LOCUS BC146846 6889 bp mRNA linear HUM 12-MAY-2008
DEFINITION Homo sapiens calcium channel, voltage-dependent, L type, alpha 1C
subunit, mRNA (cDNA clone MGC:181949 IMAGE:9056774), complete cds.
ACCESSION BC146846
VERSION BC146846.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 6889)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 6889)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (26-JUN-2007) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: Mike Brownstein, NIMH
cDNA Library Preparation: British Columbia Cancer Research Center
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Genome Sequence Centre,
BC Cancer Agency, Vancouver, BC, Canada
info@bcgsc.bc.ca
Martin Hirst, Thomas Zeng, Ryan Morin, Michelle Moksa, Johnson
Pang, Diana Mah, Jing Wang, Kieth Fichter, Eric Chuah, Allen
Delaney, Rob Kirkpatrick, Agnes Baross, Sarah Barber, Mabel
Brown-John, Steve S. Chand, William Chow, Ryan Babakaiff, Dave
Wong, Corey Matsuo, Jaclyn Beland, Susan Gibson, Luis delRio, Ruth
Featherstone, Malachi Griffith, Obi Griffith, Ran Guin, Nancy Liao,
Kim MacDonald, Mike R. Mayo, Josh Moran, Diana Palmquist, JR
Santos, Duane Smailus, Jeff Stott, Miranda Tsai, George Yang,
Jacquie Schein, Asim Siddiqui,Steven Jones, Rob Holt, Marco Marra.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: LLDM Plate: 684 Row: c Column: 12.
FEATURES Location/Qualifiers
source 1..6889
/db_xref="H-InvDB:HIT000503103"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:181949 IMAGE:9056774"
/tissue_type="Brain, cerebellum, PCR rescued clones"
/clone_lib="NIH_MGC_312"
/note="Vector: pCR-XL-TOPO; Clone identification sequence
tag: CCTAGCAT"
gene 1..6889
/gene="CACNA1C"
/gene_synonym="CACH2"
/gene_synonym="CACN2"
/gene_synonym="CaV1.2"
/gene_synonym="TS"
/db_xref="GeneID:775"
/db_xref="HGNC:HGNC:1390"
/db_xref="MIM:114205"
CDS 129..6536
/gene="CACNA1C"
/gene_synonym="CACH2"
/gene_synonym="CACN2"
/gene_synonym="CaV1.2"
/gene_synonym="TS"
/codon_start=1
/product="CACNA1C protein"
/protein_id="AAI46847.1"
/db_xref="GeneID:775"
/db_xref="HGNC:HGNC:1390"
/db_xref="MIM:114205"
/translation="MVNENTRMYIPEENHQGSNYGSPRPAHANMNANAAAGLAPEHIP
TPGAALSWQAAIDAARQAKLMGSAGNATISTVSSTQRKRQQYGKPKKQGSTTATRPPR
ALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLE
RVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKA
DGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVL
FVIIIYAIIGLELFMGKMHKTCYNQEGIAAEDDPSPCALETGHGRQCQNGTVCKPGWD
GPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFF
VLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENED
EGMDEEKPRNMSMPTSETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRRWNR
FCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTA
EMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRI
FKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTR
RSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYI
LLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKE
EKIELKSITADGESPPATKINMDDLQPNENEDKSPYPNPETTGEEDEEEPEMPVGPRP
RPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISL
AAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLL
VVSVSLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIV
IVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSW
ENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIY
IIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNQ
HQYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVE
MILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDVILSETNPAEHTQCSPSMNAEENSRI
SITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVVLLIVMLFFIYAVIGMQV
FGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSN
STEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEF
KRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGT
VMFNATLFALVRTALRIKTEGNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAGDDEV
TVGKFYATFLIQEYFRKFKKRKEQGLVGKPSQRNALSLQAGLRTLHDIGPEIRRAISG
DLTAEEELDKAMKEAVSAASEDDIFRRAGGLFGNHVSYYQSDGRSAFPQTFTTQRPLH
INKAGSSQGDTESPSHEKLVDSTFTPSSYSSTGSNANINNANNTALGRLPRPAGYPST
VSTVEGHGPPLSPAIRVQEVAWKLSSNRCHSRESQAAMAGQEETSQDETYEVKMNHDT
EACSEPSLLSTEMLSYQDDENRQLTLPEEDKRDIRQSPKRGFLRSASLGRRASFHLEC
LKRQKDRGGDISQKTVLPLHLVHHQALAVAGLSPLLQRSHSPASFPRPFATPPATPGS
RGWPPQPVPTLRLEGVESSEKLNSSFPSIHCGSWAETTPGGGGSSAARRVRPVSLMVP
SQAGAPGRQFHGSASSLVEAVLISEGLGQFAQDPKFIEVTTQELADACDMTIEEMESA
ADNILSGGAPQSPNGALLPFVNCRDAGQDRAGGEEDAGCVRARGRPSEEELQDSRVYV
SSL"
BASE COUNT 1522 a 2052 c 1879 g 1436 t
ORIGIN
1 acggcttcct cgaatcttgc gcgaaagccg ccggcctcgg aggagggatt aatccagacc
61 cgccgggggg tgttttcaca tttcttcctc ttcgtggctg ctcctcctat taaaaccatt
121 tttggtccat ggtcaatgag aatacgagga tgtacattcc agaggaaaac caccaaggtt
181 ccaactatgg gagcccacgc cccgcccatg ccaacatgaa tgccaatgcg gcagcggggc
241 tggcccctga gcacatcccc accccggggg ctgccctgtc gtggcaggcg gccatcgacg
301 cagcccggca ggctaagctg atgggcagcg ctggcaatgc gaccatctcc acagtcagct
361 ccacgcagcg gaagcggcag caatatggga aacccaagaa gcagggcagc accacggcca
421 cacgcccgcc ccgagccctg ctctgcctga ccctgaagaa ccccatccgg agggcctgca
481 tcagcattgt cgaatggaaa ccatttgaaa taattatttt actgactatt tttgccaatt
541 gtgtggcctt agcgatctat attccctttc cagaagatga ttccaacgcc accaattcca
601 acctggaacg agtggaatat ctctttctca taatttttac ggtggaagcg tttttaaaag
661 taatcgccta tggactcctc tttcacccca atgcctacct ccgcaacggc tggaacctac
721 tagattttat aattgtggtt gtggggcttt ttagtgcaat tttagaacaa gcaaccaaag
781 cagatggggc aaacgctctc ggagggaaag gggccggatt tgatgtgaag gcgctgaggg
841 ccttccgcgt gctgcgcccc ctgcggctgg tgtccggagt cccaagtctc caggtggtcc
901 tgaattccat catcaaggcc atggtccccc tgctgcacat cgccctgctt gtgctgtttg
961 tcatcatcat ctacgccatc atcggcttgg agctcttcat ggggaagatg cacaagacct
1021 gctacaacca ggagggcata gcagcagaag atgacccttc cccttgtgcg ctggaaacgg
1081 gccacgggcg gcagtgccag aacggcacgg tgtgcaagcc cggctgggat ggtcccaagc
1141 acggcatcac caactttgac aactttgcct tcgccatgct cacggtgttc cagtgcatca
1201 ccatggaggg ctggacggac gtgctgtact gggtcaatga tgccgtagga agggactggc
1261 cctggatcta ttttgttaca ctaatcatca tagggtcatt ttttgtactt aacttggttc
1321 tcggtgtgct tagcggagag ttttccaaag agagggagaa ggccaaggcc cggggagatt
1381 tccagaagct gcgggagaag cagcagctag aagaggatct caaaggctac ctggattgga
1441 tcactcaggc cgaagacatc gatcctgaga atgaggacga aggcatggat gaggagaagc
1501 cccgaaacat gagcatgccc accagtgaga ccgagtccgt caacaccgaa aacgtggctg
1561 gaggtgacat cgagggagaa aactgcgggg ccaggctggc ccaccggatc tccaagtcaa
1621 agttcagccg ctactggcgc cggtggaatc ggttctgcag aaggaagtgc cgcgccgcag
1681 tcaagtctaa tgtcttctac tggctggtga ttttcctggt gttcctcaac acgctcacca
1741 ttgcctctga gcactacaac cagcccaact ggctcacaga agtccaagac acggcaaaca
1801 aggccctgct ggccctgttc acggcagaga tgctcctgaa gatgtacagc ctgggcctgc
1861 aggcctactt cgtgtccctc ttcaaccgct ttgactgctt cgtcgtgtgt ggcggcatcc
1921 tggagaccat cctggtggag accaagatca tgtccccact gggcatctcc gtgctcagat
1981 gcgtccggct gctgaggatt ttcaagatca cgaggtactg gaactccttg agcaacctgg
2041 tggcatcctt gctgaactct gtgcgctcca tcgcctccct gctccttctc ctcttcctct
2101 tcatcatcat cttctccctc ctggggatgc agctctttgg aggaaagttc aactttgatg
2161 agatgcagac ccggaggagc acattcgata acttccccca gtccctcctc actgtgtttc
2221 agatcctgac cggggaggac tggaattcgg tgatgtatga tgggatcatg gcttatggcg
2281 gcccctcttt tccagggatg ttagtctgta tttacttcat catcctcttc atctgtggaa
2341 actatatcct actgaatgtg ttcttggcca ttgctgtgga caacctggct gatgctgaga
2401 gcctcacatc tgcccaaaag gaggaggaag aggagaagga gagaaagaag ctggccagga
2461 ctgccagccc agagaagaaa caagagttgg tggagaagcc ggcagtgggg gaatccaagg
2521 aggagaagat tgagctgaaa tccatcacgg ctgacggaga gtctccaccc gccaccaaga
2581 tcaacatgga tgacctccag cccaatgaaa atgaggataa gagcccctac cccaacccag
2641 aaactacagg agaagaggat gaggaggagc cagagatgcc tgtcggccct cgcccacgac
2701 cactctctga gcttcacctt aaggaaaagg cagtgcccat gccagaagcc agcgcgtttt
2761 tcatcttcag ctctaacaac aggtttcgcc tccagtgcca ccgcattgtc aatgacacga
2821 tcttcaccaa cctgatcctc ttcttcattc tgctcagcag catttccctg gctgctgagg
2881 acccggtcca gcacacctcc ttcaggaacc atattctgtt ttattttgat attgttttta
2941 ccaccatttt caccattgaa attgctctga agatgactgc ttatggggct ttcttgcaca
3001 agggttcttt ctgccggaac tacttcaaca tcctggacct gctggtggtc agcgtgtccc
3061 tcatctcctt tggcatccag tccagtgcaa tcaatgtcgt gaagatcttg cgagtcctgc
3121 gagtactcag gcccctgagg gccatcaaca gggccaaggg gctaaagcat gtggttcagt
3181 gtgtgtttgt cgccatccgg accatcggga acatcgtgat tgtcaccacc ctgctgcagt
3241 tcatgtttgc ctgcatcggg gtccagctct tcaagggaaa gctgtacacc tgttcagaca
3301 gttccaagca gacagaggcg gaatgcaagg gcaactacat cacgtacaaa gacggggagg
3361 ttgaccaccc catcatccaa ccccgcagct gggagaacag caagtttgac tttgacaatg
3421 ttctggcagc catgatggcc ctcttcaccg tctccacctt cgaagggtgg ccagagctgc
3481 tgtaccgctc catcgactcc cacacggaag acaagggccc catctacaac taccgtgtgg
3541 agatctccat cttcttcatc atctacatca tcatcatcgc cttcttcatg atgaacatct
3601 tcgtgggctt cgtcatcgtc acctttcagg agcaggggga gcaggagtac aagaactgtg
3661 agctggacaa gaaccagcga cagtgcgtgg aatacgccct caaggcccgg cccctgcgga
3721 ggtacatccc caagaaccag caccagtaca aagtgtggta cgtggtcaac tccacctact
3781 tcgagtacct gatgttcgtc ctcatcctgc tcaacaccat ctgcctggcc atgcagcact
3841 acggccagag ctgcctgttc aaaatcgcca tgaacatcct caacatgctc ttcactggcc
3901 tcttcaccgt ggagatgatc ctgaagctca ttgccttcaa acccaagggt tactttagtg
3961 atccctggaa tgtttttgac ttcctcatcg taattggcag cataattgac gtcattctca
4021 gtgagactaa tccagctgaa catacccaat gctctccctc tatgaacgca gaggaaaact
4081 cccgcatctc catcaccttc ttccgcctgt tccgggtcat gcgtctggtg aagctgctga
4141 gccgtgggga gggcattcgg acgctgctgt ggaccttcat caagtccttc caggccctgc
4201 cctatgtggt cctcctgatc gtgatgctgt tcttcatcta cgcggtgatc gggatgcagg
4261 tgtttgggaa aattgccctg aatgatacca cagagatcaa ccggaacaac aactttcaga
4321 ccttccccca ggccgtgctg ctcctcttca ggtgtgccac cggggaggcc tggcaggaca
4381 tcatgctggc ctgcatgcca ggcaagaagt gtgccccaga gtccgagccc agcaacagca
4441 cggagggtga aacaccctgt ggtagcagct ttgctgtctt ctacttcatc agcttctaca
4501 tgctctgtgc cttcctgatc atcaacctct ttgtagctgt catcatggac aactttgact
4561 acctgacaag ggactggtcc atccttggtc cccaccacct ggatgagttt aaaagaatct
4621 gggcagagta tgaccctgaa gccaagggtc gtatcaaaca cctggatgtg gtgaccctcc
4681 tccggcggat tcagccgcca ctaggttttg ggaagctgtg ccctcaccgc gtggcttgca
4741 aacgcctggt ctccatgaac atgcctctga acagcgacgg gacagtcatg ttcaatgcca
4801 ccctgtttgc cctggtcagg acggccctga ggatcaaaac agaagggaac ctagaacaag
4861 ccaatgagga gctgcgggcg atcatcaaga agatctggaa gcggaccagc atgaagctgc
4921 tggaccaggt ggtgccccct gcaggtgatg atgaggtcac cgttggcaag ttctacgcca
4981 cgttcctgat ccaggagtac ttccggaagt tcaagaagcg caaagagcag ggccttgtgg
5041 gcaagccctc ccagaggaac gcgctgtctc tgcaggctgg cttgcgcaca ctgcatgaca
5101 tcgggcctga gatccgacgg gccatctctg gagatctcac cgctgaggag gagctggaca
5161 aggccatgaa ggaggctgtg tccgctgctt ctgaagatga catcttcagg agggccggtg
5221 gcctgttcgg caaccacgtc agctactacc aaagcgacgg ccggagcgcc ttcccccaga
5281 ccttcaccac tcagcgcccg ctgcacatca acaaggcggg cagcagccag ggcgacactg
5341 agtcgccatc ccacgagaag ctggtggact ccaccttcac cccgagcagc tactcgtcca
5401 ccggctccaa cgccaacatc aacaacgcca acaacaccgc cctgggtcgc ctccctcgcc
5461 ccgccggcta ccccagcaca gtcagcactg tggagggcca cgggcccccc ttgtcccctg
5521 ccatccgggt gcaggaggtg gcgtggaagc tcagctccaa caggtgccac tcccgggaga
5581 gccaggcagc catggcgggt caggaggaga cgtctcagga tgagacctat gaagtgaaga
5641 tgaaccatga cacggaggcc tgcagtgagc ccagcctgct ctccacagag atgctctcct
5701 accaggatga cgaaaatcgg caactgacgc tcccagagga ggacaagagg gacatccggc
5761 aatctccgaa gaggggtttc ctccgctctg cctcactagg tcgaagggcc tccttccacc
5821 tggaatgtct gaagcgacag aaggaccgag ggggagacat ctctcagaag acagtcctgc
5881 ccttgcatct ggttcatcat caggcattgg cagtggcagg cctgagcccc ctcctccaga
5941 gaagccattc ccctgcctca ttccctaggc cttttgccac cccaccagcc acacctggca
6001 gccgaggctg gcccccacag cccgtcccca ccctgcggct tgagggggtc gagtccagtg
6061 agaaactcaa cagcagcttc ccatccatcc actgcggctc ctgggctgag accacccccg
6121 gtggcggggg cagcagcgcc gcccggagag tccggcccgt ctccctcatg gtgcccagcc
6181 aggctggggc cccagggagg cagttccacg gcagtgccag cagcctggtg gaagcggtct
6241 tgatttcaga aggactgggg cagtttgctc aagatcccaa gttcatcgag gtcaccaccc
6301 aggagctggc cgacgcctgc gacatgacca tagaggagat ggagagcgcg gccgacaaca
6361 tcctcagcgg gggcgcccca cagagcccca atggcgccct cttacccttt gtgaactgca
6421 gggacgcggg gcaggaccga gccgggggcg aagaggacgc gggctgtgtg cgcgcgcggg
6481 gtcgaccgag tgaggaggag ctccaggaca gcagggtcta cgtcagcagc ctgtagtggg
6541 cgctgccaga tgcgggcttt tttttatttg tttcaatgtt cctaatgggt tcgtttcaga
6601 agtgcctcac tgttctcgtg acctggagtt aaccggaaca gcgtcttcat tcatttctgt
6661 tgggaccaga cgcggagcct gggtgcgcga gccgccctcc gggaggaagg cgcccggctg
6721 cgtctgcaga ggcggggaga ggaggcggcg agggtcccgg ggcgcgagga aggcgcctgc
6781 cctctcccag ctcgcaggcc ccgggcccgg ccgcgcctcc gcggggagag caccccggct
6841 tcccgcgcgc cctcaccaaa aggaccctac agcaaacggg tgtctttcg
//