LOCUS       HUMGULOA                 644 bp    DNA     linear   HUM 13-FEB-2003
DEFINITION  Homo sapiens GULO gene for L-gulono-gamma-lactone oxidase, exon 7.
ACCESSION   D17460
VERSION     D17460.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 644)
  AUTHORS   Nishikimi,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (23-AUG-1993) to the DDBJ/EMBL/GenBank databases.
            Contact:Morimitsu Nishikimi
            Wakayama Medical College, Dept. of Biochemistry; 27 Kyubancho,
            Wakayama, Wakayama 640, Japan
REFERENCE   2
  AUTHORS   Nishikimi,M., Koshizaka,T., Ozawa,T. and Yagi,K.
  TITLE     Occurrence in humans and guinea pigs of the gene related to their
            missing enzyme L-gulono-gamma-lactone oxidase
  JOURNAL   Arch. Biochem. Biophys. 267, 842-846 (1988)
REFERENCE   3
  AUTHORS   Nishikimi,M., Fukuyama,R., Minoshima,S., Shimizu,N. and Yagi,K.
  TITLE     Cloning and chromosomal mapping of the human nonfunctional gene
            L-gulono-.gamma.-lactone oxidase, the enzyme for L-ascorbic acid
            biosynthesis missing in man
  JOURNAL   J. Biol. Chem. 269, 13685-13688 (1994)
COMMENT     
FEATURES             Location/Qualifiers
     source          1..644
                     /chromosome="8"
                     /clone="lambda HGO8"
                     /clone_lib="lambda phage, EMBL4"
                     /db_xref="taxon:9606"
                     /mol_type="genomic DNA"
                     /organism="Homo sapiens"
                     /tissue_type="peripheral blood"
     exon            528..634
                     /EC_number="1.1.3.8"
                     /gene="GULO"
                     /note="biosynthesis of L-ascorbic acid"
                     /note="flavin enzyme"
                     /number=7
                     /product="L-gulono-gamma-lactone oxidase"
BASE COUNT          180 a          174 c          123 g          167 t
ORIGIN      
        1 ctgcagtgag ctaagatcgt gccactgcac tccagcctgg gtgacagagc aagacagccc
       61 ttttaaagaa aaagaataat agcactagaa gcagtagctg atgcctatat attgcttgcc
      121 atgtgcctga ccattttaaa caccttctag gccttagctc atttactctc cataacaatc
      181 ctgacgtgga tactgttatt aaccccattt tacagatgag gcacttgagg cccagagaca
      241 ttagataact tgcccaaact cacacagcta gtacttgctc aagccaggac aaagaagaaa
      301 tcacttctgt cctctaaact actcggggaa gtcatcatgt aagtggacca tttgaatgcc
      361 cagcatctta taaaactcat tccatgctat ttgcaatgtt atgacatctt taagtatttc
      421 cttttgatga agaagaaact gaggcacacc catgccctgg cttccattac tcgcatcacc
      481 ttcctatggc caatgtagcc tctccctttt cctcctgctg aggtcagttc ctccatagcc
      541 tggacagcat tggaagaaat ctgaggactt ctgcttcctc tggttcccac acagtgagaa
      601 cgtcagtgcc atccaccagg accacaccag caaggcagct gcag
//