LOCUS       HUMVLDLRA               3308 bp    mRNA    linear   HUM 01-OCT-2002
DEFINITION  Homo sapiens mRNA for very low density lipoprotein receptor,
            complete cds.
ACCESSION   D16493
VERSION     D16493.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3308)
  AUTHORS   Sakai,J.
  TITLE     Direct Submission
  JOURNAL   Submitted (19-JUN-1993) to the DDBJ/EMBL/GenBank databases.
            Contact:Juro Sakai
            Tohoku University Gene Research Center; 1-1 Tsutsumidori-Amamiya,
            Aoba, Sendai, Miyagi 981, Japan
REFERENCE   2
  AUTHORS   Sakai,J., Hoshino,A., Takahashi,S., Miura,Y., Ishii,H., Suzuki,H.,
            Kawarabayasi,Y. and Yamamoto,T.
  TITLE     Structure,chromosome location, and expression of the human very
            low density lipoprotein receptor gene
  JOURNAL   J. Biol. Chem. 269, 2173-2182 (1994)
COMMENT     
FEATURES             Location/Qualifiers
     source          1..3308
                     /cell_line="THP-1"
                     /cell_type="monocytic leukemia"
                     /clone="p101, p102 and phVLR1"
                     /db_xref="H-InvDB:HIT000100600"
                     /db_xref="taxon:9606"
                     /mol_type="mRNA"
                     /organism="Homo sapiens"
     CDS             71..2692
                     /codon_start=1
                     /note="homologus to the low density lipoprotein receptor"
                     /product="very low density lipoprotein receptor"
                     /protein_id="BAA03945.1"
                     /translation="MGTSALWALWLLLALCWAPRESGATGTGRKAKCEPSQFQCTNGR
                     CITLLWKCDGDEDCVDGSDEKNCVKKTCAESDFVCNNGQCVPSRWKCDGDPDCEDGSD
                     ESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDEENCGNITCSPDEFT
                     CSSGRCISRNFVCNGQDDCSDGSDELDCAPPTCGAHEFQCSTSSCIPISWVCDDDADC
                     SDQSDESLEQCGRQPVIHTKCPASEIQCGSGECIHKKWRCDGDPDCKDGSDEVNCPSR
                     TCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNCKNVNQCLGPGKFKCRSGECIDI
                     SKVCNQEQDCRDWSDEPLKECHINECLVNNGGCSHICKDLVIGYECDCAAGFELIDRK
                     TCGDIDECQNPGICSQICINLKGGYKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRD
                     IRKIGLERKEYIQLVEQLRNTVALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKM
                     IDNVYNPAAIAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPL
                     SGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHML
                     SSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLV
                     NNLNDAQDIIVYHELVQPSGKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSCPSGY
                     NVEENGRDCQSTATTVTYSETKDTNTTEISATSGLVPGGINVTTAVSEVSVPPKGTSA
                     AWAILPLLLLVMAAVGGYLMWRNWQHKNMKSMNFDNPVYLKTTEEDLSIDIGRHSASV
                     GHTYPAISVVSTDDDLA"
     sig_peptide     71..151
     mat_peptide     152..2689
                     /note="homologus to the low density lipoprotein receptor,
                     mature peptide"
                     /product="very low density lipoprotein receptor, mature
                     peptide"
     mat_peptide     152..1135
                     /product="ligand binding domain composed of eight
                     cystein-rich repeats homologusto complement factor C9"
     mat_peptide     1136..2320
                     /product="EGF precursor homology domain with three growth
                     factor repeat"
     mat_peptide     2321..2407
                     /product="O-linked sugars domain"
     variation       2322..2405
                     /note="this region is lacking in the variant form
                     receptor"
                     /replace=""
     mat_peptide     2462..2527
                     /product="transmembrane domain"
     mat_peptide     2528..2689
                     /product="cytoplasmic domain with FDNPVY sequence"
     mat_peptide     2564..2581
                     /product="FDNPVY sequence"
     regulatory      3285..3290
                     /regulatory_class="polyA_signal_sequence"
BASE COUNT          941 a          708 c          824 g          835 t
ORIGIN      
        1 tttcggaagg gctggtaact tgttgtgcgg agcgaacggc ggcggcggcg gcaccatcca
       61 ggcgggcacc atgggcacgt ccgcgctctg ggcgctctgg ctgctgctcg cgctgtgctg
      121 ggcgccccgg gagagcggcg ccaccggaac cgggagaaaa gccaaatgtg aaccctccca
      181 attccagtgc acaaatggtc gctgtattac gctgttgtgg aaatgtgatg gggatgaaga
      241 ctgtgttgac ggcagtgatg aaaagaactg tgtaaagaag acgtgtgctg aatctgactt
      301 cgtgtgcaac aatggccagt gtgttcccag ccgatggaag tgtgatggag atcctgactg
      361 cgaagatggt tcagatgaaa gcccagaaca gtgccatatg agaacatgcc gcatacatga
      421 aatcagctgt ggcgcccatt ctactcagtg tatcccagtg tcctggagat gtgatggtga
      481 aaatgattgt gacagtggag aagatgaaga aaactgtggc aatataacat gtagtcccga
      541 cgagttcacc tgctccagtg gccgctgcat ctccaggaac tttgtatgca atggccagga
      601 tgactgcagc gatggcagtg atgagctgga ctgtgccccg ccaacctgtg gcgcccatga
      661 gttccagtgc agcacctcct cctgcatccc catcagctgg gtatgcgacg atgatgcaga
      721 ctgctccgac caatctgatg agtccctgga gcagtgtggc cgtcagccag tcatacacac
      781 caagtgtcca gccagcgaaa tccagtgcgg ctctggcgag tgcatccata agaagtggcg
      841 atgtgatggg gaccctgact gcaaggatgg cagtgatgag gtcaactgtc cctctcgaac
      901 ttgccgacct gaccaatttg aatgtgagga tggcagctgc atccatggca gcaggcagtg
      961 taatggtatc cgagactgtg tcgatggttc cgatgaagtc aactgcaaaa atgtcaatca
     1021 gtgcttgggc cctggaaaat tcaagtgcag aagtggagaa tgcatagata tcagcaaagt
     1081 atgtaaccag gagcaggact gcagggactg gagtgatgag cccctgaaag agtgtcatat
     1141 aaacgaatgc ttggtaaata atggtggatg ttctcatatc tgcaaagacc tagttatagg
     1201 ctacgagtgt gactgtgcag ctgggtttga actgatagat aggaaaacct gtggagatat
     1261 tgatgaatgc caaaatccag gaatctgcag tcaaatttgt atcaacttaa aaggcggtta
     1321 caagtgtgaa tgtagtcgtg gctatcaaat ggatcttgct actggcgtgt gcaaggcagt
     1381 aggcaaagag ccaagtctga tcttcactaa tcgaagagac atcaggaaga ttggcttaga
     1441 gaggaaagaa tatatccaac tagttgaaca gctaagaaac actgtggctc tcgatgctga
     1501 cattgctgcc cagaaactat tctgggccga tctaagccaa aaggctatct tcagtgcctc
     1561 aattgatgac aaggttggta gacatgttaa aatgatcgac aatgtctata atcctgcagc
     1621 cattgctgtt gattgggtgt acaagaccat ctactggact gatgcggctt ctaagactat
     1681 ttcagtagct accctagatg gaaccaagag gaagttcctg tttaactctg acttgcgaga
     1741 gcctgcctcc atagctgtgg acccactgtc tggctttgtt tactggtcag actggggtga
     1801 accagctaaa atagaaaaag caggaatgaa tggattcgat agacgtccac tggtgacagc
     1861 ggatatccag tggcctaacg gaattacact tgaccttata aaaagtcgcc tctattggct
     1921 tgattctaag ttgcacatgt tatccagcgt ggacttgaat ggccaagatc gtaggatagt
     1981 actaaagtct ctggagttcc tagctcatcc tcttgcacta acaatatttg aggatcgtgt
     2041 ctactggata gatggggaaa atgaagcagt ctatggtgcc aataaattca ctggatcaga
     2101 gctagccact ctagtcaaca acctgaatga tgcccaagac atcattgtct atcatgaact
     2161 tgtacagcca tcaggtaaaa attggtgtga agaagacatg gagaatggag gatgtgaata
     2221 cctatgcctg ccagcaccac agattaatga tcactctcca aaatatacct gttcctgtcc
     2281 cagtgggtac aatgtagagg aaaatggccg agactgtcaa agtactgcaa ctactgtgac
     2341 ttacagtgag acaaaagata cgaacacaac agaaatttca gcaactagtg gactagttcc
     2401 tggagggatc aatgtgacca cagcagtatc agaggtcagt gttcccccaa aagggacttc
     2461 tgccgcatgg gccattcttc ctctcttgct cttagtgatg gcagcagtag gtggctactt
     2521 gatgtggcgg aattggcaac acaagaacat gaaaagcatg aactttgaca atcctgtgta
     2581 cttgaaaacc actgaagagg acctctccat agacattggt agacacagtg cttctgttgg
     2641 acacacgtac ccagcaatat cagttgtaag cacagatgat gatctagctt gacttctgtg
     2701 acaaatgttg acctttgagg tctaaacaaa taataccccc gtcggaatgg aaccgagcca
     2761 gcagctgaag tctctttttc ttcctctcgg ctggaagaac atcaagatac ctttgcgtgg
     2821 atcaagcttg tgtacttgac cgtttttata ttacttttgt aaatattctt gtccacattc
     2881 tacttcagct ttggatgtgg ttaccgagta tctgtaaccc ttgaatttct agacagtatt
     2941 gccacctctg gccaaatatg cactttccct agaaagccat attccagcag tgaaacttgt
     3001 gctatagtgt ataccacctg tacatacatt gtataggcca tctgtaaata tcccagagaa
     3061 caatcactat tcttaagcac tttgaaaata tttctatgta aattattgta aactttttca
     3121 atggttggga caatggcaat aggacaaaac gggttactaa gatgaaattg ccaaaaaaat
     3181 ttataaacta attttgtacg tatgaatgat atctttgacc tcaatggagg tttgcaaaga
     3241 ctgagtgttc aaactactgt acattttttt tcaagtgcta aaaaattaaa ccaagcagct
     3301 taaccatg
//