LOCUS HUMELAFIN 1878 bp DNA linear HUM 21-JUL-2005
DEFINITION Homo sapiens gene for elafin, complete cds.
ACCESSION D13156
VERSION D13156.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1878)
AUTHORS Hirose,S.
TITLE Direct Submission
JOURNAL Submitted (01-SEP-1992) to the DDBJ/EMBL/GenBank databases.
Contact:Shigehisa Hirose
Tokyo Institute of Technology, Department of Biological Sciences;
Ookayama, Meguro-ku, Tokyo 152, Japan
REFERENCE 2
AUTHORS Saheki,T., Ito,F., Hagiwara,H., Saito,Y., Kuroki,J., Tachibana,S.
and Hirose,S.
TITLE Primary structure of the human elafin precursor preproelafin
deduced from the nucleotide sequence of its gene and the presence
of unique repetitive sequences in the prosegment
JOURNAL Biochem. Biophys. Res. Commun. 185, 240-245 (1992)
COMMENT
FEATURES Location/Qualifiers
source 1..1878
/clone="lambda hI-G1"
/clone_lib="lambda EMBL"
/db_xref="taxon:9606"
/mol_type="genomic DNA"
/organism="Homo sapiens"
regulatory 127..130
/regulatory_class="CAAT_signal"
regulatory 153..158
/regulatory_class="TATA_box"
exon <181..325
/number=1
CDS join(247..325,1185..1459)
/codon_start=1
/note="elastase inhibitor"
/product="preproelafin"
/protein_id="BAA02441.1"
/translation="MRASSFLIVVVFLIAGTLVLEAAVTGVPVKGQDTVKGRVPFNGQ
DPVKGQVSVKGQDKVKAQEPVKGPVSTKPGSCPIILIRCAMLNPPNRCLKDTDCPGIK
KCCEGSCGMACFVPQ"
sig_peptide 247..324
mat_peptide join(325,1185..1285)
/note="pro-sequence"
exon 1185..1460
/number=2
mat_peptide 1286..1456
/product="elafin"
exon 1695..1852
/number=3
regulatory 1847..1852
/regulatory_class="polyA_signal_sequence"
BASE COUNT 473 a 464 c 491 g 450 t
ORIGIN
1 ctgtgagaaa gtaggaaaac tcttgggaca atcagagatg atgtgatgta atgtccatta
61 gttcttcctg tgaataatcc tgagggaaag cccccaggtc cctcccagaa tggggtggat
121 atttcccaat acagctaagg aattatccct tgtaaatacc acagacccgc ccctggagcc
181 aggccaagct ggactgcata aagattggta tggccttagc tcttagccaa acaccttcct
241 gacaccatga gggccagcag cttcttgatc gtggtggtgt tcctcatcgc tgggacgctg
301 gttctagagg cagctgtcac gggaggtgag tgaacaggtg acctgctggg ctgggttgga
361 ctaaggggag accctctggg acaccctggg ccaggacagg gagcactact gaagcagtag
421 gcagcactgg agcccagatt tcagctttct gttctttgcc atcatattca gaaaaaatag
481 gactttggct ggtggactcc acgtgctttc cacctcagtg actgagatat caggactgtt
541 tgtggaagta atgttggtat gtggccttgg cctcagatgt caatacctgt gcagaatgtg
601 caataaaata atgaactcca ggattttaaa ccttgggtgt ggacacagtc ccccgtttct
661 ctgccccata aaagcactgg agtaatcagt actctaaaag gaggttaaga aacaacaagc
721 cttcaggaat catgttgttt gaggaccccc attttataag gagggaacca aaaatgtaga
781 aatgagtgag caattgccaa ggtaattccc agagccagga tggggctcaa gtctcctagt
841 atgtggctca gggttctttc ctactccaat gcacttccta acaaatgaca atgtgtcctc
901 ttcactgctg ggtgtcaccc cagtctgacc actgctcctg agagacttgg agtggaggaa
961 gggggaagaa acaaatactc aagggaactc tggtcctgta gaccacccca aaaaaggaag
1021 agccttccaa gagtgtagct cccagaggtg taccttccct actcaggcca tggtttgagg
1081 atgctgcagt aagcagtgga tggacccaga cccagaggaa agacatggca gctgaagcag
1141 aggcttactg ggtataaatg tgggctcgtt tcttctttta acagttcctg ttaaaggtca
1201 agacactgtc aaaggccgtg ttccattcaa tggacaagat cccgttaaag gacaagtttc
1261 agttaaaggt caagataaag tcaaagcgca agagccagtc aaaggtccag tctccactaa
1321 gcctggctcc tgccccatta tcttgatccg gtgcgccatg ttgaatcccc ctaaccgctg
1381 cttgaaagat actgactgcc caggaatcaa gaagtgctgt gaaggctctt gcgggatggc
1441 ctgtttcgtt ccccagtgag gtgagcacta gctggagaac gaggagaccc ctgaagacac
1501 aaaagaaggc tgagcggtgg ggaagcatcc caggttggtg ggagggaggt tgtgggaggt
1561 gacagaaaga ctgggagagc tgaggggtct gagaggctat aaccagagtg cctagaagga
1621 tgatctgtct tcctcactgc ctctgagtgc tttgatgtgc tgactctcac ctctgatact
1681 cttctcttcc acagagggag ccggtccttg ctgcacctgt gccgtcccca gagctacagg
1741 ccccatctgg tcctaagtcc ctgctgccct tccccttccc acactgtcca ttcttcctcc
1801 cattcaggat gcccacggct ggagctgcct ctctcatcca ctttccaata aagagttcct
1861 tctgctccac ttgtttct
//