LOCUS HUMLYK 4366 bp mRNA linear HUM 03-FEB-1999
DEFINITION Homo sapiens mRNA for ITK, complete cds.
ACCESSION D13720
VERSION D13720.1
KEYWORDS ATP-binding; SH2 domain; SH3 domain; non-receptor type tyrosin
kinase.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4366)
AUTHORS Tanaka,N.
TITLE Direct Submission
JOURNAL Submitted (19-NOV-1992) to the DDBJ/EMBL/GenBank databases.
Contact:Nobuyuki Tanaka
Tohoku University, School of Medicine, Department of Microbiology
and Immunology; 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan
REFERENCE 2
AUTHORS Tanaka,N., Asao,H., Ohtani,K., Nakamura,M. and Sugamura,K.
TITLE A novel human tyrosine kinase gene inducible in T cells by
interleukin 2
JOURNAL FEBS Lett. 324, 1-5 (1993)
COMMENT
FEATURES Location/Qualifiers
source 1..4366
/cell_type="phytohemagglutinin(PHA)-stimulated peripheral
blood lymphocytes(PBL)"
/db_xref="H-InvDB:HIT000100512"
/db_xref="taxon:9606"
/mol_type="mRNA"
/organism="Homo sapiens"
CDS 83..1945
/codon_start=1
/note="originally named lyk"
/product="ITK"
/protein_id="BAA02873.1"
/translation="MNNFILLEEQLIKKSQQKRRTSPSNFKVRFFVLTKASLAYFEDR
HGKKRTLKGSIELSRIKCVEIVKSDISIPCHYKYPFQVVHDNYLLYVFAPDRESRQRW
VLALKEETRNNNSLVPKYHPNFWMDGKWRCCSQLEKLATGCAQYDPTKNASKKPLPPT
PEDNRRPLWEPEETVVIALYDYQTNDPQELALRRNEEYCLLDSSEIHWWRVQDRNGHE
GYVPSSYLVEKSPNNLETYEWYNKSISRDKAEKLLLDTGKEGAFMVRDSRTAGTYTVS
VFTKAVVSENNPCIKHYHIKETNDNPKRYYVAEKYVFDSIPLLINYHQHNGGGLVTRL
RYPVCFGRQKAPVTAGLRYGKWVIDPSELTFVQEIGSGQFGLVHLGYWLNKDKVAIKT
IREGAMSEEDFIEEAEVMMKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQ
RGLFAAETLLGMCLDVCEGMAYLEEACVIHRDLAARNCLVGENQVIKVSDFGMTRFVL
DDQYTSSTGTKFPVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSE
VVEDISTGFRLYKPRLASTHVYQIMNHCWKERPEDRPAFSRLLRQLAEIAESGL"
regulatory 4349..4354
/regulatory_class="polyA_signal_sequence"
polyA_site 4366
BASE COUNT 1195 a 957 c 1020 g 1193 t
ORIGIN
1 tgcattcttt gccccaaaac tctttccttt ggttgtgcta agaggtgatg cccaaggtgc
61 accacctttc aagaactgga tcatgaacaa ctttatcctc ctggaagaac agctcatcaa
121 gaaatcccaa caaaagagaa gaacttctcc ctcgaacttt aaagtccgct tcttcgtgtt
181 aaccaaagcc agcctggcat actttgaaga tcgtcatggg aagaagcgca cgctgaaggg
241 gtccattgag ctctcccgaa tcaaatgtgt tgagattgtg aaaagtgaca tcagcatccc
301 atgccactat aaatacccgt ttcaggtggt gcatgacaac tacctcctat atgtgtttgc
361 tccagatcgt gagagccggc agcgctgggt gctggccctt aaagaagaaa cgaggaataa
421 taacagtttg gtgcctaaat atcatcctaa tttctggatg gatgggaagt ggaggtgctg
481 ttctcagctg gagaagcttg caacaggctg tgcccaatat gatccaacca agaatgcttc
541 aaagaagcct cttcctccta ctcctgaaga caacaggcga ccactttggg aacctgaaga
601 aactgtggtc attgccttat atgactacca aaccaatgat cctcaggaac tcgcactgcg
661 gcgcaacgaa gagtactgcc tgctggacag ttctgagatt cactggtgga gagtccagga
721 caggaatggg catgaaggat atgtaccaag cagttatctg gtggaaaaat ctccaaataa
781 tctggaaacc tatgagtggt acaataagag tatcagccga gacaaagctg aaaaacttct
841 tttggacaca ggcaaagaag gagccttcat ggtaagggat tccaggactg caggaacata
901 caccgtgtct gttttcacca aggctgttgt aagtgagaac aatccctgta taaagcatta
961 tcacatcaag gaaacaaatg acaatcctaa gcgatactat gtggctgaaa agtatgtgtt
1021 cgattccatc cctcttctca tcaactatca ccaacataat ggaggaggcc tggtgactcg
1081 actccggtat ccagtttgtt ttgggaggca gaaagcccca gttacagcag ggctgagata
1141 cgggaaatgg gtgatcgacc cctcagagct cacttttgtg caagagattg gcagtgggca
1201 atttgggttg gtgcatctgg gctactggct caacaaggac aaggtggcta tcaaaaccat
1261 tcgggaaggg gctatgtcag aagaggactt catagaggag gctgaagtaa tgatgaaact
1321 ctctcatccc aaactggtgc agctgtatgg ggtgtgcctg gagcaggccc ccatctgcct
1381 ggtgtttgag ttcatggagc acggctgcct gtcagattat ctacgcaccc agcggggact
1441 ttttgctgca gagaccctgc tgggcatgtg tctggatgtg tgtgagggca tggcctacct
1501 ggaagaggca tgtgtcatcc acagagactt ggctgccaga aattgtttgg tgggagaaaa
1561 ccaagtcatc aaggtgtctg actttgggat gacaaggttc gttctggatg atcagtacac
1621 cagttccaca ggcaccaaat tcccggtgaa gtgggcatcc ccagaggttt tctctttcag
1681 tcgctatagc agcaagtccg atgtgtggtc atttggtgtg ctgatgtggg aagttttcag
1741 tgaaggcaaa atcccgtatg aaaaccgaag caactcagag gtggtggaag acatcagtac
1801 cggatttcgg ttgtacaagc cccggctggc ctccacacac gtctaccaga ttatgaatca
1861 ctgctggaaa gagagaccag aagatcggcc agccttctcc agactgctgc gtcaactggc
1921 tgaaattgca gaatcaggac tttagtagag actgagtacc aggccacggg ctgcagatcc
1981 tgaatggagg aaggatatgt cctcattcca tagagcatta gaagctgcca ccagcccagg
2041 accctccaga ggcagcctgg cctgtggcat cagtccctga gtcaccatgg aagcagcatc
2101 ctgaccacag ctggcagtca agccacagct ggagggtcag ccaccaagct gggagctgag
2161 ccagaacagg agtgatgtct ctgcccttcc tctagcctct tgtcacatgt ggtgcacaaa
2221 cctcaacctg acagctttca gacagcattc ttgcacttct tagcaacaga gagagacatg
2281 agtaagaccc agattgctat ttttattgtt atttttaaca tgaatctaaa gnttatggtt
2341 ccagggactt tttatttgac ccaacaacac agtatcccag gatatggagg caaggggaac
2401 aaagagcatg agtctttttc caagaaaact ggtgagttaa gtaagattag agtgagtgtg
2461 ctctgttgct gtgatgctgt cagccacagc ttcctgccgt agagaatgat agagcagctg
2521 ctcacacagg aggccggata ttctgagaag cagctttatg aggttttaca gagtatgctg
2581 ctacctctct ccttgaaggg agcatggcga gacccattgg atggattggg gtgaacagtt
2641 caggtcccat gcttggagca ttgggtatct gatgtctgca ccagaacaag agaacctctg
2701 acggtggaga accatgtggt gcaagaagag atcttaggtc tcttctttta taccaagctc
2761 atcttttata ccaagctgtg caggtgacta tgcctcctct tctgcacaga atgcttccac
2821 cagcatcctg agaagaaatg attacttctg aaaaacatcc ttttttccag cctctgggaa
2881 tcagcccccc ctctctgcac tatccgatcc tcatcaacag agggcagcat tgtgttggtc
2941 aatgttccct tggcgagcaa ttgaaacttg tttaggccct agggttgagc aattttaagg
3001 ttgagactcc aagtctccta aaattctagg agagaaataa agagtctgtt tttgctcaaa
3061 ccatcaggat ggaaacagtc aggcactgac tggggtgctt ccaagaggca tgagagtgcc
3121 tactctggct tgagcacttc tatatgcaag gtgaatatgt actgagctag gagacttccc
3181 tgcaaaatct ctgttcaccc tgggttcaca tccccatgag gtaatattat tattcccatt
3241 ttacaaataa tgtaactgag gctttaaaaa gccaagacat ctgcccaaag tgatggaact
3301 agaaagtcta gagctggtat tctagcccaa atctgtctga ccgcaataca cagattcttt
3361 attcctattc gacactggct tctactgaaa atgaaacgga ttgcagaggg aataaataca
3421 aagatggaaa gccagtaaag aagtcagtat agaaccacta gcgaatagtg ttgctctggc
3481 acagaccact gtggttgatg gcatggccct ccaacttgga ataggatttt ccttttccta
3541 ttctgtatcc ttaccttggt catgttaatg actttggagt tattcagtta atgacccttt
3601 aattctcaca accaaccagt catgttgctt gaagccattt atagacgagc ttcaaagcaa
3661 ctttaaaaga ttcttctgta gaagtatgag ttcttccttt aattatcatt ccaactttca
3721 gctgtagtct tcttgaacac ttcatgagga gggacattcc ctgatataag agaggatggt
3781 gttgcaattg gctctttcta aatcatgtga cgttttgact ggcttgagat tcagatgcat
3841 aatttttaat tataattatt gtgaagtgga gagcctcaag ataaaactct gtcattcaga
3901 agatgatttt actcagctta tccaaaatta tctctgttta ctttttagaa ttttgtacat
3961 tatcttttgg gatccttaat tagagatgat ttctggaaca ttcagtctag aaagaaaaca
4021 ttggaattga ctgatctctg tggtttggtt tagaaaattc ccctgtgcat ggtattacct
4081 ttttcaagct cagattcatc taatcctcaa ctgtacatgt gtacattctt cacctcctgg
4141 tgccctatcc cgcaaaatgg gcttcctgcc tggtttttct cttctcacat tttttaaatg
4201 gtcccctgtg tttgtagaga actcccttat acagagtttt ggttctagtt ttatttcgta
4261 gattttgcat tttgtacctt ttgagactat gtatttatat ttggatcaga tgcatattta
4321 ttaatgtaca gtcactgcta gtgttcaaaa taaaaatgtt acaaat
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