LOCUS       BC143611                1629 bp    mRNA    linear   HUM 08-JAN-2009
DEFINITION  Homo sapiens tyrosine hydroxylase, mRNA (cDNA clone MGC:177141
            IMAGE:9052124), complete cds.
ACCESSION   BC143611
VERSION     BC143611.1
KEYWORDS    MGC.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1629)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
   PUBMED   12477932
REFERENCE   2  (bases 1 to 1629)
  CONSRTM   NIH MGC Project
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2007) National Institutes of Health, Mammalian
            Gene Collection (MGC), Bethesda, MD 20892-2590, USA
  REMARK    NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT     Contact: MGC help desk
            Email: cgapbs-r@mail.nih.gov
            Tissue Procurement: Mike Brownstein, NIMH
            cDNA Library Preparation: British Columbia Cancer Research Center
            cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
            DNA Sequencing by: Genome Sequence Centre,
            BC Cancer Agency, Vancouver, BC, Canada
            info@bcgsc.bc.ca
            Martin Hirst, Thomas Zeng, Ryan Morin, Michelle Moksa, Johnson
            Pang, Diana Mah, Jing Wang, Kieth Fichter, Eric Chuah, Allen
            Delaney, Rob Kirkpatrick, Agnes Baross, Sarah Barber, Mabel
            Brown-John, Steve S. Chand, William Chow, Ryan Babakaiff, Dave
            Wong, Corey Matsuo, Jaclyn Beland, Susan Gibson, Luis delRio, Ruth
            Featherstone, Malachi Griffith, Obi Griffith, Ran Guin, Nancy Liao,
            Kim MacDonald,  Mike R. Mayo, Josh Moran, Diana Palmquist, JR
            Santos, Duane Smailus, Jeff Stott, Miranda Tsai, George Yang,
            Jacquie Schein, Asim Siddiqui,Steven Jones, Rob Holt, Marco Marra.
            
            Clone distribution: MGC clone distribution information can be found
            through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
            Series: IRCB Plate: 15 Row: L Column: 12.
FEATURES             Location/Qualifiers
     source          1..1629
                     /db_xref="H-InvDB:HIT000502061"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /clone="MGC:177141 IMAGE:9052124"
                     /tissue_type="Brain, cerebral cortex and lung, PCR rescued
                     clones"
                     /clone_lib="NIH_MGC_323"
                     /note="Vector: pCR4-TOPO with reversed insert; Clone
                     identification sequence tag: AGTCAGCA"
     gene            1..1629
                     /gene="TH"
                     /gene_synonym="TYH"
                     /db_xref="GeneID:7054"
                     /db_xref="HGNC:HGNC:11782"
                     /db_xref="MIM:191290"
     CDS             90..1583
                     /gene="TH"
                     /gene_synonym="TYH"
                     /codon_start=1
                     /product="tyrosine hydroxylase"
                     /protein_id="AAI43612.1"
                     /db_xref="GeneID:7054"
                     /db_xref="HGNC:HGNC:11782"
                     /db_xref="MIM:191290"
                     /translation="MPTPDATTPQAKGFRRAVSELDAKQAEAIMSPRFIGRRQSLIED
                     ARKEREAAVAAAAAAVPSEPGDPLEAVAFEEKEGKAVLNLLFSPRATKPSALSRAVKV
                     FETFEAKIHHLETRPAQRPRAGGPHLEYFVRLEVRRGDLAALLSGVRQVSEDVRSPAG
                     PKVPWFPRKVSELDKCHHLVTKFDPDLDLDHPGFSDQVYRQRRKLIAEIAFQYRHGDP
                     IPRVEYTAEEIATWKEVYTTLKGLYATHACGEHLEAFALLERFSGYREDNIPQLEDVS
                     RFLKERTGFQLRPVAGLLSARDFLASLAFRVFQCTQYIRHASSPMHSPEPDCCHELLG
                     HVPMLADRTFAQFSQDIGLASLGASDEEIEKLSTLYWFTVEFGLCKQNGEVKAYGAGL
                     LSSYGELLHCLSEEPEIRAFDPEAAAVQPYQDQTYQSVYFVSESFSDAKDKLRSYASR
                     IQRPFSVKFDPYTLAIDVLDSPQAVRRSLEGVQDELDTLAHALSAIG"
BASE COUNT          278 a          546 c          526 g          279 t
ORIGIN      
        1 acccagaggg ggctttgacg tcagctcagc ttataagagg ctgctgggcc agggctgtgg
       61 agacggagcc cggacctcca cactgagcca tgcccacccc cgacgccacc acgccacagg
      121 ccaagggctt ccgcagggcc gtgtctgagc tggacgccaa gcaggcagag gccatcatgt
      181 ccccgcggtt cattgggcgc aggcagagcc tcatcgagga cgcccgcaag gagcgggagg
      241 cggcggtggc agcagcggcc gctgcagtcc cctcggagcc cggggacccc ctggaggctg
      301 tggcctttga ggagaaggag gggaaggccg tgctaaacct gctcttctcc ccgagggcca
      361 ccaagccctc ggcgctgtcc cgagctgtga aggtgtttga gacgtttgaa gccaaaatcc
      421 accatctaga gacccggccc gcccagaggc cgcgagctgg gggcccccac ctggagtact
      481 tcgtgcgcct cgaggtgcgc cgaggggacc tggccgccct gctcagtggt gtgcgccagg
      541 tgtcagagga cgtgcgcagc cccgcggggc ccaaggtccc ctggttccca agaaaagtgt
      601 cagagctgga caagtgtcat cacctggtca ccaagttcga ccctgacctg gacttggacc
      661 acccgggctt ctcggaccag gtgtaccgcc agcgcaggaa gctgattgct gagatcgcct
      721 tccagtacag gcacggcgac ccgattcccc gtgtggagta caccgccgag gagattgcca
      781 cctggaagga ggtctacacc acgctgaagg gcctctacgc cacgcacgcc tgcggggagc
      841 acctggaggc ctttgctttg ctggagcgct tcagcggcta ccgggaagac aatatccccc
      901 agctggagga cgtctcccgc ttcctgaagg agcgcacggg cttccagctg cggcctgtgg
      961 ccggcctgct gtccgcccgg gacttcctgg ccagcctggc cttccgcgtg ttccagtgca
     1021 cccagtatat ccgccacgcg tcctcgccca tgcactcccc tgagccggac tgctgccacg
     1081 agctgctggg gcacgtgccc atgctggccg accgcacctt cgcgcagttc tcgcaggaca
     1141 ttggcctggc gtccctgggg gcctcggatg aggaaattga gaagctgtcc acgctgtact
     1201 ggttcacggt ggagttcggg ctgtgtaagc agaacgggga ggtgaaggcc tatggtgccg
     1261 ggctgctgtc ctcctacggg gagctcctgc actgcctgtc tgaggagcct gagattcggg
     1321 ccttcgaccc tgaggctgcg gccgtgcagc cctaccaaga ccagacgtac cagtcagtct
     1381 acttcgtgtc tgagagcttc agtgacgcca aggacaagct caggagctat gcctcacgca
     1441 tccagcgccc cttctccgtg aagttcgacc cgtacacgct ggccatcgac gtgctggaca
     1501 gcccccaggc cgtgcggcgc tccctggagg gtgtccagga tgagctggac acccttgccc
     1561 atgcgctgag tgccattggc taggtgcacg gcgtccctga gggcccttcc caacctcccc
     1621 tggtcctgc
//