LOCUS       HUM2OGDH                4122 bp    mRNA    linear   HUM 27-SEP-2007
DEFINITION  Homo sapiens mRNA for 2-oxoglutarate dehydrogenase, complete cds.
ACCESSION   D10523 D90499
VERSION     D10523.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4122)
  AUTHORS   Koike,K.
  TITLE     Direct Submission
  JOURNAL   Submitted (11-SEP-1991) to the DDBJ/EMBL/GenBank databases.
            Contact:Kichiko Koike
            Atomic Disease Institute, Nagasaki Univ. School of Medicine,
            Department of Pathological Biochemistry; Sakamoto 1-12-4,
            Nagasaki, Nagasaki 852, Japan
REFERENCE   2
  AUTHORS   Koike,K., Urata,Y. and Goto,S.
  TITLE     Cloning and nucleotide sequence of the cDNA encoding human
            2-oxoglutarate dehydrogenase (lipoamide)
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 89, 1963-1967 (1992)
REFERENCE   3
  AUTHORS   Koike,K.
  TITLE     Human mRNA for 2-oxoglutarate dehydrogenase, complete cds.
  JOURNAL   Unpublished (1994)
REFERENCE   4
  AUTHORS   Koike,K.
  TITLE     The gene encoding human 2-oxoglutarate dehydrogenase: structural
            organization and mapping to chromosome 7p13-p14
  JOURNAL   Gene 159, 261-266 (1995)
COMMENT     
FEATURES             Location/Qualifiers
     source          1..4122
                     /clone_lib="lamda gt11"
                     /db_xref="H-InvDB:HIT000100430"
                     /db_xref="taxon:9606"
                     /mol_type="mRNA"
                     /organism="Homo sapiens"
     3'UTR           1..57
     misc_difference 39
                     /citation=[2]
                     /replace="g"
     CDS             58..3066
                     /codon_start=1
                     /product="2-oxoglutarate dehydrogenase precursor"
                     /protein_id="BAA01393.1"
                     /translation="MFHLRTCAAKLRPLTASQTVKTFSQNRPAAARTFQQIRCYSAPV
                     AAEPFLSGTSSNYVEEMYCAWLENPKSVHKSWDIFFRNTNAGAPPGTAYQSPLPLSRG
                     SLAAVAHAQSLVEAQPNVDKLVEDHLAVQSLIRAYQIRGHHVAQLDPLGILDADLDSS
                     VPADIISSTDKLGFYGLDESDLDKVFHLPTTTFIGGQESALPLREIIRRLEMAYCQHI
                     GVEFMFINDLEQCQWIRQKFETPGIMQFTNEEKRTLLARLVRSTRFEEFLQRKWSSEK
                     RFGLEGCEVLIPALKTIIDKSSENGVDYVIMGMPHRGRLNVLANVIRKELEQIFCQFD
                     SKLEAADEGSGDVKYHLGMYHRRINRVTDRNITLSLVANPSHLEAADPVVMGKTKAEQ
                     FYCGDTEGKKVMSILLHGDAAFAGQGIVYETFHLSDLPSYTTHGTVHVVVNNQIGFTT
                     DPRMARSSPYPTDVARVVNAPIFHVNSDDPEAVMYVCKVAAEWRSTFHKDVVVDLVCY
                     RRNGHNEMDEPMFTQPLMYKQIRKQKPVLQKYAELLVSQGVVNQPEYEEEISKYDKIC
                     EEAFARSKDEKILHIKHWLDSPWPGFFTLDGQPRSMSCPSTGLTEDILTHIGNVASSV
                     PVENFTIHGGLSRILKTRGEMVKNRTVDWALAEYMAFGSLLKEGIHIRLSGQDVERGT
                     FSHRHHVLHDQNVDKRTCIPMNHLWPNQAPYTVCNSSLSEYGVLGFEAGLRMASPNAL
                     VLWEAQFGDFHNTAQCIIDQFICPGQAKWVRQNGIVLLLPHGMEGMGPEHSSARPERF
                     LQMCNDDPDVLPDLKEANFDINQLYDCNWVVVNCSTPGNFFHVLRRQILLPFRKPLII
                     FTPKSLLRHPEARSSFDEMLPGTHFQRVIPEDGPAAQNPENVKRLLFCTGKVYYDLTR
                     ERKARDMVGQVAITRIEQLSPFPFDLLLKEVQKYPNAELAWCQEEHKNQGYYDYVKPR
                     LRTTISRAKPVWYAGRNPAAAPATGNKKTH"
     sig_peptide     58..177
     mat_peptide     178..3063
                     /EC_number="1.2.4.2"
                     /product="2-oxoglutarate dehydrogenase"
     misc_difference 322
                     /citation=[2]
                     /replace=""
     misc_difference 325
                     /citation=[2]
                     /replace=""
     misc_difference 332
                     /citation=[2]
                     /replace=""
     misc_difference 350
                     /citation=[2]
                     /replace=""
     misc_difference 538..540
                     /citation=[2]
                     /replace="tgc"
     misc_difference 627
                     /citation=[2]
                     /replace="c"
     misc_difference 1087
                     /citation=[2]
                     /replace="g"
     misc_difference 1149
                     /citation=[2]
                     /replace="c"
     misc_difference 2247
                     /citation=[2]
                     /replace="a"
     misc_difference 2403..2404
                     /citation=[2]
                     /replace="ta"
     misc_difference 2440
                     /citation=[2]
                     /replace="g"
     misc_difference 2452
                     /citation=[2]
                     /replace="g"
     misc_difference 2779
                     /citation=[2]
                     /replace="g"
     misc_difference 2857..2858
                     /citation=[2]
                     /replace="cg"
     misc_difference 3026
                     /citation=[2]
                     /replace="g"
     misc_difference 3044..3045
                     /citation=[2]
                     /replace="cg"
     5'UTR           3067..4122
     misc_difference 3152..3153
                     /citation=[2]
                     /replace=""
     misc_difference 3209
                     /citation=[2]
                     /replace="t"
     misc_difference 3231..3232
                     /citation=[2]
                     /replace="cc"
     misc_difference 3425
                     /citation=[2]
                     /replace="c"
     misc_difference 3435
                     /citation=[2]
                     /replace="a"
     misc_difference 3590..3595
                     /citation=[2]
                     /replace="ggagtc"
     misc_difference 3620..3623
                     /citation=[2]
                     /replace="ggag"
     misc_difference 3663
                     /citation=[2]
                     /replace="a"
     misc_difference 3671
                     /citation=[2]
                     /replace="g"
     misc_difference 3674
                     /citation=[2]
                     /replace="g"
     misc_difference 3688..3689
                     /citation=[2]
                     /replace="tg"
     misc_difference 3710
                     /citation=[2]
                     /replace="a"
     misc_difference 4066
                     /citation=[2]
                     /replace=""
     misc_difference 4078..4089
                     /citation=[2]
                     /replace=""
     polyA_site      4122
BASE COUNT          895 a         1196 c         1142 g          889 t
ORIGIN      
        1 cgggttcggg tggagctgag ccggagacag gcaattgtga aaaacttcag gacaaaaatg
       61 tttcatttaa ggacttgtgc tgctaagttg aggccattga cggcttccca gactgttaag
      121 acattttcac aaaacagacc agcagcagct aggacatttc aacagattcg gtgctattct
      181 gcacctgttg ctgctgagcc ctttctcagt gggactagtt cgaactatgt ggaggagatg
      241 tactgtgctt ggctggaaaa ccccaaaagt gtacataagt catgggacat tttttttcgc
      301 aacacgaatg ccggagcccc accgggcact gcctaccaga gtccccttcc cctgagccga
      361 ggctccctgg ctgctgtggc ccatgcacag tccctggtag aagcacagcc caacgtggac
      421 aagctcgtgg aggaccacct ggcagtgcag tcactcatca gggcatatca gatacgaggg
      481 caccatgtag cacagctgga ccccctgggg attttggatg ctgatctgga ctcctccgtg
      541 cccgctgaca ttatctcatc cacagacaaa cttgggttct atggcctgga tgagtctgac
      601 ctcgacaagg tcttccactt gcccaccacc actttcatcg ggggacagga atcagcactt
      661 cctctgcggg agatcatccg tcggctggag atggcctact gccagcatat tggggtggag
      721 ttcatgttca tcaatgacct ggagcagtgc cagtggatcc ggcagaagtt tgagacccct
      781 gggatcatgc agttcacaaa tgaggagaaa cggaccctgc tggccaggct tgtgcggtcc
      841 accaggtttg aggagttcct acagcggaag tggtcctctg agaagcgctt tggtctagaa
      901 ggctgcgagg tactgatccc tgccctcaag accatcattg acaagtctag tgagaatggc
      961 gtggactacg tgatcatggg catgccacac agagggcggc tgaacgtgct tgcaaatgtc
     1021 atcaggaagg agctggaaca gatcttctgt caattcgatt caaagctgga ggcagctgat
     1081 gagggctccg gagatgtgaa gtaccacctg ggcatgtatc accgcaggat caatcgtgtc
     1141 accgacagga acattacctt gtccttggtg gccaaccctt cccaccttga ggccgctgac
     1201 cccgtggtga tgggcaagac caaagccgaa cagttttact gtggcgacac tgaagggaaa
     1261 aaggtcatgt ccatcctgtt gcatggggat gctgcatttg ctggccaggg cattgtgtac
     1321 gagaccttcc acctcagcga cctgccatcc tacacaactc atggcaccgt gcacgtggtc
     1381 gtcaacaacc agatcggctt caccaccgac cctcggatgg cccgctcctc cccctacccc
     1441 actgacgtgg cccgagtggt gaatgccccc attttccacg tgaactcaga tgaccccgag
     1501 gctgtcatgt acgtgtgcaa agtggcggcc gagtggagga gcaccttcca caaggacgtg
     1561 gttgtcgatt tggtgtgtta ccggcgcaac ggccacaacg agatggatga gcccatgttc
     1621 acgcagccgc tcatgtacaa gcagatccgc aagcagaagc ctgtgttaca gaagtacgct
     1681 gagctgctgg tgtcgcaggg tgtggtcaac cagcctgagt atgaggagga aatttccaag
     1741 tatgataaga tctgtgagga agcttttgcc agatctaaag atgagaagat cttgcacatt
     1801 aagcactggc tggactctcc ctggcctggc ttcttcaccc tggacgggca gcccaggagc
     1861 atgtcctgcc cctccacggg tctgacggag gatattctga cacacatcgg gaatgtggct
     1921 agttctgtgc ctgtggaaaa ctttactatt catggagggc tgagccggat cttgaagact
     1981 cgtggggaaa tggtgaagaa ccggactgtg gactgggctc tagcggagta catggcgttt
     2041 ggctcgctcc tgaaggaggg catccacatt cggctgagcg gccaggacgt ggagcggggc
     2101 acattcagcc accgccacca tgtgctccat gaccagaatg tggacaagag aacctgcatc
     2161 cccatgaacc atctctggcc caatcaggcc ccctatactg tgtgcaacag ctcactgtct
     2221 gagtacggcg tgctgggctt tgaagctggg cttcgcatgg ccagtcctaa tgccctggtc
     2281 ctctgggaag cccaatttgg tgacttccac aacacggccc agtgtatcat cgaccagttc
     2341 atctgcccgg gacaagccaa gtgggtgcgg cagaatggca tcgtgttgct gctgccccat
     2401 ggcatggagg gcatgggtcc agaacattcc tccgcccgcc cagagcggtt cttgcagatg
     2461 tgcaacgatg acccagatgt cctgccagac cttaaagaag ccaacttcga catcaatcag
     2521 ctatatgact gcaattgggt tgttgtcaac tgctccactc ctggcaactt cttccacgtg
     2581 ctacgacgcc agatcctgct gccattccgg aagccgttaa ttatcttcac ccccaaatcc
     2641 ctgttgcgcc accccgaggc cagatccagc tttgatgaga tgcttccagg aacccacttc
     2701 cagcgggtga tcccagaaga tggccctgca gctcagaacc cagaaaatgt caaaaggctt
     2761 ctcttctgca ccggcaaagt gtattatgac ctcacccggg agcgcaaagc acgcgacatg
     2821 gtggggcagg tggccatcac aaggattgag cagctgtcgc cattcccctt tgacctcctg
     2881 ctgaaggagg tgcagaagta ccccaatgct gagctggcct ggtgccagga ggagcacaag
     2941 aaccaaggct actatgacta cgtgaagcca agacttcgga ccaccatcag ccgcgccaag
     3001 cccgtctggt atgccggccg gaacccagcg gctgctccag ccaccggcaa caagaagacc
     3061 cactgacgga gctgcagcgc ctcctggaca cggccttcga cctggacgtc ttcaagaact
     3121 tctcgtagat gctgcctagg gttgcttggg ccactgccct ctccacaccc atgactgccc
     3181 cttgcttctc aactaaagaa tagtgcctca gcgctgccca caccaccgtc ctcctcgctg
     3241 tgccaccacc cctccctctg ctctcatagg agttaggctg tcgtccccct ccagtgcttg
     3301 gctgccccac aggccacacg ctgcccaggc tctgctgact tctgagcagt tttccaggag
     3361 gccgggggga gcaggaggag gaaaggtagc ccccgaggga tgtccttggg gaggggtcag
     3421 ctctggcccc aatcctcccc accagtctca cccactagga taggaactgg gccttgtgtg
     3481 ctggcttccg ctgtcaccca gcaaggcaca ggctcctgta tttgagacta ggatagcttc
     3541 atcttgagcc tgagccttag aatctgtaga ggagcctgga gtcggatcta gccatggctg
     3601 gcagaggttt ctagggtggg ccccagccgt ggcgtgaact gaggatgacc cggggcagct
     3661 ggcaggagag agccttggcc tgacctggca cagaaagggc agcttcagtc tctgcagtgt
     3721 ccattatctg ctgttccttc gagggttcca ggctgtgtgt ggggcccaag catgccccac
     3781 ccaccctcct gggcccaggc agcacctgga gcccacagag tctgtgtgta gccaggaagc
     3841 cccgctcagg tagccaccgc cggggcactg gctgctctgt cttggtcctg ttaaccctcc
     3901 acctcctctc ttggactccc tccccacccc aaccactctt tctttctcct ttaacccaat
     3961 ggagactttc tgatgcatcg ttttctttgc tgtgccaaag caggtcagaa gagggagagg
     4021 aggggctggg ggtgaggggc caggccatgg ccaaggggcc agctgcccct catttatcac
     4081 tctgaccttc acagggacag atctgattta tttattttgg tt
//