LOCUS HUMLIC 1362 bp mRNA linear HUM 23-DEC-1997
DEFINITION Homo sapiens mRNA for lipocortin II, complete cds.
ACCESSION D00017 M14043 N00017
VERSION D00017.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1
AUTHORS Huang,K.S., Wallner,B.P., Mattaliano,R.J., Tizard,R., Burne,C.,
Frey,A., Hession,C., McGray,P., Sinclair,L.K., Chow,E.P.,
Browning,J.L., Ramachandran,K.L., Tang,J., Smart,J.E. and
Pepinsky,R.B.
TITLE Two human 35 kd inhibitors of phospholipase A-2 are related to
substrates of pp60-v-src and of the epidermal growth factor
receptor/kinase
JOURNAL Cell 46, 191-199 (1986)
COMMENT A cDNA of human lipocortin II, one of two phospholipase A2
inhibitors, was cloned and sequenced. It contains 1017 bp coding
region and a polyadenylation signal, AATAAA, is identified in 3'
untranslated region. The two human phospholipase A2 inhibitors,
lipocortin I and II, share about 50% amino acid sequence homology
and thus are derived evolutionarily from a common gene.
FEATURES Location/Qualifiers
source 1..1362
/db_xref="H-InvDB:HIT000100379"
/db_xref="taxon:9606"
/mol_type="mRNA"
/organism="Homo sapiens"
/tissue_type="placenta"
CDS 50..1069
/codon_start=1
/product="lipocortin II"
/protein_id="BAA00013.1"
/translation="MSTVHEILCKLSLEGDHSTPPSAYGSVKAYTNFDAERDALNIET
AIKTKGVDEVTIVNILTNRSNAQRQDIAFAYQRRTKKELASALKSALSGHLETVILGL
LKTPAQYDASELKASMKGLGTDEDSLIEIICSRTNQELQEINRVYKEMYKTDLEKDII
SDTSGDFRKLMVALAKGRRAEDGSVIDYELIDQDARDLYDAGVKRKGTDVPKWISIMT
ERSVPHLQKVFDRYKSYSPYDMLESIRKEVKGDLENAFLNLVQCIQNKPLYFADRLYD
SMKGKGTRDKVLIRIMVSRSEVDMLKIRSEFKRKYGKSLYYYIQQDTKGDYQKALLYL
CGGDD"
regulatory 1342..1347
/regulatory_class="polyA_signal_sequence"
BASE COUNT 384 a 316 c 343 g 319 t
ORIGIN
1 catttgggga cgctctcagc tctcggcgca cggcccagct tccttcaaaa tgtctactgt
61 tcacgaaatc ctgtgcaagc tcagcttgga gggtgatcac tctacacccc caagtgcata
121 tgggtctgtc aaagcctata ctaactttga tgctgagcgg gatgctttga acattgaaac
181 agccatcaag accaaaggtg tggatgaggt caccattgtc aacattttga ccaaccgcag
241 caatgcacag agacaggata ttgccttcgc ctaccagaga aggaccaaaa aggaacttgc
301 atcagcactg aagtcagcct tatctggcca cctggagacg gtgattttgg gcctattgaa
361 gacacctgct cagtatgacg cttctgagct aaaagcttcc atgaaggggc tgggaaccga
421 cgaggactct ctcattgaga tcatctgctc cagaaccaac caggagctgc aggaaattaa
481 cagagtctac aaggaaatgt acaagactga tctggagaag gacattattt cggacacatc
541 tggtgacttc cgcaagctga tggttgccct ggcaaagggt agaagagcag aggatggctc
601 tgtcattgat tatgaactga ttgaccaaga tgctcgggat ctctatgacg ctggagtgaa
661 gaggaaagga actgatgttc ccaagtggat cagcatcatg accgagcgga gcgtgcccca
721 cctccagaaa gtatttgata ggtacaagag ttacagccct tatgacatgt tggaaagcat
781 caggaaagag gttaaaggag acctggaaaa tgctttcctg aacctggttc agtgcattca
841 gaacaagccc ctgtattttg ctgatcggct gtatgactcc atgaagggca aggggacgcg
901 agataaggtc ctgatcagaa tcatggtctc ccgcagtgaa gtggacatgt tgaaaattag
961 gtctgaattc aagagaaagt acggcaagtc cctgtactat tatatccagc aagacactaa
1021 gggcgactac cagaaagcgc tgctgtacct gtgtggtgga gatgactgaa gcccgacacg
1081 gcctgagcgt ccagaaatgg tgctcaccat gcttccagct aacaggtcta gaaaaccagc
1141 ttgcgaataa cagtccccgt ggccatccct gtgagggtga cgttagcatt acccccaacc
1201 tcattttagt tgcctaagca ttgcctggcc ttcctgtcta gtctctcctg taagccaaag
1261 aaatgaacat tccaaggagt tggaagtgaa gtctatgatg tgaaacactt tgcctcctgt
1321 gtactgtgtc ataaacagat gaataaactg aatttgtact tt
//