LOCUS       HUMSPM                  1929 bp    mRNA    linear   HUM 01-FEB-2000
DEFINITION  Homo sapiens mRNA for major structural protein of myelin, complete
            cds.
ACCESSION   D10537 D90501
VERSION     D10537.1
KEYWORDS    glycoprotein; transmembrane protein.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1929)
  AUTHORS   Hayasaka,K.
  TITLE     Direct Submission
  JOURNAL   Submitted (13-SEP-1991) to the DDBJ/EMBL/GenBank databases.
            Contact:Kiyoshi Hayasaka
            Yamagata University School of Medicine, Department of Pediatrics;
            2-2-2 Iida Nishi, Yamagata, Yamagata 990-23, Japan
REFERENCE   2
  AUTHORS   Hayasaka,K., Nanao,K., Tahara,M., Sato,W., Takada,G., Miura,M. and
            Uyemura,K.
  TITLE     Isolation and sequence determination of cDNA encoding the major
            structural protein of human peripheral myelin
  JOURNAL   Biochem. Biophys. Res. Commun. 180, 515-518 (1991)
REFERENCE   3
  AUTHORS   Hayasaka,K., Ohnishi,A., Takada,G., Fukushima,Y. and Murai,Y.
  TITLE     Mutation of the myelin Po gene in Charcot-Marie-tooth neuropathy
            type 1
  JOURNAL   Cell. Mol. Biol. Res. 194, 1317-1322 (1993)
REFERENCE   4
  AUTHORS   Hayasaka,K., Himoro,M., Wang,Y., Takata,M., Minoshima,S.,
            Shimizu,N., Miura,M., Uyemura,K. and Takada,G.
  TITLE     Structure and chromosomal localization of the gene encoding the
            human myelin protein zero (MPZ)
  JOURNAL   Genomics 17, 755-758 (1993)
REFERENCE   5
  AUTHORS   Hayasaka,K., Takada,G. and Lonasescu,V.V.
  TITLE     Mutation of the myelin Po gene in Charcot-Marie-Tooth neuropathy
            type 1B
  JOURNAL   Hum. Mol. Genet. 9, 1369-1372 (1993)
REFERENCE   6
  AUTHORS   Hayasaka,K., Himoro,M., Sawaishi,Y., Nanao,K., Takahashi,T.,
            Takada,G., Nicholson,G.A., Ouvirier,R.A. and Tachi,N.
  TITLE     De novo mutation of the myelin Po gene in Dejerine-Sottas disease
            (hereditary motor and sensory neuropathy type III)
  JOURNAL   Nat. Genet. 5, 266-268 (1993)
COMMENT     
FEATURES             Location/Qualifiers
     source          1..1929
                     /clone="N7t"
                     /clone_lib="lamda gt11"
                     /db_xref="H-InvDB:HIT000100431"
                     /db_xref="taxon:9606"
                     /dev_stage="fetus"
                     /mol_type="mRNA"
                     /organism="Homo sapiens"
                     /tissue_type="spinal cord"
     CDS             44..790
                     /codon_start=1
                     /product="major structural protein of myelin"
                     /protein_id="BAA01395.1"
                     /translation="MAPGAPSSSPSPILAVLLFSSLVLSPAQAIVVYTDREVHGAVGS
                     RVTLHCSFWSSEWVSDDISFTWRYQPEGGRDAISIFHYAKGQPYIDEVGTFKERIQWV
                     GDPRWKDGSIVIHNLDYSDNGTFTCDVKNPPDIVGKTSQVTLYVFEKVPTRYGVVLGA
                     VIGGVLGVVLLLLLLFYVVRYCWLRRQAALQRRLSAMEKGKLHKPGKDASKRGRQTPV
                     LYAMLDHSRSTKAVSEKKAKGLGESRKDKK"
     sig_peptide     44..130
     mat_peptide     131..787
                     /product="major structural protein of myelin"
     polyA_site      1929
BASE COUNT          414 a          569 c          512 g          434 t
ORIGIN      
        1 ctcaacccca cagatgctcc gggcccctgc ccctgcccca gctatggctc ctggggctcc
       61 ctcatccagc cccagcccta tcctggctgt gctgctcttc tcttctttgg tgctgtcccc
      121 ggcccaggcc atcgtggttt acaccgacag ggaggtccat ggtgctgtgg gctcccgggt
      181 gaccctgcac tgctccttct ggtccagtga gtgggtctca gatgacatct ccttcacctg
      241 gcgctaccag cccgaaggag gcagagatgc catttcgatc ttccactatg ccaagggaca
      301 accctacatt gacgaggtgg ggaccttcaa agagcgcatc cagtgggtag gggaccctcg
      361 ctggaaggat ggctccattg tcatacacaa cctagactac agtgacaatg gcacgttcac
      421 ttgtgacgtc aaaaaccctc cagacatagt gggcaagacc tctcaggtca cgctgtatgt
      481 ctttgaaaaa gtgccaacta ggtacggggt cgttctggga gctgtgatcg ggggtgtcct
      541 cggggtggtg ctgttgctgc tgctgctttt ctacgtggtt cggtactgct ggctacgcag
      601 gcaggcggcc ctgcagagga ggctcagtgc tatggagaag gggaaattgc acaagccagg
      661 aaaggacgcg tcgaagcgcg ggcggcagac gccagtgctg tatgcaatgc tggaccacag
      721 cagaagcacc aaagctgtca gtgagaagaa ggccaagggg ctgggggagt ctcgcaagga
      781 taagaaatag cggttagcgg gccgggcggg ggatcggggg ttaggggtgg agtccgccaa
      841 aggcccaaag gtgatggtca tcgagatgga gctacgaaag gatgagcaga gcccggagct
      901 ccggcctgct gtcaagtccc ccagcagaac cagcctcaaa aacgccctca agaacatgat
      961 gggcctgaac tcggacaagt gatcgccacc cccccacccc aggccctgcc agagcagggg
     1021 gacctaggct cctcttaccc ccgtctaggt gctttccctc tttgctcccc cgccctgccc
     1081 tgccctcacc tccctttgag acgtaagttt cattccagaa ttcattcccc aggcaattgt
     1141 attctccccc accttcaccc ctggctttct gggagcccag gagctaatcc tacccctcac
     1201 ctgccccggg ggctgtgtgt ttggtgcctg tccacctgag cactgagaag aaagggactt
     1261 tgataccctc tgcctcaagt ccaggccacc tggcattccc atctcctgca tcccccagcc
     1321 tgtccccctg gctgtttcct ctcccgtccc tccctcccct ctaccaggtg gcccagctcc
     1381 atactctgtc cccccagcta atacccagag cacccagatc agactctcct tcagggttta
     1441 tttaggttat tattttttat tttttaatcc attctttgtt tgtttacctg tgctcatcct
     1501 ctgcccttac acccatgact gaggaccaat gacgtcatgt ggcttttgca attcacgccc
     1561 cccttaagtc cttaatgaag agccagccca agtagagggg cccctgatcc tcacacttca
     1621 gtatagcatt ggttccccct gaccactttg gagcactgtt ctgggactcc aggtcttgag
     1681 gagagagaca gagagagaga atggatcctc ataggtcagg gagtggggga gggggcaaat
     1741 gagccttaag aaatggtttt taaacaacca aacaaaaagc aggaaaaaca aatgggaaat
     1801 gggggggcgg gggggaggaa gaggctgcac tgcagccaca ggggattctt aggatttttc
     1861 tacattctgt atatttcttc tcaaacctcc aaatgtcctt aaatgtttaa taaacactga
     1921 catttccag
//