LOCUS BC144264 3870 bp mRNA linear HUM 08-JAN-2009
DEFINITION Homo sapiens phosphoinositide-3-kinase, catalytic, delta
polypeptide, mRNA (cDNA clone MGC:177801 IMAGE:9052784), complete
cds.
ACCESSION BC144264
VERSION BC144264.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3870)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 3870)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (12-JUN-2007) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: Mike Brownstein, NIMH
cDNA Library Preparation: British Columbia Cancer Research Center
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Genome Sequence Centre,
BC Cancer Agency, Vancouver, BC, Canada
info@bcgsc.bc.ca
Martin Hirst, Thomas Zeng, Ryan Morin, Michelle Moksa, Johnson
Pang, Diana Mah, Jing Wang, Kieth Fichter, Eric Chuah, Allen
Delaney, Rob Kirkpatrick, Agnes Baross, Sarah Barber, Mabel
Brown-John, Steve S. Chand, William Chow, Ryan Babakaiff, Dave
Wong, Corey Matsuo, Jaclyn Beland, Susan Gibson, Luis delRio, Ruth
Featherstone, Malachi Griffith, Obi Griffith, Ran Guin, Nancy Liao,
Kim MacDonald, Mike R. Mayo, Josh Moran, Diana Palmquist, JR
Santos, Duane Smailus, Jeff Stott, Miranda Tsai, George Yang,
Jacquie Schein, Asim Siddiqui,Steven Jones, Rob Holt, Marco Marra.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRCB Plate: 17 Row: H Column: 23.
FEATURES Location/Qualifiers
source 1..3870
/db_xref="H-InvDB:HIT000502690"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:177801 IMAGE:9052784"
/tissue_type="Pooled, cerebellum, kidney, placenta,
testis, lung, colon, liver, heart, thyroid, bladder,
uterus, PCR rescued clones"
/clone_lib="NIH_MGC_362"
/lab_host="DH10B"
/note="Vector: pCR4-TOPO with reversed insert; Clone
identification sequence tag: CTTCAGTA"
gene 1..3870
/gene="PIK3CD"
/gene_synonym="p110D"
/db_xref="GeneID:5293"
/db_xref="HGNC:HGNC:8977"
/db_xref="MIM:602839"
CDS 123..3254
/gene="PIK3CD"
/gene_synonym="p110D"
/codon_start=1
/product="PIK3CD protein"
/protein_id="AAI44265.1"
/db_xref="GeneID:5293"
/db_xref="HGNC:HGNC:8977"
/db_xref="MIM:602839"
/translation="MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLST
IKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLV
AREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWE
AWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMA
CALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTM
VHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVN
ADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCF
ALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKG
ELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEL
QLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYL
LCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYL
DCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLM
KQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLL
AEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDV
LWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLN
WLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHF
LGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLL
FLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKV
NWLAHNVSKDNRQ"
BASE COUNT 806 a 1183 c 1126 g 755 t
ORIGIN
1 agggcgggat gacactcatt gattctaaag catctttaat ctgccaggcg gagggggctt
61 tgctggtctt tcttggacta ttccagagag gacaactgtc atctgggaag taacaacgca
121 ggatgccccc tggggtggac tgccccatgg aattctggac caaggaggag aatcagagcg
181 ttgtggttga cttcctgctg cccacagggg tctacctgaa cttccctgtg tcccgcaatg
241 ccaacctcag caccatcaag cagctgctgt ggcaccgcgc ccagtatgag ccgctcttcc
301 acatgctcag tggccccgag gcctatgtgt tcacctgcat caaccagaca gcggagcagc
361 aagagctgga ggacgagcaa cggcgtctgt gtgacgtgca gcccttcctg cccgtcctgc
421 gcctggtggc ccgtgagggc gaccgcgtga agaagctcat caactcacag atcagcctcc
481 tcatcggcaa aggcctccac gagtttgact ccttgtgcga cccagaagtg aacgactttc
541 gcgccaagat gtgccaattc tgcgaggagg cggccgcccg ccggcagcag ctgggctggg
601 aggcctggct gcagtacagt ttccccctgc agctggagcc ctcggctcaa acctgggggc
661 ctggtaccct gcggctcccg aaccgggccc ttctggtcaa cgttaagttt gagggcagcg
721 aggagagctt caccttccag gtgtccacca aggacgtgcc gctggcgctg atggcctgtg
781 ccctgcggaa gaaggccaca gtgttccggc agccgctggt ggagcagccg gaagactaca
841 cgctgcaggt gaacggcagg catgagtacc tgtatggcag ctacccgctc tgccagttcc
901 agtacatctg cagctgcctg cacagtgggt tgacccctca cctgaccatg gtccattcct
961 cctccatcct cgccatgcgg gatgagcaga gcaaccctgc cccccaggtc cagaaaccgc
1021 gtgccaaacc acctcccatt cctgcgaaga agccttcctc tgtgtccctg tggtccctgg
1081 agcagccgtt ccgcatcgag ctcatccagg gcagcaaagt gaacgccgac gagcggatga
1141 agctggtggt gcaggccggg cttttccacg gcaacgagat gctgtgcaag acggtgtcca
1201 gctcggaggt gagcgtgtgc tcggagcccg tgtggaagca gcggctggag ttcgacatca
1261 acatctgcga cctgccccgc atggcccgtc tctgctttgc gctgtacgcc gtgatcgaga
1321 aagccaagaa ggctcgctcc accaagaaga agtccaagaa ggcggactgc cccattgcct
1381 gggccaacct catgctgttt gactacaagg accagcttaa gaccggggaa cgctgcctct
1441 acatgtggcc ctccgtccca gatgagaagg gcgagctgct gaaccccacg ggcactgtgc
1501 gcagtaaccc caacacggat agcgccgctg ccctgctcat ctgcctgccc gaggtggccc
1561 cgcaccccgt gtactacccc gccctggaga agatcttgga gctggggcga cacagcgagt
1621 gtgtgcatgt caccgaggag gagctgcagc tgcgggaaat cctggagcgg cgggggtctg
1681 gggagctgta tgagcacgag aaggacctgg tgtggaagct gcggcatgaa gtccaggagc
1741 acttcccgga ggcgctagcc cggctgctgc tggtcaccaa gtggaacaag catgaggatg
1801 tggcccagat gctctacctg ctgtgctcct ggccggagct gcccgtcctg agcgccctgg
1861 agctgctaga cttcagcttc cccgattgcc acgtaggctc cttcgccatc aagtcgctgc
1921 ggaaactgac ggacgatgag ctgttccagt acctgctgca gctggtgcag gtgctcaagt
1981 acgagtccta cctggactgc gagctgacca aattcctgct ggaccgggcc ctggccaacc
2041 gcaagatcgg ccacttcctt ttctggcacc tccgctccga gatgcacgtg ccgtcggtgg
2101 ccctgcgctt cggcctcatc ctggaggcct actgcagggg cagcacccac cacatgaagg
2161 tgctgatgaa gcagggggaa gcactgagca aactgaaggc cctgaatgac ttcgtcaagc
2221 tgagctctca gaagaccccc aagccccaga ccaaggagct gatgcacttg tgcatgcggc
2281 aggaggccta cctagaggcc ctctcccacc tgcagtcccc actcgacccc agcaccctgc
2341 tggctgaagt ctgcgtggag cagtgcacct tcatggactc caagatgaag cccctgtgga
2401 tcatgtacag caacgaggag gcaggcagcg gcggcagcgt gggcatcatc tttaagaacg
2461 gggatgacct ccggcaggac atgctgaccc tgcagatgat ccagctcatg gacgtcctgt
2521 ggaagcagga ggggctggac ctgaggatga ccccctatgg ctgcctcccc accggggacc
2581 gcacaggcct cattgaggtg gtactccgtt cagacaccat cgccaacatc caactcaaca
2641 agagcaacat ggcagccaca gccgccttca acaaggatgc cctgctcaac tggctgaagt
2701 ccaagaaccc gggggaggcc ctggatcgag ccattgagga gttcaccctc tcctgtgctg
2761 gctattgtgt ggccacatat gtgctgggca ttggcgatcg gcacagcgac aacatcatga
2821 tccgagagag tgggcagctg ttccacattg attttggcca ctttctgggg aatttcaaga
2881 ccaagtttgg aatcaaccgc gagcgtgtcc cattcatcct cacctacgac tttgtccatg
2941 tgattcagca ggggaagact aataatagtg agaaatttga acggttccgg ggctactgtg
3001 aaagggccta caccatcctg cggcgccacg ggcttctctt cctccacctc tttgccctga
3061 tgcgggcggc aggcctgcct gagctcagct gctccaaaga catccagtat ctcaaggact
3121 ccctggcact ggggaaaaca gaggaggagg cactgaagca cttccgagtg aagtttaacg
3181 aagccctccg tgagagctgg aaaaccaaag tgaactggct ggcccacaac gtgtccaaag
3241 acaacaggca gtagtggctc ctcccagccc tgggcccaag aggaggcggc tgcgggtcgt
3301 ggggaccaag cacattggtc ctaaaggggc tgaagagcct gaactgcacc taacgggaaa
3361 gaaccgacat ggctgccttt tgtttacact ggttatttat ttatgacttg aaatagttta
3421 aggagctaaa cagccataaa cggaaacgcc tccttcatgc agcggcggtg ctgggccccc
3481 cgaggctgca cctggctctc ggctgaggat tgtcacccca agtcttccag ctggtggatc
3541 tgggcccagc aaagactgtt ctcctcccga gggaaccttc ttcccaggcc tcccgccaga
3601 ctgcctgggt cctggcgcct ggcggtcacc tggtgcctac tgtccgacag gatgcctcga
3661 tcctcgtgcg acccaccctg tgtatcctcc ctagactgag ttctggcagc tccccgaggc
3721 agccggggta ccctctagat tcagggatgc ttgctctcca cttttcaagt gggtcttggg
3781 tacgagaatt ccctcatctt tctctactgt aaagtgattt tgtttgcagg taagaaaata
3841 atagatgact caccacacct ctacggctgg
//