LOCUS BC143756 4001 bp mRNA linear HUM 18-MAR-2009
DEFINITION Homo sapiens NPC1 (Niemann-Pick disease, type C1, gene)-like 1,
mRNA (cDNA clone MGC:177287 IMAGE:9052270), complete cds.
ACCESSION BC143756
VERSION BC143756.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4001)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 4001)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (12-JUN-2007) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: Mike Brownstein, NIMH
cDNA Library Preparation: British Columbia Cancer Research Center
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Genome Sequence Centre,
BC Cancer Agency, Vancouver, BC, Canada
info@bcgsc.bc.ca
Martin Hirst, Thomas Zeng, Ryan Morin, Michelle Moksa, Johnson
Pang, Diana Mah, Jing Wang, Kieth Fichter, Eric Chuah, Allen
Delaney, Rob Kirkpatrick, Agnes Baross, Sarah Barber, Mabel
Brown-John, Steve S. Chand, William Chow, Ryan Babakaiff, Dave
Wong, Corey Matsuo, Jaclyn Beland, Susan Gibson, Luis delRio, Ruth
Featherstone, Malachi Griffith, Obi Griffith, Ran Guin, Nancy Liao,
Kim MacDonald, Mike R. Mayo, Josh Moran, Diana Palmquist, JR
Santos, Duane Smailus, Jeff Stott, Miranda Tsai, George Yang,
Jacquie Schein, Asim Siddiqui,Steven Jones, Rob Holt, Marco Marra.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRCB Plate: 16 Row: E Column: 14.
FEATURES Location/Qualifiers
source 1..4001
/db_xref="H-InvDB:HIT000502199"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:177287 IMAGE:9052270"
/tissue_type="Liver, PCR rescued clones"
/clone_lib="NIH_MGC_292"
/note="Vector: pCR-XL-TOPO; Clone identification sequence
tag: AAAGGAAG"
gene 1..4001
/gene="NPC1L1"
/gene_synonym="NPC11L1"
/db_xref="GeneID:29881"
/db_xref="HGNC:HGNC:7898"
/db_xref="MIM:608010"
CDS 55..3915
/gene="NPC1L1"
/gene_synonym="NPC11L1"
/codon_start=1
/product="NPC1L1 protein"
/protein_id="AAI43757.1"
/db_xref="GeneID:29881"
/db_xref="HGNC:HGNC:7898"
/db_xref="MIM:608010"
/translation="MAEAGLRGWLLWALLLRLAQSEPYTTIHQPGYCAFYDECGKNPE
LSGSLMTLSNVSCLSNTPARKITGDHLILLQKICPRLYTGPNTQACCSAKQLVSLEAS
LSITKALLTRCPACSDNFVNLHCHNTCSPNQSLFINVTRVAQLGAGQLPAVVAYEAFY
QHSFAEQSYDSCSRVRVPAAATLAVGTMCGVYGSALCNAQRWLNFQGDTGNGLAPLDI
TFHLLEPGQAVGSGIQPLNEGVARCNESQGDDVATCSCQDCAASCPAIARPQALDSTF
YLGQMPGSLVLIIILCSVFAVVTILLVGFRVAPARDKSKMVDPKKGTSLSDKLSFSTH
TLLGQFFQGWGTWVASWPLTILVLSVIPVVALAAGLVFTELTTDPVELWSAPNSQARS
EKAFHDQHFGPFFRTNQVILTAPNRSSYRYDSLLLGPKNFSGILDLDLLLELLELQER
LRHLQVWSPEAQRNISLQDICYAPLNPDNTSLYDCCINSLLQYFQNNRTLLLLTANQT
LMGQTSQVDWKDHFLYCANAPLTFKDGTALALSCMADYGAPVFPFLAIGGYKGKDYSE
AEALIMTFSLNNYPAGDPRLAQAKLWEEAFLEEMRAFQRRMAGMFQVTFMAERSLEDE
INRTTAEDLPIFATSYIVIFLYISLALGSYSSWSRVMVDSKATLGLGGVAVVLGAVMA
AMGFFSYLGIRSSLVILQVVPFLVLSVGADNIFIFVLEYQRLPRRPGEPREVHIGRAL
GRVAPSMLLCSLSEAICFFLGALTPMPAVRTFALTSGLAVILDFLLQMSAFVALLSLD
SKRQEASRLDVCCCVKPQELPPPGQGEGLLLGFFQKAYAPFLLHWITRGVVVGAPVYF
VTTLGYNFSSEAGMNAICSSAGCNNFSFTQKIQYATEFPEQSYLAIPASSWVDDFIDW
LTPSSCCRLYISGPNKDKFCPSTVNSLNCLKNCMSITMGSVRPSVEQFHKYLPWFLND
RPNIKCPKGGLAAYSTSVNLTSDGQVLASRFMAYHKPLKNSQDYTEALRAARELAANI
TADLRKVPGTDPAFEVFPYTITNVFYEQYLTILPEGLFMLSLCLVPTFAVSCLLLGLD
LRSGLLNLLSIVMILVDTVGFMALWGISYNAVSLINLVSAVGMSVEFVSHITRSFAIS
TKPTWLERAKEATISMGSAVFAGVAMTNLPGILVLGLAKAQLIQIFFFRLNLLITLLG
LLHGLVFLPVILSYVGPDVNPALALEQKRAEEAVAAVMVASCPNHPSRVSTADNIYVN
HSFEGSIKGAGAISNFLPNNGRQF"
BASE COUNT 722 a 1319 c 1063 g 897 t
ORIGIN
1 tggctgttcc tgaggcctgg cctggctccc cgctgacccc ttcccagacc tgggatggcg
61 gaggccggcc tgaggggctg gctgctgtgg gccctgctcc tgcgcttggc ccagagtgag
121 ccttacacaa ccatccacca gcctggctac tgcgccttct atgacgaatg tgggaagaac
181 ccagagctgt ctggaagcct catgacactc tccaacgtgt cctgcctgtc caacacgccg
241 gcccgcaaga tcacaggtga tcacctgatc ctattacaga agatctgccc ccgcctctac
301 accggcccca acacccaagc ctgctgctcc gccaagcagc tggtatcact ggaagcgagt
361 ctgtcgatca ccaaggccct cctcacccgc tgcccagcct gctctgacaa ttttgtgaac
421 ctgcactgcc acaacacgtg cagccccaat cagagcctct tcatcaatgt gacccgcgtg
481 gcccagctag gggctggaca actcccagct gtggtggcct atgaggcctt ctaccagcat
541 agctttgccg agcagagcta tgactcctgc agccgtgtgc gcgtccctgc agctgccacg
601 ctggctgtgg gcaccatgtg tggcgtgtat ggctctgccc tttgcaatgc ccagcgctgg
661 ctcaacttcc agggagacac aggcaatggt ctggccccac tggacatcac cttccacctc
721 ttggagcctg gccaggccgt ggggagtggg attcagcctc tgaatgaggg ggttgcacgt
781 tgcaatgagt cccaaggtga cgacgtggcg acctgctcct gccaagactg tgctgcatcc
841 tgtcctgcca tagcccgccc ccaggccctg gactccacct tctacctggg ccagatgccg
901 ggcagtctgg tcctcatcat catcctctgc tctgtcttcg ctgtggtcac catcctgctt
961 gtgggattcc gtgtggcccc cgccagggac aaaagcaaga tggtggaccc caagaagggc
1021 accagcctct ctgacaagct cagcttctcc acccacaccc tccttggcca gttcttccag
1081 ggctggggca cgtgggtggc ttcgtggcct ctgaccatct tggtgctatc tgtcatcccg
1141 gtggtggcct tggcagcggg cctggtcttt acagaactca ctacggaccc cgtggagctg
1201 tggtcggccc ccaacagcca agcccggagt gagaaagctt tccatgacca gcatttcggc
1261 cccttcttcc gaaccaacca ggtgatcctg acggctccta accggtccag ctacaggtat
1321 gactctctgc tgctggggcc caagaacttc agcggaatcc tggacctgga cttgctgctg
1381 gagctgctag agctgcagga gaggctgcgg cacctccagg tatggtcgcc cgaagcacag
1441 cgcaacatct ccctgcagga catctgctac gcccccctca atccggacaa taccagtctc
1501 tacgactgct gcatcaacag cctcctgcag tatttccaga acaaccgcac gctcctgctg
1561 ctcacagcca accagacact gatggggcag acctcccaag tcgactggaa ggaccatttt
1621 ctgtactgtg ccaatgcccc gctcaccttc aaggatggca cagccctggc cctgagctgc
1681 atggctgact acggggcccc tgtcttcccc ttccttgcca ttggggggta caaaggaaag
1741 gactattctg aggcagaggc cctgatcatg acgttctccc tcaacaatta ccctgccggg
1801 gacccccgtc tggcccaggc caagctgtgg gaggaggcct tcttagagga aatgcgagcc
1861 ttccagcgtc ggatggctgg catgttccag gtcacgttca tggctgagcg ctctctggaa
1921 gacgagatca atcgcaccac agctgaagac ctgcccatct ttgccaccag ctacattgtc
1981 atattcctgt acatctctct ggccctgggc agctattcca gctggagccg agtgatggtg
2041 gactccaagg ccacgctggg cctcggcggg gtggccgtgg tcctgggagc agtcatggct
2101 gccatgggct tcttctccta cttgggtatc cgctcctccc tggtcatcct gcaagtggtt
2161 cctttcctgg tgctgtccgt gggggctgat aacatcttca tctttgttct cgagtaccag
2221 aggctgcccc ggaggcctgg ggagccacga gaggtccaca ttgggcgagc cctaggcagg
2281 gtggctccca gcatgctgtt gtgcagcctc tctgaggcca tctgcttctt cctaggggcc
2341 ctgaccccca tgccagctgt gcggaccttt gccctgacct ctggccttgc agtgatcctt
2401 gacttcctcc tgcagatgtc agcctttgtg gccctgctct ccctggacag caagaggcag
2461 gaggcctccc ggttggacgt ctgctgctgt gtcaagcccc aggagctgcc cccgcctggc
2521 cagggagagg ggctcctgct tggcttcttc caaaaggctt atgccccctt cctgctgcac
2581 tggatcactc gaggtgttgt ggtgggggcc ccggtgtact ttgttaccac cttgggctac
2641 aacttctcca gcgaggctgg gatgaatgcc atctgctcca gtgcaggctg caacaacttc
2701 tccttcaccc agaagatcca gtatgccaca gagttccctg agcagtctta cctggccatc
2761 cctgcctcct cctgggtgga tgacttcatt gactggctga ccccgtcctc ctgctgccgc
2821 ctttatatat ctggccccaa taaggacaag ttctgcccct cgaccgtcaa ctctctgaac
2881 tgcctaaaga actgcatgag catcacgatg ggctctgtga ggccctcggt ggagcagttc
2941 cataagtatc ttccctggtt cctgaacgac cggcccaaca tcaaatgtcc caaaggcggc
3001 ctggcagcat acagcacctc tgtgaacttg acttcagatg gccaggtttt agcctccagg
3061 ttcatggcct atcacaagcc cctgaaaaac tcacaggatt acacagaagc tctgcgggca
3121 gctcgagagc tggcagccaa catcactgct gacctgcgga aagtgcctgg aacagacccg
3181 gcttttgagg tcttccccta cacgatcacc aatgtgtttt atgagcagta cctgaccatc
3241 ctccctgagg ggctcttcat gctcagcctc tgccttgtgc ccaccttcgc tgtctcctgc
3301 ctcctgctgg gcctggacct gcgctccggc ctcctcaacc tgctctccat tgtcatgatc
3361 ctcgtggaca ctgtcggctt catggccctg tggggcatca gttacaatgc tgtgtccctc
3421 atcaacctgg tctcggcggt gggcatgtct gtggagtttg tgtcccacat tacccgctcc
3481 tttgccatca gcaccaagcc cacctggctg gagagggcca aagaggccac catctctatg
3541 ggaagtgcgg tgtttgcagg tgtggccatg accaacctgc ctggcatcct tgtcctgggc
3601 ctcgccaagg cccagctcat tcagatcttc ttcttccgcc tcaacctcct gatcactctg
3661 ctgggcctgc tgcatggctt ggtcttcctg cccgtcatcc tcagctacgt ggggcctgac
3721 gttaacccgg ctctggcact ggagcagaag cgggctgagg aggcggtggc agcagtcatg
3781 gtggcctctt gcccaaatca cccctcccga gtctccacag ctgacaacat ctatgtcaac
3841 cacagctttg aaggttctat caaaggtgct ggtgccatca gcaacttctt gcccaacaat
3901 gggcggcagt tctgatacag ccagaggccc tgtctaggct ctatggccct gaaccaaagg
3961 gttatgggga tcttccttgt gactgcccct tgacacacgc c
//