggtggggaga agatgggaag actggaccta
3421 ggcatattta tcagttcagt tgcccctgga ggaccagctg acttggatgg atgcttgaag
3481 ccaggagacc gtttgatatc tgtgaatagt gtgagtctgg agggagtcag ccaccatgct
3541 gcaattgaaa ttttgcaaaa tgcacctgaa gatgtgacac ttgttatctc tcagccaaaa
3601 gaaaagatat ccaaagtgcc ttctactcct gtgcatctca ccaatgagat gaaaaactac
3661 atgaagaaat cttcctacat gcaagacagt gctatagatt cttcttccaa ggatcaccac
3721 tggtcacgtg gtaccctgag gcacatctcg gagaactcct ttgggccatc tgggggcctg
3781 cgggaaggaa gcctgagttc tcaagattcc aggactgaga gtgccagctt gtctcaaagc
3841 caggtcaatg gtttctttgc cagccattta ggtgaccaaa cctggcagga atcacagcat
3901 ggcagccctt ccccatctgt aatatccaaa gccaccgaga aagagacttt cactgatagt
3961 aaccaaagca aaactaaaaa gccaggcatt tctgatgtaa ctgattactc agaccgtgga
4021 gattcagaca tggatgaagc cacttactcc agcagtcagg atcatcaaac accaaaacag
4081 gaatcttcct cttcagtgaa tacatccaac aagatgaatt ttaaaacttt ttcttcatca
4141 cctcctaagc ctggagatat ctttgaggtt gaactggcta aaaatgataa cagcttgggg
4201 ataagtgtca cgggaggtgt gaatacgagt gtcagacatg gtggcattta tgtgaaagct
4261 gttattcccc agggagcagc agagtctgat ggtagaattc acaaaggtga tcgcgtccta
4321 gctgtcaatg gagttagtct agaaggagcc acccataagc aagctgtgga aacactgaga
4381 aatacaggac aggtggttca tctgttatta gaaaagggac aatctccaac atctaaagaa
4441 catgtcccgg taaccccaca gtgtaccctt tcagatcaga atgcccaagg tcaaggccca
4501 gaaaaagtga agaaaacaac tcaggtcaaa gactacagct ttgtcactga agaaaataca
4561 tttgaggtaa aattatttaa aaatagctca ggtctaggat tcagtttttc tcgagaagat
4621 aatcttatac cggagcaaat taatgccagc atagtaaggg ttaaaaagct ctttcctgga
4681 cagccagcag cagaaagtgg aaaaattgat gtaggagatg ttatcttgaa agtgaatgga
4741 gcctctttga aaggactatc tcagcaggaa gtcatatctg ctctcagggg aactgctcca
4801 gaagtattct tgcttctctg cagacctcca cctggtgtgc taccggaaat tgatactgcg
4861 cttttgaccc cacttcagtc tccagcacaa gtacttccaa acagcagtaa agactcttct
4921 cagccatcat gtgtggagca aagcaccagc tcagatgaaa atgaaatgtc agacaaaagc
4981 aaaaaacagt gcaagtcccc atccagaaga gacagttaca gtgacagcag tgggagtgga
5041 gaagatgact tagtgacagc tccagcaaac atatcaaatt cgacctggag ttcagctttg
5101 catcagactc taagcaacat ggtatcacag gcacagagtc atcatgaagc acccaagagt
5161 caagaagata ccatttgtac catgttttac tatcctcaga aaattcccaa taaaccagag
5221 tttgaggaca gtaatccttc ccctctacca ccggatatgg ctcctgggca gagttatcaa
5281 ccccaatcag aatctgcttc ctctagttcg atggataagt atcatataca tcacatttct
5341 gaaccaacta gacaagaaaa ctggacacct ttgaaaaatg acttggaaaa tcaccttgaa
5401 gactttgaac tggaagtaga actcctcatt accctaatta aatcagaaaa aggaagcctg
5461 ggttttacag taaccaaagg caatcagaga attggttgtt atgttcatga tgtcatacag
5521 gatccagcca aaagtgatgg aaggctaaaa cctggggacc ggctcataaa ggttaatgat
5581 acagatgtta ctaatatgac tcatacagat gcagttaatc tgctccgggc tgcatccaaa
5641 acagtcagat tagttattgg acgagttcta gaattaccca gaataccaat gttgcctcat
5701 ttgctaccgg acataacact aacgtgcaac aaagaggagt tgggtttttc cttatgtgga
5761 ggtcatgaca gcctttatca agtggtatat attagtgata ttaatccaag gtccgtcgca
5821 gccattgagg gtaatctcca gctattagat gtcatccatt atgtgaacgg agtcagcaca
5881 caaggaatga ccttggagga agttaacaga gcattagaca tgtcacttcc ttcattggta
5941 ttgaaagcaa caagaaatga tcttccagtg gtccccagct caaagaggtc tgctgtttca
6001 gctccaaagt caaccaaagg caatggttcc tacagtgtgg ggtcttgcag ccagcctgcc
6061 ctcactccta atgattcatt ctccacggtt gctggggaag aaataaatga aatatcgtac
6121 cccaaaggaa aatgttctac ttatcagata aagggatcac caaacttgac tctgcccaaa
6181 gaatcttata tacaagaaga tgacatttat gatgattccc aagaagctga agttatccag
6241 tctctgctgg atgttgtgga tgaggaagcc cagaatcttt taaacgaaaa taatgcagca
6301 ggatactcct gtggtccagg tacattaaag atgaatggga agttatcaga agagagaaca
6361 gaagatacag actgcgatgg ttcaccttta cctgagtatt ttactgaggc caccaaaatg
6421 aatggctgtg aagaatattg tgaagaaaaa gtaaaaagtg aaagcttaat tcagaagcca
6481 caagaaaaga agactgatga tgatgaaata acatggggaa atgatgagtt gccaatagag
6541 agaacaaacc atgaagattc tgataaagat cattcctttc tgacaaacga tgagctcgct
6601 gtactccctg tcgtcaaagt gcttccctct ggtaaataca cgggtgccaa cttaaaatca
6661 gtcattcgag tcctgcgggg tttgctagat caaggaattc cttctaagga gctggagaat
6721 cttcaagaat taaaaccttt ggatcagtgt ctaattgggc aaactaagga aaacagaagg
6781 aagaacagat ataaaaatat acttccctat gatgctacaa gagtgcctct tggagatgaa
6841 ggtggctata tcaatgccag cttcattaag ataccagttg ggaaagaaga gttcgtttac
6901 attgcctgcc aaggaccact gcctacaact gttggagact tctggcagat gatttgggag
6961 caaaaatcca cagtgatagc catgatgact caagaagtag aaggagaaaa aatcaaatgc
7021 cagcgctatt ggcccaacat cctaggcaaa acaacaatgg tcagcaacag acttcgactg
7081 gctcttgtga gaatgcagca gctgaagggc tttgtggtga gggcaatgac ccttgaagat
7141 attcagacca gagaggtgcg ccatatttct catctgaatt tcactgcctg gccagaccat
7201 gatacacctt ctcaaccaga tgatctgctt acttttatct cctacatgag acacatccac
7261 agatcaggcc caatcattac gcactgcagt gctggcattg gacgttcagg gaccctgatt
7321 tgcatagatg tggttctggg attaatcagt caggatcttg attttgacat ctctgatttg
7381 gtgcgctgca tgagactaca aagacacgga atggttcaga cagaggatca atatattttc
7441 tgctatcaag tcatccttta tgtcctgaca cgtcttcaag cagaagaaga gcaaaaacag
7501 cagcctcagc ttctgaagtg acatgaaaag agcctctgga tgcatttcca tttctctcct
7561 taacctccag cagactcctg ctctctatcc aaaataaaga tcacagagca gcaagttcat
7621 acaacatgca tgttctcctc tatcttagag gggtattctt cttgaaaata aaaaatattg
7681 aaatgctgta tttttacagc tactttaacc tatgataatt atttacaaaa ttttaacact
7741 aaccaaacaa tgcagatctt agggatgatt aaaggcagca tttgatgata gcagacattg
7801 ttacaaggac atggtgagtc tatttttaat gcaccaatct tgtttatagc aaaaatgttt
7861 tccaatattt taataaagta gttattttat aggggatact tgaaaccagt atttaagctt
7921 taaatgacag taatattggc atagaaaaaa gtagcaaatg tttactgtat caatttctaa
7981 tgtttactat atagaatttc ctgtaatata tttatatact ttttcatgaa aatggagtta
8041 tcagttatct gtttgttact gcatcatctg tttgtaatca ttatctcact ttgtaaataa
8101 aaacacacct taaaacatg
//