LOCUS HUMNKATPA 4108 bp mRNA linear HUM 11-MAR-1998 DEFINITION Homo sapiens mRNA for Na,K-ATPase alpha-subunit, complete cds. ACCESSION D00099 VERSION D00099.1 KEYWORDS Na,K-ATPase; alpha-subunit. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 AUTHORS Kawakami,K., Ohta,T., Nojima,H. and Nagano,K. TITLE Primary structure of the alpha-subunit of human Na,K-ATPase deduced from cDNA sequence JOURNAL J. Biochem. 100, 389-397 (1986) COMMENT The alpha-subunit of the human Na,K-ATPase exhibited 87% homology with its Torpedo counterpart and 98% homology with its sheep counterpart. FEATURES Location/Qualifiers source 1..4108 /cell_line="Hela cell" /clone="pHNKA3, pHNKA21, and pHNKA54" /clone_lib="cDNA library in lambda-gt11, a gift from Dr. P. Nielsen" /db_xref="taxon:9606" /mol_type="mRNA" /organism="Homo sapiens" CDS 319..3390 /codon_start=1 /product="Na,K-ATPase alpha-subunit" /protein_id="BAA00061.1" /translation="MGKGVGRDKYEPAAVSEQGDKKGKKGKKDRDMDELKKEVSMDDH KLSLDELHRKYGTDLSRGLTSARAAEILARDGPNALTPPPTTPEWIKFCRQLFGGFSM LLWIGAILCFLAYSIQAATEEEPQNDNLYLGVVLSAVVIITGCFSYYQEAKSSKIMES FKNMVPQQALVIRNGEKMSINAEEVVVGDLVEVKGGDRIPADLRIISANGCKVDNSSL TGESEPQTRSPDFTNENPLETRNIAFFSTNCVEGTARGIVVYTGDRTVMGRIATLASG LEGGQTPIAAEIEHFIHIITGVAVFLGVSFFILSLILEYTWLEAVIFLIGIIVANVPE GLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMW FDNQIHEADTTENQSGVSFDKTSATWLALSRIAGLCNRAVFQANQENLPILKRAVAGD ASESALLKCIELCCGSVKEMRERYAKIVEIPFNSTNKYQLSIHKNPNTSEPQHLLVMK GAPERILDRCSSILLHGKEQPLDEELKDAFQNAYLELGGLGERVLGFCHLFLPDEQFP EGFQFDTDDVNFPIDNLCFVGLISMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITA KAIAKGVGIISEGNETVEDIAARLNIPVSQVNPRDAKACVVHGSDLKDMTSEQLDDIL KYHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIAGSD VSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLIFIIANI PLPLGTVTILCIDLGTDMVPAISLAYEQAESDIMKRQPRNPKTDKLVNERLISMAYGQ IGMIQALGGFFTYFVILAENGFLPIHLLGLRVDWDDRWINDVEDSYGQQWTYEQRKIV EFTCHTAFFVSIVVVQWADLVICKTRRNSVFQQGMKNKILIFGLFEETALAAFLSYCP GMGVALRMYPLKPTWWFCAFPYSLLIFVYDEVRKLIIRRRPGGWVEKETYY" regulatory 3696..3701 /note="putative" /regulatory_class="polyA_signal_sequence" BASE COUNT 1048 a 1019 c 1036 g 1005 t ORIGIN 1 gaattcttaa gtctaaggga cttgctcctg atcttcctga agatctctac catttaatta 61 agaaagcagt tgctgttcga aagcatcttg agaggaacgg acacgtggca acagcggtac 121 gagcccgggc ggcggcagca acagcggcgg cggcatcggc ccgagccgcg gcccgctccc 181 accctcccgc cccgcggcag ccctagctcc ctccacttgg ctcccctggt cccgctcgct 241 cggccgggag ctgctctgtg cttttctctc tgattctcca gcgacaggac ccggcgccgg 301 gcactgagca ccgccaccat ggggaagggg gttggacgtg ataagtatga gcctgcagct 361 gtttcagaac aaggtgataa aaagggcaaa aagggcaaaa aagacaggga catggatgaa 421 ctgaagaaag aagtttctat ggatgatcat aaacttagcc ttgatgaact tcatcgtaaa 481 tatggaacag acttgagccg gggattaaca tctgctcgtg cagctgagat cctggcgcga 541 gatggtccca acgccctcac tccccctccc actactcctg aatggatcaa gttttgtcgg 601 cagctctttg gggggttctc aatgttactg tggattggag cgattctttg tttcttggct 661 tatagcatcc aagctgctac agaagaggaa cctcaaaacg ataatctgta cctgggtgtg 721 gtgctatcag ccgttgtaat cataactggt tgcttctcct actatcaaga agctaaaagt 781 tcaaagatca tggaatcctt caaaaacatg gtccctcagc aagcccttgt gattcgaaat 841 ggtgagaaaa tgagcataaa tgcggaggaa gttgtggttg gggatctggt ggaagtaaaa 901 ggaggagacc gaattcctgc tgacctcaga atcatatctg caaatggctg caaggtggat 961 aactcctcgc tcactggtga atcagaaccc cagactaggt ctccagattt cacaaatgaa 1021 aaccccctgg agacgaggaa cattgccttc ttttcaacaa attgtgttga aggcaccgca 1081 cgtggtattg ttgtctacac tggggatcgc actgtgatgg gaagaattgc cacacttgct 1141 tctgggctgg aaggaggcca gacccccatt gctgcagaaa ttgaacattt tatccacatc 1201 atcacgggtg tggctgtgtt cctgggtgtg tctttcttca tcctttctct catccttgag 1261 tacacctggc ttgaggctgt catcttcctc atcggtatca tcgtagccaa tgtgccggaa 1321 ggtttgctgg ccactgtcac ggtctgtctg acacttactg ccaaacgcat ggcaaggaaa 1381 aactgcttag tgaagaactt agaagctgtg gagaccttgg ggtccacgtc caccatctgc 1441 tctgataaaa ctggaactct gactcagaac cggatgacag tggcccacat gtggtttgac 1501 aatcaaatcc atgaagctga tacgacagag aatcagagtg gtgtctcttt tgacaagact 1561 tcagctacct ggcttgctct gtccagaatt gcaggtcttt gtaacagggc agtgtttcag 1621 gctaaccagg aaaacctacc tattcttaag cgggcagttg caggagatgc ctctgagtca 1681 gcactcttaa agtgcataga gctgtgctgt ggttccgtga aggagatgag agaaagatac 1741 gccaaaatcg tcgagatacc cttcaactcc accaacaagt accagttgtc tattcataag 1801 aaccccaaca catcggagcc ccaacacctg ttggtgatga agggcgcccc agaaaggatc 1861 ctagaccgtt gcagctctat cctcctccac ggcaaggagc agcccctgga tgaggagctg 1921 aaagacgcct ttcagaacgc ctatttggag ctggggggcc tcggagaacg agtcctaggt 1981 ttctgccacc tctttctgcc agatgaacag tttcctgaag ggttccagtt tgacactgac 2041 gatgtgaatt tccctatcga taatctgtgc tttgttgggc tcatctccat gattgaccct 2101 ccacgggcgg ccgttcctga tgccgtgggc aaatgtcgaa gtgctggaat taaggtcatc 2161 atggtcacag gagaccatcc aatcacagct aaagctattg ccaaaggtgt gggcatcatc 2221 tcagaaggca atgagaccgt ggaagacatt gctgcccgcc tcaacatccc agtcagccag 2281 gtgaacccca gggatgccaa ggcctgcgta gtacacggca gtgatctaaa ggacatgacc 2341 tccgagcagc tggatgacat tttgaagtac cacactgaga tagtgtttgc caggacctcc 2401 cctcagcaga agctcatcat tgtggaaggc tgccaaagac agggtgctat cgtggctgtg 2461 actggtgacg gtgtgaatga ctctccagct ttgaagaaag cagacattgg ggttgctatg 2521 gggattgctg gctcagatgt gtccaagcaa gctgctgaca tgattcttct ggatgacaac 2581 tttgcctcaa ttgtgactgg agtagaggaa ggtcgtctga tctttgataa cttgaagaaa 2641 tccattgctt ataccttaac cagtaacatt cccgagatca ccccgttcct gatatttatt 2701 attgcaaaca ttccactacc actggggact gtcaccatcc tctgcattga cttgggcact 2761 gacatggttc ctgccatctc cctggcttat gagcaggctg agagtgacat catgaagaga 2821 cagcccagaa atcccaaaac agacaaactt gtgaatgagc ggctgatcag catggcctat 2881 gggcagattg gaatgatcca ggccctggga ggcttcttta cttactttgt gattctggct 2941 gagaacggct tcctcccaat tcacctgttg ggcctccgag tggactggga tgaccgctgg 3001 atcaacgatg tggaagacag ctacgggcag cagtggacct atgagcagag gaaaatcgtg 3061 gagttcacct gccacacagc cttcttcgtc agtatcgtgg tggtgcagtg ggccgacttg 3121 gtcatctgta agaccaggag gaattcggtc ttccagcagg ggatgaagaa caagatcttg 3181 atatttggcc tctttgaaga gacagccctg gctgctttcc tttcctactg ccctggaatg 3241 ggtgttgctc ttaggatgta tcccctcaaa cctacctggt ggttctgtgc cttcccctac 3301 tctcttctca tcttcgtata tgacgaagtc agaaaactca tcatcaggcg acgccctggc 3361 ggctgggtgg agaaggaaac ctactattag ccccccgtcc tgcacgccgt ggagcatcag 3421 gccacacact ctgcatccga cacccacccc ctctttgtgt acttcagtct tggagtttgg 3481 aactctaccc tggtaggaaa gcaccgcagc atgtggggaa gcaagacgtc ctggaatgaa 3541 gcatgtagct ctatgggggg aggggggagg gctgcctgaa aaccatccat ctgtggaaat 3601 gacagcgggg aaggttttta tgtgcctttt tgtttttgta aaaaaggaac acccggaaag 3661 actgaaagaa tacattttat atctggattt ttacaaataa agatggcaga aactgacttt 3721 attttaaggg ttccagcatc ccagagccaa aaacaaatag tgccatctgc cccagtagaa 3781 gatagatatc tctttgagcc actgcacaat ggtgagaact gtagtgatgt aatagatgca 3841 ctatggccct gaagaacagc caaaggtgca caggttcgaa gacaccagac tcggatcatt 3901 ttatcacaac ttccagctgc tatcatggta ttctcatagt ttacagccat gtctgatatt 3961 tcagcagcat gtcctcttaa ggtagctaac aacctcccat catctgttgc ccatattttc 4021 acaagacagt catcagaacc agtaaatatc cgtctgccag ttcgatcaaa agttacacag 4081 tacacagatg acaagtgtcc aagaattc //