LOCUS HUMPRSI 2075 bp mRNA linear HUM 17-JUN-1998
DEFINITION Homo sapiens mRNA for phosphoribosyl pyrophosphate synthetase
subunit I, complete cds.
ACCESSION D00860
VERSION D00860.1
KEYWORDS PRSI.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1
AUTHORS Sonoda,T., Taira,M., Ishijima,S., Ishizuka,T., Iizasa,T. and
Tatibana,M.
TITLE Complete nucleotide sequence of human phosphoribosyl pyrophosphate
synthetase subunit I (PRS I) cDNA and a comparison with human and
rat PRPS gene families
JOURNAL J. Biochem. 109, 361-364 (1991)
REFERENCE 2
AUTHORS Roessler,B.J.
TITLE Cloning of two distinct copies of human phosphoribosyl
pyrophosphate synthetase cDNA
JOURNAL Nucleic Acids Res. 18, 193 (1990)
COMMENT
FEATURES Location/Qualifiers
source 1..2075
/cell_line="MGC 1"
/clone="lambda hPRSI-5"
/db_xref="H-InvDB:HIT000100411"
/db_xref="taxon:9606"
/mol_type="mRNA"
/organism="Homo sapiens"
/tissue_type="glioblastoma"
CDS 123..1079
/codon_start=1
/EC_number="2.7.6.1"
/note="PRPSI"
/product="phosphoribosyl pyrophosphate synthetase subunit
I"
/protein_id="BAA00733.1"
/translation="MPNIKIFSGSSHQDLSQKIADRLGLELGKVVTKKFSNQETCVEI
GESVRGEDVYIVQSGCGEINDNLMELLIMINACKIASASRVTAVIPCFPYARQDKKDK
SRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPAVLKWIRENIS
EWRNCTIVSPDAGGAKRVTSIADRLNVDFALIHKERKKANEVDRMVLVGDVKDRVAIL
VDDMADTCGTICHAADKLLSAGATRVYAILTHGIFSGPAISRINNACFEAVVVTNTIP
QEDKMKHCSKIQVIDISMILAEAIRRTHNGESVSYLFSHVPL"
regulatory 2050..2055
/note="put. poly(A) signal"
/regulatory_class="polyA_signal_sequence"
BASE COUNT 521 a 450 c 515 g 589 t
ORIGIN
1 gggaatgtaa gatggcggag tagcaacgca aagcgcttgg tattgagtct gtggccgact
61 tcggttccgg tctctgcagc agccgtgatc gcttagtgga gtgcttaggg tagttggcca
121 ggatgccgaa tatcaaaatc ttcagcggca gctcccacca ggacttatct cagaaaattg
181 ctgaccgcct gggcctggag ctaggcaagg tggtgactaa gaaattcagc aaccaggaga
241 cctgtgtgga aattggtgaa agtgtacgtg gagaggatgt ctacattgtt cagagtggtt
301 gtggcgaaat caatgacaat ttaatggagc ttttgatcat gattaatgcc tgcaagattg
361 cttcagccag ccgggttact gcagtcatcc catgcttccc ttatgcccgg caggataaga
421 aagataagag ccgggcgcca atctcagcca agcttgttgc aaatatgcta tctgtagcag
481 gtgcagatca tattatcacc atggacctac atgcttctca aattcagggc ttttttgata
541 tcccagtaga caatttgtat gcagagccgg ctgtcctaaa gtggataagg gagaatatct
601 ctgagtggag gaactgcact attgtctcac ctgatgctgg tggagctaag agagtgacct
661 ccattgcaga caggctgaat gtggactttg ccttgattca caaagaacgg aagaaggcca
721 atgaagtgga ccgcatggtg cttgtgggag atgtgaagga tcgggtggcc atccttgtgg
781 atgacatggc tgacacttgt ggcacaatct gccatgcagc tgacaaactt ctctcagctg
841 gcgccaccag agtttatgcc atcttgactc atggaatctt ctccggtcct gctatttctc
901 gcatcaacaa cgcatgcttt gaggcagtag tagtcaccaa taccatacct caggaggaca
961 agatgaagca ttgctccaaa atacaggtga ttgacatctc tatgatcctt gcagaagcca
1021 tcaggagaac tcacaatgga gaatccgttt cttacctatt cagccatgtc cctttataat
1081 agagtaactt ctgaggcttt ttgagaataa aatccacccc acccttgttt ccccttggta
1141 tttgatgaca aattcagcag aagacccggc ttgctccagt gtagctttct acatcccaca
1201 tcaggtatat tagagcttat ccgaactggg gaaagacgga ttgagattaa ctgctgggac
1261 ctcctacctg cattatctca ttctggcttc cttgataatt ctgtgggcct tgcagcttta
1321 actatagctc agctgctgca agatttcaga cttttgagga tgttgtgtga gggtgtttga
1381 ctgtgactgg ggaagctcag actactttgt atgtgaatgc ttcagggttt tctttgttga
1441 gaacaactag caacaaaggc aacccatgtg tgaccagttc tccccaaggt ctatgctaaa
1501 ttatagcaag agccctgggc aaccccaaac ctagtcctgg tagctgagca ccctgtaagg
1561 caggagcagg cagctcagct tgagcagaca ttgggtgggg ggtggggggt ggttgagggg
1621 ggaggcagca cagtgcagca aatgtttctt gggaggaaga agcctgatcc atcaccatct
1681 gcttgactat gtagcttgga ttctcctttg tacctatccc tttcgatttg gctttacctt
1741 catctatctt gatcctttcc tggccaaata tcctcttggg cccaaatgaa cattgtacca
1801 tagtcttctg gaaagcaaac atgcttcctg ctatgtaatt gctaacattc atattagatg
1861 atgtgctgta gcttgatctt ccttagccta ctgccactga ggcagtaggt tttaggtggt
1921 atcgtagtgc cttttgatta atttaagtat ttaattttca tcttccttct ttggatctat
1981 ttggcctctc aaatgaactg agattcctgt taaaaaagat tgatgttatt gtctcttgta
2041 gaggaaacta ataaagtgtg tgtacctgtg tgaat
//