LOCUS       HUMELS2                  896 bp    mRNA    linear   HUM 01-FEB-2000
DEFINITION  Homo sapiens mRNA for pancreatic elastase 2 precursor, complete
            cds.
ACCESSION   D00236
VERSION     D00236.1
KEYWORDS    serine protease.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1
  AUTHORS   Shirasu,Y., Yoshida,H., Matsuki,S., Takemura,K., Ikeda,N.,
            Shimada,Y., Ozawa,T., Mikayama,T., Iijima,H., Ishida,A., Sato,Y.,
            Tamai,Y., Tanaka,J. and Ikenaga,H.
  TITLE     Molecular cloning and expression in Escherichia coli of a cDNA
            encoding human pancreatic elastase 2
  JOURNAL   J. Biochem. 102, 1555-1563 (1987)
COMMENT     The deduced amino acid sequence contains a 16-amino-acid peptide
            identical with the N-terminal sequence determined for native human
            pancreatic proelastase 2.  An activation peptide is located at
            positions 53 to 88.
FEATURES             Location/Qualifiers
     source          1..896
                     /clone="pHEL2"
                     /db_xref="H-InvDB:HIT000100394"
                     /db_xref="taxon:9606"
                     /mol_type="mRNA"
                     /organism="Homo sapiens"
                     /tissue_type="pancreas"
     CDS             5..814
                     /codon_start=1
                     /product="pancreatic elastase 2 precursor"
                     /protein_id="BAA00165.1"
                     /translation="MIRTLLLSTLVAGALSCGDPTYPPYVTRVVGGEEARPNSWPWQV
                     SLQYSSNGKWYHTCGGSLIANSWVLTAAHCISSSRTYRVGLGRHNLYVAESGSLAVSV
                     SKIVVHKDWNSNQISKGNDIALLKLANPVSLTDKIQLACLPPAGTILPNNYPCYVTGW
                     GRLQTNGAVPDVLQQGRLLVVDYATCSSSAWWGSSVKTSMIVAGGDGVISSCNGDSGG
                     PLNCQASDGRWQVHGIVSFGSRLGCNYYHKPSVFTRVSNYIDWINSVIANN"
     sig_peptide     5..52
     mat_peptide     89..811
                     /product="pancreatic elastase 2"
     regulatory      869..874
                     /regulatory_class="polyA_signal_sequence"
BASE COUNT          193 a          270 c          251 g          182 t
ORIGIN      
        1 caccatgata aggacgctgc tgctgtccac tttggtggct ggagccctca gttgtgggga
       61 ccccacttac ccaccttatg tgactagggt ggttggcggt gaagaagcga ggcccaacag
      121 ctggccctgg caggtctccc tgcagtacag ctccaatggc aagtggtacc acacctgcgg
      181 agggtccctg atagccaaca gctgggtcct gacggctgcc cactgcatca gctcctccag
      241 gacctaccgc gtggggctgg gccggcacaa cctctacgtt gcggagtccg gctcgctggc
      301 agtcagtgtc tctaagattg tggtgcacaa ggactggaac tccaaccaaa tctccaaagg
      361 gaacgacatt gccctgctca aactggctaa ccccgtctcc ctcaccgaca agatccagct
      421 ggcctgcctc cctcctgccg gcaccattct acccaacaac tacccctgct acgtcacggg
      481 ctggggaagg ctgcagacca acggggctgt tcctgatgtc ctgcagcagg gccggttgct
      541 ggttgtggac tatgccacct gctccagctc tgcctggtgg ggcagcagcg tgaaaaccag
      601 tatgatcgtg gctgggggtg atggcgtgat ctccagctgc aacggagact ctggcgggcc
      661 actgaactgt caggcgtctg acggccggtg gcaggtgcac ggcatcgtca gcttcgggtc
      721 tcgcctcggc tgcaactact accacaagcc ctccgtcttc acgcgggtct ccaattacat
      781 cgactggatc aattcggtga ttgcaaataa ctaaccaaaa gaagtccctg ggactgtttc
      841 agacttggaa aggtcacaga aggaaataat ataataaagt gacaactatg caaatc
//