LOCUS BC144095 4156 bp mRNA linear HUM 18-MAR-2009
DEFINITION Homo sapiens 5-methyltetrahydrofolate-homocysteine
methyltransferase, mRNA (cDNA clone MGC:177632 IMAGE:9052615),
complete cds.
ACCESSION BC144095
VERSION BC144095.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4156)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 4156)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (12-JUN-2007) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: Mike Brownstein, NIMH
cDNA Library Preparation: British Columbia Cancer Research Center
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Genome Sequence Centre,
BC Cancer Agency, Vancouver, BC, Canada
info@bcgsc.bc.ca
Martin Hirst, Thomas Zeng, Ryan Morin, Michelle Moksa, Johnson
Pang, Diana Mah, Jing Wang, Kieth Fichter, Eric Chuah, Allen
Delaney, Rob Kirkpatrick, Agnes Baross, Sarah Barber, Mabel
Brown-John, Steve S. Chand, William Chow, Ryan Babakaiff, Dave
Wong, Corey Matsuo, Jaclyn Beland, Susan Gibson, Luis delRio, Ruth
Featherstone, Malachi Griffith, Obi Griffith, Ran Guin, Nancy Liao,
Kim MacDonald, Mike R. Mayo, Josh Moran, Diana Palmquist, JR
Santos, Duane Smailus, Jeff Stott, Miranda Tsai, George Yang,
Jacquie Schein, Asim Siddiqui,Steven Jones, Rob Holt, Marco Marra.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRCB Plate: 17 Row: A Column: 24.
FEATURES Location/Qualifiers
source 1..4156
/db_xref="H-InvDB:HIT000502526"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:177632 IMAGE:9052615"
/tissue_type="Pooled, cerebellum, kidney, placenta,
testis, lung, colon, liver, heart, thyroid, bladder,
uterus, PCR rescued clones"
/clone_lib="NIH_MGC_364"
/lab_host="DH10B"
/note="Vector: pCR-XL-TOPO with reversed insert; Clone
identification sequence tag: CCCACATG"
gene 1..4156
/gene="MTR"
/gene_synonym="cblG"
/gene_synonym="MS"
/db_xref="GeneID:4548"
/db_xref="HGNC:HGNC:7468"
/db_xref="MIM:156570"
CDS 23..3667
/gene="MTR"
/gene_synonym="cblG"
/gene_synonym="MS"
/codon_start=1
/product="MTR protein"
/protein_id="AAI44096.1"
/db_xref="GeneID:4548"
/db_xref="HGNC:HGNC:7468"
/db_xref="MIM:156570"
/translation="MSPALQDLSQPEGLKKTLRDEINAILQKRIMVLDGGMGTMIQRE
KLNEEHFRGQEFKDHARPLKGNNDILSITQPDVIYQIHKEYLLAGADIIETNTFSSTS
IAQADYGLEHLAYRMNMCSAGVARKAAEEVTLQTGIKRFVAGALGPTNKTLSVSPSVE
RPDYRNITFDELVEAYQEQAKGLLDGGVDILLIETIFDTANAKAALFALQNLFEEKYA
PRPIFISGTIVDKSGRTLSGQTGEGFVISVSHGEPLCIGLNCALGAAEMRPFIEIIGK
CTTAYVLCYPNAGLPNTFGDYDETPSMMAKHLKDFAMDGLVNIVGGCCGSTPDHIREI
AEAVKNCKPRVPPATAFEGHMLLSGLEPFRIGPYTNFVNIGERCNVAGSRKFAKLIMA
GNYEEALCVAKVQVEMGAQVLDVNMDDGMLDGPSAMTRFCNLIASEPDIAKVPLCIDS
SNFAVIEAGLKCCQGKCIVNSISLKEGEDDFLEKARKIKKYGAAMVVMAFDEEGQATE
TDTKIRVCTRAYHLLVKKLGFNPNDIIFDPNILTIGTGMEEHNLYAINFIHATKVIKE
TLPGARISGGLSNLSFSFRGMEAIREAMHGVFLYHAIKSGMDMGIVNAGNLPVYDDIH
KELLQLCEDLIWNKDPEATEKLLRYAQTQGTGGKKVIQTDEWRNGPVEERLEYALVKV
IKSARVMKKAVGHLIPFMEKEREETRVLNGTVEEEDPYQGTIVLATVKGDVHDIGKNI
VGVVLGCNNFRVIDLGVMTPCDKILKAALDHKADIIGLSGLITPSLDEMIFVAKEMER
LAIRIPLLIGGATTSKTHTAVKIAPRYSAPVIHVLDASKSVVVCSQLLDENLKDEYFE
EIMEEYEDIRQDHYESLKERRYLPLSQARKSGFQMDWLSEPHPVKPTFIGTQVFEDYD
LQKLVDYIDWKPFFDVWQLRGKYPNRGFPKIFNDKTVGGEARKVYDDAHNMLNTLISQ
KKLRARGVVGFWPAQSIQDDIHLYAEAAVPQAAEPIATFYGLRQQAEKDSASTEPYYC
LSDFIAPLHSGIRDYLGLFAVACFGVEELSKAYEDDGDDYSSIMVKALGDRLAEAFAE
ELHERVRRELWAYCGSEQLDVADLRRLRYKGIRPAPGYPSQPDHTEKLTMWRLADIEQ
STGIRLTESLAMAPASAVSGLYFSNLKSKYFAVGKISKDQVEDYALRKNISVAEVEKW
LGPILGYDTD"
BASE COUNT 1161 a 879 c 1077 g 1039 t
ORIGIN
1 cgcaaggagg agactcgaca acatgtcacc cgcgctccaa gacctgtcgc aacccgaagg
61 tctgaagaaa accctgcggg atgagatcaa tgccattctg cagaagagga ttatggtgct
121 ggatggaggg atggggacca tgatccagcg ggagaagcta aacgaagaac acttccgagg
181 tcaggaattt aaagatcatg ccaggccgct gaaaggcaac aatgacattt taagtataac
241 tcagcctgat gtcatttacc aaatccataa ggaatacttg ctggctgggg cagatatcat
301 tgaaacaaat acttttagca gcactagtat tgcccaagct gactatggcc ttgaacactt
361 ggcctaccgg atgaacatgt gctctgcagg agtggccaga aaagctgccg aggaggtaac
421 tctccagaca ggaattaaga ggtttgtggc aggggctctg ggtccgacta ataagacact
481 ctctgtgtcc ccatctgtgg aaaggccgga ttataggaac atcacatttg atgagcttgt
541 tgaagcatac caagagcagg ccaaaggact tctggatggc ggggttgata tcttactcat
601 tgaaactatt tttgatactg ccaatgccaa ggcagccttg tttgcactcc aaaatctttt
661 tgaggagaaa tatgctcccc ggcctatctt tatttcaggg acgatcgttg ataaaagtgg
721 gcggactctt tccggacaga caggagaggg atttgtcatc agcgtgtctc atggagaacc
781 actctgcatt ggattaaatt gtgctttggg tgcagctgaa atgagacctt ttattgaaat
841 aattggaaaa tgtacaacag cctatgtcct ctgttatccc aatgcaggtc ttcccaacac
901 ctttggtgac tatgatgaaa cgccttctat gatggccaag cacctaaagg attttgctat
961 ggatggcttg gtcaatatag ttggaggatg ctgtgggtca acaccagatc atatcaggga
1021 aattgctgaa gctgtgaaaa attgtaagcc tagagttcca cctgccactg cttttgaagg
1081 acatatgtta ctgtctggtc tagagccctt caggattgga ccgtacacca actttgttaa
1141 cattggagag cgctgtaatg ttgcaggatc aaggaagttt gctaaactca tcatggcagg
1201 aaactatgaa gaagccttgt gtgttgccaa agtgcaggtg gaaatgggag cccaggtgtt
1261 ggatgtcaac atggatgatg gcatgctaga tggtccaagt gcaatgacca gattttgcaa
1321 cttaattgct tccgagccag acatcgcaaa ggtacctttg tgcatcgact cctccaattt
1381 tgctgtgatt gaagctgggt taaagtgctg ccaagggaag tgcattgtca atagcattag
1441 tctgaaggaa ggagaggacg acttcttgga gaaggccagg aagattaaaa agtatggagc
1501 tgctatggtg gtcatggctt ttgatgaaga aggacaggca acagaaacag acacaaaaat
1561 cagagtgtgc acccgggcct accatctgct tgtgaaaaaa ctgggcttta atccaaatga
1621 cattattttt gaccctaata tcctaaccat tgggactgga atggaggaac acaacttgta
1681 tgccattaat tttatccatg caacaaaagt cattaaagaa acattacctg gagccagaat
1741 aagtggaggt ctttccaact tgtccttctc cttccgagga atggaagcca ttcgagaagc
1801 aatgcatggg gttttccttt accatgcaat caagtctggc atggacatgg ggatagtgaa
1861 tgctggaaac ctccctgtgt atgatgatat ccataaggaa cttctgcagc tctgtgaaga
1921 tctcatctgg aataaagacc ctgaggccac tgagaagctc ttacgttatg cccagactca
1981 aggcacagga gggaagaaag tcattcagac tgatgagtgg agaaatggcc ctgtcgaaga
2041 acgccttgag tatgcccttg tgaaggttat aaagtcagcc cgggttatga agaaggctgt
2101 tggccacctt atccctttca tggaaaaaga aagagaagaa accagagtgc ttaacggcac
2161 agtagaagaa gaggaccctt accagggcac catcgtgctg gccactgtta aaggcgacgt
2221 gcacgacata ggcaagaaca tagttggagt agtccttggc tgcaataatt tccgagttat
2281 tgatttagga gtcatgactc catgtgataa gatactgaaa gctgctcttg accacaaagc
2341 agatataatt ggcctgtcag gactcatcac tccttccctg gatgaaatga tttttgttgc
2401 caaggaaatg gagagattag ctataaggat tccattgttg attggaggag caaccacttc
2461 aaaaacccac acagcagtta aaatagctcc gagatacagt gcacctgtaa tccatgtcct
2521 ggacgcgtcc aagagtgtgg tggtgtgttc ccagctgtta gatgaaaatc taaaggatga
2581 atactttgag gaaatcatgg aagaatatga agatattaga caggaccatt atgagtctct
2641 caaggagagg agatacttac ccttaagtca agccagaaaa agtggtttcc aaatggattg
2701 gctgtctgaa cctcacccag tgaagcccac gtttattggg acccaggtct ttgaagacta
2761 tgacctgcag aagctggtgg actacattga ctggaagcct ttctttgatg tctggcagct
2821 ccggggcaag tacccgaatc gaggctttcc caagatattt aacgacaaaa cagtaggtgg
2881 agaggccagg aaggtctacg atgatgccca caatatgctg aacacactga ttagtcaaaa
2941 gaaactccgg gcccggggtg tggttgggtt ctggccagca cagagtatcc aagacgacat
3001 tcacctgtac gcagaggctg ctgtgcccca ggctgcagag cccatagcca ccttctatgg
3061 gttaaggcaa caggctgaga aggactctgc cagcacggag ccatactact gcctctcaga
3121 cttcatcgct cccttgcatt ctggcatccg tgactacctg ggcctgtttg ccgttgcctg
3181 ctttggggta gaagagctga gcaaggccta tgaggatgat ggtgacgact acagcagcat
3241 catggtcaag gcgctggggg accggctggc agaggccttt gcagaagagc tccatgaaag
3301 agttcgccga gaactgtggg cctactgtgg cagtgagcag ctggacgtcg cagacctgcg
3361 caggctgcgg tacaagggca tccgcccggc tcctggctac cccagccagc ccgaccacac
3421 cgagaagctc accatgtgga gactcgcaga catcgagcag tctacaggca ttaggttaac
3481 agaatcatta gcaatggcac ctgcttcagc agtctcaggc ctctacttct ccaatttgaa
3541 gtccaaatat tttgctgtgg ggaagatttc caaggatcag gttgaggatt atgcattgag
3601 gaagaacata tctgtggctg aggttgagaa atggcttgga cccattttgg gatatgatac
3661 agactaactt tttttttttt ttgccttttt tattcttgat gatcctcaag gaaatacaac
3721 ctagggtgcc ttaaaaataa caacaacaaa aaacctgtgt gcatctggct gacacttacc
3781 tgcttctggt tttcgaagac tatttagtgg aaccttgtag aggagcaggg tcttcctgca
3841 gtgcctggaa aacaggcgct gtttttttgg gaccttgcgt gaagagcagt gagcagggtt
3901 cctgtggttt ccctggtccc tctgagatgg ggacagactg aagacagagg tcgtttgatt
3961 tcaaagcaag tcaacctgct tttttctgtt tttacagtgg aatctaggag gccacttagt
4021 cgtctttttt tcctcttaga agaaaagcct gaaactgagt tgaatagaga agtgtgaccc
4081 tgtgacaaaa tgatactgtg agaaatgggg cattttaatc taagtggtta taacagtgga
4141 ttctgacggg gaaggt
//