LOCUS BC144239 2509 bp mRNA linear HUM 08-JAN-2009
DEFINITION Homo sapiens neurotrophic tyrosine kinase, receptor, type 1, mRNA
(cDNA clone MGC:177776 IMAGE:9052759), complete cds.
ACCESSION BC144239
VERSION BC144239.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2509)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 2509)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (12-JUN-2007) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: Mike Brownstein, NIMH
cDNA Library Preparation: British Columbia Cancer Research Center
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Genome Sequence Centre,
BC Cancer Agency, Vancouver, BC, Canada
info@bcgsc.bc.ca
Martin Hirst, Thomas Zeng, Ryan Morin, Michelle Moksa, Johnson
Pang, Diana Mah, Jing Wang, Kieth Fichter, Eric Chuah, Allen
Delaney, Rob Kirkpatrick, Agnes Baross, Sarah Barber, Mabel
Brown-John, Steve S. Chand, William Chow, Ryan Babakaiff, Dave
Wong, Corey Matsuo, Jaclyn Beland, Susan Gibson, Luis delRio, Ruth
Featherstone, Malachi Griffith, Obi Griffith, Ran Guin, Nancy Liao,
Kim MacDonald, Mike R. Mayo, Josh Moran, Diana Palmquist, JR
Santos, Duane Smailus, Jeff Stott, Miranda Tsai, George Yang,
Jacquie Schein, Asim Siddiqui,Steven Jones, Rob Holt, Marco Marra.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: LLDM Plate: 676 Row: l Column: 5
isoform, single-stranded.
FEATURES Location/Qualifiers
source 1..2509
/db_xref="H-InvDB:HIT000502666"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:177776 IMAGE:9052759"
/tissue_type="Pooled, cerebellum, kidney, placenta,
testis, lung, colon, liver, heart, thyroid, bladder,
uterus, PCR rescued clones"
/clone_lib="NIH_MGC_361"
/lab_host="DH10B"
/note="Vector: pCR4-TOPO; Clone identification sequence
tag: TCCTCTTT"
gene 1..2509
/gene="NTRK1"
/gene_synonym="MTC"
/gene_synonym="p140-TrkA"
/gene_synonym="TRK"
/gene_synonym="TRK1"
/gene_synonym="TRKA"
/db_xref="GeneID:4914"
/db_xref="HGNC:HGNC:8031"
/db_xref="MIM:191315"
CDS 101..2473
/gene="NTRK1"
/gene_synonym="MTC"
/gene_synonym="p140-TrkA"
/gene_synonym="TRK"
/gene_synonym="TRK1"
/gene_synonym="TRKA"
/codon_start=1
/product="neurotrophic tyrosine kinase, receptor, type 1"
/protein_id="AAI44240.1"
/db_xref="GeneID:4914"
/db_xref="HGNC:HGNC:8031"
/db_xref="MIM:191315"
/translation="MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHG
SSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSG
LRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQ
RWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVE
GRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEV
SVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLE
PAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIP
DTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVL
APEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKW
ELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHI
VRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAV
ASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTM
LPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGREL
ERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG"
BASE COUNT 440 a 781 c 808 g 480 t
ORIGIN
1 tctttaacac cgcccagcgc acatgtcggg ggaggcctgg cagctgcagc tgggagcgca
61 cagacggctg ccccgcctga gcgaggcggg cgccgccgcg atgctgcgag gcggacggcg
121 cgggcagctt ggctggcaca gctgggctgc ggggccgggc agcctgctgg cttggctgat
181 actggcatct gcgggcgccg caccctgccc cgatgcctgc tgcccccacg gctcctcggg
241 actgcgatgc acccgggatg gggccctgga tagcctccac cacctgcccg gcgcagagaa
301 cctgactgag ctctacatcg agaaccagca gcatctgcag catctggagc tccgtgatct
361 gaggggcctg ggggagctga gaaacctcac catcgtgaag agtggtctcc gtttcgtggc
421 gccagatgcc ttccatttca ctcctcggct cagtcgcctg aatctctcct tcaacgctct
481 ggagtctctc tcctggaaaa ctgtgcaggg cctctcctta caggaactgg tcctgtcggg
541 gaaccctctg cactgttctt gtgccctgcg ctggctacag cgctgggagg aggagggact
601 gggcggagtg cctgaacaga agctgcagtg tcatgggcaa gggcccctgg cccacatgcc
661 caatgccagc tgtggtgtgc ccacgctgaa ggtccaggtg cccaatgcct cggtggatgt
721 gggggacgac gtgctgctgc ggtgccaggt ggaggggcgg ggcctggagc aggccggctg
781 gatcctcaca gagctggagc agtcagccac ggtgatgaaa tctgggggtc tgccatccct
841 ggggctgacc ctggccaatg tcaccagtga cctcaacagg aagaacgtga cgtgctgggc
901 agagaacgat gtgggccggg cagaggtctc tgttcaggtc aacgtctcct tcccggccag
961 tgtgcagctg cacacggcgg tggagatgca ccactggtgc atccccttct ctgtggatgg
1021 gcagccggca ccgtctctgc gctggctctt caatggctcc gtgctcaatg agaccagctt
1081 catcttcact gagttcctgg agccggcagc caatgagacc gtgcggcacg ggtgtctgcg
1141 cctcaaccag cccacccacg tcaacaacgg caactacacg ctgctggctg ccaacccctt
1201 cggccaggcc tccgcctcca tcatggctgc cttcatggac aaccctttcg agttcaaccc
1261 cgaggacccc atccctgaca ctaacagcac atctggagac ccggtggaga agaaggacga
1321 aacacctttt ggggtctcgg tggctgtggg cctggccgtc tttgcctgcc tcttcctttc
1381 tacgctgctc cttgtgctca acaaatgtgg acggagaaac aagtttggga tcaaccgccc
1441 ggctgtgctg gctccagagg atgggctggc catgtccctg catttcatga cattgggtgg
1501 cagctccctg tcccccaccg agggcaaagg ctctgggctc caaggccaca tcatcgagaa
1561 cccacaatac ttcagtgatg cctgtgttca ccacatcaag cgccgggaca tcgtgctcaa
1621 gtgggagctg ggggagggcg cctttgggaa ggtcttcctt gctgagtgcc acaacctcct
1681 gcctgagcag gacaagatgc tggtggctgt caaggcactg aaggaggcgt ccgagagtgc
1741 tcggcaggac ttccagcgtg aggctgagct gctcaccatg ctgcagcacc agcacatcgt
1801 gcgcttcttc ggcgtctgca ccgagggccg ccccctgctc atggtctttg agtatatgcg
1861 gcacggggac ctcaaccgct tcctccgatc ccatggacct gatgccaagc tgctggctgg
1921 tggggaggat gtggctccag gccccctggg tctggggcag ctgctggctg tggctagcca
1981 ggtcgctgcg gggatggtgt acctggcggg tctgcatttt gtgcaccggg acctggccac
2041 acgcaactgt ctagtgggcc agggactggt ggtcaagatt ggtgattttg gcatgagcag
2101 ggatatctac agcaccgact attaccgtgt gggaggccgc accatgctgc ccattcgctg
2161 gatgccgccc gagagcatcc tgtaccgtaa gttcaccacc gagagcgacg tgtggagctt
2221 cggcgtggtg ctctgggaga tcttcaccta cggcaagcag ccctggtacc agctctccaa
2281 cacggaggca atcgactgca tcacgcaggg acgtgagttg gagcggccac gtgcctgccc
2341 accagaggtc tacgccatca tgcggggctg ctggcagcgg gagccccagc aacgccacag
2401 catcaaggat gtgcacgccc ggctgcaagc cctggcccag gcacctcctg tctacctgga
2461 tgtcctgggc tagggggccg gcccaggggc tgggagtggt tagccggaa
//