LOCUS HUMTRP2 2291 bp mRNA linear HUM 21-APR-2009
DEFINITION Homo sapiens TRP-2 mRNA for DOPAchrome tautomerase precursor,
complete cds.
ACCESSION D17547
VERSION D17547.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2291)
AUTHORS Shibahara,S.
TITLE Direct Submission
JOURNAL Submitted (04-SEP-1993) to the DDBJ/EMBL/GenBank databases.
Contact:Shigeki Shibahara
Tohoku University School of Medicine, Dept. of Applied Physiol.
and Mol. Biol.; 2-1 Seiryomachi, Aoba-ku, Sendai, Miyagi 980, Japan
REFERENCE 2
AUTHORS Yokoyama,K., Suzuki,H., Yasumoto,K., Tomita,Y. and Shibahara,S.
TITLE Molecular cloning and functional analysis of a cDNA coding for
human DOPAchrome tautomerase/tyrosinase-related protein-2
JOURNAL Biochim. Biophys. Acta 1217, 317-321 (1994)
COMMENT
FEATURES Location/Qualifiers
source 1..2291
/cell_line="HMV-II melanoma"
/db_xref="H-InvDB:HIT000101076"
/db_xref="taxon:9606"
/mol_type="mRNA"
/organism="Homo sapiens"
CDS 415..1974
/codon_start=1
/experiment="experimental evidence, no additional details
recorded"
/gene="TRP-2"
/note="melanin formation"
/product="DOPAchrome tautomerase precursor"
/protein_id="BAA04484.1"
/standard_name="tyrosinase-related protein-2"
/translation="MSPLWWGFLLSCLGCKILPGAQGQFPRVCMTVDSLVNKECCPRL
GAESANVCGSQQGRGQCTEVRADTRPWSGPYILRNQDDRELWPRKFFHRTCKCTGNFA
GYNCGDCKFGWTGPNCERKKPPVIRQNIHSLSPQEREQFLGALDLAKKRVHPDYVITT
QHWLGLLGPNGTQPQFANCSVYDFFVWLHYYSVRDTLLGPGRPYRAIDFSHQGPAFVT
WHRYHLLCLERDLQRLIGNESFALPYWNFATGRNECDVCTDQLFGAARPDDPTLISRN
SRFSSWETVCDSLDDYNHLVTLCNGTYEGLLRRNQMGRNSMKLPTLKDIRDCLSLQKF
DNPPFFQNSTFSFRNALEGFDKADGTLDSQVMSLHNLVHSFLNGTNALPHSAANDPIF
VVLHSFTDAIFDEWMKRFNPPADAWPQELAPIGHNRMYNMVPFFPPVTNEELFLTSDQ
LGYSYAIDLPVSVEETPGWPTTLLVVMGTLVALVGLFVLLAFLQYRRLRKGYTPLMET
HLSSKRYTEEA"
sig_peptide 415..483
/note="putative"
mat_peptide 484..1971
/EC_number="5.3.3.12"
/gene="TRP-2"
/note="originally submitted as EC number: 5.3.2.3"
/note="putative"
/product="DOPAchrome tautomerase"
BASE COUNT 641 a 510 c 545 g 595 t
ORIGIN
1 gcaattaaag tcaagagcta aggagggagg gagagggttt agaaatacca gcataataag
61 tagtatgact gggtgctctg taaattaact caattagaca aagcctgact taacggggga
121 agatggtgag aagcgctacc ctcattaaat ttggttgtta gaggcgcttc taaggaaatt
181 aagtctgtta gttgtttgaa tcacataaaa ttgtgtgtgc acgttcatgt acacatgtgc
241 acacatgtaa cctctgtgat tcttgtgggt atttttttaa gaagaaagga atagaaagca
301 aagaaaaata aaaaatactg aaaagaaaag actgaaagag tagaagataa ggagaaaagt
361 acgacagaga caaggaaagt aagagagaga gagagctctc ccaattataa agccatgagc
421 cccctttggt gggggtttct gctcagttgc ttgggctgca aaatcctgcc aggagcccag
481 ggtcagttcc cccgagtctg catgacggtg gacagcctag tgaacaagga gtgctgccca
541 cgcctgggtg cagagtcggc caatgtctgt ggctctcagc aaggccgggg gcagtgcaca
601 gaggtgcgag ccgacacaag gccctggagt ggtccctaca tcctacgaaa ccaggatgac
661 cgtgagctgt ggccaagaaa attcttccac cggacctgca agtgcacagg aaactttgcc
721 ggctataatt gtggagactg caagtttggc tggaccggtc ccaactgcga gcggaagaaa
781 ccaccagtga ttcggcagaa catccattcc ttgagtcctc aggaaagaga gcagttcttg
841 ggcgccttag atctcgcgaa gaagagagta caccccgact acgtgatcac cacacaacac
901 tggctgggcc tgcttgggcc caatggaacc cagccgcagt ttgccaactg cagtgtttat
961 gatttttttg tgtggctcca ttattattct gttagagata cattattagg accaggacgc
1021 ccctacaggg ccatagattt ctcacatcaa ggacctgcat ttgttacctg gcaccggtac
1081 catttgttgt gtctggaaag agatctccag cgactcattg gcaatgagtc ttttgctttg
1141 ccctactgga actttgccac tgggaggaac gagtgtgatg tgtgtacaga ccagctgttt
1201 ggggcagcga gaccagacga tccgactctg attagtcgga actcaagatt ctccagctgg
1261 gaaactgtct gtgatagctt ggatgactac aaccacctgg tcaccttgtg caatggaacc
1321 tatgaaggtt tgctgagaag aaatcaaatg ggaagaaaca gcatgaaatt gccaacctta
1381 aaagacatac gagattgcct gtctctccag aagtttgaca atcctccctt cttccagaac
1441 tctaccttca gtttcaggaa tgctttggaa gggtttgata aagcagatgg gactctggat
1501 tctcaagtga tgagccttca taatttggtt cattccttcc tgaacgggac aaacgctttg
1561 ccacattcag ccgccaatga tcccattttt gtggttcttc attcctttac tgatgccatc
1621 tttgatgagt ggatgaaaag atttaatcct cctgcagatg cctggcctca ggagctggcc
1681 cctattggtc acaatcggat gtacaacatg gttcctttct tccctccagt gactaatgaa
1741 gaactctttt taacctcaga ccaacttggc tacagctatg ccatcgatct gccagtttca
1801 gttgaagaaa ctccaggttg gcccacaact ctcttagtag tcatgggaac actggtggct
1861 ttggttggtc tttttgtgct gttggctttt cttcaatata gaagacttcg aaaaggatat
1921 acacccctaa tggagacaca tttaagcagc aagagataca cagaagaagc ctagggtgct
1981 catgccttac ctaagagaag aggctggcca agccacagtt ctgacgctga caataaagga
2041 actaatcctc actgttcctt cttgagttga agatctttga cataggttct tctatagtga
2101 tgatgatctc attcagaaga tgcttagctg tagtttccgc tttgcttgct tgtttaacaa
2161 acccaactaa agtgcttgag gctacctcta ccttcaaata aagatagacc tgacaatttg
2221 tgatatctaa taataacccc ccccccaata ttgattaagc ctcctccttt tctgaaagca
2281 tttaaaaaaa a
//