LOCUS HUMVLDLRB 3155 bp mRNA linear HUM 01-OCT-2002
DEFINITION Homo sapiens mRNA for very low density lipoprotein receptor,
complete cds.
ACCESSION D16494
VERSION D16494.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3155)
AUTHORS Sakai,J.
TITLE Direct Submission
JOURNAL Submitted (19-JUN-1993) to the DDBJ/EMBL/GenBank databases.
Contact:Juro Sakai
Tohoku University Gene Research Center; 1-1 Tsutsumidori-Amamiya,
Aoba, Sendai, Miyagi 981, Japan
REFERENCE 2
AUTHORS Sakai,J., Hoshino,A., Takahashi,S., Miura,Y., Ishii,H., Suzuki,H.,
Kawarabayasi,Y. and Yamamoto,T.
TITLE Structure,chromosome location, and expression of the human very
low density lipoprotein receptor gene
JOURNAL J. Biol. Chem. 269, 2173-2182 (1994)
COMMENT
FEATURES Location/Qualifiers
source 1..3155
/cell_line="THP-1"
/cell_type="monocytic leukemia"
/clone="phVLR1"
/db_xref="H-InvDB:HIT000100601"
/db_xref="taxon:9606"
/mol_type="mRNA"
/organism="Homo sapiens"
CDS 2..2539
/codon_start=1
/note="variant form lacking the O-linked sugar domain"
/product="very low density lipoprotein receptor"
/protein_id="BAA03946.1"
/translation="MGTSALWALWLLLALCWAPRESGATGTGRKAKCEPSQFQCTNGR
CITLLWKCDGDEDCVDGSDEKNCVKKTCAESDFVCNNGQCVPSRWKCDGDPDCEDGSD
ESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDEENCGNITCSPDEFT
CSSGRCISRNFVCNGQDDCSDGSDELDCAPPTCGAHEFQCSTSSCIPISWVCDDDADC
SDQSDESLEQCGRQPVIHTKCPASEIQCGSGECIHKKWRCDGDPDCKDGSDEVNCPSR
TCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNCKNVNQCLGPGKFKCRSGECIDI
SKVCNQEQDCRDWSDEPLKECHINECLVNNGGCSHICKDLVIGYECDCAAGFELIDRK
TCGDIDECQNPGICSQICINLKGGYKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRD
IRKIGLERKEYIQLVEQLRNTVALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKM
IDNVYNPAAIAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPL
SGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHML
SSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLV
NNLNDAQDIIVYHELVQPSGKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSCPSGY
NVEENGRDCQRINVTTAVSEVSVPPKGTSAAWAILPLLLLVMAAVGGYLMWRNWQHKN
MKSMNFDNPVYLKTTEEDLSIDIGRHSASVGHTYPAISVVSTDDDLA"
sig_peptide 2..82
mat_peptide 83..2536
/note="homologus to the low density lipoprotein
receptor,mature peptide"
/product="very low density lipoprotein receptor,variant
form lacking theO-linked sugar domain,mature peptide"
mat_peptide 83..1066
/product="ligand binding domain composed of eight
cystein-rich repeats homologusto complement factor C9"
mat_peptide 1067..2251
/product="EGF precursor homology domain with three growth
factor repeat"
mat_peptide 2309..2374
/product="transmembrane domain"
mat_peptide 2375..2536
/product="cytoplasmic domain with FDNPVY sequence"
mat_peptide 2411..2428
/product="FDNPVY sequence"
regulatory 3132..3137
/regulatory_class="polyA_signal_sequence"
BASE COUNT 899 a 673 c 777 g 806 t
ORIGIN
1 catgggcacg tccgcgctct gggcgctctg gctgctgctc gcgctgtgct gggcgccccg
61 ggagagcggc gccaccggaa ccgggagaaa agccaaatgt gaaccctccc aattccagtg
121 cacaaatggt cgctgtatta cgctgttgtg gaaatgtgat ggggatgaag actgtgttga
181 cggcagtgat gaaaagaact gtgtaaagaa gacgtgtgct gaatctgact tcgtgtgcaa
241 caatggccag tgtgttccca gccgatggaa gtgtgatgga gatcctgact gcgaagatgg
301 ttcagatgaa agcccagaac agtgccatat gagaacatgc cgcatacatg aaatcagctg
361 tggcgcccat tctactcagt gtatcccagt gtcctggaga tgtgatggtg aaaatgattg
421 tgacagtgga gaagatgaag aaaactgtgg caatataaca tgtagtcccg acgagttcac
481 ctgctccagt ggccgctgca tctccaggaa ctttgtatgc aatggccagg atgactgcag
541 cgatggcagt gatgagctgg actgtgcccc gccaacctgt ggcgcccatg agttccagtg
601 cagcacctcc tcctgcatcc ccatcagctg ggtatgcgac gatgatgcag actgctccga
661 ccaatctgat gagtccctgg agcagtgtgg ccgtcagcca gtcatacaca ccaagtgtcc
721 agccagcgaa atccagtgcg gctctggcga gtgcatccat aagaagtggc gatgtgatgg
781 ggaccctgac tgcaaggatg gcagtgatga ggtcaactgt ccctctcgaa cttgccgacc
841 tgaccaattt gaatgtgagg atggcagctg catccatggc agcaggcagt gtaatggtat
901 ccgagactgt gtcgatggtt ccgatgaagt caactgcaaa aatgtcaatc agtgcttggg
961 ccctggaaaa ttcaagtgca gaagtggaga atgcatagat atcagcaaag tatgtaacca
1021 ggagcaggac tgcagggact ggagtgatga gcccctgaaa gagtgtcata taaacgaatg
1081 cttggtaaat aatggtggat gttctcatat ctgcaaagac ctagttatag gctacgagtg
1141 tgactgtgca gctgggtttg aactgataga taggaaaacc tgtggagata ttgatgaatg
1201 ccaaaatcca ggaatctgca gtcaaatttg tatcaactta aaaggcggtt acaagtgtga
1261 atgtagtcgt ggctatcaaa tggatcttgc tactggcgtg tgcaaggcag taggcaaaga
1321 gccaagtctg atcttcacta atcgaagaga catcaggaag attggcttag agaggaaaga
1381 atatatccaa ctagttgaac agctaagaaa cactgtggct ctcgatgctg acattgctgc
1441 ccagaaacta ttctgggccg atctaagcca aaaggctatc ttcagtgcct caattgatga
1501 caaggttggt agacatgtta aaatgatcga caatgtctat aatcctgcag ccattgctgt
1561 tgattgggtg tacaagacca tctactggac tgatgcggct tctaagacta tttcagtagc
1621 taccctagat ggaaccaaga ggaagttcct gtttaactct gacttgcgag agcctgcctc
1681 catagctgtg gacccactgt ctggctttgt ttactggtca gactggggtg aaccagctaa
1741 aatagaaaaa gcaggaatga atggattcga tagacgtcca ctggtgacag cggatatcca
1801 gtggcctaac ggaattacac ttgaccttat aaaaagtcgc ctctattggc ttgattctaa
1861 gttgcacatg ttatccagcg tggacttgaa tggccaagat cgtaggatag tactaaagtc
1921 tctggagttc ctagctcatc ctcttgcact aacaatattt gaggatcgtg tctactggat
1981 agatggggaa aatgaagcag tctatggtgc caataaattc actggatcag agctagccac
2041 tctagtcaac aacctgaatg atgcccaaga catcattgtc tatcatgaac ttgtacagcc
2101 atcaggtaaa aattggtgtg aagaagacat ggagaatgga ggatgtgaat acctatgcct
2161 gccagcacca cagattaatg atcactctcc aaaatatacc tgttcctgtc ccagtgggta
2221 caatgtagag gaaaatggcc gagactgtca aaggatcaat gtgaccacag cagtatcaga
2281 ggtcagtgtt cccccaaaag ggacttctgc cgcatgggcc attcttcctc tcttgctctt
2341 agtgatggca gcagtaggtg gctacttgat gtggcggaat tggcaacaca agaacatgaa
2401 aagcatgaac tttgacaatc ctgtgtactt gaaaaccact gaagaggacc tctccataga
2461 cattggtaga cacagtgctt ctgttggaca cacgtaccca gcaatatcag ttgtaagcac
2521 agatgatgat ctagcttgac ttctgtgaca aatgttgacc tttgaggtct aaacaaataa
2581 tacccccgtc ggaatggaac cgagccagca gctgaagtct ctttttcttc ctctcggctg
2641 gaagaacatc aagatacctt tgcgtggatc aagcttgtgt acttgaccgt ttttatatta
2701 cttttgtaaa tattcttgtc cacattctac ttcagctttg gatgtggtta ccgagtatct
2761 gtaacccttg aatttctaga cagtattgcc acctctggcc aaatatgcac tttccctaga
2821 aagccatatt ccagcagtga aacttgtgct atagtgtata ccacctgtac atacattgta
2881 taggccatct gtaaatatcc cagagaacaa tcactattct taagcacttt gaaaatattt
2941 ctatgtaaat tattgtaaac tttttcaatg gttgggacaa tggcaatagg acaaaacggg
3001 ttactaagat gaaattgcca aaaaaattta taaactaatt ttgtacgtat gaatgatatc
3061 tttgacctca atggaggttt gcaaagactg agtgttcaaa ctactgtaca ttttttttca
3121 agtgctaaaa aattaaacca agcagcttaa ccatg
//