LOCUS BC144093 5206 bp mRNA linear HUM 08-JAN-2009
DEFINITION Homo sapiens DNA (cytosine-5-)-methyltransferase 1, mRNA (cDNA
clone MGC:177630 IMAGE:9052613), complete cds.
ACCESSION BC144093
VERSION BC144093.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 5206)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 5206)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (12-JUN-2007) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: Mike Brownstein, NIMH
cDNA Library Preparation: British Columbia Cancer Research Center
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Genome Sequence Centre,
BC Cancer Agency, Vancouver, BC, Canada
info@bcgsc.bc.ca
Martin Hirst, Thomas Zeng, Ryan Morin, Michelle Moksa, Johnson
Pang, Diana Mah, Jing Wang, Kieth Fichter, Eric Chuah, Allen
Delaney, Rob Kirkpatrick, Agnes Baross, Sarah Barber, Mabel
Brown-John, Steve S. Chand, William Chow, Ryan Babakaiff, Dave
Wong, Corey Matsuo, Jaclyn Beland, Susan Gibson, Luis delRio, Ruth
Featherstone, Malachi Griffith, Obi Griffith, Ran Guin, Nancy Liao,
Kim MacDonald, Mike R. Mayo, Josh Moran, Diana Palmquist, JR
Santos, Duane Smailus, Jeff Stott, Miranda Tsai, George Yang,
Jacquie Schein, Asim Siddiqui,Steven Jones, Rob Holt, Marco Marra.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRCB Plate: 17 Row: A Column: 6.
FEATURES Location/Qualifiers
source 1..5206
/db_xref="H-InvDB:HIT000502524"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:177630 IMAGE:9052613"
/tissue_type="Pooled, cerebellum, kidney, placenta,
testis, lung, colon, liver, heart, thyroid, bladder,
uterus, PCR rescued clones"
/clone_lib="NIH_MGC_363"
/lab_host="DH10B"
/note="Vector: pCR-XL-TOPO; Clone identification sequence
tag: ATAGATTT"
gene 1..5206
/gene="DNMT1"
/gene_synonym="AIM"
/gene_synonym="CXXC9"
/gene_synonym="MCMT"
/db_xref="GeneID:1786"
/db_xref="HGNC:HGNC:2976"
/db_xref="MIM:126375"
CDS 181..5079
/gene="DNMT1"
/gene_synonym="AIM"
/gene_synonym="CXXC9"
/gene_synonym="MCMT"
/codon_start=1
/product="DNA (cytosine-5-)-methyltransferase 1"
/protein_id="AAI44094.1"
/db_xref="GeneID:1786"
/db_xref="HGNC:HGNC:2976"
/db_xref="MIM:126375"
/translation="MPARTAPARVPTLAVPAISLPDDVRRRLKDLERDSLTEKECVKE
KLNLLHEFLQTEIKNQLCDLETKLRKEELSEEGYLAKVKSLLNKDLSLENGAHAYNRE
VNGRLENGNQARSEARRVGMADANSPPKPLSKPRTPRRSKSDGEAKRSRDPPASASQV
TGIRAEPSPSPRITRKSTRQTTITSHFAKGPAKRKPQEESERAKSDESIKEEDKDQDE
KRRRVTSRERVARPLPAEEPERAKSGTRTEKEEERDEKEEKRLRSQTKEPTPKQKLKE
EPDREARAGVQADEDEDGDEKDEKKHRSQPKDLAAKRRPEEKEPEKVNPQISDEKDED
EKEEKRRKTTPKEPTEKKMARAKTVMNSKTHPPKCIQCGQYLDDPDLKYGQHPPDAVD
EPQMLTNEKLSIFDANESGFESYEALPQHKLTCFSVYCKHGHLCPIDTGLIEKNIELF
FSGSAKPIYDDDPSLEGGVNGKNLGPINEWWITGFDGGEKALIGFSTSFAEYILMDPS
PEYAPIFGLMQEKIYISKIVVEFLQSNSDSTYEDLINKIETTVPPSGLNLNRFTEDSL
LRHAQFVVEQVESYDEAGDSDEQPIFLTPCMRDLIKLAGVTLGQRRAQARRQTIRHST
REKDRGPTKATTTKLVYQIFDTFFAEQIEKDDREDKENAFKRRRCGVCEVCQQPECGK
CKACKDMVKFGGSGRSKQACQERRCPNMAMKEADDDEEVDDNIPEMPSPKKMHQGKKK
KQNKNRISWVGEAVKTDGKKSYYKKVCIDAETLEVGDCVSVIPDDSSKPLYLARVTAL
WEDSSNGQMFHAHWFCAGTDTVLGATSDPLELFLVDECEDMQLSYIHSKVKVIYKAPS
ENWAMEGGMDPESLLEGDDGKTYFYQLWYDQDYARFESPPKTQPTEDNKFKFCVSCAR
LAEMRQKEIPRVLEQLEDLDSRVLYYSATKNGILYRVGDGVYLPPEAFTFNIKLSSPV
KRPRKEPVDEDLYPEHYRKYSDYIKGSNLDAPEPYRIGRIKEIFCPKKSNGRPNETDI
KIRVNKFYRPENTHKSTPASYHADINLLYWSDEEAVVDFKAVQGRCTVEYGEDLPECV
QVYSMGGPNRFYFLEAYNAKSKSFEDPPNHARSPGNKGKGKGKGKGKPKSQACEPSEP
EIEIKLPKLRTLDVFSGCGGLSEGFHQAGISDTLWAIEMWDPAAQAFRLNNPGSTVFT
EDCNILLKLVMAGETTNSRGQRLPQKGDVEMLCGGPPCQGFSGMNRFNSRTYSKFKNS
LVVSFLSYCDYYRPRFFLLENVRNFVSFKRSMVLKLTLRCLVRMGYQCTFGVLQAGQY
GVAQTRRRAIILAAAPGEKLPLFPEPLHVFAPRACQLSVVVDDKKFVSNITRLSSGPF
RTITVRDTMSDLPEVRNGASALEISYNGEPQSWFQRQLRGAQYQPILRDHICKDMSAL
VAARMRHIPLAPGSDWRDLPNIEVRLSDGTMARKLRYTHHDRKNGRSSSGALRGVCSC
VEAGKACDPAARQFNTLIPWCLPHTGNRHNHWAGLYGRLEWDGFFSTTVTNPEPMGKQ
GRVLHPEQHRVVSVRECARSQGFPDTYRLFGNILDKHRQVGNAVPPPLAKAIGLEIKL
CMLAKARESASAKIKEEEAAKD"
BASE COUNT 1345 a 1461 c 1466 g 934 t
ORIGIN
1 ggctccgttc catccttctg cacagggtat cgcctctctc cgtttggtac atcccctcct
61 cccccacgcc cggactgggg tggtagacgc cgcctccgct catcgcccct ccccatcggt
121 ttccgcgcga aaagccgggg cgcctgcgct gccgccgccg cgtctgctga agcctccgag
181 atgccggcgc gtaccgcccc agcccgggtg cccacactgg ccgtcccggc catctcgctg
241 cccgacgatg tccgcaggcg gctcaaagat ttggaaagag acagcttaac agaaaaggaa
301 tgtgtgaagg agaaattgaa tctcttgcac gaatttctgc aaacagaaat aaagaatcag
361 ttatgtgact tggaaaccaa attacgtaaa gaagaattat ccgaggaggg ctacctggct
421 aaagtcaaat cccttttaaa taaagatttg tccttggaga acggtgctca tgcttacaac
481 cgggaagtga atggacgtct agaaaacggg aaccaagcaa gaagtgaagc ccgtagagtg
541 ggaatggcag atgccaacag cccccccaaa cccctttcca aacctcgcac gcccaggagg
601 agcaagtccg atggagaggc taagcgttca agagaccctc ctgcctcagc ctcccaagta
661 actgggatta gagctgaacc ttcacctagc cccaggatta caaggaaaag caccaggcaa
721 accaccatca catctcattt tgcaaagggc cctgccaaac ggaaacctca ggaagagtct
781 gaaagagcca aatcggatga gtccatcaag gaagaagaca aagaccagga tgagaagaga
841 cgtagagtta catccagaga acgagttgct agaccgcttc ctgcagaaga acctgaaaga
901 gcaaaatcag gaacgcgcac tgaaaaggaa gaagaaagag atgaaaaaga agaaaagaga
961 ctccgaagtc aaaccaaaga accaacaccc aaacagaaac tgaaggagga gccggacaga
1021 gaagccaggg caggcgtgca ggctgacgag gacgaagatg gagacgagaa agatgagaag
1081 aagcacagaa gtcaacccaa agatctagct gccaaacgga ggcccgaaga aaaagaacct
1141 gaaaaagtaa atccacagat ttctgatgaa aaagacgagg atgaaaagga ggagaagaga
1201 cgcaaaacga cccccaaaga accaacggag aaaaaaatgg ctcgcgccaa aacagtcatg
1261 aactccaaga cccaccctcc caagtgcatt cagtgcgggc agtacctgga cgaccctgac
1321 ctcaaatatg ggcagcaccc accagacgcg gtggatgagc cacagatgct gacaaatgag
1381 aagctgtcca tctttgatgc caacgagtct ggctttgaga gttatgaggc gcttccccag
1441 cacaaactga cctgcttcag tgtgtactgt aagcacggtc acctgtgtcc catcgacacc
1501 ggcctcatcg agaagaatat cgaactcttc ttttctggtt cagcaaaacc aatctatgat
1561 gatgacccgt ctcttgaagg tggtgttaat ggcaaaaatc ttggccccat aaatgaatgg
1621 tggatcactg gctttgatgg aggtgaaaag gccctcatcg gcttcagcac ctcatttgcc
1681 gaatacattc tgatggatcc cagtcccgag tatgcgccca tatttgggct gatgcaggag
1741 aagatctaca tcagcaagat tgtggtggag ttcctgcaga gcaattccga ctcgacctat
1801 gaggacctga tcaacaagat cgagaccacg gttcctcctt ctggcctcaa cttgaaccgc
1861 ttcacagagg actccctcct gcgacacgcg cagtttgtgg tggagcaggt ggagagttat
1921 gacgaggccg gggacagtga tgagcagccc atcttcctga cgccctgcat gcgggacctg
1981 atcaagctgg ctggggtcac gctgggacag aggcgagccc aggcgaggcg gcagaccatc
2041 aggcattcta ccagggagaa ggacagggga cccacgaaag ccaccaccac caagctggtc
2101 taccagatct tcgatacttt cttcgcagag caaattgaaa aggatgacag agaagacaag
2161 gagaacgcct ttaagcgccg gcgatgtggc gtctgtgagg tgtgtcagca gcctgagtgt
2221 gggaaatgta aagcctgcaa ggacatggtt aaatttggtg gcagtggacg gagcaagcag
2281 gcttgccaag agcggaggtg tcccaatatg gccatgaagg aggcagatga cgatgaggaa
2341 gtcgatgata acatcccaga gatgccgtca cccaaaaaaa tgcaccaggg gaagaagaag
2401 aaacagaaca agaatcgcat ctcttgggtc ggagaagccg tcaagactga tgggaagaag
2461 agttactata agaaggtgtg cattgatgcg gaaaccctgg aagtggggga ctgtgtctct
2521 gttattccag atgattcctc aaaaccgctg tatctagcaa gggtcacggc gctgtgggag
2581 gacagcagca acgggcagat gtttcacgcc cactggttct gcgctgggac agacacagtc
2641 ctcggggcca cgtcggaccc tctggagctg ttcttggtgg atgaatgtga ggacatgcag
2701 ctttcatata tccacagcaa agtgaaagtc atctacaaag ccccctccga aaactgggcc
2761 atggagggag gcatggatcc cgagtccctg ctggaggggg acgacgggaa gacctacttc
2821 taccagctgt ggtatgatca agactacgcg agattcgagt cccctccaaa aacccagcca
2881 acagaggaca acaagttcaa attctgtgtg agctgtgccc gtctggctga gatgaggcaa
2941 aaagaaatcc ccagggtcct ggagcagctc gaggacctgg atagccgggt cctctactac
3001 tcagccacca agaacggcat cctgtaccga gttggtgatg gtgtgtacct gccccctgag
3061 gccttcacgt tcaacatcaa gctgtccagt cccgtgaaac gcccacggaa ggagcccgtg
3121 gatgaggacc tgtacccaga gcactaccgg aaatactccg actacatcaa aggcagcaac
3181 ctggatgccc ctgagcccta ccgaattggc cggatcaaag agatcttctg tcccaagaag
3241 agcaacggca ggcccaatga gactgacatc aaaatccggg tcaacaagtt ctacaggcct
3301 gagaacaccc acaagtccac tccagcgagc taccacgcag acatcaacct gctctactgg
3361 agcgacgagg aggccgtggt ggacttcaag gctgtgcagg gccgctgcac cgtggagtat
3421 ggggaggacc tgcccgagtg cgtccaggtg tactccatgg gcggccccaa ccgcttctac
3481 ttcctcgagg cctataatgc aaagagcaaa agctttgaag atcctcccaa ccatgcccgt
3541 agccctggaa acaaagggaa gggcaaggga aaagggaagg gcaagcccaa gtcccaagcc
3601 tgtgagccga gcgagccaga gatagagatc aagctgccca agctgcggac cctggatgtg
3661 ttttctggct gcggggggtt gtcggaggga ttccaccaag caggcatctc tgacacgctg
3721 tgggccatcg agatgtggga ccctgcggcc caggcgttcc ggctgaacaa ccccggctcc
3781 acagtgttca cagaggactg caacatcctg ctgaagctgg tcatggctgg ggagaccacc
3841 aactcccgcg gccagcggct gccccagaag ggagacgtgg agatgctgtg cggcgggccg
3901 ccctgccagg gcttcagcgg catgaaccgc ttcaattcgc gcacctactc caagttcaaa
3961 aactctctgg tggtttcctt cctcagctac tgcgactact accggccccg gttcttcctc
4021 ctggagaatg tcaggaactt tgtctccttc aagcgctcca tggtcctgaa gctcaccctc
4081 cgctgcctgg tccgcatggg ctatcagtgc accttcggcg tgctgcaggc cggtcagtac
4141 ggcgtggccc agactaggag gcgggccatc atcctggccg cggcccctgg agagaagctc
4201 cctctgttcc cggagccact gcacgtgttt gctccccggg cctgccagct gagcgtggtg
4261 gtggatgaca agaagtttgt gagcaacata accaggttga gctcgggtcc tttccggacc
4321 atcacggtgc gagacacgat gtccgacctg ccggaggtgc ggaatggagc ctcggcactg
4381 gagatctcct acaacgggga gcctcagtcc tggttccaga ggcagctccg gggcgcacag
4441 taccagccca tcctcaggga ccacatctgt aaggacatga gtgcattggt ggctgcccgc
4501 atgcggcaca tccccttggc cccagggtca gactggcgcg atctgcccaa catcgaggtg
4561 cggctctcag acggcaccat ggccaggaag ctgcggtata cccaccatga caggaagaac
4621 ggccgcagca gctctggggc cctccgtggg gtctgctcct gcgtggaagc cggcaaagcc
4681 tgcgaccccg cagccaggca gttcaacacc ctcatcccct ggtgcctgcc ccacaccggg
4741 aaccggcaca accactgggc tggcctctat ggaaggctcg agtgggacgg cttcttcagc
4801 acaaccgtca ccaaccccga gcccatgggc aagcagggcc gcgtgctcca cccagagcag
4861 caccgtgtgg tgagcgtgcg ggagtgtgcc cgctcccagg gcttccctga cacctaccgg
4921 ctcttcggca acatcctgga caagcaccgg caggtgggca atgccgtgcc accgcccctg
4981 gccaaagcca ttggcttgga gatcaagctt tgtatgttgg ccaaagcccg agagagtgcc
5041 tcagctaaaa taaaggagga ggaagctgct aaggactagt tctgccctcc cgtcacccct
5101 gtttctggca ccaggaatcc ccaacatgca ctgatgttgt gtttttaaca tgtcaatctg
5161 tccgttcaca tgtgtggtac atggtgtttg tggccttggc tgacat
//