LOCUS BC143614 1635 bp mRNA linear HUM 18-MAR-2009
DEFINITION Homo sapiens tyrosine hydroxylase, mRNA (cDNA clone MGC:177144
IMAGE:9052127), complete cds.
ACCESSION BC143614
VERSION BC143614.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1635)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 1635)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (12-JUN-2007) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: Mike Brownstein, NIMH
cDNA Library Preparation: British Columbia Cancer Research Center
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Genome Sequence Centre,
BC Cancer Agency, Vancouver, BC, Canada
info@bcgsc.bc.ca
Martin Hirst, Thomas Zeng, Ryan Morin, Michelle Moksa, Johnson
Pang, Diana Mah, Jing Wang, Kieth Fichter, Eric Chuah, Allen
Delaney, Rob Kirkpatrick, Agnes Baross, Sarah Barber, Mabel
Brown-John, Steve S. Chand, William Chow, Ryan Babakaiff, Dave
Wong, Corey Matsuo, Jaclyn Beland, Susan Gibson, Luis delRio, Ruth
Featherstone, Malachi Griffith, Obi Griffith, Ran Guin, Nancy Liao,
Kim MacDonald, Mike R. Mayo, Josh Moran, Diana Palmquist, JR
Santos, Duane Smailus, Jeff Stott, Miranda Tsai, George Yang,
Jacquie Schein, Asim Siddiqui,Steven Jones, Rob Holt, Marco Marra.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRCB Plate: 15 Row: L Column: 14.
FEATURES Location/Qualifiers
source 1..1635
/db_xref="H-InvDB:HIT000502064"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:177144 IMAGE:9052127"
/tissue_type="Brain, cerebral cortex and lung, PCR rescued
clones"
/clone_lib="NIH_MGC_322"
/note="Vector: pCR4-TOPO; Clone identification sequence
tag: GGTCCTGC"
gene 1..1635
/gene="TH"
/gene_synonym="TYH"
/db_xref="GeneID:7054"
/db_xref="HGNC:HGNC:11782"
/db_xref="MIM:191290"
CDS 92..1597
/gene="TH"
/gene_synonym="TYH"
/codon_start=1
/product="TH protein"
/protein_id="AAI43615.1"
/db_xref="GeneID:7054"
/db_xref="HGNC:HGNC:11782"
/db_xref="MIM:191290"
/translation="MPTPDATTPQAKGFRRAVSELDAKQAEAIMVRGQSPRFIGRRQS
LIEDARKEREAAVAAAAAAVPSEPGDPLEAVAFEEKEGKAMLNLLFSPRATKPSALSR
AVKVFETFEAKIHHLETRPAQRPRAGGPHLEYFVRLEVRRGDLAALLSGVRQVSEDVR
SPAGPKVPWFPRKVSELDKCHHLVTKFDPDLDLDHPGFSDQVYRQRRKLIAEIAFQYR
HGDPIPRVEYTAEEIATWKEVYTTLKGLYATHACGEHLEAFALLERFSGYREDNIPQL
EDVSRFLKERTGFQLRPVAGLLSARDFLASLAFRVFQCTQYIRHASSPMHSPEPDCCH
ELLGHVPMLADHTFAQFSQDIGLASLGASDEEIEKLSTLYWFTVEFGLCKQNGEVKAY
GAGLLSSYGELLHCLSEEPEIRAFDPEAAAVQPYQDQTYQSVYFVSESFSDAKDKLRS
YASRIQRPFSVKFDPYTLAIDVLDSPQAVRRSLEGVQDELDTLAHALSAIG"
BASE COUNT 284 a 544 c 529 g 278 t
ORIGIN
1 ggacccagag ggggctttga cgtcagctca gcttataaga ggctgctggg ccagggctgt
61 ggagacggag cccggacctc cacactgagc catgcccacc cccgacgcca ccacgccaca
121 ggccaagggc ttccgcaggg ccgtgtctga gctggacgcc aagcaggcag aggccatcat
181 ggtaagaggg cagtccccgc ggttcattgg gcgcaggcag agcctcatcg aggacgcccg
241 caaggagcgg gaggcggcgg tggcagcagc ggccgctgca gtcccctcgg agcccgggga
301 ccccctggag gctgtggcct ttgaggagaa ggaggggaag gccatgctaa acctgctctt
361 ctccccgagg gccaccaagc cctcggcgct gtcccgagct gtgaaggtgt ttgagacgtt
421 tgaagccaaa atccaccatc tagagacccg gcccgcccag aggccgcgag ctgggggccc
481 ccacctggag tacttcgtgc gcctcgaggt gcgccgaggg gacctggccg ccctgctcag
541 tggtgtgcgc caggtgtcag aggacgtgcg cagccccgcg gggcccaagg tcccctggtt
601 cccaagaaaa gtgtcagagc tggacaagtg tcatcacctg gtcaccaagt tcgaccctga
661 cctggacttg gaccacccgg gcttctcgga ccaggtgtac cgccagcgca ggaagctgat
721 tgctgagatc gccttccagt acaggcacgg cgacccgatt ccccgtgtgg agtacaccgc
781 cgaggagatt gccacctgga aggaggtcta caccacgctg aagggcctct acgccacgca
841 cgcctgcggg gagcacctgg aggcctttgc tttgctggag cgcttcagcg gctaccggga
901 agacaatatc ccccagctgg aggacgtctc ccgcttcctg aaggagcgca cgggcttcca
961 gctgcggcct gtggccggcc tgctgtccgc ccgggacttc ctggccagcc tggccttccg
1021 cgtgttccag tgcacccagt atatccgcca cgcgtcctcg cccatgcact cccctgagcc
1081 ggactgctgc cacgagctgc tggggcacgt gcccatgctg gccgaccaca ccttcgcgca
1141 gttctcgcag gacattggcc tggcgtccct gggggcctcg gatgaggaaa ttgagaagct
1201 gtccacgctg tactggttca cggtggagtt cgggctgtgt aagcagaacg gggaggtgaa
1261 ggcctatggt gccgggctgc tgtcctccta cggggagctc ctgcactgcc tgtctgagga
1321 gcctgagatt cgggccttcg accctgaggc tgcggccgtg cagccctacc aagaccagac
1381 gtaccagtca gtctacttcg tgtctgagag cttcagtgac gccaaggaca agctcaggag
1441 ctatgcctca cgcatccagc gccccttctc cgtgaagttc gacccgtaca cgctggccat
1501 cgacgtgctg gacagccccc aggccgtgcg gcgctccctg gagggtgtcc aggatgagct
1561 ggacaccctt gcccatgcgc tgagtgccat tggctaggtg cacggcgtcc ctgagggccc
1621 ttcccaacct cccct
//