LOCUS       HUMNKATPA               4108 bp    mRNA    linear   HUM 11-MAR-1998
DEFINITION  Homo sapiens mRNA for Na,K-ATPase alpha-subunit, complete cds.
ACCESSION   D00099
VERSION     D00099.1
KEYWORDS    Na,K-ATPase; alpha-subunit.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1
  AUTHORS   Kawakami,K., Ohta,T., Nojima,H. and Nagano,K.
  TITLE     Primary structure of the alpha-subunit of human Na,K-ATPase
            deduced from cDNA sequence
  JOURNAL   J. Biochem. 100, 389-397 (1986)
COMMENT     The alpha-subunit of the human Na,K-ATPase exhibited 87% homology
            with its Torpedo counterpart and 98% homology with its sheep
            counterpart.
FEATURES             Location/Qualifiers
     source          1..4108
                     /cell_line="Hela cell"
                     /clone="pHNKA3, pHNKA21, and pHNKA54"
                     /clone_lib="cDNA library in lambda-gt11, a gift from Dr.
                     P. Nielsen"
                     /db_xref="taxon:9606"
                     /mol_type="mRNA"
                     /organism="Homo sapiens"
     CDS             319..3390
                     /codon_start=1
                     /product="Na,K-ATPase alpha-subunit"
                     /protein_id="BAA00061.1"
                     /translation="MGKGVGRDKYEPAAVSEQGDKKGKKGKKDRDMDELKKEVSMDDH
                     KLSLDELHRKYGTDLSRGLTSARAAEILARDGPNALTPPPTTPEWIKFCRQLFGGFSM
                     LLWIGAILCFLAYSIQAATEEEPQNDNLYLGVVLSAVVIITGCFSYYQEAKSSKIMES
                     FKNMVPQQALVIRNGEKMSINAEEVVVGDLVEVKGGDRIPADLRIISANGCKVDNSSL
                     TGESEPQTRSPDFTNENPLETRNIAFFSTNCVEGTARGIVVYTGDRTVMGRIATLASG
                     LEGGQTPIAAEIEHFIHIITGVAVFLGVSFFILSLILEYTWLEAVIFLIGIIVANVPE
                     GLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMW
                     FDNQIHEADTTENQSGVSFDKTSATWLALSRIAGLCNRAVFQANQENLPILKRAVAGD
                     ASESALLKCIELCCGSVKEMRERYAKIVEIPFNSTNKYQLSIHKNPNTSEPQHLLVMK
                     GAPERILDRCSSILLHGKEQPLDEELKDAFQNAYLELGGLGERVLGFCHLFLPDEQFP
                     EGFQFDTDDVNFPIDNLCFVGLISMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITA
                     KAIAKGVGIISEGNETVEDIAARLNIPVSQVNPRDAKACVVHGSDLKDMTSEQLDDIL
                     KYHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIAGSD
                     VSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLIFIIANI
                     PLPLGTVTILCIDLGTDMVPAISLAYEQAESDIMKRQPRNPKTDKLVNERLISMAYGQ
                     IGMIQALGGFFTYFVILAENGFLPIHLLGLRVDWDDRWINDVEDSYGQQWTYEQRKIV
                     EFTCHTAFFVSIVVVQWADLVICKTRRNSVFQQGMKNKILIFGLFEETALAAFLSYCP
                     GMGVALRMYPLKPTWWFCAFPYSLLIFVYDEVRKLIIRRRPGGWVEKETYY"
     regulatory      3696..3701
                     /note="putative"
                     /regulatory_class="polyA_signal_sequence"
BASE COUNT         1048 a         1019 c         1036 g         1005 t
ORIGIN      
        1 gaattcttaa gtctaaggga cttgctcctg atcttcctga agatctctac catttaatta
       61 agaaagcagt tgctgttcga aagcatcttg agaggaacgg acacgtggca acagcggtac
      121 gagcccgggc ggcggcagca acagcggcgg cggcatcggc ccgagccgcg gcccgctccc
      181 accctcccgc cccgcggcag ccctagctcc ctccacttgg ctcccctggt cccgctcgct
      241 cggccgggag ctgctctgtg cttttctctc tgattctcca gcgacaggac ccggcgccgg
      301 gcactgagca ccgccaccat ggggaagggg gttggacgtg ataagtatga gcctgcagct
      361 gtttcagaac aaggtgataa aaagggcaaa aagggcaaaa aagacaggga catggatgaa
      421 ctgaagaaag aagtttctat ggatgatcat aaacttagcc ttgatgaact tcatcgtaaa
      481 tatggaacag acttgagccg gggattaaca tctgctcgtg cagctgagat cctggcgcga
      541 gatggtccca acgccctcac tccccctccc actactcctg aatggatcaa gttttgtcgg
      601 cagctctttg gggggttctc aatgttactg tggattggag cgattctttg tttcttggct
      661 tatagcatcc aagctgctac agaagaggaa cctcaaaacg ataatctgta cctgggtgtg
      721 gtgctatcag ccgttgtaat cataactggt tgcttctcct actatcaaga agctaaaagt
      781 tcaaagatca tggaatcctt caaaaacatg gtccctcagc aagcccttgt gattcgaaat
      841 ggtgagaaaa tgagcataaa tgcggaggaa gttgtggttg gggatctggt ggaagtaaaa
      901 ggaggagacc gaattcctgc tgacctcaga atcatatctg caaatggctg caaggtggat
      961 aactcctcgc tcactggtga atcagaaccc cagactaggt ctccagattt cacaaatgaa
     1021 aaccccctgg agacgaggaa cattgccttc ttttcaacaa attgtgttga aggcaccgca
     1081 cgtggtattg ttgtctacac tggggatcgc actgtgatgg gaagaattgc cacacttgct
     1141 tctgggctgg aaggaggcca gacccccatt gctgcagaaa ttgaacattt tatccacatc
     1201 atcacgggtg tggctgtgtt cctgggtgtg tctttcttca tcctttctct catccttgag
     1261 tacacctggc ttgaggctgt catcttcctc atcggtatca tcgtagccaa tgtgccggaa
     1321 ggtttgctgg ccactgtcac ggtctgtctg acacttactg ccaaacgcat ggcaaggaaa
     1381 aactgcttag tgaagaactt agaagctgtg gagaccttgg ggtccacgtc caccatctgc
     1441 tctgataaaa ctggaactct gactcagaac cggatgacag tggcccacat gtggtttgac
     1501 aatcaaatcc atgaagctga tacgacagag aatcagagtg gtgtctcttt tgacaagact
     1561 tcagctacct ggcttgctct gtccagaatt gcaggtcttt gtaacagggc agtgtttcag
     1621 gctaaccagg aaaacctacc tattcttaag cgggcagttg caggagatgc ctctgagtca
     1681 gcactcttaa agtgcataga gctgtgctgt ggttccgtga aggagatgag agaaagatac
     1741 gccaaaatcg tcgagatacc cttcaactcc accaacaagt accagttgtc tattcataag
     1801 aaccccaaca catcggagcc ccaacacctg ttggtgatga agggcgcccc agaaaggatc
     1861 ctagaccgtt gcagctctat cctcctccac ggcaaggagc agcccctgga tgaggagctg
     1921 aaagacgcct ttcagaacgc ctatttggag ctggggggcc tcggagaacg agtcctaggt
     1981 ttctgccacc tctttctgcc agatgaacag tttcctgaag ggttccagtt tgacactgac
     2041 gatgtgaatt tccctatcga taatctgtgc tttgttgggc tcatctccat gattgaccct
     2101 ccacgggcgg ccgttcctga tgccgtgggc aaatgtcgaa gtgctggaat taaggtcatc
     2161 atggtcacag gagaccatcc aatcacagct aaagctattg ccaaaggtgt gggcatcatc
     2221 tcagaaggca atgagaccgt ggaagacatt gctgcccgcc tcaacatccc agtcagccag
     2281 gtgaacccca gggatgccaa ggcctgcgta gtacacggca gtgatctaaa ggacatgacc
     2341 tccgagcagc tggatgacat tttgaagtac cacactgaga tagtgtttgc caggacctcc
     2401 cctcagcaga agctcatcat tgtggaaggc tgccaaagac agggtgctat cgtggctgtg
     2461 actggtgacg gtgtgaatga ctctccagct ttgaagaaag cagacattgg ggttgctatg
     2521 gggattgctg gctcagatgt gtccaagcaa gctgctgaca tgattcttct ggatgacaac
     2581 tttgcctcaa ttgtgactgg agtagaggaa ggtcgtctga tctttgataa cttgaagaaa
     2641 tccattgctt ataccttaac cagtaacatt cccgagatca ccccgttcct gatatttatt
     2701 attgcaaaca ttccactacc actggggact gtcaccatcc tctgcattga cttgggcact
     2761 gacatggttc ctgccatctc cctggcttat gagcaggctg agagtgacat catgaagaga
     2821 cagcccagaa atcccaaaac agacaaactt gtgaatgagc ggctgatcag catggcctat
     2881 gggcagattg gaatgatcca ggccctggga ggcttcttta cttactttgt gattctggct
     2941 gagaacggct tcctcccaat tcacctgttg ggcctccgag tggactggga tgaccgctgg
     3001 atcaacgatg tggaagacag ctacgggcag cagtggacct atgagcagag gaaaatcgtg
     3061 gagttcacct gccacacagc cttcttcgtc agtatcgtgg tggtgcagtg ggccgacttg
     3121 gtcatctgta agaccaggag gaattcggtc ttccagcagg ggatgaagaa caagatcttg
     3181 atatttggcc tctttgaaga gacagccctg gctgctttcc tttcctactg ccctggaatg
     3241 ggtgttgctc ttaggatgta tcccctcaaa cctacctggt ggttctgtgc cttcccctac
     3301 tctcttctca tcttcgtata tgacgaagtc agaaaactca tcatcaggcg acgccctggc
     3361 ggctgggtgg agaaggaaac ctactattag ccccccgtcc tgcacgccgt ggagcatcag
     3421 gccacacact ctgcatccga cacccacccc ctctttgtgt acttcagtct tggagtttgg
     3481 aactctaccc tggtaggaaa gcaccgcagc atgtggggaa gcaagacgtc ctggaatgaa
     3541 gcatgtagct ctatgggggg aggggggagg gctgcctgaa aaccatccat ctgtggaaat
     3601 gacagcgggg aaggttttta tgtgcctttt tgtttttgta aaaaaggaac acccggaaag
     3661 actgaaagaa tacattttat atctggattt ttacaaataa agatggcaga aactgacttt
     3721 attttaaggg ttccagcatc ccagagccaa aaacaaatag tgccatctgc cccagtagaa
     3781 gatagatatc tctttgagcc actgcacaat ggtgagaact gtagtgatgt aatagatgca
     3841 ctatggccct gaagaacagc caaaggtgca caggttcgaa gacaccagac tcggatcatt
     3901 ttatcacaac ttccagctgc tatcatggta ttctcatagt ttacagccat gtctgatatt
     3961 tcagcagcat gtcctcttaa ggtagctaac aacctcccat catctgttgc ccatattttc
     4021 acaagacagt catcagaacc agtaaatatc cgtctgccag ttcgatcaaa agttacacag
     4081 tacacagatg acaagtgtcc aagaattc
//