LOCUS BK000138 5515 bp mRNA linear HUM 03-FEB-2006
DEFINITION TPA_exp: Homo sapiens stereocilin (STRC) mRNA, complete cds.
ACCESSION BK000138 AF375594
VERSION BK000138.1
KEYWORDS Third Party Data; TPA; TPA:experimental.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 5515)
AUTHORS Verpy,E., Masmoudi,S., Zwaenepoel,I., Leibovici,M., Hutchin,T.P.,
Del Castillo,I., Nouaille,S., Blanchard,S., Laine,S., Popot,J.L.,
Moreno,F., Mueller,R.F. and Petit,C.
TITLE Mutations in a new gene encoding a protein of the hair bundle cause
non-syndromic deafness at the DFNB16 locus
JOURNAL Nat. Genet. 29 (3), 345-349 (2001)
PUBMED 11687802
REFERENCE 2 (bases 1 to 5515)
AUTHORS Verpy,E., Masmoudi,S., Zwaenepoel,I., Leibovici,M. and Petit,C.
TITLE Direct Submission
JOURNAL Submitted (02-MAY-2001) Unite de Genetique des Deficits Sensoriels,
Institut Pasteur, 25, rue du Dr. Roux, Paris 75015, France
COMMENT THIRD PARTY DATABASE: This TPA record uses data from
DDBJ/EMBL/GenBank entries AC011330.8, AC016135.3, AC016164.1,
AC018512.6, AC021754.6 and AC087537.3.
FEATURES Location/Qualifiers
source 1..5515
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="15"
/map="15q15.3"
gene 1..5515
/gene="STRC"
/gene_synonym="DFNB16"
CDS 79..5406
/gene="STRC"
/gene_synonym="DFNB16"
/codon_start=1
/product="stereocilin"
/protein_id="DAA00085.1"
/translation="MALSLWPLLLLLLLLLLLSFAVTLAPTGPHSLDPGLSFLKSLLS
TLDQAPQGSLSRSRFFTFLANISSSFEPGRMGEGPVGEPPPLQPPALRLHDFLVTLRG
SPDWEPMLGLLGDMLALLGQEQTPRDFLVHQAGVLGGLVEVLLGALVPGGPPTPTRPP
CTRDGPSDCVLAADWLPSLLLLLEGTRWQALVQVQPSVDPTNATGLDGREAAPHFLQG
LLGLLTPTGELGSKEALWGGLLRTVGAPLYAAFQEGLLRVTHSLQDEVFSILGQPEPD
TNGQCQGGNLQQLLLWGVRHNLSWDVQALGFLSGSPPPPPALLHCLSTGVPLPRASQP
SAHISPRQRRAITVEALCENHLGPAPPYSISNFSIHLLCQHTKPATPQPHPSTTAICQ
TAVWYAVSWAPGAQGWLQACHDQFPDEFLDAICSNLSFSALSGSNRRLVKRLCAGLLP
PPTSCPEGLPPVPLTPDIFWGCFLENETLWAERLCGEASLQAVPPSNQAWVQHVCQGP
TPDVTASPPCHIGPCGERCPDGGSFLVMVCANDTMYEVLVPFWPWLAGQCRISRGGND
TCFLEGLLGPLLPSLPPLGPSPLCLTPGPFLLGMLSQLPRCQSSVPALAHPTRLHYLL
RLLTFLLGPGAGGAEAQGMLGRALLLSSLPDNCSFWDAFRPEGRRSVLRTIGEYLEQD
EEQPTPSGFEPTVNPSSGISKMELLACFSPVLWDLLQREKSVWALQILVQAYLHMPPE
NLQQLVLSAEREAAQGFLTLMLQGKLQGKLQVPPSEEQALGRLTALLLQRYPRLTSQL
FIDLSPLIPFLAVSDLMRFPPSLLANDSVLAAIRDYSPGMRPEQKEALAKRLLAPELF
GEVPAWPQELLWAVLPLLPHLPLENFLQLSPHQIQALEDSWPAAGLGPGHARHVLRSL
VNQSVQDGEEQVRRLGPLACFLSPEELQSLVPLSDPTGPVERGLLECAANGTLSPEGR
VAYELLGVLRSSGGAVLSPRELRVWAPLFSQLGLRFLQELSEPQLRAMLPVLQGTSVT
PAQAVLLLGRLLPRHDLSLEELCSLHLLLPGLSPQTLQAIPRRVLVGACSCLAPELSR
LSACQTAALLQTFRVKDGVKNMGTTGAGPAVCIPGQPIPTTWPDCLLPLLPLKLLQLD
SLALLANRRRYWELPWSEQQAQFLWKKMQVPTNLTLRNLQALGTLAGGMSCEFLQQIN
SMVDFLEVVHMIYQLPTRVRGSLRACIWAELQRRMAMPEPEWTTVGPELNGLDSKLLL
DLPIQLMDRLSNESIMLVVELVQRAPEQLLALTPLHQAALAERALQNLAPKETPVSGE
VLETLGPLVGFLGTESTRQIPLQILLSHLSQLQGFCLGETFATELGWLLLQESVLGKP
ELWSQDEVEQAGRLVFTLSTEAISLIPREALGPETLERLLEKQQSWEQSRVGQLCREP
QLAAKKAALVAGVVRPAAEDLPEPVPNCADVRGTFPAAWSATQIAEMELSDFEDCLTL
FAGDPGLGPEELRAAMGKAKQLWGPPRGFRPEQILQLGRLLIGLGDRELQELILVDWG
VLSTLGQIDGWSTTQLRIVVSSFLRQSGRHVSHLDFVHLTALGYTLCGLRPEELQHIS
SWEFSQAALFLGTLHLQCSEEQLEVLAHLLVLPGGFGPISNWGPEIFTEIGTIAAGIP
DLALSALLRGQIQGVTPLAISVIPPPKFAVVFSPIQLSSLTSAQAVAVTPEQMAFLSP
EQRRAVAWAQHEGKESPEQQGRSTAWGLQDWSRPSWSLVLTISFLGHLL"
BASE COUNT 1053 a 1689 c 1561 g 1212 t
ORIGIN
1 gccctgccct cacctggcta tcccacacag gtgagaataa ccagaactca cctccggtac
61 cagtgttcac ttggaaacat ggctctcagc ctctggcccc tgctgctgct gctgctgctg
121 ctgctgctgc tgtcctttgc agtgactctg gcccctactg ggcctcattc cctggaccct
181 ggtctctcct tcctgaagtc attgctctcc actctggacc aggctcccca gggctccctg
241 agccgctcac ggttctttac attcctggcc aacatttctt cttcctttga gcctgggaga
301 atgggggaag gaccagtagg agagccccca cctctccagc cgcctgctct gcggctccat
361 gattttctag tgacactgag aggtagcccc gactgggagc caatgctagg gctgctaggg
421 gatatgctgg cactgctggg acaggagcag actccccgag atttcctggt gcaccaggca
481 ggggtgctgg gtggacttgt ggaggtgctg ctgggagcct tagttcctgg gggcccccct
541 accccaactc ggcccccatg cacccgtgat gggccgtctg actgtgtcct ggctgctgac
601 tggttgcctt ctctgctgct gttgttagag ggcacacgct ggcaagctct ggtgcaggtg
661 cagcccagtg tggaccccac caatgccaca ggcctcgatg ggagggaggc agctcctcac
721 tttttgcagg gtctgttggg tttgcttacc ccaacagggg agctaggctc caaggaggct
781 ctttggggcg gtctgctacg cacagtgggg gcccccctct atgctgcctt tcaggagggg
841 ctgctccgtg tcactcactc cctgcaggat gaggtcttct ccattttggg gcagccagag
901 cctgatacca atgggcagtg ccagggaggt aaccttcaac agctgctctt atggggcgtc
961 cggcacaacc tttcctggga tgtccaggcg ctgggctttc tgtctggatc accaccccca
1021 ccccctgccc tccttcactg cctgagcacg ggcgtgcctc tgcccagagc ttctcagccg
1081 tcagcccaca tcagcccacg ccaacggcga gccatcactg tggaggccct ctgtgagaac
1141 cacttaggcc cagcaccacc ctacagcatt tccaacttct ccatccactt gctctgccag
1201 cacaccaagc ctgccactcc acagccccat cccagcacca ctgccatctg ccagacagct
1261 gtgtggtatg cagtgtcctg ggcaccaggt gcccaaggct ggctacaggc ctgccacgac
1321 cagtttcctg atgagttttt ggatgcgatc tgcagtaacc tctccttttc agccctgtct
1381 ggctccaacc gccgcctggt gaagcggctc tgtgctggcc tgctcccacc ccctaccagc
1441 tgccctgaag gcctgccccc tgttcccctc accccagaca tcttttgggg ctgcttcttg
1501 gagaatgaga ctctgtgggc tgagcgactg tgtggggagg caagtctaca ggctgtgccc
1561 cccagcaacc aggcttgggt ccagcatgtg tgccagggcc ccaccccaga tgtcactgcc
1621 tccccaccat gccacattgg accctgtggg gaacgctgcc cggatggggg cagcttcctg
1681 gtgatggtct gtgccaatga caccatgtat gaggtcctgg tgcccttctg gccttggcta
1741 gcaggccaat gcaggataag tcgtgggggc aatgacactt gcttcctaga agggctgctg
1801 ggcccccttc tgccctctct gccaccactg ggaccatccc cactctgtct gacccctggc
1861 cccttcctcc ttggcatgct atcccagttg ccacgctgtc agtcctctgt cccagctctt
1921 gctcacccca cacgcctaca ctatctcctc cgcctgctga ccttcctctt gggtccaggg
1981 gctgggggcg ctgaggccca ggggatgctg ggtcgggccc tactgctctc cagtctccca
2041 gacaactgct ccttctggga tgcctttcgc ccagagggcc ggcgcagtgt gctacggacg
2101 attggggaat acctggaaca agatgaggag cagccaaccc catcaggctt tgaacccact
2161 gtcaacccca gctctggtat aagcaagatg gagctgctgg cctgctttag tcctgtgctg
2221 tgggatctgc tccagaggga aaagagtgtt tgggccctgc agattctagt gcaggcgtac
2281 ctgcatatgc ccccagaaaa cctccagcag ctggtgcttt cagcagagag ggaggctgca
2341 cagggcttcc tgacactcat gctgcagggg aagctgcagg ggaagctgca ggtaccacca
2401 tccgaggagc aggccctggg tcgcctgaca gccctgctgc tccagcggta cccacgcctc
2461 acctcccagc tcttcattga cctgtcacca ctcatccctt tcttggctgt ctctgacctg
2521 atgcgcttcc caccatccct gttagccaac gacagtgtcc tggctgccat ccgggattac
2581 agcccaggaa tgaggcctga acagaaggag gctctggcaa agcgactgct ggcccctgaa
2641 ctgtttgggg aagtgcctgc ctggccccag gagctgctgt gggcagtgct gcccctgctc
2701 ccccacctcc ctctggagaa ctttttgcag ctcagccctc accagatcca ggccctggag
2761 gatagctggc cagcagcagg tctggggcca gggcatgccc gccatgtgct gcgcagcctg
2821 gtaaaccaga gtgtccagga tggtgaggag caggtacgca ggcttgggcc cctcgcctgt
2881 ttcctgagcc ctgaggagct gcagagccta gtgcccctga gtgatccaac ggggccagta
2941 gaacgggggc tgctggaatg tgcagccaat gggaccctca gcccagaagg acgggtggca
3001 tatgaacttc tgggtgtgtt gcgctcatct ggaggagcgg tgctgagccc ccgggagctg
3061 cgggtctggg cccctctctt ctctcagctg ggcctccgct tccttcagga gctgtcagag
3121 ccccagctta gagccatgct tcctgtcctg cagggaacta gtgttacacc tgctcaggct
3181 gtcctgctgc ttggacggct ccttcctagg cacgatctat ccctggagga actctgctcc
3241 ttgcaccttc tgctaccagg cctcagcccc cagacactcc aggccatccc taggcgagtc
3301 ctggtcgggg cttgttcctg cctggcccct gaactgtcac gcctctcagc ctgccagacc
3361 gcagcactgc tgcagacctt tcgggttaaa gatggtgtta aaaatatggg tacaacaggt
3421 gctggtccag ctgtgtgtat ccctggtcag cctattccca ccacctggcc agactgcctg
3481 cttcccctgc tcccattaaa gctgctacaa ctggattcct tggctcttct ggcaaatcga
3541 agacgctact gggagctgcc ctggtctgag cagcaggcac agtttctctg gaagaagatg
3601 caagtaccca ccaaccttac cctcaggaat ctgcaggctc tgggcaccct ggcaggaggc
3661 atgtcctgtg agtttctgca gcagatcaac tccatggtag acttccttga agtggtgcac
3721 atgatctatc agctgcccac tagagttcga gggagcctga gggcctgtat ctgggcagag
3781 ctacagcgga ggatggcaat gccagaacca gaatggacaa ctgtagggcc agaactgaac
3841 gggctggata gcaagctact cctggactta ccgatccagt tgatggacag actatccaat
3901 gaatccatta tgttggtggt ggagctggtg caaagagctc cagagcagct gctggcactg
3961 acccccctcc accaggcagc cctggcagag agggcactac aaaacctggc tccaaaggag
4021 actccagtct caggggaagt gctggagacc ttaggccctt tggttggatt cctggggaca
4081 gagagcacac gacagatccc cctacagatc ctgctgtccc atctcagtca gctgcaaggc
4141 ttctgcctag gagagacatt tgccacagag ctgggatggc tgctattgca ggagtctgtt
4201 cttgggaaac cagagttgtg gagccaggat gaagtagagc aagctggacg cctagtattc
4261 actctgtcta ctgaggcaat ttccttgatc cccagggagg ccttgggtcc agagaccctg
4321 gagcggcttc tagaaaagca gcagagctgg gagcagagca gagttggaca gctgtgtagg
4381 gagccacagc ttgctgccaa gaaagcagcc ctggtagcag gggtggtgcg accagctgct
4441 gaggatcttc cagaacctgt gccaaattgt gcagatgtac gagggacatt cccagcagcc
4501 tggtctgcaa cccagattgc agagatggag ctctcagact ttgaggactg cctgacatta
4561 tttgcaggag acccaggact tgggcctgag gaactgcggg cagccatggg caaagcaaaa
4621 cagttgtggg gtcccccccg gggatttcgt cctgagcaga tcctgcagct tggtaggctc
4681 ttaataggtc taggagatcg ggaactacag gagctgatcc tagtggactg gggagtgctg
4741 agcaccctgg ggcagataga tggctggagc accactcagc tccgcattgt ggtctccagt
4801 ttcctacggc agagtggtcg gcatgtgagc cacctggact tcgttcatct gacagcgctg
4861 ggttatactc tctgtggact gcggccagag gagctccagc acatcagcag ttgggagttc
4921 agccaagcag ctctcttcct cggcaccctg catctccagt gctctgagga acaactggag
4981 gttctggccc acctacttgt actgcctggt gggtttggcc caatcagtaa ctgggggcct
5041 gagatcttca ctgaaattgg caccatagca gctgggatcc cagacctggc tctttcagca
5101 ctgctgcggg gacagatcca gggcgttact cctcttgcca tttctgtcat ccctcctcct
5161 aaatttgctg tggtgtttag tcccatccaa ctatctagtc tcaccagtgc tcaggctgtg
5221 gctgtcactc ctgagcaaat ggcctttctg agtcctgagc agcgacgagc agttgcatgg
5281 gcccaacatg agggaaagga gagcccagaa cagcaaggtc gaagtacagc ctggggcctc
5341 caggactggt cacgaccttc ctggtccctg gtattgacta tcagcttcct tggccacctg
5401 ctatgagcct gtctctacag tagaaggaga ttgtggggag agaaatctta agtcataatg
5461 aataaagtgc aaacagaagt gcatcctgat tattttcaga agctgatgag gaata
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